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medicines optimisation

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https://www.readbyqxmd.com/read/29148164/protein-profiling-of-non-model-plant-cuminum-cyminum-by-gel-based-proteomic-approach
#1
Uzma Zaman, Henning Urlaub, Atiya Abbasi
INTRODUCTION: Cumin (Cuminum cyminum), a popular spice has been widely used in traditional medicine to cure various ailments. Despite the existence of scientific literature about its pharmacological properties, no successful proteome profiling has yet been attempted. OBJECTIVE: To optimise extraction of cumin proteins and analyse its profile by shotgun proteomics, using one-dimensional electrophoresis coupled with nano-ESI-LC-MS/MS. METHODOLOGY: As a first step, we have compared three extraction protocols for total proteins extraction from cumin...
November 16, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29132230/combination-therapy-for-obesity
#2
John Ph Wilding
Obesity is a chronic disease with serious consequences and although lifestyle modification is considered first line treatment, it is often ineffective, especially in the long term. Relatively few people with obesity will undergo the most effective currently available treatment of bariatric surgery. Pharmacotherapy can bridge the gap between lifestyle modification and surgery, but many monotherapies have only modest efficacy or require high doses with unacceptable side effects. As with many other areas of medicine, combination therapy is now becoming accepted as a way of optimising efficacy for weight management, whilst minimising adverse effects...
November 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29108136/application-and-optimisation-of-the-comparison-on-extreme-laboratory-tests-cert-algorithm-for-detection-of-adverse-drug-reactions-transferability-across-national-boundaries
#3
Mun Yee Tham, Qing Ye, Pei San Ang, Liza Y Fan, Dukyong Yoon, Rae Woong Park, Zheng Jye Ling, James W Yip, Bee Choo Tai, Stephen Jw Evans, Cynthia Sung
PURPOSE: The Singapore regulatory agency for health products (Health Sciences Authority), in performing active surveillance of medicines and their potential harms, is open to new methods to achieve this goal. Laboratory tests are a potential source of data for this purpose. We have examined the performance of the Comparison on Extreme Laboratory Tests (CERT) algorithm, developed by Ajou University, Korea, as a potential tool for adverse drug reaction detection based on the electronic medical records of the Singapore health care system...
November 6, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29101128/oral-chinese-herbal-medicine-for-psoriasis-vulgaris-protocol-for-a-randomised-double-blind-double-dummy-multicentre-clinical-trial
#4
Jingwen Deng, Danni Yao, Chuanjian Lu, Zehuai Wen, Yuhong Yan, Ziyang He, Huimei Wu, Hao Deng
INTRODUCTION: Psoriasis vulgaris is a common skin disease that is characterised by persistent localised erythematous scaly plaques. Yinxieling is a Chinese herbal formula for psoriasis that has been used for more than 20 years in China. To facilitate application, PSORI-CM01 was developed based on the optimisation and simplification of Yinxieling tablets performed in a previous study and in clinical practice. However, the scientific evidence regarding whether PSORI-CM01 is more effective for psoriasis than the original Yinxieling remains insufficient...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29089347/factors-influencing-the-decisions-of-senior-uk-doctors-to-retire-or-remain-in-medicine-national-surveys-of-the-uk-trained-medical-graduates-of-1974-and-1977
#5
Fay Smith, Shelly Lachish, Michael J Goldacre, Trevor W Lambert
OBJECTIVE: To report attitudes to retirement of late-career doctors. DESIGN: Questionnaires sent in 2014 to all UK medical graduates of 1974 and 1977. SETTING: United Kingdom. PARTICIPANTS: 3695 medical graduates. MAIN OUTCOME MEASURES: Factors which influenced doctors' decisions to retire and factors which encouraged doctors to remain in work. RESULTS: The response rate was 85% (3695/4369)...
October 31, 2017: BMJ Open
https://www.readbyqxmd.com/read/29082007/assessing-the-global-reach-and-value-of-a-provider-facing-healthcare-app-using-large-scale-analytics
#6
Vikas O'Reilly-Shah, George Easton, Scott Gillespie
BACKGROUND: The rapid global adoption of mobile health (mHealth) smartphone apps by healthcare providers presents challenges and opportunities in medicine. Challenges include ensuring the delivery of high-quality, up-to-date and optimised information. Opportunities include the ability to study global practice patterns, access to medical and surgical care and continuing medical education needs. METHODS: We studied users of a free anaesthesia calculator app used worldwide...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29076236/choosing-public-or-private-emergency-departments-in-australia
#7
Katherine Walker, Michael Ben-Meir
Emergency medicine was once exclusively provided in public hospitals in Australia, but now over half a million consultations per annum are in private (7% total emergency consultations). Private EDs have excess capacity and are staffed by senior doctors (majority FACEM) with open access to investigations and broad specialist inpatient services. Public EDs struggle with rising attendances and overcapacity. Private hospitals have high levels of patient satisfaction and aim to optimise service provision. A major barrier to private ED attendances is out-of-pocket costs...
October 26, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29066972/adapting-pharmacoeconomics-to-shape-efficient-health-systems-en-route-to-uhc-lessons-from-two-continents
#8
Jacqui Miot, Michael Thiede
Background: Pharmacoeconomics is receiving increasing attention globally as a set of tools ensuring efficient use of resources in health systems, albeit with different applications depending on the contextual, cultural and development stages of each country. The factors guiding design, implementation and optimisation of pharmacoeconomics as a steering tool under the universal health coverage paradigm are explored using case studies of Germany and South Africa. Findings: German social health insurance is subject to the efficiency precept...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29061605/suitability-of-current-definitions-of-ambulatory-care-sensitive-conditions-for-research-in-emergency-department-patients-a-secondary-health-data-analysis
#9
Johann Frick, Martin Möckel, Reinhold Muller, Julia Searle, Rajan Somasundaram, Anna Slagman
OBJECTIVE: The aim of this study was to investigate the suitability of existing definitions of ambulatory care sensitive conditions (ACSC) in the setting of an emergency department (ED) by assessing ACSC prevalence in patients admitted to hospital after their ED stay. The secondary aim was to identify ACSC suitable for specific application in the ED setting. DESIGN: Observational clinical study with secondary health data. SETTING: Two EDs of the Charité-Universitätsmedizin Berlin...
October 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29040783/patient-exposure-from-nuclear-medicine-in-france-national-follow-up-and-influence-of-the-technology-through-diagnostic-reference-levels-data-analysis
#10
Patrice Roch, David Celier, Cécile Dessaud, Cécile Etard
The Nuclear Safety and Radiation Protection French Institute (IRSN) presents its latest assessment from up-to-date diagnostic reference levels (DRL) national data in nuclear medicine (NM). NM departments annually send data to IRSN to estimate the representativeness of current DRLs. Complementary analyses of the data have been performed to evaluate the influence of equipment evolution on practice and patient radiation exposure. Based on data from almost 90% of the French NM departments, some DRL update are proposed...
October 13, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29036509/medication-usage-change-in-older-people-65-in-england-over-20-years-findings-from-cfas-i-and-cfas-ii
#11
L Gao, Ian Maidment, Fiona E Matthews, Louise Robinson, Carol Brayne
Background: medical practice has changed over the last decades reflecting the ageing population, when multi-morbidity requiring multiple medications is more common. Objective: describe and quantify self-reported medicine use including both prescription and over the counter medicines in two comparable population-based studies of older people (65+) in England and to assess the nature and scale of polypharmacy. Methods: data used were from two separate population-based studies; the Cognitive Function Ageing Study I and II...
September 26, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29021919/safeguarding-the-future-of-independent-academic-clinical-cancer-research-in-europe-for-the-benefit-of-patients
#12
Anastassia Negrouk, Denis Lacombe, Fatima Cardoso, Franck Morin, Eva Carrasco, Joan Maurel, Rudolf Maibach, Enrique Aranda, Richard Marais, Rolf A Stahel
Cancer is a complex disease that is constantly evolving. It is now the most common cause of death in Europe after cardiovascular diseases. There are inequalities among European countries, potentially unsustainable healthcare systems impacting quality of cancer care and increasing number of patients with cancer with rare conditions. Clinical and translational research are the backbone in establishing scientific advances as novel treatments and advancing progress to the benefit of patients. Commercially sponsored clinical trials are responsible for developing new medicines that can treat various disease areas, including cancer...
2017: ESMO Open
https://www.readbyqxmd.com/read/28988261/the-sickness-of-stigmas
#13
EDITORIAL
Bronwen J Ackermann
In modern medicine, approaches to healthcare no longer only encompass injury management, but increasingly focus on understanding the performance demands and health risk exposures faced by performing artists. Quantitative and qualitative scientific and health analyses by performing artists, clinicians, educators, and researchers are increasingly helping us to develop effective, targeted, and relevant health promotion and performance optimisation strategies worldwide. While such research increasingly identifies improved methods of preventing and managing potential psychological, audiological, or physical challenges faced by performing artists, we still need to work hard to address very important barriers to implementing appropriate health approaches...
September 2017: Medical Problems of Performing Artists
https://www.readbyqxmd.com/read/28971346/combined-pet-mri-global-warming-summary-report-of-the-6th-international-workshop-on-pet-mri-march-27-29-2017-t%C3%A3-bingen-germany
#14
REVIEW
D L Bailey, B J Pichler, B Gückel, G Antoch, H Barthel, Z M Bhujwalla, S Biskup, S Biswal, M Bitzer, R Boellaard, R F Braren, C Brendle, K Brindle, A Chiti, C la Fougère, R Gillies, V Goh, M Goyen, M Hacker, L Heukamp, G M Knudsen, A M Krackhardt, I Law, J C Morris, K Nikolaou, J Nuyts, A A Ordonez, K Pantel, H H Quick, K Riklund, O Sabri, B Sattler, E G C Troost, M Zaiss, L Zender, Thomas Beyer
The 6th annual meeting to address key issues in positron emission tomography (PET)/magnetic resonance imaging (MRI) was held again in Tübingen, Germany, from March 27 to 29, 2017. Over three days of invited plenary lectures, round table discussions and dialogue board deliberations, participants critically assessed the current state of PET/MRI, both clinically and as a research tool, and attempted to chart future directions. The meeting addressed the use of PET/MRI and workflows in oncology, neurosciences, infection, inflammation and chronic pain syndromes, as well as deeper discussions about how best to characterise the tumour microenvironment, optimise the complementary information available from PET and MRI, and how advanced data mining and bioinformatics, as well as information from liquid biomarkers (circulating tumour cells and nucleic acids) and pathology, can be integrated to give a more complete characterisation of disease phenotype...
October 2, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28970452/defining-the-role-of-the-pharmacy-technician-and-identifying-their-future-role-in-medicines-optimisation
#15
Melanie Boughen, Jane Sutton, Tess Fenn, David Wright
BACKGROUND: Traditionally, pharmacy technicians have worked alongside pharmacists in community and hospital pharmacy. Changes within pharmacy provide opportunity for role expansion and with no apparent career pathway, there is a need to define the current pharmacy technician role and role in medicines optimisation. AIM: To capture the current roles of pharmacy technicians and identify how their future role will contribute to medicines optimisation. METHODS: Following ethical approval and piloting, an online survey to ascertain pharmacy technicians' views about their roles was undertaken...
July 15, 2017: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/28963282/the-potential-clinical-benefits-of-medicines-optimisation-through-comprehensive-geriatric-assessment-carried-out-by-secondary-care-geriatricians-in-a-general-practice-care-setting-in-north-staffordshire-uk-a-feasibility-study
#16
Simon Christian Lea, Keira Louise Watts, Nathan Ashley Davis, Barnabas Panayiotou, Michael John Bankart, Amit Arora, Ruth Chambers
OBJECTIVES: To evaluate the feasibility and potential clinical benefits of medicines optimisation through comprehensive geriatric assessment (CGA) of frail patients with multiple conditions, by secondary care geriatricians in a general practice care setting. METHODS: Seven general practitioner (GP) practices in one region of Stoke-on-Trent volunteered to take part. GPs selected patients (n=186) who were local permanent residents, at least 65 years old and on eight or more medications per day...
September 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28943987/hospital-discharge-what-are-the-problems-information-needs-and-objectives-of-community-pharmacists-a-mixed-method-approach
#17
Lea D Brühwiler, Kurt E Hersberger, Monika Lutters
BACKGROUND: After hospital discharge, community pharmacists are often the first health care professionals the discharged patient encounters. They reconcile and dispense prescribed medicines and provide pharmaceutical care. Compared to the roles of general practitioners, the pharmacists' needs to perform these tasks are not well known. OBJECTIVE: This study aims to a) Identify community pharmacists' current problems and roles at hospital discharge, b) Assess their information needs, specifically the availability and usefulness of information, and c) Gain insight into pharmacists' objectives and ideas for discharge optimisation...
July 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28929177/-falsified-pharmaceutical-products-legislative-measures-in-the-european-union-and-in-germany
#18
REVIEW
Burkhard Sträter
Falsified pharmaceutical products are multi-faceted and driven by great criminal power. The health risks for patients who are frequently very seriously ill are high. The problem in Europe has been recognised. The European Union has created statutory requirements that considerably improve and tighten the system of manufacturing, distribution and documentation, and of pharmaceutical product authorisations. The traceability of each package via safety features is strengthened and made binding by detailed delegated legislation...
September 19, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28915280/communication-concepts-for-prevention-and-early-intervention-in-aesthetic-medicine-consensus-and-literature-review
#19
Uliana Gout, Chytra V Anand, Andre Braz, Yates Yen Yu Chao, Sabrina Guillen Fabi, Martina Kerscher, Marina Landau, Tatjana Pavicic, Peter Hsien Li Peng, Berthold Rzany, Gerhard Sattler, Tunk Tiryaki, Heidi A Waldorf, Thierry Besins
BACKGROUND: Communication concepts relating to prevention and early intervention (P&E) within aesthetic medicine are poorly understood and highly underexplored. However, effective communication is a key criterion for successful outcomes. OBJECTIVES: To introduce the framework for P&E communication strategies within a younger population and explore the barriers that may be encountered. METHODS: A literature review on P&E communication strategies in aesthetic medicine and related topics of interest was conducted and used to construct a working framework that may be applied in clinical practice...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28914069/the-role-of-a%C3%A2-hospital-pharmacist-in-the-management-of-asthma-in-great-britain
#20
Inka Sembol, Božena Macešková
The role of the pharmacist in the asthma management is well established. However, there is still a considerable number of patients with suboptimal asthma control affecting patients quality of life and resulting in poor outcomes, morbidity and mortality. The aim was to identify patients factors, explore the hospital pharmacists role in the asthma management and identify any areas for improvement in Great Britain. Qualitative data collection was selected. Patients case studies and semi-structured open interviews with the hospital multi-disciplinary team (MDT) were applied...
2017: Ceská a Slovenská Farmacie
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