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https://www.readbyqxmd.com/read/28087312/immunisation-choice-of-host-adjuvants-and-boosting-schedules-with-emphasis-on-polyclonal-antibody-production
#1
REVIEW
Philippe Delahaut
Polyclonal antibodies are frequently used as immunodiagnostic tools in fundamental research. They are also used for routine diagnostic purposes in human and veterinary medicine and for quality control procedures in the food-processing industry. The antibody is a major component of the detection system. It binds with the molecule to be identified. This conjugate is subsequently revealed by means of binding the antibody with a radio-isotope, a fluorescent substance, an enzyme inducing a color change, or a biosensor based analytical system...
January 10, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28062471/pharmacological-guidelines-for-schizophrenia-a-systematic-review-and-comparison-of-recommendations-for-the-first-episode
#2
Dolores Keating, Stephen McWilliams, Ian Schneider, Caroline Hynes, Gráinne Cousins, Judith Strawbridge, Mary Clarke
OBJECTIVES: Clinical practice guidelines (CPGs) support the translation of research evidence into clinical practice. Key health questions in CPGs ensure that recommendations will be applicable to the clinical context in which the guideline is used. The objectives of this study were to identify CPGs for the pharmacological treatment of first-episode schizophrenia; assess the quality of these guidelines using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument; and compare recommendations in relation to the key health questions that are relevant to the pharmacological treatment of first-episode schizophrenia...
January 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28040600/predictive-and-prognostic-biomarkers-in-colorectal-cancer-a-systematic-review-of-recent-advances-and-challenges
#3
REVIEW
Vishal Das, Jatin Kalita, Mintu Pal
BACKGROUND: Colorectal cancer (CRC) is one of the leading cause of cancer deaths worldwide. Since CRC is largely asymptomatic until alarm features develop to advanced stages, the implementation of the screening programme is very much essential to reduce cancer incidence and mortality rates. CRC occurs predominantly from accumulation of genetic and epigenetic changes in colon epithelial cells, which later gets transformed into adenocarcinomas. SCOPE OF REVIEW: The current challenges of screening paradigm and diagnostic ranges are from semi-invasive methods like colonoscopy to non-invasive stool-based test, have resulted in over-diagnosis and over-treatment of CRC...
December 29, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28039181/sports-biostatistician-a-critical-member-of-all-sports-science-and-medicine-teams-for-injury-prevention
#4
REVIEW
Martí Casals, Caroline F Finch
Sports science and medicine need specialists to solve the challenges that arise with injury data. In the sports injury field, it is important to be able to optimise injury data to quantify injury occurrences, understand their aetiology and most importantly, prevent them. One of these specialty professions is that of Sports Biostatistician. The aim of this paper is to describe the emergent field of Sports Biostatistics and its relevance to injury prevention. A number of important issues regarding this profession and the science of sports injury prevention are highlighted...
December 30, 2016: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28036043/concentration-of-tea-extracts-by-osmotic-evaporation-optimisation-of-process-parameters-and-effect-on-antioxidant-activity
#5
Marisa P Marques, Vítor D Alves, Isabel M Coelhoso
In this work, the concentration process of three different tea extracts (medicinal Rosil No. 6, Black, and Forest Fruit teas) using the osmotic evaporation (OE) process, was studied. The effect of the OE process on the content of phenolic compounds and antioxidant activity was evaluated. The concentration process was carried out in a hollow-fibre membrane contactor with an effective surface area of 0.54 m². The tea extract was circulated through the shell side of the contactor, while a concentrated osmotic solution (CaCl₂ 5 M) was circulated inside the fibres...
December 28, 2016: Membranes
https://www.readbyqxmd.com/read/28012176/selection-and-early-clinical-evaluation-of-the-brain-penetrant-11%C3%AE-hydroxysteroid-dehydrogenase-type-1-11%C3%AE-hsd1-inhibitor-ue2343-xanamem-tm
#6
Scott P Webster, Andrew McBride, Margaret Binnie, Karen Sooy, Jonathan R Seckl, Ruth Andrew, T David Pallin, Hazel J Hunt, Trevor R Perrior, Vincent S Ruffles, J William Ketelbey, Alan Boyd, Brian R Walker
BACKGROUND AND PURPOSE: Reducing glucocorticoid exposure in the brain via intracellular inhibition of the cortisol-regenerating enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD1) has emerged as a therapeutic strategy to treat cognitive impairment in early Alzheimer's disease (AD). We sought to discover novel, brain-penetrant 11β-HSD1 inhibitors as potential medicines for the treatment of AD. EXPERIMENTAL APPROACH: Medicinal chemistry optimisation of a series of amido-thiophene analogues was performed to identify potent and selective 11β-HSD1 inhibitors with optimised oral pharmacokinetics able to access the brain...
December 23, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27982051/novel-inhibitors-of-mycobacterium-tuberculosis-guab2-identified-by-a-target-based-high-throughput-phenotypic-screen
#7
Jonathan A G Cox, Grace Mugumbate, Laura Vela-Glez Del Peral, Monika Jankute, Katherine A Abrahams, Peter Jervis, Stefan Jackenkroll, Arancha Perez, Carlos Alemparte, Jorge Esquivias, Joël Lelièvre, Fernando Ramon, David Barros, Lluis Ballell, Gurdyal S Besra
High-throughput phenotypic screens have re-emerged as screening tools in antibiotic discovery. The advent of such technologies has rapidly accelerated the identification of 'hit' compounds. A pre-requisite to medicinal chemistry optimisation programmes required to improve the drug-like properties of a 'hit' molecule is identification of its mode of action. Herein, we have combined phenotypic screening with a biased target-specific screen. The inosine monophosphate dehydrogenase (IMPDH) protein GuaB2 has been identified as a drugable target in Mycobacterium tuberculosis, however previously identified compounds lack the desired characteristics necessary for further development into lead-like molecules...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27959354/delivering-comprehensive-geriatric-assessment-in-new-settings-advice-for-frontline-clinicians
#8
J R Gladman
Over the decades, as the principles of comprehensive geriatric assessment have been established, there have been attempts to apply its principles to settings other than acute hospital medical wards or the general communitydwelling older population, for example, to other settings where older people with infirmity are found. The purpose of this paper is to describe and reflect upon the application of and evidence for comprehensive geriatric assessment in these new settings and give some advice to clinicians about how to optimise their contributions to these processes...
September 2016: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/27956450/medical-problems-in-pregnancy
#9
Bhaskar Narayan, Catherine Nelson-Piercy
The prevalence of medical problems in pregnancy is increasing because of a complex interplay between demographic and lifestyle factors, and developments in modern medicine. Maternal mortality and morbidity resulting from treatable medical conditions, such as venous thromboembolism, epilepsy and autoimmune disease, have not decreased in recent years. This is despite a marked decrease in overall maternal mortality. It is vital that all physicians acquire a basic knowledge and understanding of medical problems in pregnancy...
December 2016: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/27955738/evidence-based-paediatric-surgical-oncology
#10
Paul D Losty
Surgeons play a pivotal role in the decision-making and multidisciplinary management of childhood solid tumours.(1) Evidence-based medicine-"aims to optimise decision making by emphasising on the use of best evidence from well-designed conducted research." This article offers a brief overview in an effort to demonstrate how a selection of well-conducted, recently published studies can help address some topical and controversial themes in paediatric surgical oncology practice.
October 2016: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/27939616/defibrotide-in-severe-sinusoidal-obstruction-syndrome-medicine-and-economic-issues
#11
Julie Steelandt, François Bocquet, Anne-Laure Cordonnier, Charlotte De Courtivron, Isabelle Fusier, Pascal Paubel
In Europe, Defitelio (defibrotide) has a Market Authorization in curative treatment of severe sinusoidal obstruction syndrome (SOS) but not in prophylaxis (2013). In France, defibrotide has had a compassionate-use program since 2009. Today, the high cost of defibrotide remains a major hurdle for hospital budgets. Medicine and economic issues were evaluated for the 39 hospitals of the French Public Assistance-Hospitals of Paris (AP-HP). We analyzed literature reviews, consumption, and expenditures through AP-HP data in 2014 and patient profiles with defibrotide in the corresponding diagnostic-related groups (DRGs) and consulted a board of hematologists...
December 7, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27939421/efficacy-and-safety-of-yahom-as-a-traditional-thai-herbal-therapy-a-systematic-review
#12
Krongkarn Chootip, Nathorn Chaiyakunapruk, Noppamas Soonthornchareonnon, C Norman Scholfield, Anjana Fuangchan
ETHNOPHARMACOLOGICAL RELEVANCE: Yahom is a traditional Thai medicine used to treat syncope and abdominal discomfort. AIM OF THE STUDY: This study aimed to systematically review all available evidence which purports to support these claims. MATERIAL AND METHODS: The systematic review accorded with the Cochrane Collaboration framework and PRISMA reporting. Databases including MEDLINE, Excerpta Medica Database (EMBASE), Cochrane library database, and Google Scholar were searched by keywords, Yahom and Ya-hom...
December 6, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27934629/the-work-environment-of-junior-doctors-their-perspectives-and-coping-strategies
#13
Tzong-Yang Pan, Howard S Fan, Cathy A Owen
OBJECTIVE: This study explores the associations between psychological distress in junior doctors and their work environment and how they cope with work stressors. METHODS: A cross-sectional survey designed by Health Education and Training Institute was delivered in 2014 to over 1900 junior doctors across 15 hospital networks through Australian Capital Territory and New South Wales. Psychological distress was evaluated using the Kessler Psychological Distress Scale-10 (K10)...
December 1, 2016: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/27919057/principles-of-precision-medicine-in-stroke
#14
REVIEW
Jason D Hinman, Natalia S Rost, Thomas W Leung, Joan Montaner, Keith W Muir, Scott Brown, Juan F Arenillas, Edward Feldmann, David S Liebeskind
The era of precision medicine has arrived and conveys tremendous potential, particularly for stroke neurology. The diagnosis of stroke, its underlying aetiology, theranostic strategies, recurrence risk and path to recovery are populated by a series of highly individualised questions. Moreover, the phenotypic complexity of a clinical diagnosis of stroke makes a simple genetic risk assessment only partially informative on an individual basis. The guiding principles of precision medicine in stroke underscore the need to identify, value, organise and analyse the multitude of variables obtained from each individual to generate a precise approach to optimise cerebrovascular health...
January 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27910216/capillary-electrophoresis-as-tool-for-diastereomeric-separation-in-a-trichilia-catigua-fraction
#15
Ana Luiza Sereia, Renata Longhini, Gisely Cristiny Lopes, João Carlos Palazzo de Mello
INTRODUCTION: The tree Trichilia catigua, popularly known as "catuaba", shows several biological activities and has emerged as a potential source of new drugs. Considering that more than 10 species are known under the same popular name, regulatory agencies require more rigorous quality control of this medicinal plant. OBJECTIVE: To develop and validate a methodology using capillary electrophoresis (CE) with ultraviolet (UV) detection for analysing polyphenols in the ethyl-acetate fraction (EAF) of Trichilia catigua...
December 2, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/27908424/first-comprehensive-study-on-total-contents-and-hot-water-extractable-fraction-of-selected-elements-in-19-medicinal-plants-from-various-locations-in-nyamira-county-kenya
#16
Volker Nischwitz, Richard Mogwasi, Salim Zor, Zachary Getenga, David K Kariuki, Klaus Günther
A large number of medicinal plants is traditionally known in Kenya and used for treatment of various diseases, for example diabetes, where metals are supposed to be involved in pathogenesis and therapy. Therefore, detailed investigation of the concentration of a large number of metals in medicinal plants is required for improved understanding and optimisation of the therapeutic role of metals and also to exclude potentially toxic effects. Our study focused on the determination of 30 selected elements in 19 medicinal plant species each collected from 3 sampling locations in Nyamira County, Kenya...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27896882/quality-of-claims-and-references-found-in-australian-pharmacy-journal-advertisements
#17
Mona Mandoh, Colin Michael Curtain
OBJECTIVES: To evaluate the quality of pharmaceutical advertisement claims and supporting references in Australian pharmacy journals that target community pharmacists. METHODS: All full-page advertisements for a medicinal product, found in two Australian pharmacy journals from the year 2012 to 2015 were included. Advertisement claims and references were evaluated by claim type (unambiguous to immeasurable) and level of evidence (strong to irrelevant) in supporting references...
November 29, 2016: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27895827/malawian-impressions-of-expatriate-physicians-a-qualitative-study
#18
Natasha Parekh, Adam P Sawatsky, Ihunanya Mbata, Adamson S Muula, Thuy Bui
BACKGROUND: In many low-income countries, including Malawi, expatriate physicians serve diverse roles in clinical care, education, mentorship, and research. A significant proportion of physicians from high-income countries have global health experience. Despite the well-known benefits of global health experiences for expatriates, little is known about local physician and trainee impressions of their expatriate counterparts. The objective of this study was to explore University of Malawi College of Medicine (COM) physicians' and trainees' impressions of expatriate physicians...
June 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/27895096/icrp-and-radiological-protection-in-medicine
#19
Claire Cousins
Standards in relation to radiological protection in medicine are well-documented, particularly with the recent update of the Basic Safety Standards. The principles of justification and optimisation remain key, as dose limitation is not applicable in medical practice. Appropriate justification relies on the knowledge, experience and discretion of the relevant medical practitioners and this may be overlooked in the race for diagnosis and treatment. One argument would be further regulation of medical exposures, although it is difficult to see how this could be imposed without denying patients essential investigations and treatments...
November 28, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27886757/different-sample-treatments-for-the-determination-of-icm-xr-in-fish-samples-followed-by-lc-hrms
#20
Mireia Núñez, Francesc Borrull, Núria Fontanals, Eva Pocurull
Iodinated X-ray contrast media (ICM-XR) are a group of pharmaceuticals widely used in medicine. Due to their low biodegradation rate, which makes their removal at wastewater treatment plants difficult, and the high doses at which they are administered, they have been detected in aquatic environments. In the present paper, a method for the quantitative determination of a group of ICM-XR in different fish species was developed and validated for the first time. Two extraction techniques were compared: pressurised liquid extraction (PLE) and QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe), with PLE being selected, followed by liquid chromatography-high resolution mass spectrometry...
January 15, 2017: Talanta
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