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https://www.readbyqxmd.com/read/28261219/naturally-acquired-binding-inhibitory-antibodies-to-plasmodium-vivax-duffy-binding-protein-in-pregnant-women-are-associated-with-higher-birth-weight-in-a-multicenter-study
#1
Pilar Requena, Myriam Arévalo-Herrera, Michela Menegon, Flor E Martínez-Espinosa, Norma Padilla, Camila Bôtto-Menezes, Adriana Malheiro, Dhiraj Hans, Maria Eugenia Castellanos, Leanne Robinson, Paula Samol, Swati Kochar, Sanjay K Kochar, Dhanpat K Kochar, Meghna Desai, Sergi Sanz, Llorenç Quintó, Alfredo Mayor, Stephen Rogerson, Ivo Mueller, Carlo Severini, Hernando A Del Portillo, Azucena Bardají, Chetan C Chitnis, Clara Menéndez, Carlota Dobaño
A vaccine to eliminate malaria would need a multi-stage and multi-species composition to achieve robust protection, but the lack of knowledge about antigen targets and mechanisms of protection precludes the development of fully efficacious malaria vaccines, especially for Plasmodium vivax (Pv). Pregnant women constitute a risk population who would greatly benefit from a vaccine preventing the adverse events of Plasmodium infection during gestation. We hypothesized that functional immune responses against putative targets of naturally acquired immunity to malaria and vaccine candidates will be associated with protection against malaria infection and/or poor outcomes during pregnancy...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28219910/severe-plasmodium-knowlesi-with-dengue-coinfection
#2
Mohd Jazman Che Rahim, Nurashikin Mohammad, Alwi Muhd Besari, Wan Syamimee Wan Ghazali
We report a case of severe Plasmodium knowlesi and dengue coinfection in a previously healthy 59-year-old Malay man who presented with worsening shortness of breath, high-grade fever with chills and rigors, dry cough, myalgia, arthralgia, chest discomfort and poor appetite of 1 week duration. There was a history mosquito fogging around his neighbourhood in his hometown. Further history revealed that he went to a forest in Jeli (northern part of Kelantan) 3 weeks prior to the event. Initially he was treated as severe dengue with plasma leakage complicated with type 1 respiratory failure as evidenced by positive serum NS1-antigen and thrombocytopenia...
February 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28184306/effect-of-malaria-infection-on-hematological-profiles-of-people-living-with-human-immunodeficiency-virus-in-gambella-southwest-ethiopia
#3
Tsion Sahle, Tilahun Yemane, Lealem Gedefaw
BACKGROUND: Malaria and human immunodeficiency virus are the two most devastating global health problems causing more than two million deaths each year. Hematological abnormalities such as anemia, thrombocytopenia and leucopenia are the common complications in malaria and HIV co-infected individuals. The aim of this study was to determine the effect of malaria infection on hematological profiles of people living with HIV attending Gambella Hospital ART clinic, Southwestern Ethiopia. OBJECTIVE: To determine the effect of malaria infection on hematological profiles of people living with HIV attending Gambella Hospital ART clinic, Southwestern Ethiopia...
2017: BMC Hematology
https://www.readbyqxmd.com/read/28168042/coinfection-with-schistosoma-haematobium-and-plasmodium-falciparum-and-anaemia-severity-among-pregnant-women-in-munyenge-mount-cameroon-area-a-cross-sectional-study
#4
Judith K Anchang-Kimbi, Dillys Mansoh Elad, Gemain Taiwe Sotoing, Eric Akum Achidi
Background. Malaria and urogenital schistosomiasis are coendemic in Mount Cameroon Area. This study investigated the prevalence of S. haematobium, P. falciparum, and coinfections and their effect on anaemia in pregnancy. Methods. Pregnant women reporting for antenatal care (ANC) clinic visit in Munyenge were enrolled. S. haematobium and P. falciparum infections were determined by urine filtration and microscopy, respectively. Haemoglobin (Hb) levels were measured using haemoglobinometer. Of 250 women, 46.8%, 39...
2017: Journal of Parasitology Research
https://www.readbyqxmd.com/read/28129759/demography-maternal-health-and-the-epidemiology-of-malaria-and-other-major-infectious-diseases-in-the-rural-department-tsamba-magotsi-ngounie-province-in-central-african-gabon
#5
R Zoleko Manego, G Mombo-Ngoma, M Witte, J Held, M Gmeiner, T Gebru, B Tazemda, J Mischlinger, M Groger, B Lell, A A Adegnika, S T Agnandji, P G Kremsner, B Mordmüller, M Ramharter, P B Matsiegui
BACKGROUND: Sub-Saharan Africa is undergoing an epidemiological transition from a predominance of infectious diseases to non-communicable and lifestyle related conditions. However, the pace of this transition and the pattern of disease epidemiology are uneven between affluent urban and rural poor populations. To address this question for a remote rural region located in the central African rainforest region of Gabon, this study was conducted to assess reasons for health care attendance and to characterize the epidemiology of malaria and other major infectious diseases for the department of Tsamba Magotsi...
January 28, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28115672/rickettsia-felis-infection-in-febrile-children-ghana
#6
Peter Sothmann, Christian Keller, Ralf Krumkamp, Benno Kreuels, Cassandra Aldrich, Nimako Sarpong, Stefanie Steierberg, Doris Winter, Kennedy Gyau Boahen, Ellis Owusu-Dabo, Jürgen May, Daniel Eibach
Rickettsial infections are an underrecognized cause of febrile illness in sub-Saharan Africa. To evaluate the epidemiology and clinical features of rickettsial disease in pediatric patients in Ghana, we screened blood samples from febrile children aged less than 15 years presenting to an outpatient department in Ghana's Ashanti Region for the presence of rickettsial DNA. We detected Rickettsia felis in 7/470 (1.5%) blood samples, using two independent real-time polymerase chain reactions. No other Rickettsia species were found...
January 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28035638/-evaluation-of-malaria-rapid-diagnostic-test-optimal-it%C3%A2-pldh-along-the-plasmodium-falciparum-distribution-limit-in-mauritania
#7
H Ba, A D Ahouidi, C W Duffy, Y B Deh, C Diedhiou, A Tandia, M Y Diallo, S Assefa, B B Lô, M B Elkory, D J Conway
Performance of the malaria Rapid Diagnostic Test (RDT) OptiMal-IT® was evaluated in Mauritania where malaria is low and dependent on a short transmission season. Slide microscopy was considered as the reference method of diagnosis. Febrile patients with suspected malaria were recruited from six health facilities, 3 urban and 3 rural, during two periods (December 2011 to February 2012, and August 2012 to March 2013). Overall, 780 patients were sampled, with RDT and thick blood film microscopy results being obtained for 759 of them...
December 29, 2016: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28008284/implementation-of-co-trimoxazole-preventive-therapy-policy-for-malaria-in-hiv-infected-pregnant-women-in-the-public-health-facilities-in-tanzania
#8
Appolinary Ar Kamuhabwa, Richard Gordian, Ritah F Mutagonda
BACKGROUND: In 2011, Tanzania adopted a policy for provision of daily co-trimoxazole prophylaxis to HIV-infected pregnant women for prevention of malaria and other opportunistic infections. As per the policy, HIV-infected pregnant women should not be given sulfadoxine-pyrimethamine (SP) for intermittent preventive therapy. The challenges associated with this policy change and the extent to which the new policy for prevention of malaria in pregnant women coinfected with HIV was implemented need to be assessed...
2016: Drug, Healthcare and Patient Safety
https://www.readbyqxmd.com/read/27762109/a-comparative-study-of-concurrent-dengue-and-malaria-infection-with-their-monoinfection-in-a-teaching-hospital-in-mumbai
#9
Arundhati Barua, Niharika Gill
OBJECTIVE: This comparative cross sectional study was conducted in a teaching hospital in Mumbai during the monsoon of 2014.A significant number of dengue and malaria co-infection cases, along with dengue, malaria and other infective causes of acute febrile illnesses were noted. The objective of the present study was to understand the interplay of both infections. Since the first such reported case in 2005, studies and data on such cases are scarce, hence this study. AIM: To compare the clinical course, laboratory features, severity and outcome of coinfection with monoinfection of malaria and dengue...
August 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27638946/analysis-of-diagnostic-findings-from-the-european-mobile-laboratory-in-gu%C3%A3-ck%C3%A3-dou-guinea-march-2014-through-march-2015
#10
Romy Kerber, Ralf Krumkamp, Boubacar Diallo, Anna Jaeger, Martin Rudolf, Simone Lanini, Joseph Akoi Bore, Fara Raymond Koundouno, Beate Becker-Ziaja, Erna Fleischmann, Kilian Stoecker, Silvia Meschi, Stéphane Mély, Edmund N C Newman, Fabrizio Carletti, Jasmine Portmann, Misa Korva, Svenja Wolff, Peter Molkenthin, Zoltan Kis, Anne Kelterbaum, Anne Bocquin, Thomas Strecker, Alexandra Fizet, Concetta Castilletti, Gordian Schudt, Lisa Ottowell, Andreas Kurth, Barry Atkinson, Marlis Badusche, Angela Cannas, Elisa Pallasch, Andrew Bosworth, Constanze Yue, Bernadett Pályi, Heinz Ellerbrok, Claudia Kohl, Lisa Oestereich, Christopher H Logue, Anja Lüdtke, Martin Richter, Didier Ngabo, Benny Borremans, Dirk Becker, Sophie Gryseels, Saïd Abdellati, Tine Vermoesen, Eeva Kuisma, Annette Kraus, Britta Liedigk, Piet Maes, Ruth Thom, Sophie Duraffour, Sandra Diederich, Julia Hinzmann, Babak Afrough, Johanna Repits, Marc Mertens, Inês Vitoriano, Amadou Bah, Andreas Sachse, Jan Peter Boettcher, Stephanie Wurr, Sabrina Bockholt, Andreas Nitsche, Tatjana Avšič Županc, Marc Strasser, Giuseppe Ippolito, Stephan Becker, Herve Raoul, Miles W Carroll, Hilde De Clerck, Michel Van Herp, Armand Sprecher, Lamine Koivogui, N'Faly Magassouba, Sakoba Keïta, Patrick Drury, Cèline Gurry, Pierre Formenty, Jürgen May, Martin Gabriel, Roman Wölfel, Stephan Günther, Antonino Di Caro
BACKGROUND:  A unit of the European Mobile Laboratory (EMLab) consortium was deployed to the Ebola virus disease (EVD) treatment unit in Guéckédou, Guinea, from March 2014 through March 2015. METHODS:  The unit diagnosed EVD and malaria, using the RealStar Filovirus Screen reverse transcription-polymerase chain reaction (RT-PCR) kit and a malaria rapid diagnostic test, respectively. RESULTS:  The cleaned EMLab database comprised 4719 samples from 2741 cases of suspected EVD from Guinea...
October 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27619013/the-prevalence-of-malaria-in-people-living-with-hiv-in-yaounde-cameroon
#11
Anna Longdoh Njunda, Charles Njumkeng, Shey Dickson Nsagha, Jules Clement Nguedia Assob, Tebit Emmanuel Kwenti
BACKGROUND: Coinfection with malaria and HIV is common in Sub-Saharan Africa. In the advent of a decline in the global incidence of malaria, it is important to generate updated data on the burden of malaria in people living with HIV (PLWHIV). This study was designed to determine the prevalence of malaria in PLWHIV in Yaounde, Cameroon, as well determine the association between CD4 (+) T cell count and malaria in the study population. METHODS: In a cross sectional study performed between April 2015 and June 2016, 355 PLWHIV were enrolled and blood samples were collected for analysis...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27467587/high-plasmodium-malariae-prevalence-in-an-endemic-area-of-the-colombian-amazon-region
#12
Paola Andrea Camargo-Ayala, Juan Ricardo Cubides, Carlos Hernando Niño, Milena Camargo, Carlos Arturo Rodríguez-Celis, Teódulo Quiñones, Lizeth Sánchez-Suárez, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo
Malaria is a worldwide public health problem; parasites from the genus Plasmodium are the aetiological agent for this disease. The parasites are mostly diagnosed by conventional microscopy-based techniques; however, their limitations have led to under-registering the reported prevalence of Plasmodium species. This study has thus been aimed at evaluating the infection and coinfection prevalence of 3 species of Plasmodium spp., in an area of the Colombian Amazon region. Blood samples were taken from 671 symptomatic patients by skin puncture; a nested PCR amplifying the 18S ssRNA region was used on all samples to determine the presence of P...
2016: PloS One
https://www.readbyqxmd.com/read/27418744/reduced-parasite-burden-in-children-with-falciparum-malaria-and-bacteremia-coinfections-role-of-mediators-of-inflammation
#13
Gregory C Davenport, James B Hittner, Vincent Otieno, Zachary Karim, Harshini Mukundan, Paul W Fenimore, Nicolas W Hengartner, Benjamin H McMahon, Prakasha Kempaiah, John M Ong'echa, Douglas J Perkins
Bacteremia and malaria coinfection is a common and life-threatening condition in children residing in sub-Saharan Africa. We previously showed that coinfection with Gram negative (G[-]) enteric Bacilli and Plasmodium falciparum (Pf[+]) was associated with reduced high-density parasitemia (HDP, >10,000 parasites/μL), enhanced respiratory distress, and severe anemia. Since inflammatory mediators are largely unexplored in such coinfections, circulating cytokines were determined in four groups of children (n = 206, aged <3 yrs): healthy; Pf[+] alone; G[-] coinfected; and G[+] coinfected...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27405219/-the-clinical-and-epidemiological-characteristics-of-malaria-concurrent-with-other-infections-and-invasions
#14
REVIEW
A V Kondrashin, A K Tokmalaev, E N Morozov, L F Morozova
The present review considers malaria infection concurrent with different species of helminths, bacterial and viral infections, as well as mixed malaria pathogens in the subtropical and tropical countries of the world, causing the clinical picture and epidemiological situation to be different. Malaria co-infections with different pathogenic micro-organisms, such as HIV, tuberculosis, viral hepatitides, and others, affect almost one third of the planet's population. It is known that people who are at risk for malaria may be also at risk for other parasitic and infectious diseases, most commonly helminthisms...
April 2016: Meditsinskaia Parazitologiia i Parazitarnye Bolezni
https://www.readbyqxmd.com/read/27311750/hiv-coinfection-influences-the-inflammatory-response-but-not-the-outcome-of-cerebral-malaria-in-malawian-children
#15
Emmie W Mbale, Christopher A Moxon, Mavuto Mukaka, Maganizo Chagomerana, Simon Glover, Ngawina Chisala, Sofia Omar, Malcolm Molyneux, Karl Seydel, Alister G Craig, Terrie Taylor, Robert S Heyderman, Macpherson Mallewa
OBJECTIVES: Study of the effect of HIV on disease progression in heterogeneous severe malaria syndromes with imprecise diagnostic criteria has led to varying results. Characteristic retinopathy refines cerebral malaria (CM) diagnosis, enabling more precise exploration of the hypothesis that HIV decreases the cytokine response in CM, leading to higher parasite density and a poor outcome. METHODS: We retrospectively reviewed data on clinical progression and laboratory parameters in 877 retinopathy-positive CM cases admitted 1996-2011 (14...
September 2016: Journal of Infection
https://www.readbyqxmd.com/read/27128975/the-effect-of-intestinal-parasitic-infection-on-the-clinical-outcome-of-malaria-in-coinfected-children-in-cameroon
#16
Tebit E Kwenti, Franklin A Nkume, Ajime T Tanjeko, Tayong D B Kwenti
BACKGROUND: The interaction between intestinal parasites and malaria is still not clear. Data in published literature are conflicting. We studied the effect of intestinal parasitic infection (IPI) on the clinical outcome of malaria in coinfected children. METHODS: In a cross sectional study performed between October 2014 and September 2015, children infected with malaria, as demonstrated by the presence of asexual parasites in Giemsa stained blood films, were enrolled...
April 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27114297/co-circulation-of-plasmodium-and-bacterial-dnas-in-blood-of-febrile-and-afebrile-children-from-urban-and-rural-areas-in-gabon
#17
Gaël Mourembou, Sydney Maghendji Nzondo, Angélique Ndjoyi-Mbiguino, Jean Bernard Lekana-Douki, Lady Charlène Kouna, Pierre Blaise Matsiegui, Rella Zoleko Manego, Irene Pegha Moukandja, Alpha Kabinet Keïta, Hervé Tissot-Dupont, Florence Fenollar, Didier Raoult
Malaria is considered to be the most common etiology of fever in sub-Saharan Africa while bacteremias exist but are under assessed. This study aimed to assess bacteremias and malaria in children from urban and rural areas in Gabon. DNA extracts from blood samples of 410 febrile and 60 afebrile children were analyzed using quantitative polymerase chain reaction. Plasmodium spp. was the microorganism most frequently detected in febrile (78.8%, 323/410) and afebrile (13.3%, 8/60) children, (P < 0.001). DNA from one or several bacteria were detected in 15 febrile patients (3...
July 6, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27092310/epidemiology-of-plasmodium-and-helminth-coinfection-and-possible-reasons-for-heterogeneity
#18
REVIEW
Abraham Degarege, Berhanu Erko
Understanding the impact of helminth infections on clinical malaria is useful for designing effective malaria control strategies. Plenty of epidemiological studies have been conducted to unravel the nature of interactions between Plasmodium and helminth infection. Careful broad summarization of the existing literature suggests that Schistosoma mansoni and hookworm infections may increase the risk of clinical malaria and associated morbidities, but Trichuris trichiura infection is not associated with the occurrence of clinical malaria and related outcomes...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27009943/experimental-systems-for-studying-plasmodium-hiv-coinfection
#19
REVIEW
Friedrich Frischknecht, Oliver T Fackler
Coinfections with Human Immunodeficiency Virus (HIV) and Plasmodium, the causative agents of AIDS and malaria, respectively, are frequent and their comorbidity especially in sub-Saharan Africa is high. While clinical studies suggest an influence of the two pathogens on the outcome of the respective infections, experimental studies on the molecular and immunological impact of coinfections are rare. This reflects the limited availability of suitable model systems that reproduce key properties of both pathologies...
July 2016: FEBS Letters
https://www.readbyqxmd.com/read/26949790/subtle-morbidities-associated-with-malaria-co-infection-with-schistosomiasis-among-children-in-south-west-nigeria
#20
V S Oladele, H O Awobode, C I Anumudu
BACKGROUND: Malaria co-infection with schistosomiasis is known to modulate the immune response and thereby to potentially alter the pathophysiological and immunological profile of the diseases. The aim of the study was to determine the relationship between subtle morbidities and co-infection with malaria and schistosomiasis, and the immunological responses to the two diseases, among children in rural southwest Nigeria. METHODS: A cross-sectional survey was conducted between April and July 2012 among primary and secondary school children in Eggua, Yewa...
December 2014: African Journal of Medicine and Medical Sciences
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