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Kenneth Soderhall

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https://www.readbyqxmd.com/read/27203572/correction-caspase-1-like-regulation-of-the-propo-system-and-role-of-ppa-and-caspase-1-like-cleaved-peptides-from-propo-in-innate-immunity
#1
Miti Jearaphunt, Chadanat Noonin, Pikul Jiravanichpaisal, Seiko Nakamura, Anchalee Tassanakajon, Irene Söderhäll, Kenneth Söderhäll
[This corrects the article DOI: 10.1371/journal.ppat.1004059.].
May 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27144534/retraction-bacteria-induced-dscam-isoforms-of-the-crustacean-pacifastacus-leniusculus
#2
Apiruck Watthanasurorot, Pikul Jiravanichpaisal, Haipeng Liu, Irene Söderhäll, Kenneth Söderhäll
No abstract text is available yet for this article.
May 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/26493017/announcing-the-appointment-of-mike-belosevic-as-coeditor-in-chief
#3
EDITORIAL
Kenneth Söderhäll
No abstract text is available yet for this article.
February 2016: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/26285030/interaction-of-vibrio-spp-with-the-inner-surface-of-the-digestive-tract-of-penaeus-monodon
#4
Wipasiri Soonthornchai, Sage Chaiyapechara, Padermsak Jarayabhand, Kenneth Söderhäll, Pikul Jiravanichpaisal
Several species of Vibrio are the causative agent of gastroenteritis in humans. In aquaculture, Vibrio harveyi (Vh) and V. parahaemolyticus (Vp) have long been considered as shrimp pathogens in freshwater, brackish and marine environments. Here we show by using scanning electron microscopy (SEM) that Penaeus monodon orally inoculated with each of these two pathogens via an Artemia diet had numerous bacteria attached randomly across the stomach surface, in single and in large biofilm-like clusters 6 h post-infection...
2015: PloS One
https://www.readbyqxmd.com/read/25042057/thermolysin-damages-animal-life-through-degradation-of-plasma-proteins-enhanced-by-rapid-cleavage-of-serpins-and-activation-of-proteases
#5
Lulu Kong, Anrui Lu, Jingmin Guan, Bing Yang, Muwang Li, Julián F Hillyer, Nalini Ramarao, Kenneth Söderhäll, Chaoliang Liu, Erjun Ling
Thermolysin, a metallopeptidase secreted by pathogenic microbes, is concluded as an important virulence factor due to cleaving purified host proteins in vitro. Using the silkworm Bombyx mori as a model system, we found that thermolysin injection into larvae induces the destruction of the coagulation response and the activation of hemolymph melanization, which results in larval death. Thermolysin triggers the rapid degradation of insect and mammalian plasma proteins at a level that is considerably greater than expected in vitro and/or in vivo...
January 2015: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/24807724/hijacking-of-host-calreticulin-is-required-for-the-white-spot-syndrome-virus-replication-cycle
#6
Apiruck Watthanasurorot, Enen Guo, Sirinit Tharntada, Chu-Fang Lo, Kenneth Söderhäll, Irene Söderhäll
We have previously shown that multifunctional calreticulin (CRT), which resides in the endoplasmic reticulum (ER) and is involved in ER-associated protein processing, responds to infection with white spot syndrome virus (WSSV) by increasing mRNA and protein expression and by forming a complex with gC1qR and thereby delaying apoptosis. Here, we show that CRT can directly interact with WSSV structural proteins, including VP15 and VP28, during an early stage of virus infection. The binding of VP28 with CRT does not promote WSSV entry, and CRT-VP15 interaction was detected in the viral genome in virally infected host cells and thus may have an effect on WSSV replication...
July 2014: Journal of Virology
https://www.readbyqxmd.com/read/24722332/caspase-1-like-regulation-of-the-propo-system-and-role-of-ppa-and-caspase-1-like-cleaved-peptides-from-propo-in-innate-immunity
#7
Miti Jearaphunt, Chadanat Noonin, Pikul Jiravanichpaisal, Seiko Nakamura, Anchalee Tassanakajon, Irene Söderhäll, Kenneth Söderhäll
Invertebrates rely on innate immunity to respond to the entry of foreign microorganisms. One of the important innate immune responses in arthropods is the activation of prophenoloxidase (proPO) by a proteolytic cascade finalized by the proPO-activating enzyme (ppA), which leads to melanization and the elimination of pathogens. Proteolytic cascades play a crucial role in innate immune reactions because they can be triggered more quickly than immune responses that require altered gene expression. Caspases are intracellular proteases involved in tightly regulated limited proteolysis of downstream processes and are also involved in inflammatory responses to infections for example by activation of interleukin 1ß...
April 2014: PLoS Pathogens
https://www.readbyqxmd.com/read/24657220/recombinant-drosophila-prophenoloxidase-1-is-sequentially-cleaved-by-%C3%AE-chymotrypsin-during-in-vitro-activation
#8
Anrui Lu, Xuquan Li, Julián F Hillyer, Brenda T Beerntsen, Kenneth Söderhäll, Erjun Ling
Insect prophenoloxidase (PPO) is an essential innate immunity protein to induce pathogen into melanization. In Bombyx mori, pro-phenoloxidase-activating enzyme (PPAE) can directly cleave and activate PPO. However, PPO in Manduca sexta cannot be cleaved into active phenoloxidase (PO) by serine proteases unless cofactors are involved, which indicates that PPO activation is complicated. Here we use recombinant Drosophila melanogaster prophenoloxidase 1 (rPPO1) to study the mechanism of PPO activation induced by a typical serine protease, α-chymotrypsin...
July 2014: Biochimie
https://www.readbyqxmd.com/read/24259255/variable-immune-molecules-in-invertebrates
#9
Lage Cerenius, Kenneth Söderhäll
Recently it has become evident that invertebrates may mount a highly variable immune response that is dependent on which pathogen is involved. The molecular mechanisms behind this diversity are beginning to be unravelled and in several invertebrate taxa immune proteins exhibiting a broad range of diversity have been found. In some cases, evidence has been gathered suggesting that this molecular diversity translates into the ability of an affected invertebrate to mount a defence that is specifically aimed at a particular pathogen...
December 1, 2013: Journal of Experimental Biology
https://www.readbyqxmd.com/read/23565293/%C3%AE-thymosins-and-hemocyte-homeostasis-in-a-crustacean
#10
Netnapa Saelee, Chadanat Noonin, Benjamas Nupan, Kingkamon Junkunlo, Amornrat Phongdara, Xionghui Lin, Kenneth Söderhäll, Irene Söderhäll
Thymosin proteins are well known for their actin-binding activity. Thymosin beta 4 (Tβ4) has been associated with biological activities in tissue repair and cell migration via interaction with ATP-synthase in vertebrates, while the information of similar thymosin functions in invertebrates is limited. We have shown previously that ATP-synthase is present on the surface of crayfish hematopoietic tissue (HPT) cells, and that astakine 1 (Ast1, an invertebrate cytokine) was found to interact with this β-subunit of ATP synthase...
2013: PloS One
https://www.readbyqxmd.com/read/23555281/astakine-2-the-dark-knight-linking-melatonin-to-circadian-regulation-in-crustaceans
#11
Apiruck Watthanasurorot, Netnapa Saelee, Amornrat Phongdara, Sittiruk Roytrakul, Pikul Jiravanichpaisal, Kenneth Söderhäll, Irene Söderhäll
Daily, circadian rhythms influence essentially all living organisms and affect many physiological processes from sleep and nutrition to immunity. This ability to respond to environmental daily rhythms has been conserved along evolution, and it is found among species from bacteria to mammals. The hematopoietic process of the crayfish Pacifastacus leniusculus is under circadian control and is tightly regulated by astakines, a new family of cytokines sharing a prokineticin (PROK) domain. The expression of AST1 and AST2 are light-dependent, and this suggests an evolutionarily conserved function for PROK domain proteins in mediating circadian rhythms...
March 2013: PLoS Genetics
https://www.readbyqxmd.com/read/23378602/a-calreticulin-gc1qr-complex-prevents-cells-from-dying-a-conserved-mechanism-from-arthropods-to-humans
#12
Apiruck Watthanasurorot, Pikul Jiravanichpaisal, Kenneth Söderhäll, Irene Söderhäll
The crossroad between cell death and proliferation is a general target for viral infections because viruses need to obstruct apoptosis to use cells for their own replication. Inducing immunogenic cell death in proliferating cells is also an important aim of anticancer chemotherapy. The C1q-binding proteins calreticulin (CRT) and gC1qR are highly conserved ubiquitous proteins, which are putative targets for viral manipulation and are associated with cancer. Here we show that these proteins form a complex in the cytoplasm as a response to viral infection resulting in apoptosis prevention...
April 2013: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/22848488/existence-of-prophenoloxidase-in-wing-discs-a-source-of-plasma-prophenoloxidase-in-the-silkworm-bombyx-mori
#13
Yupu Diao, Anrui Lu, Bing Yang, Wenli Hu, Qing Peng, Qing-Zhi Ling, Brenda T Beerntsen, Kenneth Söderhäll, Erjun Ling
In insects, hemocytes are considered as the only source of plasma prophenoloxidase (PPO). PPO also exists in the hemocytes of the hematopoietic organ that is connected to the wing disc of Bombyx mori. It is unknown whether there are other cells or tissues that can produce PPO and release it into the hemolymph besides circulating hemocytes. In this study, we use the silkworm as a model to explore this possibility. Through tissue staining and biochemical assays, we found that wing discs contain PPO that can be released into the culture medium in vitro...
2012: PloS One
https://www.readbyqxmd.com/read/22564088/invertebrate-hematopoiesis-an-anterior-proliferation-center-as-a-link-between-the-hematopoietic-tissue-and-the-brain
#14
Chadanat Noonin, Xionghui Lin, Pikul Jiravanichpaisal, Kenneth Söderhäll, Irene Söderhäll
During evolution, the innate and adaptive immune systems were developed to protect organisms from non-self substances. The innate immune system is phylogenetically more ancient and is present in most multicellular organisms, whereas adaptive responses are restricted to vertebrates. Arthropods lack the blood cells of the lymphoid lineage and oxygen-carrying erythrocytes, making them suitable model animals for studying the regulation of the blood cells of the innate immune system. Many crustaceans have a long life span and need to continuously synthesize blood cells, in contrast to many insects...
November 20, 2012: Stem Cells and Development
https://www.readbyqxmd.com/read/22459272/an-mbl-like-protein-may-interfere-with-the-activation-of-the-propo-system-an-important-innate-immune-reaction-in-invertebrates
#15
Chenglin Wu, Walaiporn Charoensapsri, Seiko Nakamura, Anchalee Tassanakajon, Irene Söderhäll, Kenneth Söderhäll
An important characteristic of the innate immune systems of crayfish and other arthropods is the activation of a serine proteinase cascade in the hemolymph, which results in the activation of prophenoloxidase and subsequently leading to the formation of toxic quinones and melanin. Although no true complement homologues have been detected in crayfish or crustaceans, several proteins with similarities to vertebrate pattern recognition receptors (PRRs), which are involved in the lectin pathway of complement activation in vertebrates, are present...
February 2013: Immunobiology
https://www.readbyqxmd.com/read/22375003/hindgut-innate-immunity-and-regulation-of-fecal-microbiota-through-melanization-in-insects
#16
Qimiao Shao, Bing Yang, Qiuyun Xu, Xuquan Li, Zhiqiang Lu, Chengshu Wang, Yongping Huang, Kenneth Söderhäll, Erjun Ling
Many insects eat the green leaves of plants but excrete black feces in an as yet unknown mechanism. Insects cannot avoid ingesting pathogens with food that will be specifically detected by the midgut immune system. However, just as in mammals, many pathogens can still escape the insect midgut immune system and arrive in the hindgut, where they are excreted out with the feces. Here we show that the melanization of hindgut content induced by prophenoloxidase, a key enzyme that induces the production of melanin around invaders and at wound sites, is the last line of immune defense to clear bacteria before feces excretion...
April 20, 2012: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/22193393/an-insect-tep-in-a-crustacean-is-specific-for-cuticular-tissues-and-involved-in-intestinal-defense
#17
Chenglin Wu, Chadanat Noonin, Pikul Jiravanichpaisal, Irene Söderhäll, Kenneth Söderhäll
In an attempt to identify genes encoding thioester-containing proteins in the freshwater crayfish, Pacifastacus leniusculus, three different cDNAs were found. A phylogenetic analysis of these proteins indicates that they can be classified into two subfamilies: two alpha-2-macroglobulins (Pl-A2M1, Pl-A2M2) showing a close similarity to shrimp A2M, and one insect TEP-like protein (Pl-TEP). This is the first report of an insect TEP-like protein in a crustacean. Crayfish Pl-A2M1, Pl-A2M2 and Pl-TEP cDNAs encode proteins with 1480, 1586 or 1507 amino acids, respectively...
February 2012: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/22182410/a-mammalian-like-interleukin-1-receptor-associated-kinase-4-irak-4-a-tir-signaling-mediator-in-intestinal-innate-immunity-of-black-tiger-shrimp-penaeus-monodon
#18
Apiruck Watthanasurorot, Kenneth Söderhäll, Pikul Jiravanichpaisal
Interleukin-1 receptor associated kinase-4 (IRAK-4) has been identified as a central signal transduction mediator of the Toll-like receptor (TLR) and Toll/interleukin-1 receptor (TIR) pathways in vertebrate innate immunity. An IRAK-4 homologue was cloned from the black tiger shrimp (Penaeus monodon) (PmIRAK-4) and it shares domains and structures with other IRAK-4s. It was found to be mainly expressed in the hemocytes and midgut but also to a lower extent in several other tissues in shrimp. The PmIRAK-4 responded to bacterial infection in the intestine by an enhancement of its expression level...
January 6, 2012: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/21708317/developmental-and-comparative-immunology-editorial
#19
EDITORIAL
Kenneth Söderhäll, Paul Taylor
No abstract text is available yet for this article.
September 2011: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/21695245/bacteria-induced-dscam-isoforms-of-the-crustacean-pacifastacus-leniusculus
#20
Apiruck Watthanasurorot, Pikul Jiravanichpaisal, Haipeng Liu, Irene Söderhäll, Kenneth Söderhäll
The Down syndrome cell adhesion molecule, also known as Dscam, is a member of the immunoglobulin super family. Dscam plays an essential function in neuronal wiring and appears to be involved in innate immune reactions in insects. The deduced amino acid sequence of Dscam in the crustacean Pacifastacus leniusculus (PlDscam), encodes 9(Ig)-4(FNIII)-(Ig)-2(FNIII)-TM and it has variable regions in the N-terminal half of Ig2 and Ig3 and the complete Ig7 and in the transmembrane domain. The cytoplasmic tail can generate multiple isoforms...
June 2011: PLoS Pathogens
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