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Dong-Chan Oh Korea

Ju Han Kim, Shung-Chull Chae, Dong Joo Oh, Hyo-Soo Kim, Young Jo Kim, Youngkeun Ahn, Myeong Chan Cho, Chong Jin Kim, Jung-Han Yoon, Hyun-Young Park, Myung Ho Jeong
BACKGROUND: The Korea Acute Myocardial Infarction Registry (KAMIR)-National Institutes of Health (NIH) registry has the aim of evaluating the clinical characteristics, management, and long-term outcomes of patients with acute myocardial infarction (AMI) in Korea. METHODS AND RESULTS: Patients hospitalized for AMI in 20 tertiary university hospitals in Korea have been enrolled since November 2011. The study is expected to complete the scheduled enrollment of approximately 13,000 patients in October 2015, and follow-up duration is up to 5 years for each patient...
May 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
Yu Kyung Cho, Jeong Seop Moon, Dong Su Han, Yong Chan Lee, Yeol Kim, Bo Young Park, Il-Kwun Chung, Jin-Oh Kim, Jong Pil Im, Jae Myung Cha, Hyun Gun Kim, Sang Kil Lee, Hang Lak Lee, Jae Young Jang, Eun Sun Kim, Yunho Jung, Chang Mo Moon
Background/Aims: : In Korea, the nationwide gastric cancer screening program recommends biennial screening for individuals aged 40 years or older by way of either an upper gastrointestinal series or endoscopy. The national endoscopic quality assessment (QA) program began recommending endoscopy in medical institutions in 2009. We aimed to assess the effect, burden, and cost of the QA program from the viewpoint of medical institutions. Methods: : We surveyed the staff of institutional endoscopic units via e-mail...
March 2, 2016: Clinical Endoscopy
Munhyung Bae, Kyuho Moon, Jihye Kim, Hyen Joo Park, Sang Kook Lee, Jongheon Shin, Dong-Chan Oh
Mohangic acids A-E (1-5) were isolated from a marine Streptomyces sp. collected from a mudflat in Buan, Republic of Korea. Comprehensive spectroscopic analysis revealed that the mohangic acids are new members of the p-aminoacetophenonic acid class. The relative and absolute configurations of the mohangic acids were determined by J-based configuration analysis and by the application of bidentate chiral NMR solvents followed by (13)C NMR analysis, chemical derivatization, and circular dichroism spectroscopy. Mohangic acid E (5), which is the first glycosylated compound in the p-aminoacetophenonic acid family, displayed significant quinone reductase induction activity...
February 26, 2016: Journal of Natural Products
Kwangzoo Chung, Youngyih Han, Jinsung Kim, Sung Hwan Ahn, Sang Gyu Ju, Sang Hoon Jung, Yoonsun Chung, Sungkoo Cho, Kwanghyun Jo, Eun Hyuk Shin, Chae-Seon Hong, Jung Suk Shin, Seyjoon Park, Dae-Hyun Kim, Hye Young Kim, Boram Lee, Gantaro Shibagaki, Hideki Nonaka, Kenzo Sasai, Yukio Koyabu, Changhoon Choi, Seung Jae Huh, Yong Chan Ahn, Hong Ryull Pyo, Do Hoon Lim, Hee Chul Park, Won Park, Dong Ryul Oh, Jae Myung Noh, Jeong Il Yu, Sanghyuk Song, Ji Eun Lee, Bomi Lee, Doo Ho Choi
PURPOSE: The purpose of this report is to describe the proton therapy system at Samsung Medical Center (SMC-PTS) including the proton beam generator, irradiation system, patient positioning system, patient position verification system, respiratory gating system, and operating and safety control system, and review the current status of the SMC-PTS. MATERIALS AND METHODS: The SMC-PTS has a cyclotron (230 MeV) and two treatment rooms: one treatment room is equipped with a multi-purpose nozzle and the other treatment room is equipped with a dedicated pencil beam scanning nozzle...
December 2015: Radiation Oncology Journal
Hyun Soo Lee, Kee Suck Suh, Dong-Youn Lee, Kwang Hyun Cho, Sang Ho Oh, Soo-Chan Kim, Seok-Jong Lee, Dong Hoon Shin, Tae Young Yoon, Young Ho Won, You Chan Kim
The epidemiological and clinicopathological features of cutaneous lymphoma may vary by geographical area. However, only a few large-scale epidemiological studies of cutaneous lymphoma have been performed, mainly in the USA and Europe. This aim of this study was to determine the recent characteristics of cutaneous lymphoma in Korea according to the WHO/EORTC classification. A total of 422 patients with newly diagnosed cutaneous lymphoma from January 2009 to December 2013 comprising 293 cases of mature T-cell and natural killer (NK)-cell lymphoma and 39 cases of mature B-cell lymphoma were retrospectively reviewed...
May 2016: Acta Dermato-venereologica
Min Cheol Kim, Jung Hwan Lee, Bora Shin, Lalita Subedi, Jin Wook Cha, Jin-Soo Park, Dong-Chan Oh, Sun Yeou Kim, Hak Cheol Kwon
Salinazinones A (1) and B (2), two unprecedented pyrrolidinyl-oxazinones, were isolated from the culture broth of Streptomyces sp. KMF-004 from a solar saltern at Aphae Island, Korea. The structures of these salinazinones, which are unusual and consist of 2-methylpropenyl-1,3-oxazin-6-one bearing 1-oxopyrrolidinyl substituents, were assigned by spectral and chemical analyses using Mosher's method, circular dichroism (CD), and calculated ECD. Salinazinones are the first examples of a natural alkaloid class composed of an oxazinone-pyrrolidone conjugate...
October 16, 2015: Organic Letters
Si-Hyuck Kang, Jin Joo Park, Dong-Ju Choi, Chang-Hwan Yoon, Il-Young Oh, Seok-Min Kang, Byung-Su Yoo, Eun-Seok Jeon, Jae-Joong Kim, Myeong-Chan Cho, Shung Chull Chae, Kyu-Hyung Ryu, Byung-Hee Oh
OBJECTIVE: Plasma level of N-terminal-pro-brain natriuretic peptide (NT-proBNP) is a reliable prognostic factor in patients with heart failure (HF). However, it is unclear how differently the biomarker predicts adverse outcomes in HF with preserved EF (HFpEF) versus HF with reduced EF (HFrEF). METHODS: From the Korean Heart Failure registry, a prospective multicentre cohort for consecutive patients who were hospitalised for acute HF syndrome, those with available NT-proBNP and LVEF measurements were extracted...
December 2015: Heart: Official Journal of the British Cardiac Society
Munhyung Bae, Beomkoo Chung, Ki-Bong Oh, Jongheon Shin, Dong-Chan Oh
Alterations in microbial culture conditions may trigger the production of diverse bioactive secondary metabolites. While applying various culture conditions and monitoring secondary metabolite profiles using LC/MS, hormaomycins B and C (1 and 2) were discovered from a marine mudflat-derived actinomycete, Streptomyces sp., collected in Mohang, Korea. The planar structures of the hormaomycins, which bear structurally-unique units, such as 4-(Z)-propenylproline, 3-(2-nitrocyclopropyl)alanine, 5-chloro-1-hydroxypyrrol-2-carboxylic acid and b-methylphenylalanine, were established as the first natural analogues belonging to the hormaomycin peptide class...
August 2015: Marine Drugs
Keum Ji Jung, Yangsoo Jang, Dong Joo Oh, Byung-Hee Oh, Sang Hoon Lee, Seong-Wook Park, Ki-Bae Seung, Hong-Kyu Kim, Young Duk Yun, Sung Hee Choi, Jidong Sung, Tae-Yong Lee, Sung Hi Kim, Sang Baek Koh, Moon Chan Kim, Hyeon Chang Kim, Heejin Kimm, Chungmo Nam, Sungha Park, Sun Ha Jee
BACKGROUND AND AIMS: To evaluate the performance of the American College of Cardiology/American Heart Association (ACC/AHA) 2013 Pooled Cohort Equations in the Korean Heart Study (KHS) population and to develop a Korean Risk Prediction Model (KRPM) for atherosclerotic cardiovascular disease (ASCVD) events. METHODS: The KHS cohort included 200,010 Korean adults aged 40-79 years who were free from ASCVD at baseline. Discrimination, calibration, and recalibration of the ACC/AHA Equations in predicting 10-year ASCVD risk in the KHS cohort were evaluated...
September 2015: Atherosclerosis
Sung Eun Kim, Chan Woong Kim, Sang Jin Lee, Je Hyeok Oh, Dong Hoon Lee, Tae Ho Lim, Hyuk Joong Choi, Hyun Soo Chung, Ji Yeong Ryu, Hye Young Jang, Yoon Hee Choi, Su Jin Kim, Jin Hee Jung
OBJECTIVES: Although human factors are important in terms of patient safety, there have been very few reports on the attitudes of healthcare professionals working in acute care settings in South Korea. In the present study, we investigated the attitudes of such professionals, their cultures and their management systems. DESIGN: A questionnaire survey with 65 items covering nine themes affecting patient safety. Nine themes were compared via a three-or-more-way analysis of variance, with interaction, followed by multiple comparisons among several groups...
2015: BMJ Open
Myoung Shin Kim, Jae Kyung Kim, Mi Woo Lee, Kee-Chan Moon, Beom Joon Kim, Sang Wook Son, Hyo Hyun Ahn, Sang Ho Oh, Hee Joon Yu, Dong Youn Lee, Kwang Hyun Cho, Baik Kee Cho, Moon Bum Kim, Kee Suck Suh, You Chan Kim, Byung In Ro, Joon Soo Park, Jong Soo Choi, Jee Bum Lee
Deep cutaneous fungal infections (DCFI) occur worldwide and their prevalence is influenced by personal factors of the affected patients and the geographic and cultural features. Surveillance studies of DCFI with respect to the various clinical backgrounds of affected patients can ultimately help to improve their outcome. Expanding on our previous study, we performed a retrospective analysis of patients with DCFI who were treated in a group of university teaching hospitals in Korea to determine the trends within a 5-year period...
October 2015: Journal of Dermatology
Jin Joo Park, Dong-Ju Choi, Chang-Hwan Yoon, Il-Young Oh, Ju Hyun Lee, Soyeon Ahn, Byung-Su Yoo, Seok-Min Kang, Jae-Joong Kim, Sang-Hong Baek, Myeong-Chan Cho, Eun-Seok Jeon, Shung Chull Chae, Kyu-Hyung Ryu, Byung-Hee Oh
AIMS: In acute heart failure (AHF) patients, pulmonary oedema and low tissue perfusion may lead to changes in the acid-base balance, which may be associated with worse outcomes. METHODS AND RESULTS: In this prospective nationwide cohort study from 24 academic hospitals, arterial blood gas (ABG) was measured in 1982 AHF patients at hospital admission. Acidosis was defined as pH <7.36, and alkalosis as pH >7.44. Mortality was stratified according to ABG results...
June 2015: European Journal of Heart Failure
Tae Hyung Won, Chang-Kwon Kim, So-Hyoung Lee, Boon Jo Rho, Sang Kook Lee, Dong-Chan Oh, Ki-Bong Oh, Jongheon Shin
Four new iodobenzene-containing dipeptides (1-4), a related bromotryptophan-containing dipeptide (5), and an iodophenethylamine (6) were isolated from the ascidian Aplidium sp. collected off the coast of Chuja-do, Korea. The structures of these novel compounds, designated as apliamides A-E (1-5) and apliamine A (6) were determined via combined spectroscopic analyses. The absolute configuration of the amino acid residue in 1 was determined by advanced Marfey's analysis. Several of these compounds exhibited moderate cytotoxicity and significant inhibition against Na+/K+-ATPase (4)...
June 2015: Marine Drugs
Bora Shin, Seyeon Ahn, Minsoo Noh, Jongheon Shin, Dong-Chan Oh
A marine-derived Streptomyces strain, SSC21, was isolated from the sediment of Suncheon Bay, Republic of Korea. Chemical analysis of the bacterial strain resulted in the isolation of four new metabolites, suncheonosides A-D (1-4, respectively), each bearing a sulfur atom. The planar structures of the suncheonosides were identified as hexasubstituted benzothioate glycosides by combined spectroscopic analyses. Analysis of the configuration of the sugar moieties based on ROESY nuclear magnetic resonance correlations, one-bond (1)H-(13)C coupling constant analysis, and chemical derivatizations indicated that the suncheonosides incorporate only l-rhamnose...
June 26, 2015: Journal of Natural Products
Han Sung Hwang, Sung Hun Na, Sung Eun Hur, Soon Ae Lee, Kyung A Lee, Geum Joon Cho, Kwan Young Oh, Chan Hee Jin, Seung Mi Lee, Jae Eun Shin, Kyo Hoon Park, Ji Young Lim, Suk Joo Choi, Joon Ho Lee, Sae Kyung Choi, Jae-Yoon Shim, Yun Sung Jo, Gyu Yeon Choi, Young Han Kim, Ki Cheol Kil, Jong Woon Kim, Dong Wook Kwak, Yun Dan Kang, Young Ju Kim
OBJECTIVE: This study aimed to examine clinical practice patterns in the management of pregnant women admitted with threatened preterm labor (TPL) in Korea. METHODS: Data from women admitted with a diagnosis of TPL were collected from 22 hospitals. TPL was defined as regular uterine contractions with or without other symptoms such as pelvic pressure, backache, increased vaginal discharge, menstrual-like cramps, bleeding/show and cervical changes. Data on general patient information, clinical characteristics at admission, use of tocolytics, antibiotics, and corticosteroids, and pregnancy outcomes were collected using an online data collections system...
May 2015: Obstetrics & Gynecology Science
Jaewon Oh, Seok-Min Kang, Mi Kyung Song, Namki Hong, Jong-Chan Youn, Seongwoo Han, Eun-Seok Jeon, Myeong-Chan Cho, Jae-Joong Kim, Byung-Su Yoo, Shung Chull Chae, Byung-Hee Oh, Dong-Ju Choi, Myung-Mook Lee, Kyu-Hyung Ryu
BACKGROUNDS: We investigated the relationship between spironolactone use and all-cause mortality in acute decompensated heart failure (ADHF) patients with severe renal dysfunction. The clinical benefit of spironolactone in the treatment of heart failure (HF) has been described in several large randomized clinical trials. However, its clinical benefits have not been studied in hospitalized ADHF patients with severe renal dysfunction (estimated glomerular filtration rate [eGFR] <45 mL/min per 1...
May 2015: American Heart Journal
Tae Hyung Won, Inn-Hye Song, Kuk-Hwa Kim, Woo-Young Yang, Sang Kook Lee, Dong-Chan Oh, Won-Keun Oh, Ki-Bong Oh, Jongheon Shin
Twenty-four metabolites, including seven new compounds (1-7), were isolated from the dried fruits of Psoralea corylifolia. On the basis of combined spectroscopic and chemical analysis, the new compounds were determined to be six flavonoids (1-6) and a meroterpenoid (7). The absolute configurations of the natural products obtained, including the previously undetermined 16 and 17, were assigned by several methods, such as NOE spectroscopy, optical rotation, and CD spectroscopy. Several of these compounds exhibited moderate inhibitory activity toward Staphylococcus mutans-derived SrtA (2, 6, and 16) and significant stimulation of SIRT1 activity (2, 3, and 15)...
April 24, 2015: Journal of Natural Products
Hyang Mo Koo, Fa Mee Doh, Chan Ho Kim, Mi Jung Lee, Eun Jin Kim, Jae Hyun Han, Ji Suk Han, Dong-Ryeol Ryu, Hyung Jung Oh, Jung Tak Park, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang
Residual renal function (RRF) is associated with left ventricular (LV) hypertrophy as well as all-cause and cardiovascular (CV) mortality in patients with end-stage renal disease. However, no studies have yet examined the serial changes in echocardiographic findings according to the rate of RRF decline in incident dialysis patients. A total of 81 patients who started peritoneal dialysis (PD) between 2005 and 2012 at Yonsei University Health System, Seoul, South Korea, and who underwent baseline and follow-up echocardiography within the first year of PD were recruited...
February 2015: Medicine (Baltimore)
Seong-Hwan Kim, Yoonho Shin, So-Hyoung Lee, Ki-Bong Oh, Sang Kook Lee, Jongheon Shin, Dong-Chan Oh
Salternamides A-D (1-4), the first secondary metabolites discovered from saltern-derived actinomycetes, were isolated from a halophilic Streptomyces strain isolated from a saltern on Shinui Island in the Republic of Korea. The planar structures of the salternamides, which are new members of the manumycin family, were elucidated by a combination of spectroscopic analyses. The absolute configurations of the salternamides were determined by chemical and spectroscopic methods, including the modified Mosher's method, J-based configuration analysis, and circular dichroism spectroscopy...
April 24, 2015: Journal of Natural Products
Mitchell J Machiela, Chao Agnes Hsiung, Xiao-Ou Shu, Wei Jie Seow, Zhaoming Wang, Keitaro Matsuo, Yun-Chul Hong, Adeline Seow, Chen Wu, H Dean Hosgood, Kexin Chen, Jiu-Cun Wang, Wanqing Wen, Richard Cawthon, Nilanjan Chatterjee, Wei Hu, Neil E Caporaso, Jae Yong Park, Chien-Jen Chen, Yeul Hong Kim, Young Tae Kim, Maria Teresa Landi, Hongbing Shen, Charles Lawrence, Laurie Burdett, Meredith Yeager, I-Shou Chang, Tetsuya Mitsudomi, Hee Nam Kim, Gee-Chen Chang, Bryan A Bassig, Margaret Tucker, Fusheng Wei, Zhihua Yin, She-Juan An, Biyun Qian, Victor Ho Fun Lee, Daru Lu, Jianjun Liu, Hyo-Sung Jeon, Chin-Fu Hsiao, Jae Sook Sung, Jin Hee Kim, Yu-Tang Gao, Ying-Huang Tsai, Yoo Jin Jung, Huan Guo, Zhibin Hu, Amy Hutchinson, Wen-Chang Wang, Robert J Klein, Charles C Chung, In-Jae Oh, Kuan-Yu Chen, Sonja I Berndt, Wei Wu, Jiang Chang, Xu-Chao Zhang, Ming-Shyan Huang, Hong Zheng, Junwen Wang, Xueying Zhao, Yuqing Li, Jin Eun Choi, Wu-Chou Su, Kyong Hwa Park, Sook Whan Sung, Yuh-Min Chen, Li Liu, Chang Hyun Kang, Lingmin Hu, Chung-Hsing Chen, William Pao, Young-Chul Kim, Tsung-Ying Yang, Jun Xu, Peng Guan, Wen Tan, Jian Su, Chih-Liang Wang, Haixin Li, Alan Dart Loon Sihoe, Zhenhong Zhao, Ying Chen, Yi Young Choi, Jen-Yu Hung, Jun Suk Kim, Ho-Il Yoon, Qiuyin Cai, Chien-Chung Lin, In Kyu Park, Ping Xu, Jing Dong, Christopher Kim, Qincheng He, Reury-Perng Perng, Takashi Kohno, Sun-Seog Kweon, Chih-Yi Chen, Roel C H Vermeulen, Junjie Wu, Wei-Yen Lim, Kun-Chieh Chen, Wong-Ho Chow, Bu-Tian Ji, John K C Chan, Minjie Chu, Yao-Jen Li, Jun Yokota, Jihua Li, Hongyan Chen, Yong-Bing Xiang, Chong-Jen Yu, Hideo Kunitoh, Guoping Wu, Li Jin, Yen-Li Lo, Kouya Shiraishi, Ying-Hsiang Chen, Hsien-Chih Lin, Tangchun Wu, Maria Pik Wong, Yi-Long Wu, Pan-Chyr Yang, Baosen Zhou, Min-Ho Shin, Joseph F Fraumeni, Wei Zheng, Dongxin Lin, Stephen J Chanock, Nathaniel Rothman, Qing Lan
Recent evidence from several relatively small nested case-control studies in prospective cohorts shows an association between longer telomere length measured phenotypically in peripheral white blood cell (WBC) DNA and increased lung cancer risk. We sought to further explore this relationship by examining a panel of seven telomere-length associated genetic variants in a large study of 5,457 never-smoking female Asian lung cancer cases and 4,493 never-smoking female Asian controls using data from a previously reported genome-wide association study...
July 15, 2015: International Journal of Cancer. Journal International du Cancer
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