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Ejaculation enhancement in ED

Chong Siew Koon, Hatta Sidi, Jaya Kumar, Srijit Das, Ong Wan Xi, Muhammad Hizri Hatta, Cesar Alfonso
Erectile function (EF) is a prerequisite for satisfactory sexual intercourse (SI) and central to male sexual functioning. Satisfactory SI eventually leads to orgasm - a biopsychophysiological state of euphoria - leading to a sense of bliss, enjoyment and positive mental well being. For a psychiatrist, treating ED is self-propelled to harmonize these pleasurable experiences alongside with encouragement of physical wellness and sensuality. Hence, the role of PDE-5i is pivotal in the context of treating ED constitutes a therapeutic challenge...
February 15, 2017: Current Drug Targets
Nan-Hua Chou, Yung-Jui Huang, Bang-Ping Jiann
INTRODUCTION: Data concerning the impact of amphetamine on male sexual functions are limited, although amphetamine has been used as an aphrodisiac. AIMS: This cross-sectional study was to assess the impact of illicit use of amphetamine on male sexual functions. METHODS: Male illicit drug users in a Drug Abstention and Treatment Center were recruited to complete a self-administered questionnaire, and data were compared with age-matched controls...
August 2015: Journal of Sexual Medicine
Guiting Lin, Huixi Li, Xiaoyu Zhang, Jianwen Wang, Uwais Zaid, Melissa T Sanford, Victor Tu, Alex Wu, Lin Wang, Fei Tian, Helen Kotanides, Venkatesh Krishnan, Guifang Wang, Hongxiu Ning, Lia Banie, Ching-Shwun Lin, Gary G Deng, Tom F Lue
BACKGROUND: Erectile dysfunction (ED) is a major health issue in aged populations, and neurogenic ED is particularly difficult to treat. Novel therapeutic approaches are needed for treatment of neurogenic ED of peripheral origin. OBJECTIVE: To investigate the therapeutic effects of a neurotrophic tyrosine kinase receptor type 1 monoclonal antibody (TrkA-mAb) on erectile function and sexual behavior in a rat model of cavernous nerve injury (CNI). DESIGN, SETTING, AND PARTICIPANTS: In one experiment, 84 male rats were randomly assigned to seven groups...
April 2015: European Urology
Hartmut Porst, Arthur Burnett, Gerald Brock, Hussein Ghanem, Francois Giuliano, Sidney Glina, Wayne Hellstrom, Antonio Martin-Morales, Andrea Salonia, Ira Sharlip
INTRODUCTION: Erectile dysfunction (ED) is the most frequently treated male sexual dysfunction worldwide. ED is a chronic condition that exerts a negative impact on male self-esteem and nearly all life domains including interpersonal, family, and business relationships. AIM: The aim of this study is to provide an updated overview on currently used and available conservative treatment options for ED with a special focus on their efficacy, tolerability, safety, merits, and limitations including the role of combination therapies for monotherapy failures...
January 2013: Journal of Sexual Medicine
Vittorio Magri, Emanuele Montanari, Višnja Škerk, Alemka Markotić, Emanuela Marras, Antonella Restelli, Kurt G Naber, Gianpaolo Perletti
We previously demonstrated the safety and efficacy of fluoroquinolone-macrolide combination therapy in category II chronic bacterial prostatitis (CBP). The aim of this study is to retrospectively compare the microbiological and clinical findings of two treatment schemes for CBP based on the combination of azithromycin (500 mg, thrice-weekly) with a once-daily 500- or 750-mg dose of ciprofloxacin (Cipro-500 or Cipro-750 cohort, respectively). Combined administration of azithromycin (1500 mg week(-1)) with ciprofloxacin at the rate of 750 mg day(-1) for 4 weeks rather than at 500 mg day(-1) for 6 weeks increased the eradication rates from 62...
November 2011: Asian Journal of Andrology
Mauro Gacci, Ian Eardley, Francois Giuliano, Dimitris Hatzichristou, Steven A Kaplan, Mario Maggi, Kevin T McVary, Vincenzo Mirone, Hartmut Porst, Claus G Roehrborn
CONTEXT: This review focuses on the relationship among sexual dysfunction (SD), lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH), and related therapies. OBJECTIVE: We reviewed the current literature to provide an overview of current data regarding epidemiology and pathophysiology of SD and LUTS. Moreover, we analysed the impact of currently available therapies of LUTS/BPH on both erectile dysfunction (ED) and ejaculatory dysfunction and the effect of phosphodiesterase type 5 inhibitors (PDE5-Is) in patients with ED and LUTS...
October 2011: European Urology
George J Christ, Karl-Erik Andersson, Koudy Williams, Weixin Zhao, Ralph D'Agostino, Jay Kaplan, Tamer Aboushwareb, James Yoo, Giulia Calenda, Kelvin P Davies, Rani S Sellers, Arnold Melman
BACKGROUND: Despite the advent of effective oral therapies for erectile dysfunction (ED), many patients are not successfully treated, and side effects have been documented. OBJECTIVE: To further evaluate the potential utility of naked DNA-based gene transfer as an attractive treatment option for ED. DESIGN, SETTING AND PARTICIPANTS: The effects of gene transfer on erectile function and sexual behavior were evaluated in eight male cynomolgus monkeys with ED secondary to moderately severe, diet-induced atherosclerosis...
December 2009: European Urology
Jiann Bang-Ping
INTRODUCTION: Despite being seen as aphrodisiacs, illicit drugs are reported to have detrimental effects on male sexual function but most studies have been based on small case numbers with ambiguous results. AIMS: To assess the impact of illicit drugs abuse on male sexual function. MAIN OUTCOME MEASURES: International Index of Erectile Function (IIEF) and global assessment questions. METHODS: Illicit drug abusers in a Drug Abstention and Treatment Center were recruited to complete the questionnaires and their data were compared with an age-matched control...
April 2009: Journal of Sexual Medicine
N Mondaini, R Ponchietti, G H Muir, F Montorsi, F Di Loro, G Lombardi, M Rizzo
Sildenafil is one of two oral drugs approved for first-line treatment of erectile dysfunction (ED). Anecdotally, some young healthy men who wish to enhance their sexual performance are requesting or abusing sildenafil. In this randomized double-blind, placebo-controlled clinical study, we investigated the effect of sildenafil in young men without ED. A total of 60 young healthy men age 20-40 y with no reported ED were enrolled for this single-dose home-use study. Subjects had used no medication in the 6 months prior to the study...
June 2003: International Journal of Impotence Research
K Obayashi, Y Ando, H Terazaki, S Yamashita, K Nakagawa, M Nakamura, T Yamashita, M Suga, T Ishizaki, M Uchino, M Ando
A 34-year-old male patient with familial amyloidotic polyneuropathy (FAP) amyloidogenic transthyretin (ATTR) Valine30Methionine (Val30Met), who underwent a liver transplantation in Sweden in 1994, was treated with sildenafil citrate (Viagra) to ameliorate his erectile dysfunction (ED). Some clinical symptoms and the examination data for autonomic functions were improved after liver transplantation, but ED was never improved after the operation. Five years after liver transplantation, he requested a sildenafil citrate therapy to enhance his erectile potential...
April 12, 2000: Journal of the Autonomic Nervous System
D L Rowland, A H den Ouden, A K Slob
Vibrotactile stimulation, when used in combination with visual sexual stimulation, has been shown to enhance erectile response in sexually functional men. The present study attempted to describe a diagnostic methodology, including the development and application of a new mini-vibrator, that might enhance penile response in men with erection problems. Tests on 78 men with either erectile dysfunction (ED), or a combination of erectile dysfunction and premature ejaculation (ED+PE), showed that vibratory stimulation together with an erotic video (EV+VT), produced greater penile response than the erotic video alone (EV)...
September 1994: International Journal of Impotence Research
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