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https://www.readbyqxmd.com/read/28340102/impact-of-unrestricted-access-to-pregabalin-on-the-use-of-opioids-and-other-cns-active-medications-a-cross-sectional-time-series-analysis
#1
Herman Kwok, Wayne Khuu, Kimberly Fernandes, Diana Martins, Mina Tadrous, Samantha Singh, David N Juurlink, Tara Gomes
Objective. : Access to pregabalin via Ontario's public drug insurance program was expanded to an unrestricted model on April 1, 2013, from a prior authorization model. This study aims to identify the effect of expanded access on the rate of pregabalin use by publicly insured persons and to assess the characteristics of new patients initiating pregabalin following this expanded access. Methods. : We conducted a cross-sectional time series analysis using the linked health administrative records of residents of Ontario, Canada, with public drug coverage who were dispensed a prescription for pregabalin between April 1, 2006, and December 31, 2014...
March 6, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339590/reducing-antimicrobial-use-in-an-academic-pediatric-institution-evaluation-of-the-effectiveness-of-a-prospective-audit-with-real-time-feedback
#2
Zachary I Willis, Jessica Gillon, Meng Xu, James C Slaughter, M Cecilia Di Pentima
Introduction: Antimicrobial use is decreasing across freestanding children's hospitals, predominantly in institutions with antimicrobial stewardship programs (ASPs) in place. A highly effective ASP should effect a greater decrease in use than predicted by existing trends. Antimicrobial stewardship programs depend on clinician adherence to program recommendations, but little is known about factors associated with adherence. Methods: Parenteral antimicrobial-use data for our institution and 43 additional freestanding children's hospitals were obtained and normalized for patient census...
October 7, 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28339354/the-effects-of-an-educational-meeting-and-subsequent-computer-reminders-on-the-ordering-of-laboratory-tests-by-rheumatologists-an-interrupted-time-series-analysis
#3
Nienke Lesuis, Nathan den Broeder, Nadine Boers, Ester Piek, Steven Teerenstra, Marlies Hulscher, Ronald van Vollenhoven, Alfons A den Broeder
OBJECTIVES: To examine the effects of an educational meeting and subsequent computer reminders on the number of ordered laboratory tests. METHODS: Using interrupted time series analysis we assessed whether trends in the number of laboratory tests ordered by rheumatologists between September 2012 and September 2015 at the Sint Maartenskliniek (the Netherlands) changed following an educational meeting (September 2013) and the introduction of computer reminders into the Computerised Physician Order Entry System (July 2014)...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339067/characterization-of-dapk1-as-a-novel-transcriptional-target-of-brms1
#4
Xiaojing Qiao, Xi Yang, Yiren Zhou, Xinyu Mei, Jianming Dou, Wenjuan Xie, Guoqing Li, Yekai Wang, Shouyi Qiao, Jianwei Hu, Yanhua Wu
Breast cancer metastasis suppressor 1 (BRMS1) can specifically regulate tumor metastasis in many cancers. Our previous studies have demonstrated that BRMS1 can promote cell apoptosis through regulating osteopontin (OPN) expression in hepatocellular carcinoma (HCC) cells. However, the transcriptional targets of BRMS1 have not been thoroughly studied. In this study, death-associated protein kinase 1 (DAPK1), a tumor suppressor gene with multiple roles in regulating cell death, was identified as a potential transcriptional target of BRMS1 in the whole genome expression microarray...
March 23, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28339039/the-effects-of-air-pollutants-on-the-mortality-rate-of-lung-cancer-and-leukemia
#5
Mansooreh Dehghani, Laila Keshtgar, Mohammad Reza Javaheri, Zahra Derakhshan, Gea Oliveri Conti, Pietro Zuccarello, Margherita Ferrante
World Health Organization classifies air pollution as the first cause of human cancer. The present study investigated impact of air pollutants on the mortality rates of lung cancer and leukemia in Shiraz, one of the largests cities of Iran. This cross‑sectional (longitudinal) study was carried out in Shiraz. Data on six main pollutants, CO, SO2, O3, NO2, PM10 and PM2.5, were collected from Fars Environmental Protection Agency for 3,001 days starting from 1 January, 2005. Also, measures of climatic factors (temperature, humidity, and air pressure) were obtained from Shiraz Meteorological Organization...
March 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28337682/three-members-of-opisthomonorcheides-parukhin-1966-digenea-monorchiidae-from-carangid-fishes-perciformes-from-indonesia-with-a-review-of-the-genus
#6
Rodney A Bray, Harry W Palm, Scott C Cutmore, Thomas H Cribb
Three species of Opisthomonorcheides Parukhin, 1966 are reported for the first time from Indonesian waters: O. pampi (Wang, 1982) Liu, Peng, Gao, Fu, Wu, Lu, Gao & Xiao, 2010 and O. ovacutus (Mamaev, 1970) Machida, 2011 from Parastromateus niger (Bloch), and O. decapteri Parukhin, 1966 from Atule mate (Cuvier). Both O. pampi and O. ovacutus can now be considered widespread in the Indo-Pacific region, with earlier records of these species being from Fujian Province, China and Penang, Malaysia, respectively. We redescribe O...
March 23, 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28337676/logistic-proliferation-of-cells-in-scratch-assays-is-delayed
#7
Wang Jin, Esha T Shah, Catherine J Penington, Scott W McCue, Philip K Maini, Matthew J Simpson
Scratch assays are used to study how a population of cells re-colonises a vacant region on a two-dimensional substrate after a cell monolayer is scratched. These experiments are used in many applications including drug design for the treatment of cancer and chronic wounds. To provide insights into the mechanisms that drive scratch assays, solutions of continuum reaction-diffusion models have been calibrated to data from scratch assays. These models typically include a logistic source term to describe carrying capacity-limited proliferation; however, the choice of using a logistic source term is often made without examining whether it is valid...
March 23, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28337002/a-case-series-of-trigeminal-nerve-injuries-caused-by-periapical-lesions-of-mandibular-teeth
#8
M Devine, Z Yilmaz, M Hirani, T Renton
Aims Periapical lesions have been implicated in mandibular trigeminal sensory neuropathy. This study aimed to report on a case series of consecutive patients presenting with mandibular division trigeminal nerve injuries (TNI) caused by periapical lesions. Common presenting characteristics and possible strategies for management were also investigated.Materials and methods A retrospective study of 22 patients with TNI caused by periapical lesions. Data were extracted from patient records and analysed using Microsoft Excel and SPSS...
March 24, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28336187/the-chaotic-characteristic-of-the-carbon-monoxide-utilization-ratio-in-the-blast-furnace
#9
Dengfeng Xiao, Jianqi An, Yong He, Min Wu
In this paper, carbon monoxide utilization ratio (CMUR) is served as a real-time index to evaluate the energy consumption of blast furnace (BF), and the chaotic analysis method is also presented to study the characteristic of CMUR. Firstly, the time series data measured from two representative BFs are adopted as the sample to investigate the characteristics of CMUR. Secondly, the phase space model of CMUR is reconstructed, and two key related parameters of the model are derived as well. Finally, the value of the chaotic attractor's saturated correlative dimensions in the reconstructed phase space of CMUR is obtained...
March 20, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28335804/symbolic-time-series-analysis-of-electroencephalographic-eeg-epileptic-seizure-and-brain-dynamics-with-eye-open-and-eye-closed-subjects-during-resting-states
#10
Lal Hussain, Wajid Aziz, Jalal S Alowibdi, Nazneen Habib, Muhammad Rafique, Sharjil Saeed, Syed Zaki Hassan Kazmi
OBJECTIVE: Epilepsy is a neuronal disorder for which the electrical discharge in the brain is synchronized, abnormal and excessive. To detect the epileptic seizures and to analyse brain activities during different mental states, various methods in non-linear dynamics have been proposed. This study is an attempt to quantify the complexity of control and epileptic subject with and without seizure as well as to distinguish eye-open (EO) and eye-closed (EC) conditions using threshold-based symbolic entropy...
March 23, 2017: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/28335803/spatial-temporal-analysis-of-pulmonary-tuberculosis-in-the-northeast-of-the-yunnan-province-people-s-republic-of-china
#11
Li Huang, Xin-Xu Li, Eniola Michael Abe, Lin Xu, Yao Ruan, Chun-Li Cao, Shi-Zhu Li
BACKGROUND: The number of pulmonary tuberculosis (PTB) cases in China ranks third in the world. A continuous increase in cases has recently been recorded in Zhaotong prefecture-level city, which is located in the northeastern part of Yunnan province. This study explored the space-time dynamics of PTB cases in Zhaotong to provide useful information that will help guide policymakers to formulate effective regional prevention and control strategies. METHODS: The data on PTB cases were extracted from the nationwide tuberculosis online registration system...
March 24, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28334883/selective-impairment-of-hippocampus-and-posterior-hub-areas-in-alzheimer-s-disease-an-meg-based-multiplex-network-study
#12
Meichen Yu, Marjolein M A Engels, Arjan Hillebrand, Elisabeth C W van Straaten, Alida A Gouw, Charlotte Teunissen, Wiesje M van der Flier, Philip Scheltens, Cornelis J Stam
Although frequency-specific network analyses have shown that functional brain networks are altered in patients with Alzheimer's disease, the relationships between these frequency-specific network alterations remain largely unknown. Multiplex network analysis is a novel network approach to study complex systems consisting of subsystems with different types of connectivity patterns. In this study, we used magnetoencephalography to integrate five frequency-band specific brain networks in a multiplex framework...
March 16, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28334655/morpholine-or-methylpiperazine-and-salicylaldimine-based-heteroleptic-square-planner-platinum-ii-complexes-in%C3%A2-vitro-anticancer-study-and-growth-retardation-effect-on-e-%C3%A2-coli
#13
Faiz-Ur Rahman, Amjad Ali, Inam Ullah Khan, Hong-Quan Duong, Shang-Bo Yu, Yue-Jian Lin, Hui Wang, Zhan-Ting Li, Dan-Wei Zhang
Morpholine and methylpiperazine are among the most important structural parts of different drugs including organic chemotherapeutic agents. In the current study we incorporated these entities as co-ligand and a series of structurally related mono- and di-metallic square planner Pt(II) complexes (Pt(II)(salicylaldimine)(morpholine)Cl C1a-C3a, Pt(II)(salicylaldimine) (methylpiperazine)Cl C1b-C3b, di-metallic Pt(II)2(bis-salicylaldimine)(morpholine)2Cl2C4a and Pt(II)2(bis-salicylaldimine)(methylpiperazine)2Cl2C4b were prepared...
March 18, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28334094/funnel-gsea-functional-elastic-net-regression-in-time-course-gene-set-enrichment-analysis
#14
Yun Zhang, David J Topham, Juilee Thakar, Xing Qiu
Motivation: Gene set enrichment analyses (GSEAs) are widely used in genomic research to identify underlying biological mechanisms (defined by the gene sets), such as Gene Ontology terms and molecular pathways. There are two caveats in the currently available methods: (i) they are typically designed for group comparisons or regression analyses, which do not utilize temporal information efficiently in time-series of transcriptomics measurements; and (ii) genes overlapping in multiple molecular pathways are considered multiple times in hypothesis testing...
February 21, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28334091/landscape-level-patterns-of-elevated-fs1-asian-allele-frequencies-in-populations-of-gypsy-moth-lepidoptera-erebidae-at-a-northern-u-s-boundary
#15
Marissa A Streifel, Patrick C Tobin, Lucia Hunt, Hannah Nadel, John J Molongoski, Brian H Aukema
From a regulatory perspective, Asian gypsy moth is a species complex consisting of three species of Lymantria and two subspecies of Lymantria dispar (L.), differing from the European subspecies, L. dispar dispar (L.), by having consistently flight-capable females. As such, the invasion potential in North America is thought to exceed that of European gypsy moth. USDA-APHIS therefore has a monitoring program to detect Asian gypsy moth at high-risk introduction pathways. Molecular markers are used to improve the diagnosis of Asian gypsy moth...
February 17, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28334026/exploring-the-link-between-multiscale-entropy-and-fractal-scaling-behavior-in-near-surface-wind
#16
Miguel Nogueira
The equivalency between the power law behavior of Multiscale Entropy (MSE) and of power spectra opens a promising path for interpretation of complex time-series, which is explored here for the first time for atmospheric fields. Additionally, the present manuscript represents a new independent empirical validation of such relationship, the first one for the atmosphere. The MSE-fractal relationship is verified for synthetic fractal time-series covering the full range of exponents typically observed in the atmosphere...
2017: PloS One
https://www.readbyqxmd.com/read/28333769/the-incidence-of-low-seroimmunity-to-hepatitis-b-virus-in-children-with-inflammatory-bowel-disease
#17
Abhishek Watts, William E Bennett, Jean P Molleston, Sandeep K Gupta, Joseph M Croffie, Shamaila Waseem, Brian A McFerron, Steven J Steiner, Sanjay Kumar, Charles P Vanderpool, Emily C Hon, Molly A Bozic, Girish C Subbarao, Marian D Pfefferkorn
OBJECTIVES: Patients with inflammatory bowel disease (IBD) often receive immunosuppressive therapy which may make them vulnerable to infections such as hepatitis B. We hypothesized that hepatitis B virus (HBV) titers are low in the vaccinated pediatric IBD population. The aims of our study were to identify the incidence of lower titers of hepatitis B surface antibody (HBsAb) and determine which patient factors may be associated with lower HBsAb titers. METHODS: Patients with diagnosis of IBD, ages 5-18 years, were prospectively enrolled...
March 22, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28333764/determinants-of-rotavirus-transmission-a-lag-non-linear-time-series-analysis
#18
Rolina D van Gaalen, Jan van de Kassteele, Susan J M Hahné, Patricia Bruijning-Verhagen, Jacco Wallinga
Rotavirus is a common viral infection among young children. As in many countries, the infection dynamics of rotavirus in the Netherlands are characterized by an annual winter peak, which was notably low in 2014. Previous work suggested an association between weather factors and both rotavirus transmission and incidence. From epidemic theory, we know that the proportion of susceptible individuals can affect disease transmission. We investigated how these factors are associated with rotavirus transmission in the Netherlands, and their impact on rotavirus transmission in 2014...
March 22, 2017: Epidemiology
https://www.readbyqxmd.com/read/28333762/impact-of-targeted-interventions-on-trends-in-central-line-associated-bloodstream-infection-a-single-center-experience-from-the-republic-of-korea
#19
Sun Young Cho, Doo Ryeon Chung, Jae Geum Ryu, Jong Rim Choi, Nayeon Ahn, Seonwoo Kim, Min-Ji Kim, Young Eun Ha, Cheol-In Kang, Kyong Ran Peck, Jae-Hoon Song
OBJECTIVE: To assess the impact of targeted interventions on trends in central line-associated bloodstream infection. DESIGN: A before-and-after study between January 2013 and September 2014. SETTING: Tertiary hospital in the Republic of Korea. PATIENTS: All patients with central-line catheters in the hospital. INTERVENTIONS: In September 2013, interventions that targeted central line insertion practices were implemented in 10 ICUs, including compliance monitoring with a central line insertion practices bundle and use of an all-inclusive catheter kit...
March 22, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28333394/socket-shield-technique-for-immediate-implant-placement-clinical-radiographic-and-volumetric-data-after-5%C3%A2-years
#20
Daniel Bäumer, Otto Zuhr, Stephan Rebele, Markus Hürzeler
OBJECTIVES: Implant placement immediately after tooth extraction is often accompanied by resorption of surrounding tissues. A clinical technique was developed where the buccal portion of the root is retained to preserve the periodontal ligament and bundle bone. This technique is based on animal studies showing the potential to preserve the facial tissues utilizing this approach. The purpose of this study was to gain more insight regarding the safety of the technique with regard to biological and implant-related long-term complications and to observe the clinical appearance of the peri-implant tissues...
March 23, 2017: Clinical Oral Implants Research
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