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Dong-Chan Oh

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https://www.readbyqxmd.com/read/29893558/cyclopeptides-from-the-sponge-stylissa-flabelliformis
#1
Oh-Seok Kwon, Chang-Kwon Kim, Woong Sub Byun, Joonseok Oh, Yeon-Ju Lee, Hyi-Seung Lee, Chung J Sim, Dong-Chan Oh, Sang Kook Lee, Ki-Bong Oh, Jongheon Shin
Three new cyclopeptides, phakellistatins 20-22 (1-3), as well as 10 known cyclopeptides of the same structural class were isolated from the tropical sponge Stylissa flabelliformis. By a combination of chemical and spectroscopic methods, the structures of the new compounds were determined to be an epimeric mixture of cycloheptapeptides (1) and two epimeric cyclodecapeptides (2 and 3) related to the phakellistatins. The cyclopeptides were evaluated for in vitro cytotoxicity against a variety of cancer cell lines, and compounds 2 and 3 exhibited significant activity...
June 12, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29887444/effect-of-renin-angiotensin-system-blockade-in-patients-with-severe-renal-insufficiency-and-heart-failure
#2
Se Yong Jang, Shung Chull Chae, Myung Hwan Bae, Jang Hoon Lee, Dong Heon Yang, Hun Sik Park, Yongkeun Cho, Hyun-Jai Cho, Hae-Young Lee, Byung-Hee Oh, Jin-Oh Choi, Eun-Seok Jeon, Min-Seok Kim, Sang Eun Lee, Jae-Joong Kim, Kyung-Kuk Hwang, Myeong-Chan Cho, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Youngkeun Ahn, Kye Hun Kim, Hyun-Young Park
BACKGROUND: Renin-angiotensin system blockade (RAB) is the cornerstone in the management of patients with heart failure. However, the benefit of RAB in patients with accompanying severe renal impairment is not clear. We aimed to examine the effect of RAB and the differential effect of RAB depending on renal replacement (RR) in patients with severe renal insufficiency and acute heart failure. METHODS AND RESULTS: Among 5625 patients from the Korean Acute Heart Failure registry, 673 in-hospital survivors (70...
September 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29806159/inorganic-polymer-micropillar-based-solution-shearing-of-large-area-organic-semiconductor-thin-films-with-pillar-size-dependent-crystal-size
#3
Jin-Oh Kim, Jeong-Chan Lee, Min-Ji Kim, Hyunwoo Noh, Hye-In Yeom, Jong Beom Ko, Tae Hoon Lee, Sang-Hee Ko Park, Dong-Pyo Kim, Steve Park
It is demonstrated that the crystal size of small-molecule organic semiconductors can be controlled during solution shearing by tuning the shape and dimensions of the micropillars on the blade. Increasing the size and spacing of the rectangular pillars increases the crystal size, resulting in higher thin-film mobility. This phenomenon is attributed as the microstructure changing the degree and density of the meniscus line curvature, thereby controlling the nucleation process. The use of allylhybridpolycarbosilane (AHPCS), an inorganic polymer, is also demonstrated as the microstructured blade for solution shearing, which has high resistance to organic solvents, can easily be microstructured via molding, and is flexible and durable...
May 28, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29799492/depsidomycins-b-and-c-new-cyclic-peptides-from-a-ginseng-farm-soil-derived-actinomycete
#4
Yun Kwon, Woong Sub Byun, Byung-Yong Kim, Myoung Chong Song, Munhyung Bae, Yeo Joon Yoon, Jongheon Shin, Sang Kook Lee, Dong-Chan Oh
LC/MS-based chemical profiling of a ginseng farm soil-derived actinomycete strain, Streptomyces sp. BYK1371, enabled the discovery of two new cyclic heptapeptides, depsidomycins B and C ( 1 and 2 ), each containing two piperazic acid units and a formyl group at their N -terminus. The structures of 1 and 2 were elucidated by a combination of spectroscopic and chemical analyses. These new compounds were determined to possess d-leucine, d-threonine, d-valine, and S -piperazic acid based on the advanced Marfey's method and a GITC (2,3,4,6-tetra- O -acetyl-β-d-glucopyranosyl isothiocyanate) derivatization of their hydrolysates, followed by LC/MS analysis...
May 25, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29775503/artificial-rod-and-cone-photoreceptors-with-human-like-spectral-sensitivities
#5
Byeongho Park, Heehong Yang, Tai Hwan Ha, Hyun Seo Park, Seung Ja Oh, Yong-Sang Ryu, Youngho Cho, Hyo-Suk Kim, Juyeong Oh, Dong Kyu Lee, Chulki Kim, Taikjin Lee, Minah Seo, Jaebin Choi, Young Min Jhon, Deok Ha Woo, Seok Lee, Seok Hwan Kim, Hyuk-Jae Lee, Seong Chan Jun, Hyun Seok Song, Tai Hyun Park, Jae Hun Kim
Photosensitive materials contain biologically engineered elements and are constructed using delicate techniques, with special attention devoted to efficiency, stability, and biocompatibility. However, to date, no photosensitive material has been developed to replace damaged visual-systems to detect light and transmit the signal to a neuron in the human body. In the current study, artificial nanovesicle-based photosensitive materials are observed to possess the characteristics of photoreceptors similar to the human eye...
May 18, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29764713/utility-of-grace-and-acuity-horizons-risk-scores-to-guide-dual-antiplatelet-therapy-in-korean-patients-with-acute-myocardial-infarction-undergoing-drug-eluting-stenting
#6
Doo Sun Sim, Myung Ho Jeong, Hyo Soo Kim, Hyeon Cheol Gwon, Ki Bae Seung, Seung Woon Rha, Shung Chull Chae, Chong Jin Kim, Kwang Soo Cha, Jong Sun Park, Jung Han Yoon, Jei Keon Chae, Seung Jae Joo, Dong Ju Choi, Seung Ho Hur, In Whan Seong, Myeong Chan Cho, Doo Il Kim, Seok Kyu Oh, Tae Hoon Ahn, Jin Yong Hwang
BACKGROUND: Dual antiplatelet therapy (DAPT) is recommended in patients receiving drug-eluting stents (DES). However, bleeding risk should be weighed against ischemic risk. Utility of GRACE risk score and ACUITY-HORIZONS bleeding risk score was assessed in patients with acute myocardial infarction (MI) according to use of P2Y12 blocker. METHODS: From the Korea Acute Myocardial Infarction Registry-National Institute of Health database, 7791 patients with acute MI receiving DES were divided into ticagrelor (n=1554) and clopidogrel (n=6237) groups...
May 12, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29681584/fate-of-acute-heart-failure-patients-with-mid-range-ejection-fraction
#7
Hye Bin Gwag, Ga Yeon Lee, Jin-Oh Choi, Hae-Young Lee, Jae-Joong Kim, Kyung-Kuk Hwang, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Hyun-Young Park, Myeong-Chan Cho, Byung-Hee Oh, Eun-Seok Jeon
BACKGROUND: The outcomes of heart failure (HF) with mid-range ejection fraction (HFmrEF) have been rarely studied, and follow-up data on left ventricular ejection fraction (LVEF) are scarse.Methods and Results:Patients were selected from a prospective multicenter registry of patients hospitalized for acute HF and then classified in the improved group if they exhibited %LVEF change ≥5 with follow-up LVEF ≥50%. Follow-up LVEF reported at least 90 days after discharge was used for classification...
April 20, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29659509/antartin-a-cytotoxic-zizaane-type-sesquiterpenoid-from-a-streptomyces-sp-isolated-from-an-antarctic-marine-sediment
#8
Dayoung Kim, Eun Ju Lee, Jihye Lee, Alain S Leutou, Yern-Hyerk Shin, Bomi Choi, Ji Sun Hwang, Dongyup Hahn, Hyukjae Choi, Jungwook Chin, Sung Jin Cho, Yong Deog Hong, Jaeyoung Ko, Chi Nam Seong, Katherine N Maloney, Dong-Chan Oh, Inho Yang, Hayoung Hwang, Sang-Jip Nam
Antartin ( 1 ), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin ( 1 ) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase...
April 16, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29609647/higher-satisfaction-with-an-alternative-collection-device-for-stool-sampling-in-colorectal-cancer-screening-with-fecal-immunochemical-test-a-cross-sectional-study
#9
Hye Young Shin, Mina Suh, Kui Son Choi, Sang-Hyun Hwang, Jae Kwan Jun, Dong Soo Han, You Kyoung Lee, Jae Hwan Oh, Chan Wha Lee, Do-Hoon Lee
BACKGROUND: Identifying preferences for stool collection devices may help increase uptake rates for colorectal cancer screening via fecal immunochemical test (FIT). This study surveyed satisfaction with different devices utilized to collect stool samples for FIT: a conventional container and a sampling bottle (Eiken OC-Sensor). METHODS: This cross-sectional study was conducted at the National Cancer Center, Korea. Participants aged 50-74 years who used either a conventional container or a sampling bottle to collect a stool sample for FIT were asked to complete a questionnaire designed to survey their satisfaction with the stool collection process and their intentions to undergo FIT in subsequent screening rounds...
April 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29598933/the-effect-of-door-to-diuretic-time-on-clinical-outcomes-in-patients-with-acute-heart-failure
#10
Jin Joo Park, Sun-Hwa Kim, Il-Young Oh, Dong-Ju Choi, Hyun-Ah Park, Hyun-Jai Cho, Hae-Young Lee, Jae-Yeong Cho, Kye Hun Kim, Jung-Woo Son, Byung-Su Yoo, Jaewon Oh, Seok-Min Kang, Sang Hong Baek, Ga Yeon Lee, Jin Oh Choi, Eun-Seok Jeon, Sang Eun Lee, Jae-Joong Kim, Ju-Hee Lee, Myeong-Chan Cho, Se Yong Jang, Shung Chull Chae, Byung-Hee Oh
OBJECTIVES: This study sought to examine the impact of door-to-diuretic (D2D) time on mortality in patients with acute heart failure (AHF) who were presenting to an emergency department (ED). BACKGROUND: Most patients with AHF present with congestion. Early decongestion with diuretic agents could improve their clinical outcomes. METHODS: The Korea Acute Heart Failure registry enrolled 5,625 consecutive patients hospitalized for AHF. For this analysis, the study included patients who received intravenous diuretic agents within 24 h after ED arrival...
April 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29579390/discovery-of-a-novel-highly-selective-histamine-h4-receptor-antagonist-for-the-treatment-of-atopic-dermatitis
#11
Kwangseok Ko, Hye-Jung Kim, Pil-Su Ho, Soon Ok Lee, Ji-Eun Lee, Cho-Rong Min, Yu Chul Kim, Ju-Han Yoon, Eun-Jung Park, Young-Jin Kwon, Jee-Hun Yun, Dong-Oh Yoon, Jung-Sook Kim, Woul-Seong Park, Seung-Su Oh, Yu-Mi Song, Woon-Ki Cho, Kazumi Morikawa, Kyoung-June Lee, Chan-Hee Park
The histamine H4 receptor (H4R), a member of the G-protein coupled receptor family, has been considered as a potential therapeutic target for treating atopic dermatitis (AD). A large number of H4R antagonists have been disclosed, but no efficient agents controlling both pruritus and inflammation in AD have been developed yet. Here, we have discovered a novel class of orally available H4R antagonists showing strong anti-itching and anti-inflammation activity as well as excellent selectivity against off-targets...
April 12, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29557658/ws9326h-an-antiangiogenic-pyrazolone-bearing-peptide-from-an-intertidal-mudflat-actinomycete
#12
Munhyung Bae, Jedo Oh, Eun Seo Bae, Joonseok Oh, Joonseong Hur, Young-Ger Suh, Sang Kook Lee, Jongheon Shin, Dong-Chan Oh
WS9326H (1), a new cyclic peptide, was isolated from a mudflat-derived Streptomyces strain. Based on analysis by 1D/2D NMR, UV spectroscopy, and mass spectrometry, compound 1 was determined to have the gross structure of a cyclic heptapeptide bearing an unprecedented pyrazolone ring connected to a d-arabinitol via an amide bond. The absolute configuration of 1 was established by multistep chemical derivatizations, comprehensive NMR, and LC/MS analyses of the derivatives and quantum mechanics-based computational methods...
April 6, 2018: Organic Letters
https://www.readbyqxmd.com/read/29535141/predictors-and-prognostic-value-of-worsening-renal-function-during-admission-in-hfpef-versus-hfref-data-from-the-korahf-korean-acute-heart-failure-registry
#13
Jeehoon Kang, Jin Joo Park, Young-Jin Cho, Il-Young Oh, Hyun-Ah Park, Sang Eun Lee, Min-Seok Kim, Hyun-Jai Cho, Hae-Young Lee, Jin Oh Choi, Kyung-Kuk Hwang, Kye Hun Kim, Byung-Su Yoo, Seok-Min Kang, Sang Hong Baek, Eun-Seok Jeon, Jae-Joong Kim, Myeong-Chan Cho, Shung Chull Chae, Byung-Hee Oh, Dong-Ju Choi
BACKGROUND: Worsening renal function (WRF) is associated with adverse outcomes in patients with heart failure. We investigated the predictors and prognostic value of WRF during admission, in patients with preserved ejection fraction (HFpEF) versus those with reduced ejection fraction (HFrEF). METHODS AND RESULTS: A total of 5625 patients were enrolled in the KorAHF (Korean Acute Heart Failure) registry. WRF was defined as an absolute increase in creatinine of ≥0...
March 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29506690/effects-of-angiotensin-receptor-blocker-at-discharge-in-patients-with-heart-failure-with-reduced-ejection-fraction-korean-acute-heart-failure-korahf-registry
#14
Ki Hong Choi, Ga Yeon Lee, Jin-Oh Choi, Eun-Seok Jeon, Hae-Young Lee, Hyun-Jai Cho, Sang Eun Lee, Min-Seok Kim, Jae-Joong Kim, Kyung-Kuk Hwang, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Hyun-Young Park, Myeong-Chan Cho, Byung-Hee Oh
BACKGROUND: After introduction of up-titration strategy, there are limited data on comparison between the effects of angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blocker (ARB) in patients with heart failure with reduced ejection fraction (HFrEF). The study sought to investigate the association between treatment with ARB at discharge and clinical outcomes in patients with HFrEF compared with treatment with ACEI or no renin angiotensin system blocker (RASB). METHODS: The KorAHF registry is a prospective multicenter cohort and included patients who were hospitalized for acute heart failure (AHF)...
April 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29444818/sox7-promotes-high-grade-glioma-by-increasing-vegfr2-mediated-vascular-abnormality
#15
Il-Kug Kim, Kangsan Kim, Eunhyeong Lee, Dong Sun Oh, Chan Soon Park, Seongyeol Park, Jee Myung Yang, Ju-Hee Kim, Hyung-Seok Kim, David T Shima, Jeong Hoon Kim, Seok Ho Hong, Young Hyun Cho, Young Hoon Kim, Jong Bae Park, Gou Young Koh, Young Seok Ju, Heung Kyu Lee, Seungjoo Lee, Injune Kim
High-grade glioma (HGG) is highly angiogenic, but antiangiogenic therapy has transient clinical benefit in only a fraction of patients. Vascular regulators of these heterogeneous responses remain undetermined. We found up-regulation of Sox7 and down-regulation of Sox17 in tumor endothelial cells (tECs) in mouse HGG. Sox7 deletion suppressed VEGFR2 expression, vascular abnormality, hypoxia-driven invasion, regulatory T cell infiltration, and tumor growth. Conversely, Sox17 deletion exacerbated these phenotypes by up-regulating Sox7 in tECs...
March 5, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29399854/antenatal-prediction-of-neonatal-survival-in-sacrococcygeal-teratoma
#16
Seung Mi Lee, Dong Hoon Suh, So Yeon Kim, Min Kyoung Kim, Sohee Oh, Sang Hoon Song, Hyun-Young Kim, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun
OBJECTIVES: In sacrococcygeal teratoma, the presence of high-output cardiac failure resulting from arteriovenous shunting through the large tumor has been associated with an adverse outcome. The objective of this study was to determine whether the tumor size and cardiac biomarkers in cord blood can predict neonatal survival in sacrococcygeal teratoma. METHODS: The study population consisted of 25 neonates with sacrococcygeal teratoma. Tumor size was calculated by the ellipsoid formula using dimensions measured by antenatal ultrasound ([length × width × depth in cm] × 0...
February 5, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29385086/spiroketones-and-a-biphenyl-analog-from-stems-and-leaves-of-larrea-nitida-and-their-inhibitory-activity-against-il-6-production
#17
Jongmin Ahn, Yihua Pei, Hee-Sung Chae, Seong-Hwan Kim, Young-Mi Kim, Young Hee Choi, Joongku Lee, Minsun Chang, Yun Seon Song, Roberto Rodriguez, Dong-Chan Oh, Jinwoong Kim, Sangho Choi, Sang Hoon Joo, Young-Won Chin
Bioactivity-guided fractionation for the stems of leaves of Larrea nitida Cav., using interleukin-6 (IL-6) inhibitory assay in human mast cells (HMC-1), led to the isolation of three new compounds with an unprecedented skeleton in nature ( 1 - 3 ) and three known compounds ( 4 - 6 ). Their structures were elucidated through extensive spectroscopic analysis. The three new compounds were elucidated as two new spiroketones, nitidaones A ( 1 ), and B ( 2 ) and one new biphenyl analog, nitidaol ( 3 ). The known compounds were identified as nordihydroguaiaretic acid ( 4 ), 7,3',4'-tri- O -methylquercetin ( 5 ) and ayanin ( 6 )...
January 31, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29380472/conformation-enabled-total-syntheses-of-ohmyungsamycins-a-and-b-and-structural-revision-of-ohmyungsamycin-b
#18
Joonseong Hur, Jaebong Jang, Jaehoon Sim, Woo Sung Son, Hee-Chul Ahn, Tae Sung Kim, Yern-Hyerk Shin, Changjin Lim, Seungbeom Lee, Hongchan An, Seok-Ho Kim, Dong-Chan Oh, Eun-Kyeong Jo, Jichan Jang, Jeeyeon Lee, Young-Ger Suh
The first total syntheses of the bioactive cyclodepsipeptides ohmyungsamycin A and B are described. Key features of our synthesis include the concise preparation of a linear cyclization precursor that consists of N-methyl amides and non-proteinogenic amino acids, and its macrolactamization from a bent conformation. The proposed structure of ohmyungsamycin B was revised based on its synthesis. The cyclic core of the ohmyungsamycins was shown to be responsible for the excellent antituberculosis activity, and ohmyungsamycin variants with truncated chains were evaluated for their biological activity...
March 12, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29378565/comparison-of-the-efficacy-of-nafcillin-and-glycopeptides-as-definitive-therapy-for-patients-with-methicillin-susceptible-staphylococcus-aureus-bacteremia-a-retrospective-cohort-study
#19
Dong Hyun Oh, Jung Ju Kim, Jinnam Kim, Hye Seong, Se Ju Lee, Yong Chan Kim, Eun Jin Kim, In Young Jung, Woo Yong Jeong, Su Jin Jeong, Nam Su Ku, Sang Hoon Han, Jun Yong Choi, Young Goo Song, June Myung Kim
BACKGROUND: Studies have shown that the prognosis of the treatment of methicillin-susceptible S. aureus (MSSA) with glycopeptides is inferior compared to treatment with β-lactam. However, there are only few studies comparing treatment with antistaphylococcal penicillin alone to glycopeptide treatment. The aim of this study was to compare the efficacy of nafcillin, an antistaphylococcal penicillin, with that of glycopeptides as a definitive therapy for MSSA bacteremia. METHODS: Patients with MSSA bacteremia recruited from a tertiary referral hospital were enrolled in this retrospective cohort study...
January 30, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29325562/increased-epicardial-adipose-tissue-thickness-is-a-predictor-of-new-onset-diabetes-mellitus-in-patients-with-coronary-artery-disease-treated-with-high-intensity-statins
#20
Jeehoon Kang, Young-Chan Kim, Jin Joo Park, Sehun Kim, Si-Hyuck Kang, Young Jin Cho, Yeonyee E Yoon, Il-Young Oh, Chang-Hwan Yoon, Jung-Won Suh, Young-Seok Cho, Tae-Jin Youn, In-Ho Chae, Dong-Ju Choi
BACKGROUND: Statins are widely used for lipid lowering in patients with coronary artery disease (CAD), but increasing evidence indicates an association between statin use and new-onset of diabetes mellitus (NODM). Epicardial adipose tissue (EAT) refers to the visceral fat surrounding the heart, which is associated with metabolic diseases. We sought to determine the association between EAT thickness and NODM in CAD patients treated with high-intensity statins. METHODS: We conducted a retrospective medical record review of CAD patients treated with high-intensity statins for at least 6 months after percutaneous coronary intervention performed between January 2009 and June 2013 at Seoul National University Bundang Hospital...
January 11, 2018: Cardiovascular Diabetology
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