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Desflurane vs sevoflurane

Sara K Cheung, Timur Özelsel, Saifee Rashiq, Ban C Tsui
PURPOSE: This study was designed to compare waste anesthetic gas (WAG) concentrations within patients' breathing zones after removal of the patient's airway device in the postanesthesia care unit (PACU) vs in the operating room (OR). METHODS: Following Research Ethics Board approval and patient consent, we recruited patients undergoing surgery who received volatile anesthesia via an endotracheal tube or supraglottic airway. Patients had their airway device removed in the OR or in the PACU depending on the attending anesthesiologist's preference...
September 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
Hyun-Chang Kim, Won-Pyo Hong, Young-Jin Lim, Hee-Pyoung Park
PURPOSE: Catheter-related bladder discomfort (CRBD) due to an indwelling urinary catheter can cause postoperative distress, and the mechanism underlying CRBD is linked to the activation of muscarinic receptors. Inhalation of anesthetic agents, such as sevoflurane and desflurane, has differential inhibitory effects on muscarinic receptors. We aimed to compare the effect of intraoperative sevoflurane vs desflurane inhalation on postoperative CRBD. METHODS: Eighty-nine patients undergoing transurethral resection of a bladder tumour (TURBT) were randomly allocated to two groups...
May 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
M Desmet, P Vander Cruyssen, H Pottel, S Carlier, D Devriendt, F Van Rooy, W De Corte
BACKGROUND: Volatile anaesthetics have an influence on small bowel peristalsis during laparoscopic surgery. A recent study concluded that desflurane increased intestinal motility compared to sevoflurane. Hence, a desflurane-based anaesthesia protocol may reduce surgical exposure during intestinal suturing or stapling due to small bowel hyperperistalsis. The effect of propofol on intestinal motility is not well studied. We tested the hypothesis that a propofol-remifentanil anaesthesia increases intestinal contractions in comparison with a sevoflurane-remifentanil anaesthesia...
March 2016: Acta Anaesthesiologica Scandinavica
Richard H Epstein, Franklin Dexter, David P Maguire, Niraj K Agarwalla, David M Gratch
BACKGROUND: Reducing fresh gas flow (FGF) during general anesthesia reduces costs by decreasing the consumption of volatile anesthetics and attenuates their contribution to greenhouse gas pollution of the environment. The sevoflurane FGF recommendations in the Food and Drug Administration package insert relate to concern over potential toxicity from accumulation in the breathing circuit of compound A, a by-product of the reaction of the volatile agent with legacy carbon dioxide absorbents containing strong alkali such as sodium or potassium hydroxide...
April 2016: Anesthesia and Analgesia
Ikuomi Mikuni, Shuto Harada, Ryuta Yakushiji, Hiroshi Iwasaki
PURPOSE: Desflurane has the lowest solubility of currently available volatile anesthetics and may allow for more rapid emergence and recovery compared with sevoflurane. Nevertheless, after volatile induction with sevoflurane, it has not been determined whether the use of desflurane provides faster emergence and recovery. The present study aimed to elucidate the effects of changing from sevoflurane to desflurane during the early part of anesthesia. METHODS: Fifty-two patients who were scheduled for vitreous surgery with general anesthesia were enrolled in this randomized controlled study...
March 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
M Abou Hussein, F Mahmoud, R Beltagy, A Hasanin, K Yassen, A Attar
BACKGROUND: Major liver resection is associated with haemodynamic, hepatic and renal changes as a result of the procedure. AIM: To compare Desflurane (D) versus Sevoflurane (S) on hepatic, renal functions, haemodynamics and perioperative course for cirrhotic patients undergoing major liver resection. PATIENTS AND METHODS: A prospective randomized control study with 50 patients (Child A) (D, n = 25 and S, n = 25). End tidal D or S adjusted with Entropy (40-60)...
June 2015: Middle East Journal of Anesthesiology
Jatuporn Pakpirom, Jitsinee Kraithep, Ngamjit Pattaravit
OBJECTIVE: The purpose of this study was to compare the length of postanesthetic care unit (PACU) stay and recovery profiles of elderly patients after general anesthesia between sevoflurane and desflurane. DESIGN: Randomized, double-blind, controlled clinical trial. SETTING: Tertiary care hospital, university hospital. PATIENTS: Eighty elderly patients undergoing nonemergency surgery under general anesthesia. INTERVENTION: Patients were randomly allocated into 2 groups: sevoflurane group (n = 38) and desflurane group (n = 42) in a double-blind manner...
August 2016: Journal of Clinical Anesthesia
Jiwon Lee, Yong-Jae Yoo, Jung-Man Lee, Young Jae Park, Ho Geol Ryu
BACKGROUND: Various interventions to reduce postreperfusion syndrome during liver transplantation have been explored, but the effect of volatile anesthetics used during liver transplantation on the incidence of postreperfusion syndrome has not been evaluated. A randomized controlled trial was performed to compare the incidence of postreperfusion syndrome between 2 commonly used volatile anesthetics, sevoflurane and desflurane. METHODS: Sixty-two adult liver recipients scheduled for living-donor liver transplantation were randomized to receive either sevoflurane or desflurane for general anesthesia...
March 2016: Transplantation
Maria Horwitz, Jan G Jakobsson
BACKGROUND: The pharmacokinetics for sevoflurane and desflurane makes them suitable for low-flow anesthesia. The aim of the present study was to assess the use of desflurane and sevoflurane at constant vaporizer settings and fixed low fresh gas flows. METHODS: One hundred ASA 1-2 patients undergoing elective laparoscopic surgery were randomized into 4 groups (25 patients each): a fixed fresh gas flow 1.0 or 0.5 L/min with desflurane (D1.0 and D0.5) or sevoflurane (S1...
February 2016: Minerva Anestesiologica
P Biro, O Kneschke, O M Theusinger
BACKGROUND: Case-by-case assessment of volatile anesthetic (VA) consumption is necessary to perform agent sparing dosing measures and for billing purposes. The gold standard technique for this purpose is to measure the weight difference of the vaporizer that occurs during VA delivery. Because suitable equipment is rarely available and weighing the vaporizer is only possible in prospectively planned fashion, a calculation method from recorded fresh gas flow (FGF) and VA courses is a viable alternative...
May 2015: Acta Anaesthesiologica Scandinavica
Surya Kumar Dube, Mihir Prakash Pandia, Arvind Chaturvedi, Parmod Bithal, Hari Hara Dash
BACKGROUND: Post operative recovery has been reported to be faster with desflurane than sevoflurane anesthesia in previous studies. The use of desflurane is often criticized in neurosurgery due to the concerns of cerebral vasodilation and increase in ICP and studies comparing desflurane and sevoflurane in neurosurgey are scarce. So we compared the intraoperative brain condition, hemodynamics and postoperative recovery in patients undergoing elective supratentorial craniotomy receiving either desflurane or sevoflurane...
April 2015: Saudi Journal of Anaesthesia
G J Choi, C W Baek, H Kang, Y H Park, S Y Yang, H Y Shin, Y H Jung, Y C Woo, U L Lee
BACKGROUND: This study aimed to compare emergence agitation following sevoflurane and desflurane anaesthesia in adults undergoing orthognathic surgery. The hypothesis was that there might be a difference in the incidence of emergence agitation following sevoflurane and desflurane anaesthesia considering the difference in blood solubility and speed of recovery between the two. METHODS: In this prospective randomised double-blind study, 144 adults undergoing orthognathic surgery were randomly allocated to either sevoflurane or desflurane anaesthesia...
February 2015: Acta Anaesthesiologica Scandinavica
Kevin M Elias, Stephanie Kang, Xiaoxia Liu, Neil S Horowitz, Ross S Berkowitz, Gyorgy Frendl
BACKGROUND: Previous studies have offered conflicting results regarding an association between perioperative epidural analgesia and disease-free survival (DFS) following optimal primary cytoreductive surgery for stage III epithelial ovarian cancer. A possible separate role for inhalational anesthetics has not been assessed. METHODS: We conducted a historical cohort study of all women undergoing optimal primary cytoreduction (<1 cm residual disease) for Stage III epithelial ovarian cancer between January 1, 2007, and December 31, 2011, at Brigham and Women's Hospital...
April 2015: Annals of Surgical Oncology
G Kumar, C Stendall, R Mistry, K Gurusamy, D Walker
With the popularity of ambulatory surgery ever increasing, we carried out a systematic review and meta-analysis to determine whether the type of anaesthesia used had any bearing on patient outcomes. Total intravenous propofol anaesthesia was compared with two of the newer inhalational agents, sevoflurane and desflurane. In total, 18 trials were identified; only trials where nitrous oxide was administered to, or omitted from, both groups were included. A total of 1621 patients were randomly assigned to either propofol (685 patients) or inhalational anaesthesia (936 patients)...
October 2014: Anaesthesia
Nesrin Bozdogan, Halit Madenoglu, Kudret Dogru, Karamehmet Yildiz, Mustafa S Kotanoglu, Mustafa Cetin, Adem Boyaci
BACKGROUND: The primary physiologic function of platelets is to facilitate hemostasisby aggregation. Volatile anesthetics have been reported to decrease platelet aggregation in vivo and in vitro. OBJECTIVE: The aim of this study was to investigate the hematologic effectsof the anesthetics isoflurane, sevoflurane, and desflurane on hemoglobin (Hb), hematocrit (Hct), platelet count, activated partial thromboplastin time (aPTT), prothrombin time (PT), international normalized ratio (INR), and platelet aggregation after minor surgery...
July 2005: Current Therapeutic Research, Clinical and Experimental
Jahan Porhomayon, Pamela K Wendel, Leslie Defranks-Anain, Kay B Leissner, Nader D Nader
OBJECTIVES: The primary goal of this study was to assess the impact of airway devices on the incidence of nausea after knee arthroplasty and their interaction with the use of nitrous oxide. METHODS: Charts were reviewed for 499 patients after knee arthroplasty under general anesthesia. Demographic data, type of airway device, nitrous oxide, sevoflurane, desflurane, isoflurane, fentanyl, metoclopramide, ondansetron, dexamethasone, rocuronium and neostigmine were analyzed...
October 2013: Middle East Journal of Anesthesiology
Jin-Kyoung Kim, Duk-Kyung Kim, Myeong-Jin Lee
OBJECTIVE: To determine bispectral index (BIS) values produced by equipotent concentrations of commonly used volatile anaesthetics. METHODS: Female patients undergoing thyroidectomy were randomly assigned to receive isoflurane, sevoflurane or desflurane anaesthesia. After induction, anaesthesia was maintained by the volatile agent at 1 minimum alveolar concentration and supplemented with remifentanil infusion. BIS values were recorded during 1 h surgical anaesthesia after a 15 min equilibrium phase...
February 2014: Journal of International Medical Research
Hajime Iwasaki, Kenichi Takahoko, Shigeaki Otomo, Tomoki Sasakawa, Takayuki Kunisawa, Hiroshi Iwasaki
BACKGROUND: Differences in the supramaximal current (STIM) and sensitivity of the transducer (SENS) after calibration using mode "CAL2" of the neuromuscular accelermyography (TOF-Watch SX, MSD, Japan) between type 2 diabetic and non-diabetic patients were evaluated undergoing general anesthesia. METHODS: Thirty four elective surgical patients (20-69 years) were enrolled in this study. We evaluated STIM, SENS, onset time of rocuronium (onset time), time from onset to first T1 appearance (T1 appearance) and time from T1 appearance to T2 appearance (T1-T2 time) by using TOF stimulation between type 2 diabetic patients and non-diabetic patients, retrospectively...
August 2013: Masui. the Japanese Journal of Anesthesiology
G Landoni, T Greco, G Biondi-Zoccai, C Nigro Neto, D Febres, M Pintaudi, L Pasin, L Cabrini, G Finco, A Zangrillo
BACKGROUND: Many studies have compared desflurane, isoflurane, sevoflurane, total i.v. anaesthesia (TIVA), or all in cardiac surgery to assess their effects on patient survival. METHODS: We performed standard pairwise and Bayesian network meta-analyses; the latter allows indirect assessments if any of the anaesthetic agents were not compared in head-to-head trials. Pertinent studies were identified using BioMedCentral, MEDLINE/PubMed, Embase, and the Cochrane Library (last updated in June 2012)...
December 2013: British Journal of Anaesthesia
Jeong Min Kim, Jae Hoon Lee, Hye Jin Lee, Bon-Nyeo Koo
PURPOSE: In earlier analyses, desflurane has been shown to reduce average extubation time and the variability of extubation time by 20% to 25% relative to sevoflurane in adult patients. We undertook this study to determine which agents prompt less recovery time in pediatric patients undergoing minor surgery. MATERIALS AND METHODS: After obtaining Institutional Review Board approval, we retrospectively reviewed the anesthesia records of 499 patients, with an average age of 5 years, who underwent minor surgeries at Severance Eye and Ear, Nose and Throat Hospital between May 2010 and April 2011...
May 1, 2013: Yonsei Medical Journal
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