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filaria malaria

Vikarn Vishwajeet, Man Updesh Singh Sachdeva
No abstract text is available yet for this article.
March 25, 2018: American Journal of Hematology
Indu Malhotra, A Desiree LaBeaud, Nathan Morris, Maxim McKibben, Peter Mungai, Eric Muchiri, Christopher L King, Charles H King
Background: Antenatal exposure to parasites can affect infants' subsequent responses to vaccination. The present study investigated how maternal prenatal infections and newborns' antiparasite cytokine profiles relate to immunoglobulin G (IgG) responses to standard vaccination during infancy. Methods: A total of 450 Kenyan women were tested for parasitic infections during pregnancy. Their newborns' responses to Plasmodium falciparum, schistosome, and filaria antigens were assessed in cord blood lymphocytes...
April 11, 2018: Journal of Infectious Diseases
Leila Pashazanusi, Baraka Lwoya, Shreyas Oak, Tushar Khosla, Julie N L Albert, Yu Tian, Geetha Bansal, Nirbhay Kumar, Noshir S Pesika
Insects and small animals capable of adhering reversibly to a variety of surfaces employ the unique design of the distal part of their legs. In the case of mosquitoes, their feet are composed of thousands of micro- and nanoscale protruding structures, which impart superhydrophobic properties. Previous research has shown that the superhydrophobic nature of the feet allows mosquitoes to land on water, which is necessary for their reproduction cycle. Here, we show that van der Waals interactions are the main adhesion mechanism employed by mosquitoes to adhere to various surfaces...
July 19, 2017: ACS Applied Materials & Interfaces
A Desiree LaBeaud, Monica Nayakwadi Singer, Maxim McKibben, Peter Mungai, Eric M Muchiri, Elisabeth McKibben, Ginny Gildengorin, Laura J Sutherland, Charles H King, Christopher L King, Indu Malhotra
BACKGROUND: Parasitic infections, which are among the most common infections worldwide, disproportionately affect children; however, little is known about the impact of parasitic disease on growth in very early childhood. Our objective was to document the prevalence of parasitic infections and examine their association with growth during the first three years of life among children in coastal Kenya. METHODOLOGY/PRINCIPAL FINDINGS: Children enrolled in a maternal-child cohort were tested for soil transmitted helminths (STHs: Ascaris, Trichuris, hookworm, Strongyloides), protozoa (malaria, Entamoeba histolytica and Giardia lamblia), filaria, and Schistosoma infection every six months from birth until age three years...
May 2015: PLoS Neglected Tropical Diseases
Amaya L Bustinduy, Laura J Sutherland, Alicia Chang-Cojulun, Indu Malhotra, Adam S DuVall, Jessica K Fairley, Peter L Mungai, Eric M Muchiri, Francis M Mutuku, Uriel Kitron, Charles H King
In a study of children having polyparasitic infections in a Schistosoma haematobium-endemic area, we examined the hypothesis that S. haematobium-positive children, compared with S. haematobium-negative children (anti-soluble worm antigen preparation [SWAP] negative and egg negative) have increased systemic production of pro-inflammatory cytokines (interleukin [IL]-6, tumor necrosis factor [TNF]-α) and decreased down-regulatory IL-10. A total of 804 children, 2-19 years of age, were surveyed between July and December 2009 and tested for S...
May 2015: American Journal of Tropical Medicine and Hygiene
Indu Malhotra, Maxim McKibben, Peter Mungai, Elisabeth McKibben, Xuelei Wang, Laura J Sutherland, Eric M Muchiri, Charles H King, Christopher L King, A Desiree LaBeaud
BACKGROUND: Parasitic infections are prevalent among pregnant women in sub-Saharan Africa. We investigated whether prenatal exposure to malaria and/or helminths affects the pattern of infant immune responses to standard vaccinations against Haemophilus influenzae (Hib), diphtheria (DT), hepatitis B (Hep B) and tetanus toxoid (TT). METHODS AND FINDINGS: 450 Kenyan women were tested for malaria, schistosomiasis, lymphatic filariasis (LF), and intestinal helminths during pregnancy...
January 2015: PLoS Neglected Tropical Diseases
Vk Satyawali, Shanti Pandey, Vinita Rawat, Mohm Khalil
No abstract text is available yet for this article.
July 2014: Journal of Laboratory Physicians
Barton E Slatko, Ashley N Luck, Stephen L Dobson, Jeremy M Foster
Most human filarial nematode parasites and arthropods are hosts for a bacterial endosymbiont, Wolbachia. In filaria, Wolbachia are required for normal development, fertility and survival, whereas in arthropods, they are largely parasitic and can influence development and reproduction, but are generally not required for host survival. Due to their obligate nature in filarial parasites, Wolbachia have been a target for drug discovery initiatives using several approaches including diversity and focused library screening and genomic sequence analysis...
July 2014: Molecular and Biochemical Parasitology
Gregory Karadjian, Dominique Berrebi, Nathalie Dogna, Nathaly Vallarino-Lhermitte, Odile Bain, Irène Landau, Coralie Martin
Infection with multiple parasite species is clearly the norm rather than the exception, in animals as well as in humans. Filarial nematodes and Plasmodium spp. are important parasites in human public health and they are often co-endemic. Interactions between these parasites are complex. The mechanisms underlying the modulation of both the course of malaria and the outcome of filarial infection are poorly understood. Despite increasing activity in recent years, studies comparing co- and mono-infections are very much in their infancy and results are contradictory at first sight...
2014: Parasite: Journal de la Société Française de Parasitologie
Wenquan Liu, Huicong Huang, Cuicui Xing, Chunxiang Li, Feng Tan, Shaohui Liang
BACKGROUND: Anopheles anthropophagus, one of the most important mosquito-borne disease vectors in Asia, mainly takes blood meals from humans and transmits both malaria and filariae. MicroRNAs (miRNAs) are small non-coding RNAs, and play a critical role in many cellular processes, including development, differentiation, apoptosis and innate immunity. METHODS: We investigated the global miRNA expression profile of male and female adults of A. anthropophagus using illumina Hiseq2000 sequencing combined with Northern blot...
2014: Parasites & Vectors
Kostas Bourtzis, Stephen L Dobson, Zhiyong Xi, Jason L Rasgon, Maurizio Calvitti, Luciano A Moreira, Hervé C Bossin, Riccardo Moretti, Luke Anthony Baton, Grant L Hughes, Patrick Mavingui, Jeremie R L Gilles
Mosquito species, members of the genera Aedes, Anopheles and Culex, are the major vectors of human pathogens including protozoa (Plasmodium sp.), filariae and of a variety of viruses (causing dengue, chikungunya, yellow fever, West Nile). There is lack of efficient methods and tools to treat many of the diseases caused by these major human pathogens, since no efficient vaccines or drugs are available; even in malaria where insecticide use and drug therapies have reduced incidence, 219 million cases still occurred in 2010...
April 2014: Acta Tropica
Housseini Dolo, Yaya I Coulibaly, Benoit Dembele, Siaka Konate, Siaka Y Coulibaly, Salif S Doumbia, Abdallah A Diallo, Lamine Soumaoro, Michel E Coulibaly, Seidina A S Diakite, Aldiouma Guindo, Michael P Fay, Simon Metenou, Thomas B Nutman, Amy D Klion
BACKGROUND: Wuchereria bancrofti (Wb) and Mansonella perstans (Mp) are blood-borne filarial parasites that are endemic in many countries of Africa, including Mali. The geographic distribution of Wb and Mp overlaps considerably with that of malaria, and coinfection is common. Although chronic filarial infection has been shown to alter immune responses to malaria parasites, its effect on clinical and immunologic responses in acute malaria is unknown. METHODOLOGY/PRINCIPAL FINDINGS: To address this question, 31 filaria-positive (FIL+) and 31 filaria-negative (FIL-) children and young adults, matched for age, gender and hemoglobin type, were followed prospectively through a malaria transmission season...
2012: PLoS Neglected Tropical Diseases
Gilbert Le Goff, Philippe Boussès, Simon Julienne, Cécile Brengues, Nil Rahola, Gérard Rocamora, Vincent Robert
BACKGROUND: During recent periods, the islands of the Republic of Seychelles experienced many diseases such as dengue, chikungunya, Bancroft's filaria and malaria. Mosquitoes transmit the agents that cause these diseases. Published information on mosquitoes in the Seychelles is notably dispersed in the literature. The maximum number of species obtained on a single field survey does not exceed 14 species. METHODS: We performed a comprehensive bibliographic review using mosquito and Seychelles as the key words, as well as conducted a mosquito field survey for larval and adult stages during the rainy season in December 2008...
2012: Parasites & Vectors
Gavendra Singh, Soam Prakash
OBJECTIVE: To investigate lethal effect of culture filtrates of Streptomyces citreofluorescens (S. citreofluorescens) against Anopheles stephensi (An. stephensi), Culex quinquefasciatus (Cx. quinquefasciatus), and Aedes aegypti (Ae. aegypti) larvae vectors for malaria, filarial and dengue. METHODS: The culture filtrates obtained from S. citreofluorescens 2528 was grown in Potato Dextrose Broth (PDB), filtrated and used for the bioassay after a growth of 15 days...
August 2012: Asian Pacific Journal of Tropical Medicine
Gavendra Singh, Soam Prakash
Aspergillus niger is a fungus of the genus Aspergillus. It has caused a disease called black mold on certain fruits and vegetables. The culture filtrates released from the A. niger ATCC 66566 were grown in Czapek dox broth (CDB) then filtered with flash chromatograph and were used for the bioassay after a growth of thirty days. The result demonstrated these mortalities with LC(50), LC(90), and LC(99) values of Culex quinquefasciatus 0.76, 3.06, and 4.75, Anopheles stephensi 1.43, 3.2, and 3.86, and Aedes aegypti 1...
2012: TheScientificWorldJournal
Simon Metenou, Subash Babu, Thomas B Nutman
PURPOSE OF REVIEW: To examine the consequences of the immune modulation seen in chronic filarial infection on responses to intracellular pathogens (and their antigens) that are often co-endemic with filarial infections, namely Plasmodium and Mycobacterium tuberculosis. RECENT FINDINGS: Much of the recent data on filaria/mycobacteria or filaria/Plasmodium co-infection has focused on the modulation of mycobacteria-specific or malaria-specific responses by chronic filarial infection...
May 2012: Current Opinion in HIV and AIDS
Simon Metenou, Michael Kovacs, Benoit Dembele, Yaya I Coulibaly, Amy D Klion, Thomas B Nutman
In areas where polyparasitism is highly prevalent, the impact of multiple parasites on the host response is underestimated. In particular, the presence of helminth infection coincident with malaria profoundly alters the production of malaria-specific IFN-γ, IL-12p70, CXCL9, CXCL10 and CXCL11, cytokines/chemokines known to be critical in mediating malaria-specific immunity. In order to elucidate the mechanisms underlying the suppression of malaria-specific cytokines/chemokines, we assessed the expression of malaria-specific IL-12Rβ1, IL-12Rβ2 and interferon regulatory factor (IRF)-1 in blood obtained from 18 filaria-infected (Fil(+)) and 17 filaria-uninfected (Fil(-)) individuals in a filaria-malaria co-endemic region of Mali...
March 2012: European Journal of Immunology
Julia Kolbaum, Susanne Tartz, Wiebke Hartmann, Susanne Helm, Andreas Nagel, Volker Heussler, Peter Sebo, Bernhard Fleischer, Thomas Jacobs, Minka Breloer
Malaria is still responsible for up to 1 million deaths per year worldwide, highlighting the need for protective malaria vaccines. Helminth infections that are prevalent in malaria endemic areas can modulate immune responses of the host. Here we show that Strongy-Ioides ratti, a gut-dwelling nematode that causes transient infections, did not change the efficacy of vaccination against Plasmodium berghei. An ongoing infection with Litomosoides sigmodontis, a tissue-dwelling filaria that induces chronic infections in BALB/c mice, significantly interfered with vaccination efficacy...
April 2012: European Journal of Immunology
Goli Penchala Prasad, G Trimurtulu, K N Reddy, M L Naidu
Caesalpinia bonduc (L.) Roxb. (Kuberaksha) is an Ayurvedic herb used in the management of malaria, liver disorders, worms, edematous conditions, etc. Based on classical Ayurvedic textual indications and recent pharmacological studies, its leaf powder was selected for studying its effect clinically on filaria. Before conducting the clinical trails, this leaf powder was subjected to certain chemical studies to find the pH, ash value, extractive values, High Performance Thin Layer Chromatography (HPTLC), etc. for standardization of the drug...
April 2010: Ayu
Amaya L Bustinduy, Charles L Thomas, Justin J Fiutem, Isabel M Parraga, Peter L Mungai, Eric M Muchiri, Francis Mutuku, Uriel Kitron, Charles H King
BACKGROUND: To date, there has been no standardized approach to the assessment of aerobic fitness among children who harbor parasites. In quantifying the disability associated with individual or multiple chronic infections, accurate measures of physical fitness are important metrics. This is because exercise intolerance, as seen with anemia and many other chronic disorders, reflects the body's inability to maintain adequate oxygen supply (VO(2) max) to the motor tissues, which is frequently linked to reduced quality-of-life in terms of physical and job performance...
July 2011: PLoS Neglected Tropical Diseases
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