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https://www.readbyqxmd.com/read/28432932/surveillance-of-vittaforma-corneae-in-hot-springs-by-a-small-volume-procedure
#1
Jung-Sheng Chen, Tsui-Kang Hsu, Bing-Mu Hsu, Tung-Yi Huang, Yu-Li Huang, Men-Fang Shaio, Dar-Der Ji
Vittaforma corneae is an obligate intracellular fungus and can cause human ocular microsporidiosis. Although accumulating reports of V. corneae causing keratoconjunctivitis in both healthy and immunocompromised persons have been published, little is known about the organism's occurrence in aquatic environments. Limitations in detection sensitivity have meant a large sampling volume is required to detect the pathogen up to now, which is problematic. A recent study in Taiwan has shown that some individuals suffering from microsporidial keratitis (MK) were infected after exposure to the pathogen at a hot spring...
April 19, 2017: Water Research
https://www.readbyqxmd.com/read/28432804/premorbid-bmi-predicts-binge-purge-symptomatology-among-individuals-with-anorexia-nervosa
#2
Elin L Lantz, Christopher Gillberg, Maria Råstam, Elisabet Wentz, Michael R Lowe
OBJECTIVE: A finding consistent with the transdiagnostic approach to eating disorders is that about half of those with restricting anorexia nervosa (AN) eventually undergo a transition to the binge/purge (BP) subtype or to bulimia nervosa. Given evidence that individuals with bulimic symptoms exhibit elevated weights premorbidly, we tested the hypothesis that among those with AN, highest premorbid BMI would predict which individuals with AN would develop AN-BP. METHOD: The current study used longitudinal data from a community sample of adolescents with AN in Sweden...
April 22, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28432477/usefulness-of-non-magnifying-narrow-band-imaging-in-evis-exera-iii-video-systems-and-high-definition-endoscopes-to-diagnose-dysplasia-in-barrett-s-esophagus-using-the-barrett-international-nbi-group-bing-classification
#3
Oscar Nogales, Arancha Caballero-Marcos, Ana Clemente-Sánchez, Javier García-Lledó, Leticia Pérez-Carazo, Beatriz Merino, Carlos Carbonell, María López-Ibáñez, Cecilia González-Asanza
BACKGROUND: Narrow band imaging (NBI) allows identification of abnormal areas of Barrett's esophagus (BE) and could facilitate targeted biopsies. AIMS: We evaluated the diagnostic accuracy for dysplasia prediction using non-magnifying NBI in Evis Exera III processors and high-definition endoscopes using the Barrett International NBI Group (BING) classification, as well as inter/intraobserver agreement for dysplasia prediction and mucosal/vascular patterns. METHODS: Eight observers (4 staff endoscopists and 4 trainee endoscopists) evaluated 100 images selected from an anonymized bank of 470 photographs using the BING classification...
April 21, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28432102/two-distinct-%C3%AE-l-arabinofuranosidases-in-caldicellulosiruptor-species-drive-degradation-of-arabinose-based-polysaccharides
#4
Md Abu Saleh, Wen-Jie Han, Ming Lu, Bing Wang, Huayue Li, Robert M Kelly, Fu-Li Li
Species in the extremely thermophilic genus Caldicellulosiruptor can degrade unpretreated plant biomass through the action of multi-modular glycoside hydrolases. To date, most focus with these bacteria has been on hydrolysis of glucans and xylans, while biodegradation mechanism for arabinose-based polysaccharides remains unclear. Here, putative α-L-arabinofuranosidases (AbFs) were identified in Caldicellulosiruptor species by homology to less thermophilic versions of these enzymes. From this screen, an extracellular XynF was determined to be a key factor in hydrolyzing α-1,2-, α-1,3-, and α-1,5-L-arabinofuranosyl residues of arabinose-based polysaccharides...
April 21, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28432038/seeking-web-based-information-about-attention-deficit-hyperactivity-disorder-where-what-and-when
#5
Sara Rosenblum, Elad Yom-Tov
BACKGROUND: Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder, prevalent among 2-10% of the population. OBJECTIVE: The objective of this study was to describe where, what, and when people search online for topics related to ADHD. METHODS: Data were collected from Microsoft's Bing search engine and from the community question and answer site, Yahoo Answers. The questions were analyzed based on keywords and using further statistical methods...
April 21, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28431558/epidemiology-and-genotype-distribution-of-human-papillomavirus-hpv-in-southwest-china-a-cross-sectional-five-years-study-in-non-vaccinated-women
#6
Yishu Tang, Lan Zheng, Shuangshuang Yang, Bing Li, Huiting Su, Li-Ping Zhang
BACKGROUND: Large-size data on type-specific HPV prevalence in Southwest China are required to estimate the cervical cancer burden in the country and to prepare for HPV-based cervical screening program and further HPV vaccination of China. This HPV study is a pooled analysis of data from five years in Chongqing of China, which is cross-sectional in design using data collecting. RESULTS: The positivity of HPV was 26.2% (10542/40311), single type was 25.7% (10360/40311), multiple type was 8...
April 21, 2017: Virology Journal
https://www.readbyqxmd.com/read/28431280/interleukin-1-receptor-associated-kinase-1-is-a-potential-therapeutic-target-of-anti-inflammatory-therapy-for-systemic-lupus-erythematosus
#7
Mingfang Li, Datang Yu, Bing Ni, Fei Hao
Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease and currently has no effective therapy. The genome-wide analyses indicate that interleukin-1 receptor associated kinase 1 (IRAK1) is associated with the susceptibility of SLE in humans. In the present study, we identified that IRAK1 was overexpressed and hyper-activated in splenic mononuclear cells from B6.MRL-Fas(lpr)/Nju (B6.lpr) mice and peripheral blood mononuclear cells (PBMCs) from SLE patients. Intraperitoneal treatment with a small molecular inhibitor of IRAK1 (IRAK1/4 inhibitor or IRAK-Inh) significantly mitigated inflammatory responses and renal injury in B6...
April 18, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28431155/motoring-through-the-role-of-kinesin-superfamily-proteins-in-female-meiosis
#8
Nicole J Camlin, Eileen A McLaughlin, Janet E Holt
BACKGROUND: The kinesin motor protein family consists of 14 distinct subclasses and 45 kinesin proteins in humans. A large number of these proteins, or their orthologues, have been shown to possess essential function(s) in both the mitotic and the meiotic cell cycle. Kinesins have important roles in chromosome separation, microtubule dynamics, spindle formation, cytokinesis and cell cycle progression. This article contains a review of the literature with respect to the role of kinesin motor proteins in female meiosis in model species...
April 18, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28431128/binge-drinking-and-well-being-in-european-older-adults-do-gender-and-region-matter
#9
Sonsoles Fuentes, Usama Bilal, Iñaki Galán, Joan R Villalbí, Albert Espelt, Marina Bosque-Prous, Manuel Franco, Mariana Lazo
We aimed to describe gender and region differences in the prevalence of binge drinking and in the association between binge drinking and well-being, among older adult Europeans. This is a cross-sectional study using the Survey of Health, Ageing and Retirement in Europe (SHARE) wave 4, conducted between 2011 and 2012, including 58 489 individuals aged 50 years or older. Sixteen European countries were grouped in four drinking culture regions: South, Central, North and East. We categorized drinking patterns as: never, former, no-binge and binge drinkers...
April 18, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28430930/alcohol-consumption-and-binge-drinking-in-young-men-as-predictors-of-body-composition-changes-during-military-service
#10
Maria P Hagnäs, Jari Jokelainen, Henna Cederberg-Tamminen, Solja Niemelä, Ilona Mikkola, Pirjo Härkönen, Ulla Rajala, Sirkka Keinänen-Kiukaanniemi
Aims: To evaluate the influences of alcohol consumption frequency and binge drinking on changes in the body composition, lifestyle habits and physical fitness of healthy young men during military service. Methods: A population-based study of men performing their military service in the Sodankylä Jaeger Brigade, Finland in 2005. Body composition, fitness and lifestyle habits were evaluated at baseline and 6-12 months follow-up. Alcohol consumption frequency and binge drinking were categorized as: 'not at all', 'at least once a month' and 'at least once a week'...
May 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28430871/cluspro-peptidock-efficient-global-docking-of-peptide-recognition-motifs-using-fft
#11
Kathryn A Porter, Bing Xia, Dmitri Beglov, Tanggis Bohnuud, Nawsad Alam, Ora Schueler-Furman, Dima Kozakov
Summary: We present an approach for the efficient docking of peptide motifs to their free receptor structures. Using a motif based search, we can retrieve structural fragments from the Protein Data Bank (PDB) that are very similar to the peptide's final, bound conformation. We use a Fast Fourier Transform (FFT) based docking method to quickly perform global rigid body docking of these fragments to the receptor. According to CAPRI peptide docking criteria, an acceptable conformation can often be found among the top-ranking predictions...
April 18, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28430651/doxorubicin-loaded-platelets-conjugated-with-anti-cd22-mabs-a-novel-targeted-delivery-system-for-lymphoma-treatment-with-cardiopulmonary-avoidance
#12
Peipei Xu, Huaqin Zuo, Rongfu Zhou, Fan Wang, Xu Liu, Jian Ouyang, Bing Chen
B-cell lymphoma accounts for approximately 85% of all adult non-Hodgkin's lymphoma cases. Doxorubicin (DOX) is an indispensable drug for the treatment of non-Hodgkin's lymphoma. However, DOX causes severe cardiotoxicity, which limits its use in conventional treatment strategies. In this study, we developed a novel drug delivery system for lymphoma treatment: DOX-loaded platelets that were conjugated with anti-CD22 monoclonal antibodies (mAbs) (DOX-platelet-CD22). Platelets are bio- and immune-compatible drug carriers that can prolong the circulation time of drugs...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430472/random-number-generation-with-cosmic-photons
#13
Cheng Wu, Bing Bai, Yang Liu, Xiaoming Zhang, Meng Yang, Yuan Cao, Jianfeng Wang, Shaohua Zhang, Hongyan Zhou, Xiheng Shi, Xiongfeng Ma, Ji-Gang Ren, Jun Zhang, Cheng-Zhi Peng, Jingyun Fan, Qiang Zhang, Jian-Wei Pan
Random numbers are indispensable for a variety of applications ranging from testing physics foundations to information encryption. In particular, nonlocality test provide strong evidence for our current understanding of nature-quantum mechanics. All the random number generators (RNGs) used for the existing tests are constructed locally, making the test results vulnerable to the freedom-of-choice loophole. We report an experimental realization of RNGs based on the arrival time of cosmic photons. The measurement outcomes (raw data) pass the standard NIST statistical test suite...
April 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28430432/absolute-binding-free-energies-between-t4-lysozyme-and-141-small-molecules-calculations-based-on-multiple-rigid-receptor-configurations
#14
Bing Xie, Trung Hai Nguyen, David D L Minh
We demonstrate the feasibility of estimating protein-ligand binding free energies using multiple rigid receptor configurations. Based on T4 lysozyme snapshots extracted from six alchemical binding free energy calculations with a flexible receptor, binding free energies were estimated for a total of 141 ligands. For 24 ligands, the calculations reproduced flexible-receptor estimates with a correlation coefficient of 0.90 and a root mean square error of 1.59 kcal/mol. The accuracy of calculations based on Poisson-Boltzmann/Surface Area implicit solvent was comparable to previously reported free energy calculations...
April 21, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28430385/significant-reductions-in-alcohol-use-after-hepatitis-c-treatment-results-from-the-french-anrs-co13-hepavih-cohort
#15
Rod Knight, Perrine Roux, Antoine Vilotitch, Fabienne Marcellin, Eric Rosenthal, Laure Esterle, François Boué, David Rey, Lionel Piroth, Stéphanie Dominguez, Philippe Sogni, Dominique Salmon-Ceron, Bruno Spire, Maria Patrizia Carrieri
BACKGROUND AND AIMS: Few data exist on changes to substance use patterns before and after hepatitis C virus (HCV) treatment. We used longitudinal data of HIV-HCV co-infected individuals to examine whether receiving Peg-interferon (Peg-IFN)-based therapy irrespective of HCV clearance could modify tobacco, cannabis and alcohol use. DESIGN: A prospective cohort of HIV-HCV co-infected individuals was enrolled from 2006. Participants' clinical data were retrieved from medical records and socio-demographic and behavioral characteristics were collected by yearly self-administered questionnaires...
April 21, 2017: Addiction
https://www.readbyqxmd.com/read/28430125/erratum-tingting-lian-et-al-identification-of-site-specific-stroke-biomarker-candidates-by-laser-capture-microdissection-and-labeled-reference-peptide-int-j-mol-sci-2015-16-13427-13441
#16
https://www.readbyqxmd.com/read/28430050/letter-to-the-editor-risk-of-recurrence-of-lumbar-disc-herniation-after-microdiscectomy-for-scoliosis
#17
Zhiming Tu, Yawei Li, Lei Li, Guohua Lv, Bing Wang
No abstract text is available yet for this article.
April 21, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28429770/neurons-secrete-mir-132-containing-exosomes-to-regulate-brain-vascular-integrity
#18
Bing Xu, Yu Zhang, Xu-Fei Du, Jia Li, Hua-Xing Zi, Ji-Wen Bu, Yong Yan, Hua Han, Jiu-Lin Du
Vascular integrity helps maintain brain microenvironment homeostasis, which is critical for the normal development and function of the central nervous system. It is known that neural cells can regulate brain vascular integrity. However, due to the high complexity of neurovascular interactions involved, understanding of the neural regulation of brain vascular integrity is still rudimentary. Using intact zebrafish larvae and cultured rodent brain cells, we find that neurons transfer miR-132, a highly conserved and neuron-enriched microRNA, via secreting exosomes to endothelial cells (ECs) to maintain brain vascular integrity...
April 21, 2017: Cell Research
https://www.readbyqxmd.com/read/28429535/a-cross-circulated-bicephalic-model-of-head-transplantation
#19
Peng-Wei Li, Xin Zhao, Yun-Long Zhao, Bing-Jian Wang, Yang Song, Zi-Long Shen, Hong-Jun Jiang, Hai Jin, Sergio Canavero, Xiao-Ping Ren
AIMS: A successful cephalosomatic anastomosis ("head transplant") requires, among others, the ability to control long-term immune rejection and avoidance of ischemic events during the head transference phase. We developed a bicephalic model of head transplantation to study these aspects. METHODS AND RESULTS: The thoracic aorta and superior vena cava of a donor rat were anastomosed with the carotid artery and extracorporeal veins of a recipient rat by vascular grafts...
April 21, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28429006/correction-ag-induced-photoluminescence-enhancement-in-lanthanide-post-functionalized-mofs-and-ag-sensing
#20
Nana Sun, Bing Yan
Correction for 'Ag(+)-induced photoluminescence enhancement in lanthanide post-functionalized MOFs and Ag(+) sensing' by Nana Sun et al., Phys. Chem. Chem. Phys., 2017, 19, 9174-9180.
April 21, 2017: Physical Chemistry Chemical Physics: PCCP
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