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medicines optimisation

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https://www.readbyqxmd.com/read/28800526/identification-and-determination-of-related-substances-of-ceftaroline-fosamil-in-medicinal-product-by-high-performance-liquid-chromatography-with-diode-array-detection-and-tandem-mass-spectrometry
#1
Izabela Karpiuk, Katarzyna Michalska, Katarzyna Bus, Monika Kiljan, Stefan Tyski
Ceftaroline fosamil, the prodrug of ceftaroline, is an advanced-generation cephalosporin antibacterial agent approved for treatment in the European Union in 2012. The drug is dedicated to curing complicated skin and soft tissue infections and community-acquired pneumonia. The developed analytical method of high performance liquid chromatography (HPLC) followed by diode array detector (DAD) set at 243nm was used to identify and determine degradation products of ceftaroline fosamil. The elaborated method demonstrated good selectivity and linearity [r>0...
August 1, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28760817/non-pharmacological-interventions-for-management-of-fatigue-among-children-with-cancer-systematic-review-of-existing-practices-and-their-effectiveness
#2
Tushti Bhardwaj, Jonathan Koffman
OBJECTIVES: Fatigue is common among children living with cancer, particularly in advance stages. Little is known about the effectiveness of non-pharmacological approaches to manage this complex and distressing symptom among children. Thus, the present paper aim to critically examine the effectiveness and setting for non-pharmacological interventions to manage fatigue among children with cancer. METHODS: Six electronic databases were screened first in February 2013 and at second instance in March 2015...
July 31, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28756429/interacting-with-genomic-data-clinician-requirements-and-prototype-structure
#3
Dana Bradford, Shlomo Berkovsky, Melissa Martyn, Tim Bakkar, Martin Krahnert, Michelle Rodriguez, Denis Bauer, Derek Ireland, Clara Gaff
Healthcare is currently being transformed by the introduction of genomic sequencing - a major advancement in personalised medicine. This advent provides new opportunities for clinicians to use genomic data in decision making about patient diagnosis and treatment, but this can only be achieved through access to data and support in its use. Engaging with clinicians in the development of decision support tools will optimise relevance and adoption of genomic sequencing in healthcare. In this study, existing data from clinician workshops and interviews together with horizon scanning of relevant technologies were used to define clinician portal specifications...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28745564/patient-and-clinician-perspectives-of-an-integrated-electronic-medication-prescribing-and-dispensing-system-a-qualitative-study-at-a-multisite-australian-hospital-network
#4
Grace Lau, Jayde Ho, Susan Lin, Karen Yeoh, Tiffany Wan, Marisa Hodgkinson
BACKGROUND: While clinician attitudes towards electronic prescribing (e-prescribing) systems have been widely studied, little is known about the perspectives of patients, despite being the primary beneficiaries of these systems. OBJECTIVE: The objective of this study is to explore and compare patient and clinician attitudes towards an integrated e-prescribing and dispensing system, in order to guide improvements in system implementation, service delivery and enhancements to system functionality...
January 1, 2017: HIM Journal
https://www.readbyqxmd.com/read/28738623/analysis-of-illegal-peptide-drugs-via-hilic-dad-ms
#5
Steven Janvier, Evelien De Sutter, Evelien Wynendaele, Bart De Spiegeleer, Celine Vanhee, Eric Deconinck
Biopharmaceuticals have established themselves as highly efficient medicines, and are still one of the fastest growing parts of the health-product industry. Unfortunately, the introduction of these promising new drugs went hand in hand with the creation of a black market for illegal and counterfeit biotechnology drugs. Particularly popular are the lyophilised peptides with a molecular weight of less than 5kDa. Most of them are meant for subcutaneous injection and are easily accessible via the internet. In recent years, different methods based on reversed phase liquid chromatography have been developed to detect and quantify these peptides...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28733906/the-advanced-diarem-score-improves-prediction-of-diabetes-remission-1%C3%A2-year-post-roux-en-y-gastric-bypass
#6
Judith Aron-Wisnewsky, Nataliya Sokolovska, Yuejun Liu, Doron S Comaneshter, Shlomo Vinker, Tal Pecht, Christine Poitou, Jean-Michel Oppert, Jean-Luc Bouillot, Laurent Genser, Dror Dicker, Jean-Daniel Zucker, Assaf Rudich, Karine Clément
AIMS/HYPOTHESIS: Not all people with type 2 diabetes who undergo bariatric surgery achieve diabetes remission. Thus it is critical to develop methods for predicting outcomes that are applicable for clinical practice. The DiaRem score is relevant for predicting diabetes remission post-Roux-en-Y gastric bypass (RYGB), but it is not accurate for all individuals across the entire spectrum of scores. We aimed to develop an improved scoring system for predicting diabetes remission following RYGB (the Advanced-DiaRem [Ad-DiaRem])...
July 21, 2017: Diabetologia
https://www.readbyqxmd.com/read/28695561/medical-challenges-at-the-end-of-the-first-ten-decades-of-life
#7
Thomas Münzer
Demographic changes worldwide challenge the healthcare system. Advanced age is associated with a number of biological alterations that, together with concomitant comorbidities, increase the risk for functional decline by inducing functional disintegration. In this concept frailty and sarcopenia play an important role. Consequently the preservation of muscle mass and function are prominent targets of medicine in old age. In order to professionally care for persons in their last years of life several other factors influencing medical decisions regarding diagnostic and treatments are important...
July 11, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28690675/development-of-sentinel-node-biopsy-roll-and-iart-in-early-breast-cancer-at-the-european-institute-of-oncology-milan-ieo
#8
REVIEW
Giovanni Paganelli
The problem of unnecessary axillary clearance in many patients with early breast cancer was certainly a major issue at IEO when we started working with Prof. Umberto Veronesi in 1994. At that time, axillary dissection in EBC was offered to all patients and this procedure was often hotly debated during our multidisciplinary breast cancer meetings. The question as to whether we could avoid axillary dissection by using PET scans or other nuclear medicine methods was frequently asked by Veronesi. This eventually prompted us to investigate whether, as for melanoma patients, the sentinel node biopsy (SNB) approach could reliably be applied to breast cancer...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28677080/comparison-of-impact-of-two-decontamination-solutions-on-the-viability-of-the-cells-in-human-amnion
#9
Ingrida Smeringaiova, Peter Trosan, Miluse Berka Mrstinova, Jan Matecha, Jan Burkert, Jan Bednar, Katerina Jirsova
Human amniotic membrane (HAM) is used as an allograft in regenerative medicine or as a source of pluripotent cells for stem cell research. Various decontamination protocols and solutions are used to sterilize HAM before its application, but little is known about the toxicity of disinfectants on HAM cells. In this study, we tested two decontamination solutions, commercial (BASE·128) and laboratory decontamination solution (LDS), with an analogous content of antimycotic/antibiotics for their cytotoxic effect on HAM epithelial (EC) and mesenchymal stromal cells (MSC)...
July 4, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28674145/the-strataa-study-protocol-a-programme-to-assess-the-burden-of-enteric-fever-in-bangladesh-malawi-and-nepal-using-prospective-population-census-passive-surveillance-serological-studies-and-healthcare-utilisation-surveys
#10
Thomas C Darton, James E Meiring, Susan Tonks, Md Arifuzzaman Khan, Farhana Khanam, Mila Shakya, Deus Thindwa, Stephen Baker, Buddha Basnyat, John D Clemens, Gordon Dougan, Christiane Dolecek, Sarah J Dunstan, Melita A Gordon, Robert S Heyderman, Kathryn E Holt, Virginia E Pitzer, Firdausi Qadri, K Zaman, Andrew J Pollard
INTRODUCTION: Invasive infections caused by Salmonella enterica serovar Typhi and Paratyphi A are estimated to account for 12-27 million febrile illness episodes worldwide annually. Determining the true burden of typhoidal Salmonellae infections is hindered by lack of population-based studies and adequate laboratory diagnostics.The Strategic Typhoid alliance across Africa and Asia study takes a systematic approach to measuring the age-stratified burden of clinical and subclinical disease caused by typhoidal Salmonellae infections at three high-incidence urban sites in Africa and Asia...
July 2, 2017: BMJ Open
https://www.readbyqxmd.com/read/28672096/metabolomic-tools-to-assess-the-chemistry-and-bioactivity-of-endophytic-aspergillus-strain
#11
A F Tawfike, R Tate, G Abbott, L Young, C Viegelmann, M Schumacher, M Diederich, R A Edrada-Ebel
Endophytic fungi associated with medicinal plants are a potential source of novel chemistry and biology that may find applications as pharmaceutical and agrochemical drugs. In this study, a combination of metabolomics and bioactivity-guided approaches were employed to isolate anticancer secondary metabolites from an endophytic Aspergillus aculeatus. The endophyte was isolated from the Egyptian medicinal plant Terminalia laxiflora and identified using molecular biological methods. Metabolomics and dereplication studies were accomplished by utilizing the MZmine software coupled with the universal Dictionary of Natural Products database...
July 3, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28669227/understanding-untreated-hypertension-from-patients-point-of-view-a-qualitative-study-in-rural-yogyakarta-province-indonesia
#12
Riana Rahmawati, Beata Bajorek
Objectives This study aimed to explore perspectives about hypertension from patients who do not take anti-hypertensive medications. Factors that shape their perspectives as well as patients' expectations were also canvassed. Method Individual, face-to-face interviews were conducted with 30 people (≥45 years old) living in rural villages, diagnosed with hypertension, who had not taken any anti-hypertensive medications for at least one year. Interviews were audiotaped, transcribed verbatim and thematically analysed...
January 1, 2017: Chronic Illness
https://www.readbyqxmd.com/read/28658842/a-case-series-of-young-patients-with-completely-reversed-severe-pulmonary-hypertension
#13
Aniketh Vijay Balegadde, Vikrant Vijan, Rajesh Thachathodiyl
Pulmonary Arterial Hypertension (PAH) is a progressive symptomatic disorder, which may ultimately lead to death if left untreated. Although majority of PAH cases are idiopathic, pulmonary hypertension resulting due to certain underlying conditions are also observed frequently. In such cases, it becomes essential to identify any potentially treatable or reversible causes for PAH. There have been significant advances in the medical management of PAH and various medicines have been approved by US Food and Drug Administration (FDA) for various stages of PAH...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28651609/optimisation-of-a-double-centrifugation-method-for-preparation-of-canine-platelet-rich-plasma
#14
Hyeok-Soo Shin, Heung-Myong Woo, Byung-Jae Kang
BACKGROUND: Platelet-rich plasma (PRP) has been expected for regenerative medicine because of its growth factors. However, there is considerable variability in the recovery and yield of platelets and the concentration of growth factors in PRP preparations. The aim of this study was to identify optimal relative centrifugal force and spin time for the preparation of PRP from canine blood using a double-centrifugation tube method. METHODS: Whole blood samples were collected in citrate blood collection tubes from 12 healthy beagles...
June 26, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28648701/universal-genomic-testing-the-next-step-in-oncological-decision-making-or-a-dead-end-street
#15
Julian Walter Holch, Klaus Hans Metzeler, Andreas Jung, Kristina Riedmann, Philipp Jakob Jost, Wilko Weichert, Thomas Kirchner, Volker Heinemann, Christoph Benedikt Westphalen
The concept of 'personalised medicine' aims at allocating patients to different treatment options based on individual characteristics to optimise treatment benefit and side effects. In oncology, personalised treatments coupled to biomarkers have led to the approval of targeted agents with high anti-tumour activity. However, these therapies are often limited to narrow, molecularly defined subsets of patients with a specific morphomolecular tumour profile. Recently, it became obvious that the same molecular alteration might drive oncogenesis in many different tumours, and it might be beneficial to target the alteration in a histology informed but entity-overarching way...
September 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28648615/structural-biology-and-the-design-of-new-therapeutics-from-hiv-and-cancer-to-mycobacterial-infections-a-paper-dedicated-to-john-kendrew
#16
REVIEW
Sherine E Thomas, Vitor Mendes, So Yeon Kim, Sony Malhotra, Bernardo Ochoa-Montaño, Michal Blaszczyk, Tom L Blundell
Interest in applications of protein crystallography to medicine was evident, as the first high-resolution structures emerged in the 50s and 60s. In Cambridge, Max Perutz and John Kendrew sought to understand mutations in sickle cell and other genetic diseases related to hemoglobin, while in Oxford, the group of Dorothy Hodgkin became interested in long-lasting zinc-insulin crystals for treatment of diabetes and later considered insulin redesign, as synthetic insulins became possible. The use of protein crystallography in structure-guided drug discovery emerged as enzyme structures allowed the identification of potential inhibitor-binding sites and optimization of interactions of hits using the structure of the target protein...
June 23, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28623894/-doing-the-right-thing-factors-influencing-gp-prescribing-of-antidepressants-and-prescribed-doses
#17
Chris F Johnson, Brian Williams, Stephen A MacGillivray, Nadine J Dougall, Margaret Maxwell
BACKGROUND: Antidepressant prescribing continues to increase, with 5-16% of adults receiving antidepressants annually. Total prescribing growth is due in part to increased long-term use, greater selective serotonin re-uptake inhibitor (SSRI) use and the use of higher SSRI doses. Evidence does not support routine use of higher SSRI doses for depression treatment, and factors influencing the use of such doses are not well known. The aim of this study was to explore factors influencing GPs' use of antidepressants and their doses to treat depression...
June 17, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28618913/a-multidisciplinary-approach-to-prevention
#18
Catriona Jennings, Felicity Astin
Cardiovascular disease accounts for 17,500 deaths globally, representing nearly half of all non-communicable disease deaths. The World Health Organization has set nine lifestyle, risk factor and medicines targets to achieve by 2025 with the aim of reducing premature mortality from non-communicable diseases by 25%. In order to succeed in this, we need to equip our global health professional workforce with the skills to support patients and their families with making lifestyle changes and being in concordance with cardioprotective medication regimes at every opportunity...
June 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28615279/medicines-optimisation-assessment-tool-moat-a-prognostic-model-to-target-hospital-pharmacists-input-to-improve-patient-outcomes-protocol-for-an-observational-study
#19
Cathy Geeson, Li Wei, Bryony Dean Franklin
INTRODUCTION: Medicines optimisation is a key role for hospital pharmacists, but with ever-increasing demands on services there is a need to increase efficiency while maintaining patient safety. The aim of this study is to develop a prognostic model, the Medicines Optimisation Assessment Tool (MOAT), which can be used to target patients most in need of pharmacists' input while in hospital. METHODS AND ANALYSIS: The MOAT will be developed following recommendations of the Prognosis Research Strategy partnership...
June 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28613004/a-survey-of-uk-peri-operative-medicine-pre-operative-care
#20
A-M Bougeard, A Brent, M Swart, C Snowden
The majority of UK hospitals now have a Local Lead for Peri-operative Medicine (n = 115). They were asked to take part in an online survey to identify provision and practice of pre-operative assessment and optimisation in the UK. We received 86 completed questionnaires (response rate 75%). Our results demonstrate strengths in provision of shared decision-making clinics. Fifty-seven (65%, 95%CI 55.8-75.4%) had clinics for high-risk surgical patients. However, 80 (93%, 70.2-87.2%) expressed a desire for support and training in shared decision-making...
August 2017: Anaesthesia
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