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coinfections malaria

Arundhati Barua, Niharika Gill
OBJECTIVE: This comparative cross sectional study was conducted in a teaching hospital in Mumbai during the monsoon of 2014.A significant number of dengue and malaria co-infection cases, along with dengue, malaria and other infective causes of acute febrile illnesses were noted. The objective of the present study was to understand the interplay of both infections. Since the first such reported case in 2005, studies and data on such cases are scarce, hence this study. AIM: To compare the clinical course, laboratory features, severity and outcome of coinfection with monoinfection of malaria and dengue...
August 2016: Journal of the Association of Physicians of India
Romy Kerber, Ralf Krumkamp, Boubacar Diallo, Anna Jaeger, Martin Rudolf, Simone Lanini, Joseph Akoi Bore, Fara Raymond Koundouno, Beate Becker-Ziaja, Erna Fleischmann, Kilian Stoecker, Silvia Meschi, Stéphane Mély, Edmund N C Newman, Fabrizio Carletti, Jasmine Portmann, Misa Korva, Svenja Wolff, Peter Molkenthin, Zoltan Kis, Anne Kelterbaum, Anne Bocquin, Thomas Strecker, Alexandra Fizet, Concetta Castilletti, Gordian Schudt, Lisa Ottowell, Andreas Kurth, Barry Atkinson, Marlis Badusche, Angela Cannas, Elisa Pallasch, Andrew Bosworth, Constanze Yue, Bernadett Pályi, Heinz Ellerbrok, Claudia Kohl, Lisa Oestereich, Christopher H Logue, Anja Lüdtke, Martin Richter, Didier Ngabo, Benny Borremans, Dirk Becker, Sophie Gryseels, Saïd Abdellati, Tine Vermoesen, Eeva Kuisma, Annette Kraus, Britta Liedigk, Piet Maes, Ruth Thom, Sophie Duraffour, Sandra Diederich, Julia Hinzmann, Babak Afrough, Johanna Repits, Marc Mertens, Inês Vitoriano, Amadou Bah, Andreas Sachse, Jan Peter Boettcher, Stephanie Wurr, Sabrina Bockholt, Andreas Nitsche, Tatjana Avšič Županc, Marc Strasser, Giuseppe Ippolito, Stephan Becker, Herve Raoul, Miles W Carroll, Hilde De Clerck, Michel Van Herp, Armand Sprecher, Lamine Koivogui, N'Faly Magassouba, Sakoba Keïta, Patrick Drury, Cèline Gurry, Pierre Formenty, Jürgen May, Martin Gabriel, Roman Wölfel, Stephan Günther, Antonino Di Caro
BACKGROUND:  A unit of the European Mobile Laboratory (EMLab) consortium was deployed to the Ebola virus disease (EVD) treatment unit in Guéckédou, Guinea, from March 2014 through March 2015. METHODS:  The unit diagnosed EVD and malaria, using the RealStar Filovirus Screen reverse transcription-polymerase chain reaction (RT-PCR) kit and a malaria rapid diagnostic test, respectively. RESULTS:  The cleaned EMLab database comprised 4719 samples from 2741 cases of suspected EVD from Guinea...
October 15, 2016: Journal of Infectious Diseases
Anna Longdoh Njunda, Charles Njumkeng, Shey Dickson Nsagha, Jules Clement Nguedia Assob, Tebit Emmanuel Kwenti
BACKGROUND: Coinfection with malaria and HIV is common in Sub-Saharan Africa. In the advent of a decline in the global incidence of malaria, it is important to generate updated data on the burden of malaria in people living with HIV (PLWHIV). This study was designed to determine the prevalence of malaria in PLWHIV in Yaounde, Cameroon, as well determine the association between CD4 (+) T cell count and malaria in the study population. METHODS: In a cross sectional study performed between April 2015 and June 2016, 355 PLWHIV were enrolled and blood samples were collected for analysis...
2016: BMC Public Health
Paola Andrea Camargo-Ayala, Juan Ricardo Cubides, Carlos Hernando Niño, Milena Camargo, Carlos Arturo Rodríguez-Celis, Teódulo Quiñones, Lizeth Sánchez-Suárez, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo
Malaria is a worldwide public health problem; parasites from the genus Plasmodium are the aetiological agent for this disease. The parasites are mostly diagnosed by conventional microscopy-based techniques; however, their limitations have led to under-registering the reported prevalence of Plasmodium species. This study has thus been aimed at evaluating the infection and coinfection prevalence of 3 species of Plasmodium spp., in an area of the Colombian Amazon region. Blood samples were taken from 671 symptomatic patients by skin puncture; a nested PCR amplifying the 18S ssRNA region was used on all samples to determine the presence of P...
2016: PloS One
Gregory C Davenport, James B Hittner, Vincent Otieno, Zachary Karim, Harshini Mukundan, Paul W Fenimore, Nicolas W Hengartner, Benjamin H McMahon, Prakasha Kempaiah, John M Ong'echa, Douglas J Perkins
Bacteremia and malaria coinfection is a common and life-threatening condition in children residing in sub-Saharan Africa. We previously showed that coinfection with Gram negative (G[-]) enteric Bacilli and Plasmodium falciparum (Pf[+]) was associated with reduced high-density parasitemia (HDP, >10,000 parasites/μL), enhanced respiratory distress, and severe anemia. Since inflammatory mediators are largely unexplored in such coinfections, circulating cytokines were determined in four groups of children (n = 206, aged <3 yrs): healthy; Pf[+] alone; G[-] coinfected; and G[+] coinfected...
2016: Mediators of Inflammation
A V Kondrashin, A K Tokmalaev, E N Morozov, L F Morozova
The present review considers malaria infection concurrent with different species of helminths, bacterial and viral infections, as well as mixed malaria pathogens in the subtropical and tropical countries of the world, causing the clinical picture and epidemiological situation to be different. Malaria co-infections with different pathogenic micro-organisms, such as HIV, tuberculosis, viral hepatitides, and others, affect almost one third of the planet's population. It is known that people who are at risk for malaria may be also at risk for other parasitic and infectious diseases, most commonly helminthisms...
April 2016: Meditsinskaia Parazitologiia i Parazitarnye Bolezni
Emmie W Mbale, Christopher A Moxon, Mavuto Mukaka, Maganizo Chagomerana, Simon Glover, Ngawina Chisala, Sofia Omar, Malcolm Molyneux, Karl Seydel, Alister G Craig, Terrie Taylor, Robert S Heyderman, Macpherson Mallewa
OBJECTIVES: Study of the effect of HIV on disease progression in heterogeneous severe malaria syndromes with imprecise diagnostic criteria has led to varying results. Characteristic retinopathy refines cerebral malaria (CM) diagnosis, enabling more precise exploration of the hypothesis that HIV decreases the cytokine response in CM, leading to higher parasite density and a poor outcome. METHODS: We retrospectively reviewed data on clinical progression and laboratory parameters in 877 retinopathy-positive CM cases admitted 1996-2011 (14...
September 2016: Journal of Infection
Tebit E Kwenti, Franklin A Nkume, Ajime T Tanjeko, Tayong D B Kwenti
BACKGROUND: The interaction between intestinal parasites and malaria is still not clear. Data in published literature are conflicting. We studied the effect of intestinal parasitic infection (IPI) on the clinical outcome of malaria in coinfected children. METHODS: In a cross sectional study performed between October 2014 and September 2015, children infected with malaria, as demonstrated by the presence of asexual parasites in Giemsa stained blood films, were enrolled...
April 2016: PLoS Neglected Tropical Diseases
Gaël Mourembou, Sydney Maghendji Nzondo, Angélique Ndjoyi-Mbiguino, Jean Bernard Lekana-Douki, Lady Charlène Kouna, Pierre Blaise Matsiegui, Rella Zoleko Manego, Irene Pegha Moukandja, Alpha Kabinet Keïta, Hervé Tissot-Dupont, Florence Fenollar, Didier Raoult
Malaria is considered to be the most common etiology of fever in sub-Saharan Africa while bacteremias exist but are under assessed. This study aimed to assess bacteremias and malaria in children from urban and rural areas in Gabon. DNA extracts from blood samples of 410 febrile and 60 afebrile children were analyzed using quantitative polymerase chain reaction. Plasmodium spp. was the microorganism most frequently detected in febrile (78.8%, 323/410) and afebrile (13.3%, 8/60) children, (P < 0.001). DNA from one or several bacteria were detected in 15 febrile patients (3...
July 6, 2016: American Journal of Tropical Medicine and Hygiene
Abraham Degarege, Berhanu Erko
Understanding the impact of helminth infections on clinical malaria is useful for designing effective malaria control strategies. Plenty of epidemiological studies have been conducted to unravel the nature of interactions between Plasmodium and helminth infection. Careful broad summarization of the existing literature suggests that Schistosoma mansoni and hookworm infections may increase the risk of clinical malaria and associated morbidities, but Trichuris trichiura infection is not associated with the occurrence of clinical malaria and related outcomes...
2016: BioMed Research International
Friedrich Frischknecht, Oliver T Fackler
Coinfections with Human Immunodeficiency Virus (HIV) and Plasmodium, the causative agents of AIDS and malaria, respectively, are frequent and their comorbidity especially in sub-Saharan Africa is high. While clinical studies suggest an influence of the two pathogens on the outcome of the respective infections, experimental studies on the molecular and immunological impact of coinfections are rare. This reflects the limited availability of suitable model systems that reproduce key properties of both pathologies...
July 2016: FEBS Letters
V S Oladele, H O Awobode, C I Anumudu
BACKGROUND: Malaria co-infection with schistosomiasis is known to modulate the immune response and thereby to potentially alter the pathophysiological and immunological profile of the diseases. The aim of the study was to determine the relationship between subtle morbidities and co-infection with malaria and schistosomiasis, and the immunological responses to the two diseases, among children in rural southwest Nigeria. METHODS: A cross-sectional survey was conducted between April and July 2012 among primary and secondary school children in Eggua, Yewa...
December 2014: African Journal of Medicine and Medical Sciences
Se Eun Park, Gi Deok Pak, Peter Aaby, Yaw Adu-Sarkodie, Mohammad Ali, Abraham Aseffa, Holly M Biggs, Morten Bjerregaard-Andersen, Robert F Breiman, John A Crump, Ligia Maria Cruz Espinoza, Muna Ahmed Eltayeb, Nagla Gasmelseed, Julian T Hertz, Justin Im, Anna Jaeger, Leon Parfait Kabore, Vera von Kalckreuth, Karen H Keddy, Frank Konings, Ralf Krumkamp, Calman A MacLennan, Christian G Meyer, Joel M Montgomery, Aissatou Ahmet Niang, Chelsea Nichols, Beatrice Olack, Ursula Panzner, Jin Kyung Park, Henintsoa Rabezanahary, Raphaël Rakotozandrindrainy, Emmanuel Sampo, Nimako Sarpong, Heidi Schütt-Gerowitt, Arvinda Sooka, Abdramane Bassiahi Soura, Amy Gassama Sow, Adama Tall, Mekonnen Teferi, Biruk Yeshitela, Jürgen May, Thomas F Wierzba, John D Clemens, Stephen Baker, Florian Marks
BACKGROUND: Country-specific studies in Africa have indicated that Plasmodium falciparum is associated with invasive nontyphoidal Salmonella (iNTS) disease. We conducted a multicenter study in 13 sites in Burkina Faso, Ethiopia, Ghana, Guinea-Bissau, Kenya, Madagascar, Senegal, South Africa, Sudan, and Tanzania to investigate the relationship between the occurrence of iNTS disease, other systemic bacterial infections, and malaria. METHODS: Febrile patients received a blood culture and a malaria test...
March 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Li ZHANG, Shui-sen ZHOU, Jun FENG, Wen FANG, Zhi-gui XIA
The 2014 malaria epidemiological data reported through the annual malaria statistics reporting system were collected and analyzed. A total of 3 078 malaria cases were reported in 680 counties of 30 Provinces/ Municipalities/Autonomous Regions (P/M/A)(except Inner Mongolia) in 2014, decreased by 25.4% compared with the 4 128 cases in 2013. The incidence rate was 0.022 6/10 000. More cases distributed in Yunnan (17.3%, 533/3 078), Jiangsu (11.5%, 355/3 078), Sichuan (8.6%, 266/3 078), Henan (7.0%, 216/3 078) and Zhejiang (7...
October 2015: chinese Journal of Parasitology & Parasitic Diseases
Matthew K O'Shea, Katherine A Clay, Darren G Craig, Alastair J Moore, Stephen Lewis, Melanie Espina, Jeff Praught, Simon Horne, Raymond Kao, Andrew M Johnston
We describe the management of a Sierra Leonean health care worker with severe Ebola virus disease complicated by diarrhea, significant electrolyte disturbances, and falciparum malaria coinfection. With additional resources and staffing, high quality care can be provided to patients with Ebola infection and adverse prognostic factors in west Africa.
April 2016: American Journal of Tropical Medicine and Hygiene
Ruth K Nyakundi, Onkoba Nyamongo, Jeneby Maamun, Mercy Akinyi, Isaac Mulei, Idle O Farah, D'Arbra Blankenship, Brian Grimberg, Jann Hau, Indu Malhotra, Hastings Ozwara, Christopher L King, Thomas M Kariuki
Malaria and schistosomiasis coinfections are common, and chronic schistosomiasis has been implicated in affecting the severity of acute malaria. However, whether it enhances or attenuates malaria has been controversial due the lack of appropriately controlled human studies and relevant animal models. To examine this interaction, we conducted a randomized controlled study using the baboon (Papio anubis) to analyze the effect of chronic schistosomiasis on severe malaria. Two groups of baboons (n = 8 each) and a schistosomiasis control group (n = 3) were infected with 500 Schistosoma mansoni cercariae...
May 2016: Infection and Immunity
Núria Serre Delcor, Begoña Treviño Maruri, Antoni Soriano Arandes, Isabel Claveria Guiu, Hakima Ouaarab Essadik, Mateu Espasa Soley, Israel Molina Romero, Carlos Ascaso
Immigrants may be carriers of infectious diseases because of the prevalence of these diseases in their country of origin, exposure during migration, or conditions during resettlement, with this prevalence being particularly high in sub-Saharan Africans. We performed a retrospective review of 180 sub-Saharan immigrants screened for infectious diseases at an International Health Center from January 2009 to December 2012. At least one pathogenic infectious disease was diagnosed in 72.8% patients: 60.6% latent tuberculosis infection, 36...
April 2016: American Journal of Tropical Medicine and Hygiene
Todd Cutts, Bradley Cook, Guillaume Poliquin, James Strong, Steven Theriault
Malaria is an important mimic or coinfection in potential Ebolavirus disease patients. Here, we evaluated the efficacy of the 100% methanol-inactivating Zaire Ebolavirus Makona variant for malaria thin-smear preparation. We determined that 100% methanol completely inactivated the virus after 15 min.
April 2016: Journal of Clinical Microbiology
Sarah E Hochman, Theresa F Madaline, Samuel C Wassmer, Emmie Mbale, Namjong Choi, Karl B Seydel, Richard O Whitten, Julie Varughese, Georges E R Grau, Steve Kamiza, Malcolm E Molyneux, Terrie E Taylor, Sunhee Lee, Danny A Milner, Kami Kim
No abstract text is available yet for this article.
2016: MBio
Camilla H Drabe, Lasse S Vestergaard, Marie Helleberg, Nyagonde Nyagonde, Michala V Rose, Filbert Francis, Ola P Theilgaard, Jens Asbjørn, Ben Amos, Ib Christian Bygbjerg, Morten Ruhwald, Pernille Ravn
Interferon-gamma (IFN-γ) release assays (IGRAs) are used to detect cellular immune recognition of Mycobacterium tuberculosis The chemokine IFN-γ-inducible protein 10 (IP-10) is an alternative diagnostic biomarker to IFN-γ. Several conditions interfere with IGRA test performance. We aimed to assess the possible influence of Plasmodium falciparum infection on the IGRA test QuantiFERON-TB GOLD® In-Tube (QFT) test and an in-house IP-10 release assay. In total, 241 Tanzanian adults were included; 184 patients with uncomplicated malaria (88 human immunodeficiency virus [HIV] coinfected) and 57 HIV-infected patients without malaria infection...
April 2016: American Journal of Tropical Medicine and Hygiene
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