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https://www.readbyqxmd.com/read/29096790/reverse-j-curve-relationship-between-on-treatment-blood-pressure-and-mortality-in-patients-with-heart-failure
#1
Sang Eun Lee, Hae-Young Lee, Hyun-Jai Cho, Won-Seok Choe, Hokon Kim, Jin-Oh Choi, Eun-Seok Jeon, Min-Seok Kim, Kyung-Kuk Hwang, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Myeong-Chan Cho, Jae-Joong Kim, Byung-Hee Oh
OBJECTIVES: This study aimed to assess the relationship between on-treatment blood pressure (BP) and clinical outcomes of patients with heart failure (HF). BACKGROUND: Lower BP has been reported to be related to increased mortality in various cardiovascular diseases. The optimal BP level for patients already experiencing HF is contentious. METHODS: The Korean Acute Heart Failure registry prospectively enrolled a total of 5,625 consecutive patients hospitalized for acute HF in 10 tertiary university hospitals in Korea between March 2011 and February 2014...
November 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29079633/hyponatraemia-and-its-prognosis-in-acute-heart-failure-is-related-to-right-ventricular-dysfunction
#2
Heesun Lee, Sang Eun Lee, Chan Soon Park, Jin Joo Park, Ga Yeon Lee, Min-Seok Kim, Jin-Oh Choi, Hyun-Jai Cho, Hae-Young Lee, Dong-Ju Choi, Eun-Seok Jeon, Jae-Joong Kim, Byung-Hee Oh
OBJECTIVES: Hyponatraemia is a well-known predictor of clinical outcomes in heart failure (HF). However, the mechanism remains poorly understood. Previous reports suggest that hyponatraemia is related to right HF. We sought to evaluate the association between right ventricular (RV) dysfunction and hyponatraemia, and the impact of this relationship on the prognosis of patients with acute heart failure (AHF). METHODS: This is a nested case-control study of the Korean Acute Heart Failure registry...
October 27, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29061303/unique-binding-mode-of-evogliptin-with-human-dipeptidyl-peptidase-iv
#3
Hyung Ki Lee, Mi-Kyung Kim, Ha Dong Kim, Heung Jae Kim, Ji Won Kim, Jie-Oh Lee, Chan-Wha Kim, Eunice EunKyeong Kim
Evogliptin ((R)-4-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl) piperazine-2-one)) is a highly potent selective inhibitor of dipeptidyl peptidase IV (DPP4) that was approved for the treatment of type 2 diabetes in South Korea. In this study, we report the crystal structures of Evogliptin, DA-12166, and DA-12228 (S,R diastereomer of Evogliptin) complexed to human DPP4. Analysis of both the structures and inhibitory activities suggests that the binding of the trifluorophenyl moiety in the S1 pocket and the piperazine-2-one moiety have hydrophobic interactions with Phe357 in the S2 extensive subsite, and that the multiple hydrogen bonds made by the (R)-β-amine group in the S2 pocket and the contacts made by the (R)-tert-butyl group with Arg125 contribute to the high potency observed for Evogliptin...
October 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28960033/evaluation-of-the-efficacy-and-safety-of-da-9601-versus-its-new-formulation-da-5204-in-patients-with-gastritis-phase-iii-randomized-double-blind-non-inferiority-study
#4
Yoon Jin Choi, Dong Ho Lee, Myung Gyu Choi, Sung Joon Lee, Sung Kook Kim, Geun Am Song, Poong Lyul Rhee, Hwoon Yong Jung, Dae Hwan Kang, Yong Chan Lee, Si Hyung Lee, Suck Chei Choi, Ki Nam Shim, Sang Yong Seol, Jeong Seop Moon, Yong Woon Shin, Hyun Soo Kim, Soo Teik Lee, Jin Woong Cho, Eun Kwang Choi, Oh Young Lee, Jin Seok Jang
This study compared the efficacy of DA-9601 (Dong-A ST Co., Seoul, Korea) and its new formulation, DA-5204 (Dong-A ST Co.), for treating erosive gastritis. This phase III, randomized, multicenter, double-blind, non-inferiority trial randomly assigned 434 patients with endoscopically proven gastric mucosal erosions into two groups: DA-9601 3 times daily or DA-5,204 twice daily for 2 weeks. The final analysis included 421 patients (DA-5204, 209; DA-9601, 212). The primary endpoint (rate of effective gastric erosion healing) and secondary endpoints (cure rate of endoscopic erosion and gastrointestinal [GI] symptom relief) were assessed using endoscopy after the treatment...
November 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28955381/korean-guidelines-for-diagnosis-and-management-of-chronic-heart-failure
#5
REVIEW
Min-Seok Kim, Ju-Hee Lee, Eung Ju Kim, Dae-Gyun Park, Sung-Ji Park, Jin Joo Park, Mi-Seung Shin, Byung Su Yoo, Jong-Chan Youn, Sang Eun Lee, Sang Hyun Ihm, Se Yong Jang, Sang-Ho Jo, Jae Yeong Cho, Hyun-Jai Cho, Seonghoon Choi, Jin-Oh Choi, Seong Woo Han, Kyung Kuk Hwang, Eun Seok Jeon, Myeong-Chan Cho, Shung Chull Chae, Dong-Ju Choi
The prevalence of heart failure (HF) is skyrocketing worldwide, and is closely associated with serious morbidity and mortality. In particular, HF is one of the main causes for the hospitalization and mortality in elderly individuals. Korea also has these epidemiological problems, and HF is responsible for huge socioeconomic burden. However, there has been no clinical guideline for HF management in Korea. 
The present guideline provides the first set of practical guidelines for the management of HF in Korea and was developed using the guideline adaptation process while including as many data from Korean studies as possible...
September 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28950443/current-cytology-practices-in-korea-a-nationwide-survey-by-the-korean-society-for-cytopathology
#6
Eun Ji Oh, Chan Kwon Jung, Dong-Hoon Kim, Han Kyeom Kim, Wan Seop Kim, So-Young Jin, Hye Kyoung Yoon
Background: Limited data are available on the current status of cytology practices in Korea. This nationwide study presents Korean cytology statistics from 2015. Materials and Methods: A nationwide survey was conducted in 2016 as a part of the mandatory quality-control program by the Korean Society for Cytopathology. The questionnaire was sent to 208 medical institutions performing cytopathologic examinations in Korea. Individual institutions were asked to submit their annual cytology statistical reports and gynecologic cytology-histology correlation data for 2015...
September 27, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28919126/low-dose-ct-for-the-diagnosis-of-appendicitis-in-adolescents-and-young-adults-locat-a-pragmatic-multicentre-randomised-controlled-non-inferiority-trial
#7
(no author information available yet)
BACKGROUND: CT radiation is arguably carcinogenic. Results from single-centre studies, mostly retrospective, have advocated lowering the CT radiation dose for the diagnosis of appendicitis. However, adoption of low-dose CT has been slow. We aimed to assess the effectiveness of low-dose CT compared with standard-dose CT in the diagnosis of appendicitis in adolescents and young adults. METHODS: We did this pragmatic, multicentre, randomised controlled non-inferiority trial at 20 South Korean teaching hospitals with little experience with low-dose CT...
November 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28821416/short-and-long-term-prognostic-value-of-hyponatremia-in-heart-failure-with-preserved-ejection-fraction-versus-reduced-ejection-fraction-an-analysis-of-the-korean-acute-heart-failure-registry
#8
Jin Joo Park, Young-Jin Cho, Il-Young Oh, Hyun-Ah Park, Hae-Young Lee, Kye Hun Kim, Byung-Su Yoo, Seok-Min Kang, Sang Hong Baek, Eun-Seok Jeon, Jae-Joong Kim, Myeong-Chan Cho, Shung Chull Chae, Byung-Hee Oh, Dong-Ju Choi
BACKGROUND: Hyponatremia is a well-known risk factor for worse outcomes in heart failure (HF) patients. The impact of hyponatremia according to the ejection fraction (EF) is unclear. We evaluated the prognostic value of hyponatremia according to HF type. METHODS AND RESULTS: The Korea Acute Heart Failure (KorAHF) registry consecutively enrolled 5625 patients. Hyponatremia was defined as serum sodium level<135mmol/L at hospital admission. HF with preserved and reduced ejection fraction were defined as an LVEF ≥50% and LVEF ≤40%, respectively...
December 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28634823/a-nationwide-study-of-the-incidence-rate-of-herb-induced-liver-injury-in-korea
#9
Jung-Hyo Cho, Dal-Seok Oh, Sang-Hoon Hong, Heung Ko, Nam-Hun Lee, Sang-Eun Park, Chang-Woo Han, Seung-Mo Kim, Young-Chul Kim, Kang-San Kim, Chang-Won Choi, Seon-My Shin, Ki-Tae Kim, Hong-Sik Choi, Jang-Hoon Lee, Jun-Young Kim, Ji-Young Kang, Dong-Soo Lee, Yo-Chan Ahn, Chang-Gue Son
Discrepant incidence has been reported regarding the incidence of herb-induced liver injury (HILI). To address the growing worldwide concern of HILI, we evaluated the risk of HILI in a nationwide prospective study. Between April 2013 and January 2016, 1001 inpatients (360 males and 641 females) from 10 tertiary hospitals throughout South Korea were treated with herbal drugs and had their liver enzymes periodically measured. A total of six patients met the criteria for HILI with RUCAM scores ranging from 4 to 7...
June 20, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28567084/clinical-characteristics-and-outcome-of-acute-heart-failure-in-korea-results-from-the-korean-acute-heart-failure-registry-korahf
#10
Sang Eun Lee, Hae-Young Lee, Hyun-Jai Cho, Won-Seok Choe, Hokon Kim, Jin Oh Choi, Eun-Seok Jeon, Min-Seok Kim, Jae-Joong Kim, Kyung-Kuk Hwang, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Hyun-Young Park, Myeong-Chan Cho, Byung-Hee Oh
BACKGROUND AND OBJECTIVES: The burden of heart failure has increased in Korea. This registry aims to evaluate demographics, clinical characteristics, management, and long-term outcomes in patients hospitalized for acute heart failure (AHF). SUBJECTS AND METHODS: We prospectively enrolled a total of 5625 consecutive subjects hospitalized for AHF in one of 10 tertiary university hospitals from March 2011 to February 2014. Descriptive statistics were used to determine the baseline characteristics of the study population and to compare them with those from other registries...
May 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28468622/the-impact-of-production-of-extended-spectrum-%C3%AE-lactamases-on-the-28-day-mortality-rate-of-patients-with-proteus-mirabilis-bacteremia-in-korea
#11
Jin Young Ahn, Hea Won Ann, Yongduk Jeon, Mi Young Ahn, Dong Hyun Oh, Yong Chan Kim, Eun Jin Kim, Je Eun Song, In Young Jung, Moo Hyun Kim, Wooyoung Jeong, Nam Su Ku, Su Jin Jeong, Jun Yong Choi, Dongeun Yong, Young Goo Song, June Myung Kim
BACKGROUND: The incidence of Proteus mirabilis antimicrobial resistance, especially that mediated by extended-spectrum β-lactamases (ESBLs), has increased. We investigated the impact of ESBL production on the mortality of patients with P. mirabilis bacteremia in Korea. METHODS: Patients diagnosed with P. mirabilis bacteremia between November 2005 and December 2013 at a 2000-bed tertiary care center in South Korea were included in this study. Phenotypic and molecular analyses were performed to assess ESBL expression...
May 3, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28346838/short-communication-hiv-1-transmission-networks-across-south-korea
#12
Mi Young Ahn, Joel O Wertheim, Woo Joo Kim, Shin-Woo Kim, Jin Soo Lee, Hea Won Ann, Yongduk Jeon, Jin Young Ahn, Je Eun Song, Dong Hyun Oh, Yong Chan Kim, Eun Jin Kim, In Young Jung, Moo Hyun Kim, Wooyoung Jeong, Su Jin Jeong, Nam Su Ku, June Myung Kim, Davey M Smith, Jun Yong Choi
Molecular epidemiology can help clarify the properties and dynamics of HIV-1 transmission networks in both global and regional scales. We studied 143 HIV-1-infected individuals recruited from four medical centers of three cities in South Korea between April 2013 and May 2014. HIV-1 env V3 sequence data were generated (337-793 bp) and analyzed using a pairwise distance-based clustering approach to infer putative transmission networks. Participants whose viruses were ≤2.0% divergent according to Tamura-Nei 93 genetic distance were defined as clustering...
August 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28216577/qm-hifsa-aided-structure-determination-of-succinilenes-a-d-new-triene-polyols-from-a-marine-derived-streptomyces-sp
#13
Munhyung Bae, So Hyun Park, Yun Kwon, Sang Kook Lee, Jongheon Shin, Joo-Won Nam, Dong-Chan Oh
Based on profiles of secondary metabolites produced by marine bacteria obtained using LC/MS, succinilenes A-D (1-4), new triene polyols, were discovered from a culture of a Streptomyces strain SAK1, which was collected in the southern area of Jeju Island, Republic of Korea. The gross structures of 1-4 were primarily determined through analysis of NMR spectra. The double bond geometries of the succinilenes, which could not be established from conventional ¹H NMR spectra because of the highly overlapped olefinic signals, were successfully deciphered using the recently developed quantum-mechanics-driven ¹H iterative full spin analysis (QM-HiFSA)...
February 14, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28179059/phenolics-and-neolignans-isolated-from-the-fruits-of-juglans-mandshurica-maxim-and-their-effects-on-lipolysis-in-adipocytes
#14
SeonJu Park, Nanyoung Kim, Guijae Yoo, Sang-Nam Kim, Hyun-Jung Kwon, Kiwon Jung, Dong-Chan Oh, Yun-Hee Lee, Seung Hyun Kim
Juglans mandshurica Maxim. (Juglandaceae) is a traditional folk medicine used for treatment of dermatosis and to relieve aches in Korea and China. In this study, eight compounds, along with six known compounds, were isolated from the fruit of J. mandshurica. Among the six known compounds, the absolute configuration of two compounds were determined. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. All isolated compounds were tested for their lipolytic activities in differentiated adipocytes using C3H10T1/2 mouse embryonic fibroblasts...
May 2017: Phytochemistry
https://www.readbyqxmd.com/read/27899066/predictive-factors-for-unfavorable-outcomes-of-tuberculous-pericarditis-in-human-immunodeficiency-virus-uninfected-patients-in-an-intermediate-tuberculosis-burden-country
#15
In Young Jung, Young Goo Song, Jun Yong Choi, Moo Hyun Kim, Woo Yong Jeong, Dong Hyun Oh, Yong Chan Kim, Je Eun Song, Eun Jin Kim, Ji Un Lee, Su Jin Jeong, Nam Su Ku, June Myung Kim
BACKGROUND: In areas where Mycobacterium tuberculosis is endemic, tuberculosis is known to be the most common cause of pericarditis. However, the difficulty in diagnosis may lead to late complications such as constrictive pericarditis and increased mortality. Therefore, identification of patients at a high risk for poor prognosis, and prompt initiation of treatment are important in the outcome of TB pericarditis. The aim of this study is to identify the predictive factors for unfavorable outcomes of TB pericarditis in HIV-uninfected persons in an intermediate tuberculosis burden country...
November 29, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27118621/multicenter-cohort-study-of-acute-myocardial-infarction-in-korea%C3%A3-interim-analysis-of-the-korea-acute-myocardial-infarction-registry-national-institutes-of-health-registry
#16
MULTICENTER STUDY
Ju Han Kim, Shung-Chull Chae, Dong Joo Oh, Hyo-Soo Kim, Young Jo Kim, Youngkeun Ahn, Myeong Chan Cho, Chong Jin Kim, Jung-Han Yoon, Hyun-Young Park, Myung Ho Jeong
BACKGROUND: The Korea Acute Myocardial Infarction Registry (KAMIR)-National Institutes of Health (NIH) registry has the aim of evaluating the clinical characteristics, management, and long-term outcomes of patients with acute myocardial infarction (AMI) in Korea. METHODS AND RESULTS: Patients hospitalized for AMI in 20 tertiary university hospitals in Korea have been enrolled since November 2011. The study is expected to complete the scheduled enrollment of approximately 13,000 patients in October 2015, and follow-up duration is up to 5 years for each patient...
May 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/26996220/feedback-survey-of-the-effect-burden-and-cost-of-the-national-endoscopic-quality-assessment-program-during-the-past-5-years-in-korea
#17
Yu Kyung Cho, Jeong Seop Moon, Dong Su Han, Yong Chan Lee, Yeol Kim, Bo Young Park, Il-Kwun Chung, Jin-Oh Kim, Jong Pil Im, Jae Myung Cha, Hyun Gun Kim, Sang Kil Lee, Hang Lak Lee, Jae Young Jang, Eun Sun Kim, Yunho Jung, Chang Mo Moon
BACKGROUND/AIMS: In Korea, the nationwide gastric cancer screening program recommends biennial screening for individuals aged 40 years or older by way of either an upper gastrointestinal series or endoscopy. The national endoscopic quality assessment (QA) program began recommending endoscopy in medical institutions in 2009. We aimed to assess the effect, burden, and cost of the QA program from the viewpoint of medical institutions. METHODS: We surveyed the staff of institutional endoscopic units via e-mail...
November 2016: Clinical Endoscopy
https://www.readbyqxmd.com/read/26798949/mohangic-acids-a-e-p-aminoacetophenonic-acids-from-a-marine-mudflat-derived-streptomyces-sp
#18
Munhyung Bae, Kyuho Moon, Jihye Kim, Hyen Joo Park, Sang Kook Lee, Jongheon Shin, Dong-Chan Oh
Mohangic acids A-E (1-5) were isolated from a marine Streptomyces sp. collected from a mudflat in Buan, Republic of Korea. Comprehensive spectroscopic analysis revealed that the mohangic acids are new members of the p-aminoacetophenonic acid class. The relative and absolute configurations of the mohangic acids were determined by J-based configuration analysis and by the application of bidentate chiral NMR solvents followed by (13)C NMR analysis, chemical derivatization, and circular dichroism spectroscopy. Mohangic acid E (5), which is the first glycosylated compound in the p-aminoacetophenonic acid family, displayed significant quinone reductase induction activity...
February 26, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/26756034/the-first-private-hospital-based-proton-therapy-center-in-korea-status-of-the-proton-therapy-center-at-samsung-medical-center
#19
Kwangzoo Chung, Youngyih Han, Jinsung Kim, Sung Hwan Ahn, Sang Gyu Ju, Sang Hoon Jung, Yoonsun Chung, Sungkoo Cho, Kwanghyun Jo, Eun Hyuk Shin, Chae-Seon Hong, Jung Suk Shin, Seyjoon Park, Dae-Hyun Kim, Hye Young Kim, Boram Lee, Gantaro Shibagaki, Hideki Nonaka, Kenzo Sasai, Yukio Koyabu, Changhoon Choi, Seung Jae Huh, Yong Chan Ahn, Hong Ryull Pyo, Do Hoon Lim, Hee Chul Park, Won Park, Dong Ryul Oh, Jae Myung Noh, Jeong Il Yu, Sanghyuk Song, Ji Eun Lee, Bomi Lee, Doo Ho Choi
PURPOSE: The purpose of this report is to describe the proton therapy system at Samsung Medical Center (SMC-PTS) including the proton beam generator, irradiation system, patient positioning system, patient position verification system, respiratory gating system, and operating and safety control system, and review the current status of the SMC-PTS. MATERIALS AND METHODS: The SMC-PTS has a cyclotron (230 MeV) and two treatment rooms: one treatment room is equipped with a multi-purpose nozzle and the other treatment room is equipped with a dedicated pencil beam scanning nozzle...
December 2015: Radiation Oncology Journal
https://www.readbyqxmd.com/read/26560051/cutaneous-lymphoma-in-korea-a-nationwide-retrospective-study
#20
Hyun Soo Lee, Kee Suck Suh, Dong-Youn Lee, Kwang Hyun Cho, Sang Ho Oh, Soo-Chan Kim, Seok-Jong Lee, Dong Hoon Shin, Tae Young Yoon, Young Ho Won, You Chan Kim
The epidemiological and clinicopathological features of cutaneous lymphoma may vary by geographical area. However, only a few large-scale epidemiological studies of cutaneous lymphoma have been performed, mainly in the USA and Europe. This aim of this study was to determine the recent characteristics of cutaneous lymphoma in Korea according to the WHO/EORTC classification. A total of 422 patients with newly diagnosed cutaneous lymphoma from January 2009 to December 2013 comprising 293 cases of mature T-cell and natural killer (NK)-cell lymphoma and 39 cases of mature B-cell lymphoma were retrospectively reviewed...
May 2016: Acta Dermato-venereologica
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