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https://www.readbyqxmd.com/read/28922778/circulating-folate-vitamin-b6-and-methionine-in-relation-to-lung-cancer-risk-in-the-lung-cancer-cohort-consortium-lc3
#1
Anouar Fanidi, David C Muller, Jian-Min Yuan, Victoria L Stevens, Stephanie J Weinstein, Demetrius Albanes, Ross Prentice, Cynthia A Thomsen, Mary Pettinger, Qiuyin Cai, William J Blot, Jie Wu, Alan A Arslan, Anne Zeleniuch-Jacquotte, Marjorie L McCullough, Loic Le Marchand, Lynne R Wilkens, Christopher A Haiman, Xuehong Zhang, Jiali Han, Meir J Stampfer, Stephanie A Smith-Warner, Edward Giovannucci, Graham G Giles, Allison M Hodge, Gianluca Severi, Mikael Johansson, Kjell Grankvist, Arnulf Langhammer, Steinar Krokstad, Marit Næss, Renwei Wang, Yu-Tang Gao, Lesley M Butler, Woon-Puay Koh, Xiao-Ou Shu, Yong-Bing Xiang, Honglan Li, Wei Zheng, Qing Lan, Kala Visvanathan, Judith Hoffman Bolton, Per Magne Ueland, Øivind Midttun, Arve Ulvik, Neil E Caporaso, Mark Purdue, Regina G Ziegler, Neal D Freedman, Julie E Buring, I-Min Lee, Howard D Sesso, J Michael Gaziano, Jonas Manjer, Ulrika Ericson, Caroline Relton, Paul Brennan, Mattias Johansson
Background: Circulating concentrations of B vitamins and factors related to one-carbon metabolism have been found to be strongly inversely associated with lung cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The extent to which these associations are present in other study populations is unknown. Methods: Within 20 prospective cohorts from the National Cancer Institute Cohort Consortium, a nested case-control study was designed including 5364 incident lung cancer case patients and 5364 control subjects who were individually matched to case patients by age, sex, cohort, and smoking status...
January 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28922715/pm2-5-components-and-outpatient-visits-for-asthma-a-time-stratified-case-crossover-study-in-a-suburban-area
#2
Chau-Ren Jung, Li-Hao Young, Hui-Tsung Hsu, Ming-Yeng Lin, Yu-Cheng Chen, Bing-Fang Hwang, Perng-Jy Tsai
The effects of fine particles (PM2.5) on asthma have been widely confirmed by epidemiological research studies. However, a limited number of studies have investigated the relationship between exposure to different PM2.5 components and asthma. We characterized the PM2.5 components in a suburban site of central Taiwan and conducted a time-stratified case-crossover study to elaborate the effects of daily concentration of each PM2.5 component on asthma outpatient visits. We retrieved asthma outpatient claims for individuals less than 20 years old with a residential address in the Shalu district, Taiwan, from the National Health Insurance Research Database during 2000-2010...
September 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28922572/s-doped-tise2-nanoplates-fe3-o4-nanoparticles-heterostructure
#3
Jun Yang, Yufei Zhang, Yizhou Zhang, Jinjun Shao, Hongbo Geng, Yu Zhang, Yun Zheng, Mani Ulaganathan, Zhengfei Dai, Bing Li, Yun Zong, Xiaochen Dong, Qingyu Yan, Wei Huang
2D Sulfur-doped TiSe2 /Fe3 O4 (named as S-TiSe2 /Fe3 O4 ) heterostructures are synthesized successfully based on a facile oil phase process. The Fe3 O4 nanoparticles, with an average size of 8 nm, grow uniformly on the surface of S-doped TiSe2 (named as S-TiSe2 ) nanoplates (300 nm in diameter and 15 nm in thickness). These heterostructures combine the advantages of both S-TiSe2 with good electrical conductivity and Fe3 O4 with high theoretical Li storage capacity. As demonstrated potential applications for energy storage, the S-TiSe2 /Fe3 O4 heterostructures possess high reversible capacities (707...
September 18, 2017: Small
https://www.readbyqxmd.com/read/28922346/grid-seq-reveals-the-global-rna-chromatin-interactome
#4
Xiao Li, Bing Zhou, Liang Chen, Lan-Tao Gou, Hairi Li, Xiang-Dong Fu
Higher eukaryotic genomes are bound by a large number of coding and non-coding RNAs, but approaches to comprehensively map the identity and binding sites of these RNAs are lacking. Here we report a method to capture in situ global RNA interactions with DNA by deep sequencing (GRID-seq), which enables the comprehensive identification of the entire repertoire of chromatin-interacting RNAs and their respective binding sites. In human, mouse, and Drosophila cells, we detected a large set of tissue-specific coding and non-coding RNAs that are bound to active promoters and enhancers, especially super-enhancers...
September 18, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28922138/finite-time-adaptive-control-for-a-class-of-nonlinear-systems-with-nonstrict-feedback-structure
#5
Yumei Sun, Bing Chen, Chong Lin, Honghong Wang
This paper focuses on finite-time adaptive neural tracking control for nonlinear systems in nonstrict feedback form. A semiglobal finite-time practical stability criterion is first proposed. Correspondingly, the finite-time adaptive neural control strategy is given by using this criterion. Unlike the existing results on adaptive neural/fuzzy control, the proposed adaptive neural controller guarantees that the tracking error converges to a sufficiently small domain around the origin in finite time, and other closed-loop signals are bounded...
September 18, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28921947/large-scale-fabrication-of-silicon-nanowires-for-solar-energy-applications
#6
Bing-Chang Zhang, Jiansheng Jie, Xiujuan Zhang, Xue-Mei Ou, Xiao-Hong Zhang
The development of silicon (Si) materials during the past decades has boosted up the prosperity of modern semiconductor industry. In comparison with the bulk Si materials, Si nanowires (SiNWs) possess superior structural, optical and electrical properties and have attracted increasing attention in solar energy applications. To achieve the practical applications of SiNWs, both large-scale synthesis of SiNWs at low cost and rational design of energy conversion devices with high efficiency are the prerequisite...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28921689/associations-between-eating-disorder-related-symptoms-and-participants-utilization-of-an-individualized-internet-based-prevention-and-early-intervention-program
#7
Sally Kindermann, Markus Moessner, Fikret Ozer, Stephanie Bauer
OBJECTIVE: Flexible, individualized interventions allow participants to adjust the intensity of support to their current needs. Between-persons, participants with greater needs can receive more intense support, within-persons, participants can adjust utilization to their current level of symptoms. The purpose of the present study was to analyze associations between ED-related symptoms and utilization of the individualized program ProYouth both between- and within-persons, aiming to investigate whether participants adapt utilization intensity to their current needs...
September 18, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28921473/the-development-and-diversity-of-ilcs-nk-cells-and-their-relevance-in-health-and-diseases
#8
Yuxia Zhang, Bing Huang
Next to T and B cells, natural killer (NK) cells are the third largest lymphocyte population. They are recently re-categorized as innate lymphocytes (ILCs), which also include ILC1, ILC2, ILC3, and the lymphoid tissue inducer (LTi) cells. Both NK cells and ILC1 cells are designated as group 1 ILCs because they secrete interferon-γ (IFN-γ) and tumor necrosis factor (TNF). However, in contrast to ILC1 and all other ILCs, NK cells possess potent cytolytic functions that resemble cytotoxic T lymphocytes (CTL)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28921397/a-binding-block-ion-selective-mechanism-revealed-by-a-na-k-selective-channel
#9
Jie Yu, Bing Zhang, Yixiao Zhang, Cong-Qiao Xu, Wei Zhuo, Jingpeng Ge, Jun Li, Ning Gao, Yang Li, Maojun Yang
Mechanosensitive (MS) channels are extensively studied membrane protein for maintaining intracellular homeostasis through translocating solutes and ions across the membrane, but its mechanisms of channel gating and ion selectivity are largely unknown. Here, we identified the YnaI channel as the Na(+)/K(+) cation-selective MS channel and solved its structure at 3.8 Å by cryo-EM single-particle method. YnaI exhibits low conductance among the family of MS channels in E. coli, and shares a similar overall heptamer structure fold with previously studied MscS channels...
September 18, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28920667/warm-white-light-emitting-diode-based-on-a-dye-loaded-metal-organic-framework-for-fast-white-light-communication
#10
Zhiye Wang, Zi Wang, Bangjiang Lin, Xuefu Hu, YunFeng Wei, Cankun Zhang, Bing An, Cheng Wang, Wenbin Lin
A dye@metal-organic framework (MOF) hybrid was used as a phosphor in a white light emitting diode (WLED) for fast visible-light communication (VLC). The white light was generated from a combination of blue emission of the 9,10-dibenzoate anthracene (DBA) linkers and yellow emission of the encapsulated Rhodamine B molecules. The MOF structure not only prevents dye molecules from aggregation-induced quenching, but also efficiently transfers energy to the dye for dual emission. This light-emitting material shows emission lifetimes of 1...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28920083/differential-alterations-of-intracellular-ca-2-dynamics-induced-by-cocaine-and-methylphenidate-in-thalamocortical-ventrobasal-neurons
#11
José L Rozas, Belén Goitia, Verónica Bisagno, Francisco J Urbano
The ventrobasal (VB) thalamus relay nucleus processes information from rodents' whiskers, projecting to somatosensory cortex. Cocaine and methylphenidate (MPH) have been described to differentially alter intrinsic properties of, and spontaneous GABAergic input to, VB neurons. Here we studied using bis-fura 2 ratiometric fluorescence the effects of cocaine and MPH on intracellular [Ca(2+)] dynamics at the soma and dendrites of VB neurons. Cocaine increased baseline fluorescence in VB somatic and dendritic compartments...
July 2017: Translational Brain Rhythmicity
https://www.readbyqxmd.com/read/28919778/improvement-of-survival-for-non-small-cell-lung-cancer-over-time
#12
Wenjie Xia, Xinnian Yu, Qixing Mao, Wenying Xia, Anpeng Wang, Gaochao Dong, Bing Chen, Weidong Ma, Lin Xu, Feng Jiang
Non-small cell lung cancer (NSCLC) is the main histological subtype of lung cancer, which is the leading cause of cancer death. It is unclear whether the improved survival seen at high-volume centers applies to the general population and, more importantly, whether the improvement in lung cancer survival was just a consequence of improved screening work. Data from the Surveillance, Epidemiology, and End Results (SEER) registry was used to identify 405,580 patients with NSCLC diagnosed from 1988 to 2008. The patients were divided into four groups according to the year of diagnosis...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28919754/preparation-of-coffee-oil-algae-oil-based-nanoemulsions-and-the-study-of-their-inhibition-effect-on-uva-induced-skin-damage-in-mice-and-melanoma-cell-growth
#13
Chu-Ching Yang, Chi-Feng Hung, Bing-Huei Chen
Coffee grounds, a waste by-product generated after making coffee, contains approximately 15% coffee oil which can be used as a raw material in cosmetics. Algae oil rich in docosahexaenoic acid (DHA) has been demonstrated to possess anticancer and anti-inflammation functions. The objectives of this study were to develop a gas chromatography-mass spectrometry (GC-MS) method for the determination of fatty acids in coffee oil and algae oil and prepare a nanoemulsion for studying its inhibition effect on ultraviolet A-induced skin damage in mice and growth of melanoma cells B16-F10...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28919487/effect-of-ultrasound-treatment-conditions-on-saccharomyces-cerevisiae-by-response-surface-methodology
#14
Junyan Liu, Lin Li, Lizhen Zhou, Bing Li, Zhenbo Xu
OBJECTIVES: This study aimed to investigate the effect of different ultrasound treatment conditions on the inactivation of Saccharomyces cerevisiae with the application of response surface methodology (RSM). METHODS: Ultrasound treatment were applied on different concentrations of S. cerevisiae cells with different pH, temperature, ultrasound power, irradiating time, and pulse duty ratio. Cell viability was determined by plate counting method. Response surface methodology was used to analysis the correlation among various factors...
September 15, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28919433/the-p2x7-receptor-in-dorsal-root-ganglia-is-involved-in-hiv-gp120-associated-neuropathic-pain
#15
Bing Wu, Lichao Peng, Jinyan Xie, Lifang Zou, Qicheng Zhu, Huaide Jiang, Zhihua Yi, Shouyu Wang, Yun Xue, Yun Gao, Guilin Li, Shuangmei Liu, Chunping Zhang, Guodong Li, Shangdong Liang, Huangui Xiong
Human immunodeficiency virus (HIV)-associated neuropathic pain is common, and studies have shown that HIV envelope glycoprotein 120 (gp120) can directly stimulate primary sensory afferent neurons causing hyperalgesia. The P2X7 receptor in the dorsal root ganglia (DRG) is involved in pain transmission and is closely related to the inflammatory and immune response. In this study, we aimed to explore the role of the P2X7 receptor in gp120-induced neuropathic pain using a rat model specific for this type of pain...
September 14, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28919395/gastroprotective-effect-of-aucubin-against-ethanol-induced-gastric-mucosal-injury-in-mice
#16
Yang Yang, Bing Yin, Le Lv, Ziye Wang, Jiao He, Ziyang Chen, Xin Wen, Yongmin Zhang, Wenji Sun, Yang Li, Ye Zhao
AIMS: Aucubin, an iridoid glycoside, was isolated from seeds of Eucommia ulmoides Oliver. This study was aimed to evaluate the protective effect of aucubin against ethanol-induced gastric mucosal injury in mice. MATERIALS AND METHODS: Mice were orally administrated with aucubin (20, 40 and 80mg/kg) for 3 consecutive days. On the 3rd day, the mice of gastric mucosal injury were induced with 70% ethanol after the last administration of aucubin. Gastric tissue of mice were submitted for evaluating the severity of gastric mucosal injury...
September 14, 2017: Life Sciences
https://www.readbyqxmd.com/read/28918833/recurrence-of-barcelona-clinic-liver-cancer-stage-a-hepatocellular-carcinoma-after-hepatectomy
#17
Hao Zou, Cheng-Zhan Zhu, Chang Wang, Zu-Sen Wang, Xiang Ma, Bing Han, Li-Qun Wu
BACKGROUND: The Barcelona Clinic Liver Cancer (BCLC) staging system is widely used to classify hepatocellular carcinoma (HCC). This study was performed to investigate the prognostic factors for patients with BCLC stage A HCC after R0 hepatectomy. METHODS: A total of 592 patients with BCLC stage A HCC following R0 hepatectomy from 1997-2012 were enrolled in this study. Kaplan-Meier analysis and Cox regression were used to analyze the risk factors associated with recurrence...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28918581/concurrent-improvement-in-both-binge-eating-and-depressive-symptoms-with-naltrexone-bupropion-therapy-in-overweight-or-obese-subjects-with-major-depressive-disorder-in-an-open-label-uncontrolled-study
#18
Anna I Guerdjikova, Brandon Walsh, Kevin Shan, Amy E Halseth, Eduardo Dunayevich, Susan L McElroy
INTRODUCTION: Binge eating disorder (BED) is associated with obesity and major depressive disorder (MDD). Naltrexone extended-release (ER)/bupropion ER (NB) is approved as an adjunct to diet and physical activity for chronic weight management. In a prospectively designed 24-week open-label, single-arm, single-site trial of 25 women with MDD and overweight/obesity, NB reduced weight and depressive symptoms. METHODS: This post hoc analysis investigated the relationship between change in self-reported binge eating behavior (evaluated with the Binge Eating Scale [BES]) and changes in weight, control of eating, and depressive symptoms...
September 16, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28918332/control-of-absence-epilepsy-seizures-in-specific-relay-nuclei-of-thalamus
#19
Bing Hu, Xiaoqiang Zou, Yu Guo, Zhejia Yang, Feng Shi, Wangyuan Dong
In this paper, we used a classic basal ganglia-corticothalamic model(BGCT) to study the onset and control mechanism of absence epilepsy in specific relay nuclei (SRN) of thalamus. It was found that the seizure state may appear in SRN by turning the coupling strength -vsr and signal transmission delay τ on the route "Thalamic reticular nuclei (TRN) of thalamus ⟶ SRN ". With increasing of -vsr, the seizure state appeared two times, and its onset mechanism has not been discussed in previous studies. The seizure activity can be well controlled by adjusting the activation level of the substantia nigra pars reticulata (SNr) in basal ganglia, which is a main output tissue to the corticothalamic system through two direct inhibitory pathways "SNr ⟶ SRN" and "SNr ⟶ TRN " in our model...
September 13, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28918081/developmental-alcohol-exposure-impairs-synaptic-plasticity-without-overtly-altering-microglial-function-in-mouse-visual-cortex
#20
Elissa L Wong, Nina M Lutz, Victoria A Hogan, Cassandra E Lamantia, Helene R McMurray, Jason R Myers, John M Ashton, Ania K Majewska
Fetal alcohol spectrum disorder (FASD), caused by gestational ethanol (EtOH) exposure, is one of the most common causes of non-heritable and life-long mental disability worldwide, with no standard treatment or therapy available. While EtOH exposure can alter the function of both neurons and glia, it is still unclear how EtOH influences brain development to cause deficits in sensory and cognitive processing later in life. Microglia play an important role in shaping synaptic function and plasticity during neural circuit development and have been shown to mount an acute immunological response to EtOH exposure in certain brain regions...
September 13, 2017: Brain, Behavior, and Immunity
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