Rachael S Allen, Cara T Khayat, Andrew J Feola, Alice S Win, Allison R Grubman, Kyle C Chesler, Li He, Jendayi A Dixon, Timothy S Kern, P Michael Iuvone, Peter M Thule, Machelle T Pardue
PURPOSE: Limited research exists on the time course of long-term retinal and cerebral deficits in diabetic rodents. Previously, we examined short term (4-8 weeks) deficits in the Goto-Kakizaki (GK) rat model of Type II diabetes. Here, we investigated the long-term (1-8 months) temporal appearance of functional deficits (retinal, cognitive, and motor), retinal vascular pathology, and retinal dopamine levels in the GK rat. METHODS: In GK rats and Wistar controls, retinal neuronal function (electroretinogram), cognitive function (Y-maze), and motor function (rotarod) were measured at 1, 2, 4, 6, and 8 months of age...
2023: Frontiers in Neuroscience