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https://www.readbyqxmd.com/read/29879935/global-prevalence-and-distribution-of-coinfection-of-malaria-dengue-and-chikungunya-a-systematic-review
#1
Nasir Salam, Shoeb Mustafa, Abdul Hafiz, Anis Ahmad Chaudhary, Farah Deeba, Shama Parveen
BACKGROUND: Malaria, Dengue and Chikungunya are vector borne diseases with shared endemic profiles and symptoms. Coinfections with any of these diseases could have fatal outcomes if left undiagnosed. Understanding the prevalence and distribution of coinfections is necessary to improve diagnosis and designing therapeutic interventions. METHODS: We have carried out a systematic search of the published literature based on PRISMA guidelines to identify cases of Malaria, Dengue and Chikungunya coinfections...
June 8, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29780010/imported-malaria-in-turkey-the-importance-of-diagnosis-and-treatment-of-plasmodium-falciparum-plasmodium-vivax-mixed-infection
#2
Özlem Tünger, Akide Çakmak, Ahmet Özbilgin, Varol Tunalı, Çiğdem Banu Çetin
The most common types of malaria in the world are Plasmodium vivax and P. falciparum. In countries where both species are endemic, P. vivax and P. falciparum coinfection also occurs. Thus, the possibility of mixed malaria in Turkey should always be considered in cases with a traveling history to these countries. Here, we report a case of P. vivax/P. falciparum mixed infection that was diagnosed as P. falciparum malaria in Ethiopia. However, the administered treatment was inadequate, and infection recurred because of the miss in the diagnosis of P...
May 21, 2018: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29764843/poorly-cytotoxic-terminally-differentiated-cd56-neg-cd16-pos-nk-cells-accumulate-in-kenyan-children-with-burkitt-lymphomas
#3
Catherine S Forconi, Cormac P Cosgrove, Pryia Saikumar-Lakshmi, Christina E Nixon, Joslyn Foley, John Michael Ong'echa, Juliana A Otieno, Galit Alter, Christian Münz, Ann M Moormann
Natural killer (NK) cells are critical for restricting viral infections and mediating tumor immunosurveillance. Epstein-Barr virus (EBV) and Plasmodium falciparum malaria are known risk factors for endemic Burkitt lymphoma (eBL), the most common childhood cancer in equatorial Africa. To date, the composition and function of NK cells have not been evaluated in eBL etiology or pathogenesis. Therefore, using multiparameter flow cytometry and in vitro killing assays, we compared NK cells from healthy children and children diagnosed with eBL in Kenya...
May 22, 2018: Blood Advances
https://www.readbyqxmd.com/read/29592839/high-resolution-mass-spectrometry-based-methodologies-for-identification-of-etravirine-bioactivation-to-reactive-metabolites-in-vitro-and-in-vivo-approaches
#4
Ana L A Godinho, Inês L Martins, João Nunes, Catarina Charneira, Jorge Grilo, Diogo M Silva, Sofia A Pereira, Karina Soto, M Conceição Oliveira, M Matilde Marques, Cristina C Jacob, Alexandra M M Antunes
Drug bioactivation to reactive metabolites capable of covalent adduct formation with bionucleophiles is a major cause of drug-induced adverse reactions. Therefore, elucidation of reactive metabolites is essential to unravel the toxicity mechanisms induced by drugs and thereby identify patient subgroups at higher risk. Etravirine (ETR) was the first second-generation Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) to be approved, as a therapeutic option for HIV-infected patients who developed resistance to the first-generation NNRTIs...
July 1, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29408951/malaria-coinfections-in-febrile-pediatric-inpatients-a-hospital-based-study-from-ghana
#5
Benedikt Hogan, Daniel Eibach, Ralf Krumkamp, Nimako Sarpong, Denise Dekker, Benno Kreuels, Oumou Maiga-Ascofaré, Kennedy Gyau Boahen, Charity Wiafe Akenten, Yaw Adu-Sarkodie, Ellis Owusu-Dabo, Jürgen May
Background: The epidemiology of pediatric febrile illness is shifting in sub-Saharan Africa, but malaria remains a major cause of childhood morbidity and mortality. The present study describes causes of febrile illness in hospitalized children in Ghana and aims to determine the burden of malaria coinfections and their association with parasite densities. Methods: In a prospective study, children (aged ≥30 days and ≤15 years) with fever ≥38.0°C were recruited after admission to the pediatric ward of a primary hospital in Ghana...
February 2, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29373600/schistosoma-mansoni-infection-suppresses-the-growth-of-plasmodium-yoelii-parasites-in-the-liver-and-reduces-gametocyte-infectivity-to-mosquitoes
#6
Taeko Moriyasu, Risa Nakamura, Sharmina Deloer, Masachika Senba, Masato Kubo, Megumi Inoue, Richard Culleton, Shinjiro Hamano
Malaria and schistosomiasis are major parasitic diseases causing morbidity and mortality in the tropics. Epidemiological surveys have revealed coinfection rates of up to 30% among children in Sub-Saharan Africa. To investigate the impact of coinfection of these two parasites on disease epidemiology and pathology, we carried out coinfection studies using Plasmodium yoelii and Schistosoma mansoni in mice. Malaria parasite growth in the liver following sporozoite inoculation is significantly inhibited in mice infected with S...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29315306/modeling-the-genetic-relatedness-of-plasmodium-falciparum-parasites-following-meiotic-recombination-and-cotransmission
#7
Wesley Wong, Edward A Wenger, Daniel L Hartl, Dyann F Wirth
Unlike in most pathogens, multiple-strain (polygenomic) infections of P. falciparum are frequently composed of genetic siblings. These genetic siblings are the result of sexual reproduction and can coinfect the same host when cotransmitted by the same mosquito. The degree with which coinfecting strains are related varies among infections and populations. Because sexual recombination occurs within the mosquito, the relatedness of cotransmitted strains could depend on transmission dynamics, but little is actually known of the factors that influence the relatedness of cotransmitted strains...
January 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29143406/oncogenic-spiral-by-infectious-pathogens-cooperation-of-multiple-factors-in-cancer-development
#8
REVIEW
Jun-Ichirou Yasunaga, Masao Matsuoka
Chronic infection is one of the major causes of cancer, and there are several mechanisms for infection-mediated oncogenesis. Some pathogens encode gene products that behave like oncogenic factors, hijacking cellular pathways to promote the survival and proliferation of infected cells in vivo. Some of these viral oncoproteins trigger a cellular damage defense response leading to senescence; however, other viral factors hinder this suppressive effect, suggesting that cooperation of those viral factors is important for malignant transformation...
January 2018: Cancer Science
https://www.readbyqxmd.com/read/29121978/coinfection-of-intestinal-schistosomiasis-and-malaria-and-association-with-haemoglobin-levels-and-nutritional-status-in-school-children-in-mara-region-northwestern-tanzania-a-cross-sectional-exploratory-study
#9
Safari M Kinung'hi, Humphrey D Mazigo, David W Dunne, Stella Kepha, Godfrey Kaatano, Coleman Kishamawe, Samuel Ndokeji, Teckla Angelo, Fred Nuwaha
BACKGROUND: Schistosomiasis represents a major public health problem in Tanzania despite ongoing national control efforts. This study examined whether intestinal schistosomiasis is associated with malaria and assessed the contribution of intestinal schistosomiasis and malaria on anaemia and undernutrition in school children in Mara region, North-western Tanzania. METHODS: Stool samples were collected from each of 928 school children randomly selected from 5 schools and examined for intestinal schistosomiasis using the Kato Katz method...
November 9, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29034876/quantifying-the-contribution-of-plasmodium-falciparum-malaria-to-febrile-illness-amongst-african-children
#10
Ursula Dalrymple, Ewan Cameron, Samir Bhatt, Daniel J Weiss, Sunetra Gupta, Peter W Gething
Suspected malaria cases in Africa increasingly receive a rapid diagnostic test (RDT) before antimalarials are prescribed. While this ensures efficient use of resources to clear parasites, the underlying cause of the individual's fever remains unknown due to potential coinfection with a non-malarial febrile illness. Widespread use of RDTs does not necessarily prevent over-estimation of clinical malaria cases or sub-optimal case management of febrile patients. We present a new approach that allows inference of the spatiotemporal prevalence of both Plasmodium falciparum malaria-attributable and non-malarial fever in sub-Saharan African children from 2006 to 2014...
October 16, 2017: ELife
https://www.readbyqxmd.com/read/28978319/acute-undifferentiated-fever-in-india-a-multicentre-study-of-aetiology-and-diagnostic-accuracy
#11
MULTICENTER STUDY
Kristine Mørch, Anand Manoharan, Sara Chandy, Novin Chacko, Gerardo Alvarez-Uria, Suvarna Patil, Anil Henry, Joel Nesaraj, Cijoy Kuriakose, Ashita Singh, Siby Kurian, Christel Gill Haanshuus, Nina Langeland, Bjørn Blomberg, George Vasanthan Antony, Dilip Mathai
BACKGROUND: The objectives of this study were to determine the proportion of malaria, bacteraemia, scrub typhus, leptospirosis, chikungunya and dengue among hospitalized patients with acute undifferentiated fever in India, and to describe the performance of standard diagnostic methods. METHODS: During April 2011-November 2012, 1564 patients aged ≥5 years with febrile illness for 2-14 days were consecutively included in an observational study at seven community hospitals in six states in India...
October 4, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28932617/visceral-leishmaniasis-malaria-coinfection-and-their-associated-factors-in-patients-attending-metema-hospital-northwest-ethiopia-suggestion-for-integrated-vector-management
#12
Getachew Ferede, Ermias Diro, Sisay Getie, Gebeyaw Getnet, Yegnasew Takele, Anteneh Amsalu, Yitayih Wondimeneh
BACKGROUND: Despite high prevalence of visceral leishmaniasis and malaria in the study area, their coinfection remains unknown. Therefore, this study was aimed to document VL-malaria coinfections and their associated factors. METHODS: A cross-sectional study was conducted among clinical suspected VL patients attending Metema hospital, Northwest Ethiopia, from January 2014 to June 2014. Blood sample was tested by rk39 antigen-based DiaMed IT-Leish dipstick and Giemsa stain microscopic examination of thick and thin blood smears for malaria detection was performed...
2017: Malaria Research and Treatment
https://www.readbyqxmd.com/read/28861046/genomic-physiologic-and-symbiotic-characterization-of-serratia-marcescens-strains-isolated-from-the-mosquito-anopheles-stephensi
#13
Shicheng Chen, Jochen Blom, Edward D Walker
Strains of Serratia marcescens, originally isolated from the gut lumen of adult female Anopheles stephensi mosquitoes, established persistent infection at high rates in adult A. stephensi whether fed to larvae or in the sugar meal to adults. By contrast, the congener S. fonticola originating from Aedes triseriatus had lower infection in A. stephensi, suggesting co-adaptation of Serratia strains in different species of host mosquitoes. Coinfection at high infection rate in adult A. stephensi resulted after feeding S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28814840/epidemiology-and-synergistic-hepatopathology-of-malaria-and-hepatitis-c-virus-coinfection
#14
REVIEW
Idris Abdullahi Nasir, Sa'adatu Yakubu, Jelili Olaide Mustapha
Malaria and hepatitis C virus (HCV) infections are very common causes of human suffering with overlapping global geographic distributions. With the growing incidence of HCV infections in malaria-endemic zones and malaria in areas with exceptionally high HCV prevalence, coinfections and syndemism of both pathogens are likely to occur. However, studies of malaria and HCV coinfections are very rare despite the fact that liver-stage plasmodiasis and hepatitis C develop in hepatocytes which may synergistically interact...
2017: Virology: Research and Treatment
https://www.readbyqxmd.com/read/28721101/survey-of-malaria-and-anti-dengue-virus-igg-among-febrile-hiv-infected-patients-attending-a-tertiary-hospital-in-abuja-nigeria
#15
Jelili Olaide Mustapha, Anthony Uchenna Emeribe, Idris Abdullahi Nasir
BACKGROUND: Dengue and malaria are infections, of great public health concern, especially in sub-Saharan Africa where the burden of HIV infection is high. This study was conducted to determine the seroprevalence of dengue virus IgG antibodies and dengue/malaria coinfection among febrile HIV-infected patients attending the University of Abuja Teaching Hospital, Gwagwalada, Abuja. METHODS: In this cross-sectional study, blood samples from 178 consenting HIV-infected patients receiving antiretroviral therapy were collected and tested for plasmodiasis and anti-Dengue virus IgG using malaria microscopy and ELISA, respectively...
2017: HIV/AIDS: Research and Palliative Care
https://www.readbyqxmd.com/read/28533315/malaria-pathogenesis
#16
REVIEW
Danny A Milner
In the mosquito-human life cycle, the six species of malaria parasites infecting humans ( Plasmodium falciparum , Plasmodium vivax , Plasmodium ovale wallickeri , Plasmodium ovale curtisi , Plasmodium malariae , and Plasmodium knowlesi ) undergo 10 or more morphological states, replicate from single to 10,000+ cells, and vary in total population from one to many more than 106 organisms. In the human host, only a small number of these morphological stages lead to clinical disease and the vast majority of all malaria-infected patients in the world produce few (if any) symptoms in the human...
January 2, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28526680/decrease-in-numbers-of-naive-and-resting-b-cells-in-hiv-infected-kenyan-adults-leads-to-a-proportional-increase-in-total-and-plasmodium-falciparum-specific-atypical-memory-b-cells
#17
Anne E Frosch, Oludare A Odumade, Justin J Taylor, Kathleen Ireland, George Ayodo, Bartholomew Ondigo, David L Narum, John Vulule, Chandy C John
Human immunodeficiency virus type 1 (HIV-1) infection is associated with B cell activation and exhaustion, and hypergammaglobulinemia. How these changes influence B cell responses to coinfections such as malaria is poorly understood. To address this, we compared B cell phenotypes and Abs specific for the Plasmodium falciparum vaccine candidate apical membrane Ag-1 (AMA1) in HIV-infected and uninfected adults living in Kenya. Surprisingly, HIV-1 infection was not associated with a difference in serum AMA1-specific Ab levels...
June 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28459015/falciparum-malaria-and-parvovirus-b19-coinfection-a-rare-entity
#18
Rakesh Agarwal, Rashmi Baid, Rajarshi Datta, Manjari Saha, Nirmalendu Sarkar
No abstract text is available yet for this article.
January 2017: Tropical Parasitology
https://www.readbyqxmd.com/read/28406404/risk-of-daytime-transmission-of-malaria-in-the-french-guiana-rain-forest
#19
V Pommier de Santi, I Dusfour, E de Parseval, B Lespinet, C Nguyen, P Gaborit, R Carinci, G Hyvert, R Girod, S Briolant
Between 2008 and 2014, there were 1070 malaria cases reported in French Guiana among members of the armed forces. Most of the malaria outbreaks investigated were multifactorial and followed missions conducted at illegal gold mining sites. For example, a malaria outbreak occurred in September 2013, three weeks after the deployment of 15 soldiers at Dagobert, which is such a site. The attack rate was 53%, with seven Plasmodium vivax infections and one coinfection with both Plasmodium vivax and Plasmodium falciparum...
February 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28352651/clinical-virological-and-biological-parameters-associated-with-outcomes-of-ebola-virus-infection-in-macenta-guinea
#20
Marie-Astrid Vernet, Stéphanie Reynard, Alexandra Fizet, Justine Schaeffer, Delphine Pannetier, Jeremie Guedj, Max Rives, Nadia Georges, Nathalie Garcia-Bonnet, Aboubacar I Sylla, Péma Grovogui, Jean-Yves Kerherve, Christophe Savio, Sylvie Savio-Coste, Marie-Laure de Séverac, Philippe Zloczewski, Sandrine Linares, Souley Harouna, Bing M'Lebing Abdoul, Frederic Petitjean, Nenefing Samake, Susan Shepherd, Moumouni Kinda, Fara Roger Koundouno, Ludovic Joxe, Mathieu Mateo, Patrick Lecine, Audrey Page, Tang Maleki Tchamdja, Matthieu Schoenhals, Solenne Barbe, Bernard Simon, Tuan Tran-Minh, Christophe Longuet, François L'Hériteau, Sylvain Baize
BACKGROUND. The pathogenesis of Ebola virus (EBOV) disease (EVD) is poorly characterized. The establishment of well-equipped diagnostic laboratories close to Ebola treatment centers (ETCs) has made it possible to obtain relevant virological and biological data during the course of EVD and to assess their association with the clinical course and different outcomes of the disease. METHODS. We were responsible for diagnosing EBOV infection in patients admitted to two ETCs in forested areas of Guinea. The pattern of clinical signs was recorded, and an etiological diagnosis was established by RT-PCR for EBOV infection or a rapid test for malaria and typhoid fever...
March 23, 2017: JCI Insight
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