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https://www.readbyqxmd.com/read/29399854/antenatal-prediction-of-neonatal-survival-in-sacrococcygeal-teratoma
#1
Seung Mi Lee, Dong Hoon Suh, So Yeon Kim, Min Kyoung Kim, Sohee Oh, Sang Hoon Song, Hyun-Young Kim, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun
OBJECTIVES: In sacrococcygeal teratoma, the presence of high-output cardiac failure resulting from arteriovenous shunting through the large tumor has been associated with an adverse outcome. The objective of this study was to determine whether the tumor size and cardiac biomarkers in cord blood can predict neonatal survival in sacrococcygeal teratoma. METHODS: The study population consisted of 25 neonates with sacrococcygeal teratoma. Tumor size was calculated by the ellipsoid formula using dimensions measured by antenatal ultrasound ([length × width × depth in cm] × 0...
February 5, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29385086/spiroketones-and-a-biphenyl-analog-from-stems-and-leaves-of-larrea-nitida-and-their-inhibitory-activity-against-il-6-production
#2
Jongmin Ahn, Yihua Pei, Hee-Sung Chae, Seong-Hwan Kim, Young-Mi Kim, Young Hee Choi, Joongku Lee, Minsun Chang, Yun Seon Song, Roberto Rodriguez, Dong-Chan Oh, Jinwoong Kim, Sangho Choi, Sang Hoon Joo, Young-Won Chin
Bioactivity-guided fractionation for the stems of leaves of Larrea nitida Cav., using interleukin-6 (IL-6) inhibitory assay in human mast cells (HMC-1), led to the isolation of three new compounds with an unprecedented skeleton in nature (1-3) and three known compounds (4-6). Their structures were elucidated through extensive spectroscopic analysis. The three new compounds were elucidated as two new spiroketones, nitidaones A (1), and B (2) and one new biphenyl analog, nitidaol (3). The known compounds were identified as nordihydroguaiaretic acid (4), 7,3',4'-tri-O-methylquercetin (5) and ayanin (6)...
January 31, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29380472/conformationally-inspired-total-syntheses-of-ohmyungsamycins-a-and-b-and-structural-revision-of-ohmyungsamycin-b
#3
Joonseong Hur, Jaebong Jang, Jaehoon Sim, Woo Sung Son, Hee-Chul Ahn, Tae Sung Kim, Yern-Hyerk Shin, Changjin Lim, Seungbeom Lee, Hongchan An, Seok-Ho Kim, Dong-Chan Oh, Eun-Kyeong Jo, Jichan Jang, Jeeyeon Lee, Young-Ger Suh
The first total syntheses of bioactive cyclodepsipeptides ohmyungsamycin A and B have been achieved. The key features of our synthesis involve the concise preparation of the linear cyclization precursor, which consists of N-methyl amides and non-proteinogenic amino acids, and a bent conformationally-inspired macrolactamization. The revised structure of ohmyungsamycin B was established by our synthesis. The cyclic core of the ohmyungsamycins that is responsible for the excellent anti-TB activity was also elucidated via our synthesis and biological evaluation of a chain-truncated variant of the ohmyungsamycins...
January 30, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29378565/comparison-of-the-efficacy-of-nafcillin-and-glycopeptides-as-definitive-therapy-for-patients-with-methicillin-susceptible-staphylococcus-aureus-bacteremia-a-retrospective-cohort-study
#4
Dong Hyun Oh, Jung Ju Kim, Jinnam Kim, Hye Seong, Se Ju Lee, Yong Chan Kim, Eun Jin Kim, In Young Jung, Woo Yong Jeong, Su Jin Jeong, Nam Su Ku, Sang Hoon Han, Jun Yong Choi, Young Goo Song, June Myung Kim
BACKGROUND: Studies have shown that the prognosis of the treatment of methicillin-susceptible S. aureus (MSSA) with glycopeptides is inferior compared to treatment with β-lactam. However, there are only few studies comparing treatment with antistaphylococcal penicillin alone to glycopeptide treatment. The aim of this study was to compare the efficacy of nafcillin, an antistaphylococcal penicillin, with that of glycopeptides as a definitive therapy for MSSA bacteremia. METHODS: Patients with MSSA bacteremia recruited from a tertiary referral hospital were enrolled in this retrospective cohort study...
January 30, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29325562/increased-epicardial-adipose-tissue-thickness-is-a-predictor-of-new-onset-diabetes-mellitus-in-patients-with-coronary-artery-disease-treated-with-high-intensity-statins
#5
Jeehoon Kang, Young-Chan Kim, Jin Joo Park, Sehun Kim, Si-Hyuck Kang, Young Jin Cho, Yeonyee E Yoon, Il-Young Oh, Chang-Hwan Yoon, Jung-Won Suh, Young-Seok Cho, Tae-Jin Youn, In-Ho Chae, Dong-Ju Choi
BACKGROUND: Statins are widely used for lipid lowering in patients with coronary artery disease (CAD), but increasing evidence indicates an association between statin use and new-onset of diabetes mellitus (NODM). Epicardial adipose tissue (EAT) refers to the visceral fat surrounding the heart, which is associated with metabolic diseases. We sought to determine the association between EAT thickness and NODM in CAD patients treated with high-intensity statins. METHODS: We conducted a retrospective medical record review of CAD patients treated with high-intensity statins for at least 6 months after percutaneous coronary intervention performed between January 2009 and June 2013 at Seoul National University Bundang Hospital...
January 11, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29322561/effect-of-an-oxygen-generating-scaffold-on-the-viability-and-insulin-secretion-function-of-porcine-neonatal-pancreatic-cell-clusters
#6
Eun Mi Lee, Ji-In Jung, Zahid Alam, Hee-Gyeong Yi, Heejin Kim, Jin Woo Choi, Sunghoon Hurh, Young June Kim, Jong Cheol Jeong, Jaeseok Yang, Kook-Hwan Oh, Hee Chan Kim, Byeong Chun Lee, Inho Choi, Dong-Woo Cho, Curie Ahn
BACKGROUND: Islet encapsulation techniques have shown limited success in maintaining islet survival and function because encapsulation decreases oxygen supply. In this study, an oxygen-generating scaffold was fabricated to prevent hypoxic cell damage and improve the viability and insulin secretion of islets. METHODS: We fabricated an oxygen-generating scaffold by mixing calcium peroxide (CaO2 ) with polydimethylsiloxane (PDMS). We evaluated the effects of the oxygen-generating PDMS + CaO2 scaffold on viability, caspase-3 and caspase-7 activity, oxygen consumption rate (OCR), glucose-stimulated insulin secretion (GSIS), hypoxic cell marker expression, and reactive oxygen species (ROS) levels in porcine neonatal pancreatic cell clusters (NPCCs)...
January 10, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29219847/strong-enhancement-of-emission-efficiency-in-gan-light-emitting-diodes-by-plasmon-coupled-light-amplification-of-graphene
#7
Jong Min Kim, Sung Kim, Sung Won Hwang, Chang Oh Kim, Dong Hee Shin, Ju Hwan Kim, Chan Wook Jang, Soo Seok Kang, Euyheon Hwang, Suk-Ho Choi, Sherif H El-Gohary, Kyung Min Byun
Recently, we have demonstrated that excitation of plasmon-polaritons in a mechanically-derived graphene sheet on the top of a ZnO semiconductor considerably enhances its light emission efficiency. If this scheme is also applied to device structures, it is then expected that the energy efficiency of light-emitting diodes (LEDs) increases substantially and the commercial potential will be enormous. Here, we report that the plasmon-induced light coupling amplifies emitted light by ~1.6 times in doped large-area chemical-vapor-deposition-grown graphene, which is useful for practical applications...
December 8, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29182331/polyoxygenated-steroids-from-the-sponge-clathria-gombawuiensis
#8
Jung-Kyun Woo, Thi Kim Quy Ha, Dong-Chan Oh, Won-Keun Oh, Ki-Bong Oh, Jongheon Shin
Six new polyoxygenated steroids (1-6) along with clathriol (7) were isolated from the Korean marine sponge Clathria gombawuiensis. Based upon the results of combined spectroscopic analyses, the structures of gombasterols A-F (1-6) were elucidated to be those of highly oxygenated steroids possessing a 3β,4α,6α,7β-tetrahydroxy or equivalent (7β-sodium O-sulfonato for 3) substitution pattern and a C-15 keto group as common structural motifs. The relative and absolute configurations of these steroids, including the rare 14β configuration of 1-4, were determined by a combination of NOESY, J-based analyses, the 2-methoxy-2-(trifluoromethyl)phenylacetic acid (MTPA) method, and X-ray crystallographic analysis...
November 28, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29174850/association-between-pepsin-in-the-saliva-and-the-subjective-symptoms-in-patients-with-laryngopharyngeal-reflux
#9
Ah Ra Jung, Oh Eun Kwon, Jung Min Park, Sung Hwa Dong, Su Young Jung, Young Chan Lee, Young-Gyu Eun
OBJECTIVES: Our study was designed to further evaluate the relationships between the saliva pepsin level and the symptoms and quality of life of patients with laryngopharyngeal reflux (LPR). STUDY DESIGN: A prospective cohort study without controls. SETTING: Tertiary teaching hospital. SUBJECTS AND METHODS: We analyzed 50 patients diagnosed with LPR by 24-hour multichannel intraluminal impedance pH monitoring. All subjects were instructed to collect saliva samples upon waking in the morning...
November 24, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29162885/an-increased-chloride-level-in-hypochloremia-is-associated-with-decreased-mortality-in-patients-with-severe-sepsis-or-septic-shock
#10
Hyung Jung Oh, Seung Jun Kim, Yong Chan Kim, Eun Jin Kim, In Young Jung, Dong Hyun Oh, Su Jin Jeong, Nam Su Ku, Sang Hoon Han, Jun Yong Choi, Young Goo Song, Dong-Ryeol Ryu, June Myung Kim
Only a few observational studies investigated the association between hypochloremia and mortality in critically ill patients, and these studies included small number of septic patients. Also, no study has evaluated the effect of an increase in chloride (Cl-) concentration in hypochloremia on the mortality. A total of 843 Korean septic patients were divided into three groups based on their baseline Cl- level, and Cox analyses were performed to evaluate the 28-day mortality. Moreover, the change in Cl- level (ΔCl) from baseline to 24, 48, or 72 hour was determined, and Cox analyses were also conducted to evaluate the relationship of ΔCl with mortality...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29112406/nicrophorusamides-a-and-b-antibacterial-chlorinated-cyclic-peptides-from-a-gut-bacterium-of-the-carrion-beetle-nicrophorus-concolor
#11
Yern-Hyerk Shin, Suhyun Bae, Jaehoon Sim, Joonseong Hur, Shin-Il Jo, Jongheon Shin, Young-Ger Suh, Ki-Bong Oh, Dong-Chan Oh
Nicrophorusamides A and B (1 and 2) were discovered from a rare actinomycete, Microbacterium sp., which was isolated from the gut of the carrion beetle Nicrophorus concolor. The structures of the nicrophorusamides were established as new chlorinated cyclic hexapeptides bearing uncommon amino acid units mainly based on 1D and 2D NMR spectroscopic analysis. The absolute configurations of the amino acid residues 5-chloro-l-tryptophan, d-threo-β-hydroxyasparagine/d-asparagine, l-ornithine, l-allo-isoleucine, d-leucine, and d-valine were determined using Marfey's method and chemical derivatization with 2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl isothiocyanate followed by LC/MS analysis...
November 7, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29096790/reverse-j-curve-relationship-between-on-treatment-blood-pressure-and-mortality-in-patients-with-heart-failure
#12
Sang Eun Lee, Hae-Young Lee, Hyun-Jai Cho, Won-Seok Choe, Hokon Kim, Jin-Oh Choi, Eun-Seok Jeon, Min-Seok Kim, Kyung-Kuk Hwang, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Myeong-Chan Cho, Jae-Joong Kim, Byung-Hee Oh
OBJECTIVES: This study aimed to assess the relationship between on-treatment blood pressure (BP) and clinical outcomes of patients with heart failure (HF). BACKGROUND: Lower BP has been reported to be related to increased mortality in various cardiovascular diseases. The optimal BP level for patients already experiencing HF is contentious. METHODS: The Korean Acute Heart Failure registry prospectively enrolled a total of 5,625 consecutive patients hospitalized for acute HF in 10 tertiary university hospitals in Korea between March 2011 and February 2014...
November 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29090916/deinococcucins-a-d-aminoglycolipids-from-deinococcus-sp-a-gut-bacterium-of-the-carpenter-ant-camponotus-japonicus
#13
Bora Shin, So Hyun Park, Byung-Yong Kim, Shin-Il Jo, Sang Kook Lee, Jongheon Shin, Dong-Chan Oh
Four new aminoglycolipids, deinococcucins A-D (1-4), were discovered from a Deinococcus sp. strain isolated from the gut of queen carpenter ants, Camponotus japonicus. The structures of deinococcucins A-D were elucidated as a combination of N-acetyl glucosamine, 2,3-dihydroxypropanoic acid, and an alkyl amine with a C16 or C17 hydrocarbon chain primarily based on 1D and 2D NMR and mass spectroscopic data. The exact location of the olefinic double bond in deinococcucins C and D (3 and 4) was assigned based on the liquid chromatography-mass spectroscopy data obtained after olefin metathesis...
November 1, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29079633/hyponatraemia-and-its-prognosis-in-acute-heart-failure-is-related-to-right-ventricular-dysfunction
#14
Heesun Lee, Sang Eun Lee, Chan Soon Park, Jin Joo Park, Ga Yeon Lee, Min-Seok Kim, Jin-Oh Choi, Hyun-Jai Cho, Hae-Young Lee, Dong-Ju Choi, Eun-Seok Jeon, Jae-Joong Kim, Byung-Hee Oh
OBJECTIVES: Hyponatraemia is a well-known predictor of clinical outcomes in heart failure (HF). However, the mechanism remains poorly understood. Previous reports suggest that hyponatraemia is related to right HF. We sought to evaluate the association between right ventricular (RV) dysfunction and hyponatraemia, and the impact of this relationship on the prognosis of patients with acute heart failure (AHF). METHODS: This is a nested case-control study of the Korean Acute Heart Failure registry...
October 27, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29070814/persistent-elevation-of-postoperative-neutrophil-to-lymphocyte-ratio-a-better-predictor-of-survival-in-gastric-cancer-than-elevated-preoperative-neutrophil-to-lymphocyte-ratio
#15
Kyueng-Whan Min, Mi Jung Kwon, Dong-Hoon Kim, Byoung Kwan Son, Eun-Kyung Kim, Young Ha Oh, Young Chan Wi
Postoperative neutrophil-to-lymphocyte ratio change (NLRc) reflects the dynamic change of balance between host inflammatory response and immune response after treatment. In gastric cancer, an elevated initial NLR (iNLR) is reported to be a prognostic predictor, but the clinical application of the NLRc remains unclear. The NLRc was assessed in 734 patients undergoing total/subtotal gastrectomy and endoscopic submucosal dissection for gastric adenocarcinoma. The iNLR and NLRc were recorded within 10 days of the first diagnosis and 3-6 months after surgery, respectively...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29061303/unique-binding-mode-of-evogliptin-with-human-dipeptidyl-peptidase-iv
#16
Hyung Ki Lee, Mi-Kyung Kim, Ha Dong Kim, Heung Jae Kim, Ji Won Kim, Jie-Oh Lee, Chan-Wha Kim, Eunice EunKyeong Kim
Evogliptin ((R)-4-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl) piperazine-2-one)) is a highly potent selective inhibitor of dipeptidyl peptidase IV (DPP4) that was approved for the treatment of type 2 diabetes in South Korea. In this study, we report the crystal structures of Evogliptin, DA-12166, and DA-12228 (S,R diastereomer of Evogliptin) complexed to human DPP4. Analysis of both the structures and inhibitory activities suggests that the binding of the trifluorophenyl moiety in the S1 pocket and the piperazine-2-one moiety have hydrophobic interactions with Phe357 in the S2 extensive subsite, and that the multiple hydrogen bonds made by the (R)-β-amine group in the S2 pocket and the contacts made by the (R)-tert-butyl group with Arg125 contribute to the high potency observed for Evogliptin...
December 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28982721/outcomes-of-de-novo-and-acute-decompensated-heart-failure-patients-according-to-ejection-fraction
#17
Ki Hong Choi, Ga Yeon Lee, Jin-Oh Choi, Eun-Seok Jeon, Hae-Young Lee, Hyun-Jai Cho, Sang Eun Lee, Min-Seok Kim, Jae-Joong Kim, Kyung-Kuk Hwang, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Hyun-Young Park, Myeong-Chan Cho, Byung-Hee Oh
OBJECTIVE: There are conflicting results among previous studies regarding the prognosis of heart failure with preserved ejection fraction (HFpEF) compared with heart failure with reduced ejection fraction (HFrEF). This study aimed to compare the outcomes of patients with de novo acute heart failure (AHF) or acute decompensated HF (ADHF) according to HFpEF (EF≥50%), or HFrEF (EF<40%) and to define the prognosis of patients with HF with mid-range EF (HFmrEF, 40≤EF<50%). METHODS: Between March 2011 and February 2014, 5625 consecutive patients with AHF were recruited from 10 university hospitals...
October 5, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28960033/evaluation-of-the-efficacy-and-safety-of-da-9601-versus-its-new-formulation-da-5204-in-patients-with-gastritis-phase-iii-randomized-double-blind-non-inferiority-study
#18
Yoon Jin Choi, Dong Ho Lee, Myung Gyu Choi, Sung Joon Lee, Sung Kook Kim, Geun Am Song, Poong Lyul Rhee, Hwoon Yong Jung, Dae Hwan Kang, Yong Chan Lee, Si Hyung Lee, Suck Chei Choi, Ki Nam Shim, Sang Yong Seol, Jeong Seop Moon, Yong Woon Shin, Hyun Soo Kim, Soo Teik Lee, Jin Woong Cho, Eun Kwang Choi, Oh Young Lee, Jin Seok Jang
This study compared the efficacy of DA-9601 (Dong-A ST Co., Seoul, Korea) and its new formulation, DA-5204 (Dong-A ST Co.), for treating erosive gastritis. This phase III, randomized, multicenter, double-blind, non-inferiority trial randomly assigned 434 patients with endoscopically proven gastric mucosal erosions into two groups: DA-9601 3 times daily or DA-5,204 twice daily for 2 weeks. The final analysis included 421 patients (DA-5204, 209; DA-9601, 212). The primary endpoint (rate of effective gastric erosion healing) and secondary endpoints (cure rate of endoscopic erosion and gastrointestinal [GI] symptom relief) were assessed using endoscopy after the treatment...
November 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28955391/relation-of-renal-function-with-left-ventricular-systolic-function-and-nt-probnp-level-and-its-prognostic-implication-in-heart-failure-with-preserved-versus-reduced-ejection-fraction-an-analysis-from-the-korean-heart-failure-korhf-registry
#19
Chan Soon Park, Jin Joo Park, Il-Young Oh, Chang-Hwan Yoon, Dong-Ju Choi, Hyun-Ah Park, Seok-Min Kang, Byung-Su Yoo, Eun-Seok Jeon, Jae-Joong Kim, Myeong-Chan Cho, Shung Chull Chae, Kyu-Hyung Ryu, Byung-Hee Oh
BACKGROUND AND OBJECTIVES: The relationship between ejection fraction (EF), N-terminal pro-brain natriuretic peptide (NT-proBNP) levels and renal function is unknown as stratified by heart failure (HF) type. We investigated their relation and the prognostic value of renal function in heart failure with preserved ejection fraction (HFpEF) vs. reduced ejection fraction (HFrEF). MATERIALS AND METHODS: NT-proBNP, glomerular filtration rate (GFR), and EF were obtained in 1,932 acute heart failure (AHF) patients...
September 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28955381/korean-guidelines-for-diagnosis-and-management-of-chronic-heart-failure
#20
REVIEW
Min-Seok Kim, Ju-Hee Lee, Eung Ju Kim, Dae-Gyun Park, Sung-Ji Park, Jin Joo Park, Mi-Seung Shin, Byung Su Yoo, Jong-Chan Youn, Sang Eun Lee, Sang Hyun Ihm, Se Yong Jang, Sang-Ho Jo, Jae Yeong Cho, Hyun-Jai Cho, Seonghoon Choi, Jin-Oh Choi, Seong Woo Han, Kyung Kuk Hwang, Eun Seok Jeon, Myeong-Chan Cho, Shung Chull Chae, Dong-Ju Choi
The prevalence of heart failure (HF) is skyrocketing worldwide, and is closely associated with serious morbidity and mortality. In particular, HF is one of the main causes for the hospitalization and mortality in elderly individuals. Korea also has these epidemiological problems, and HF is responsible for huge socioeconomic burden. However, there has been no clinical guideline for HF management in Korea. 
The present guideline provides the first set of practical guidelines for the management of HF in Korea and was developed using the guideline adaptation process while including as many data from Korean studies as possible...
September 2017: Korean Circulation Journal
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