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https://www.readbyqxmd.com/read/29325456/dual-purpose-vardenafil-hydrochloride-dapoxetine-hydrochloride-orodispersible-tablets-in-vitro-formulation-evaluation-stability-study-and-in-vivo-comparative-pharmacokinetic-study-in-healthy-human-subjects
#1
Khaled El-Refaie, Mahmoud H Teaima, Mohamed A El-Nabarawi
Erectile Dysfunction (ED) is the most important disorder after premature ejaculation for sexual activity in men. Vardenafil Hydrochloride (VH) is an oral therapy for the treatment of erectile dysfunction. VH oral disintegrating tablets (ODTs) have been prepared by freeze drying technique to improve its dissolution profile and the overall clinical performance. Dapoxetine Hydrochloride (DH) was added to the best three formulae of the prepared VH ODTs to treat premature ejaculation. All the ODTs formulae were evaluated for weight variation, friability, drug content, in-vitro disintegration time, wetting time, and the dissolution study...
January 11, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29299903/delayed-ejaculation-pathophysiology-diagnosis-and-treatment
#2
REVIEW
Ibrahim A Abdel-Hamid, Omar I Ali
Delayed ejaculation (DE) is a poorly defined and uncommon form of male sexual dysfunction, characterized by a marked delay in ejaculation or an inability to achieve ejaculation. It is often quite concerning to patients and their partners, and sometimes frustrates couples' attempts to conceive. This article aims to review the pathophysiology of DE and anejaculation (AE), to explore our current understanding of the diagnosis, and to present the treatment options for this condition. Electronic databases were searched from 1966 to October 2017, including PubMed (MEDLINE) and Embase...
January 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29219281/impact-on-sexual-function-of-surgical-treatment-in-rectal-cancer
#3
Pedro Costa, João M Cardoso, Hugo Louro, Jorge Dias, Luís Costa, Raquel Rodrigues, Paulo Espiridião, Jorge Maciel, Luís Ferraz
INTRODUCTION: The development of new surgical techniques and medical devices, like therapeutical multimodal approaches has allowed for better outcomes on patients with rectal cancer (RCa). Owing to that, an increased awareness and investment towards better outcomes regarding patients' sexual and urinary function has been recently observed. AIM: Evaluate and characterize the sexual dysfunction of patients submitted to surgical treatment for RCa. MATERIALS AND METHODS: An observational retrospective study including all male patients who underwent a surgical treatment for RCa between January 2011 December 2014 (n=43) was performed, complemented with an inquiry questionnaire to every patient about its sexual habits and level of function before and after surgery...
December 11, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29191197/in-vitro-and-in-vivo-aphrodisiac-properties-of-the-seed-extract-from-allium-tuberosum-on-corpus-cavernosum-smooth-muscle-relaxation-and-sexual-behavior-parameters-in-male-wistar-rats
#4
Xingli Tang, Opeyemi J Olatunji, Yifeng Zhou, Xilin Hou
BACKGROUND: Allium tuberosum is a well-known spice as well as a herb in traditional Chinese medicine, used for increasing libido and treating erectile dysfunction. However, not many studies have been done to evaluate the sexual enhancing properties of A. tuberosum. The aim of this study was to evaluate the aphrodisiac and vasorelaxant properties of A. tuberosum on corpus cavernosum smooth muscle (CCSM) as well as checking the effect on enhancing male rat sexual behavior, libido, potency as well as its spermatogenic properties...
December 1, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29189663/decrease-of-sphincter-preserving-length-lowers-the-postoperative-genital-function-for-patients-with-rectal-cancer
#5
Zhihua Liu, Liang Kang, Meijin Huang, Chao Li, Chao Tong, Xingwei Zhang, Yanxin Luo, Lei Wang, Xiaojian Wu, Ping Lan, Ji Cui, Jianping Wang
BACKGROUND AND OBJECTIVE: With the increase in sphincter preserving rate of rectal cancer (RC) cancer, postoperative quality-of-life, such as genital dysfunction, has become a major issue in the patient management. In this study, we proposed a measurement, namely, the sphincter preserving length (SPL), and investigated the relationship between SPL and postoperative genital function and survival in RC patients. METHODS: A total of 536 male patients who had a diagnosis of RC and underwent sphincter preserving rectal resection in the Sixth Affiliated Hospital of Sun Yat-sen University and the First Affiliated Hospital of Sun Yat-sen University between October 1997 and December 2013 were included in our study...
November 16, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29177237/the-etiologies-of-dna-abnormalities-in-male-infertility-an-assessment-and-review
#6
REVIEW
Soheila Pourmasumi, Parvin Sabeti, Tahereh Rahiminia, Esmat Mangoli, Nasim Tabibnejad, Ali Reza Talebi
The sperm DNA damage may occur in testis, genital ducts, and also after ejaculation. Mechanisms altering chromatin remodeling are abortive apoptosis and oxidative stress resulting from reactive oxygen species. Three classifications of intratesticular, post-testicular, and external factors have been correlated with increased levels of human sperm DNA damage which can affect the potential of fertility. Lifestyle, environment, medical, and iatrogenic factors might be considered to cause dysmetabolism to make distracting interactions and endocrine disrupting compounds...
June 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29161211/sexual-cognitions-trait-anxiety-sexual-anxiety-and-distress-in-men-with-different-subtypes-of-premature-ejaculation-and-in-their-partners
#7
Philippe Kempeneers, Robert Andrianne, Marion Cuddy, Sylvie Blairy
This study examined trait anxiety and sexual cognitions in 610 men with premature ejaculation (PE) (DSM-IV-TR criteria) and in 107 partners of these men, and compared their scores to normative data. Sexual anxiety, intra-vaginal ejaculatory latency time, feeling of control over ejaculation, and PE-related distress were also assessed. The scores of 343 participants (56.23%) with clearly identifiable subtypes of PE according to Waldinger's classification system (lifelong, acquired, variable and subjective subtypes) were compared in these domains...
November 21, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/29102483/the-digital-environment-in-men-s-sexual-disorders-a-systematic-review
#8
E García-Cruz, J Romero-Otero, M Fode, A Alcaraz
CONTEXT: The revolution of digital technologies constitutes a new setting for the patient-physician relationship and provides patients with a scenario of privacy and universal access to a vast amount of information. However, there is little information on how digital resources are used and what their advantages and disadvantages are. OBJECTIVES: To explore the scope of the scientific research on the use of digital technology related to men's sexual disorders and to analyze the primary sources of digital information related to this field...
November 1, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29059347/sim1-neurons-are-sufficient-for-mc4r-mediated-sexual-function-in-male-mice
#9
Erin Semple, Jennifer W Hill
Sexual dysfunction is a poorly understood condition that affects up to one-third of men around the world. Existing treatments that target the periphery do not work for all men. Previous studies have shown that central melanocortins, which are released by pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus, can lead to male erection and increased libido. Several studies specifically implicate the melanocortin 4 receptor (MC4R) in the central control of sexual function, but the specific neural circuitry involved is unknown...
October 19, 2017: Endocrinology
https://www.readbyqxmd.com/read/29048208/an-innovative-technique-of-transurethral-seminal-vesiculoscopy-with-ultrasonic-lithotripter-for-severe-persistent-hematospermia
#10
Wei Zhang, Guang'an Xiao, Shenfei Qin, Amanda B Reed-Maldonado, Jian Xu, Guanghua Chen, Lei Wang, Tie Zhou
BACKGROUND AND PURPOSE: Transurethral seminal vesiculoscopy (TSV) provides an efficient approach to diagnose and treat the hematospermia but still need further improvement in manipulation and corresponding instruments. In this study, we develop an innovative technique with ultrasonic lithotripter (EMS) to treat severe, persistent hematospermia. PATIENTS AND METHODS: Data of patients who underwent TSV with or without ultrasonic lithotripter between May 2012 and December 2015 was reviewed...
October 19, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29046995/aquablation-of-the-prostate-for-symptomatic-benign-prostatic-hyperplasia-early-results
#11
REVIEW
Omid Yassaie, Joshua A Silverman, Peter J Gilling
Aquablation is a novel technique for the surgical management of bladder outlet obstruction secondary to benign prostatic hyperplasia. Following first-in-man studies, a multicenter trial was conducted with results now out to 1 year. Aquablation resulted in a mean International Prostate Symptom Score improvement of 16 points (p < 0.01) and a mean maximum urinary flow rate increase from 8.7 to 18.3 ml/s (p < 0.01) at 12 months. Due to the precise prostate mapping, aquablation has also demonstrated favorable sexual and urinary outcomes with no new erectile dysfunction, retrograde ejaculation, or urinary incontinence as often experienced with other techniques...
October 18, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/29044968/a-prospective-randomised-placebo-controlled-study-of-the-impact-of-dutasteride-tamsulosin-combination-therapy-on-sexual-function-domains-in-sexually-active-men-with-lower-urinary-tract-symptoms-luts-secondary-to-benign-prostatic-hyperplasia-bph
#12
Claus G Roehrborn, Michael J Manyak, Juan Manuel Palacios-Moreno, Timothy H Wilson, Erik Pm Roos, Javier Cambronero Santos, Dimitrios Karanastasis, Janet Plastino, Francois Giuliano, Raymond C Rosen
OBJECTIVE: To prospectively assess the impact of the fixed-dose combination of the 5-alpha reductase inhibitor (5ARI), dutasteride 0.5 mg and the alpha-1 blocker, tamsulosin 0.4 mg (DUT-TAM FDC) therapy on sexual function domain scores in sexually active males with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH), using the Men's Sexual Health Questionnaire (MSHQ). PATIENTS AND METHODS: This European and Australian double-blind, placebo-controlled, parallel-group study was conducted at 51 centres...
October 16, 2017: BJU International
https://www.readbyqxmd.com/read/29031313/routes-to-diagnosis-for-men-with-prostate-cancer-men-s-cultural-beliefs-about-how-changes-to-their-bodies-and-symptoms-influence-help-seeking-actions-a-narrative-review-of-the-literature
#13
REVIEW
Michelle King-Okoye, Anne Arber, Sara Faithfull
PURPOSE: To examine the findings of existing studies in relation to men's cultural beliefs about changes to their bodies relevant to prostate cancer and how these affect interpretation of bodily changes and help-seeking actions. METHOD: We undertook a narrative review of studies conducted from 2004 to 2017 in 6 databases that highlighted men's beliefs and help-seeking actions for bodily changes suggestive of prostate cancer. RESULTS: Eighteen (18) studies reflecting men from various ethnicities and nationalities were included...
October 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29019272/amitriptyline-and-sexual-function-a-systematic-review-updated-for-sexual-health-practice
#14
Louis Wei-Hsi Chen, Melody Yun-Si Chen, Zhi-Ping Lian, Hung-Sheng Lin, Chia-Chang Chien, Hsin-Ling Yin, Yuan-Hsiang Chu, Kuo-Yen Chen
Amitriptyline is an old drug but is still prevalently used as the first-line treatment for a variety of common diseases. Surprisingly, knowledge of sexual risks with amitriptyline comes from only one clinical trial and several case reports from three decades ago. In the current study, a systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) related to amitriptyline and sexual dysfunction (SD) was performed. The frequency, gender-difference, types, disease-specificity and time course of SD, and the relationship between SD and nonsexual adversity were studied...
October 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28992374/male-accessory-gland-inflammation-infertility-and-sexual-dysfunctions-a-practical-approach-to-diagnosis-and-therapy
#15
REVIEW
A E Calogero, Y Duca, R A Condorelli, S La Vignera
The role of urogenital inflammation in causing infertility and sexual dysfunctions has long been a matter of debate in the international scientific literature. The most recent scientific evidences show that male accessory gland infection/inflammation could alter, with various mechanisms, both conventional and biofunctional sperm parameters, and determine worst reproductive outcome. At the same time, the high prevalence of erectile dysfunction and premature ejaculation in patients with male accessory gland infection/inflammation underlines the close link between these diseases and sexual dysfunctions...
October 9, 2017: Andrology
https://www.readbyqxmd.com/read/28992003/rearing-in-captivity-affects-spermatogenesis-and-sperm-quality-in-greater-amberjack-seriola-dumerili-risso-1810
#16
R Zupa, C Fauvel, C C Mylonas, C Pousis, N Santamaria, Μ Papadaki, I Fakriadis, V Cicirelli, S Mangano, L Passantino, G M Lacalandra, Aldo Corriero
The greater amberjack, (Risso, 1810), is a promising candidate for the diversification of European aquaculture production, but inconsistent reproduction in captivity prevents commercial production. Recent studies showed that greater amberjack confined in sea cages exhibited scarce gonad development and early interruption of gametogenic activity during the reproductive season. The aim of the present study was to improve our understanding of the observed impairment of spermatogenesis. Adult wild and captive-reared males were sampled during 3 different phases of the reproductive cycle: early gametogenesis (EARLY; late April to early May), advanced gametogenesis (ADVANCED; late May to early June), and spawning (SPAWNING; late June to July)...
September 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28920056/management-of-refractory-ischemic-priapism-current-perspectives
#17
REVIEW
Marco Capece, Arianna Gillo, Andrea Cocci, Giulio Garaffa, Massimiliano Timpano, Marco Falcone
OBJECTIVES: The aim of the present manuscript is to review the current literature on priapism, focusing on the state-of-the-art knowledge of both the diagnosis and the treatment of the refractory ischemic priapism (IP). METHODS: Pubmed and EMBASE search engines were used to search for words "priapism", "refractory priapism", "penile prosthesis", "diagnosis priapism", "priapism treatment", "penile fibrosis", "priapism therapy". All the studies were carefully examined by the authors and then included in the review...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28874333/prevalence-and-risk-factors-for-erectile-dysfunction-in-chinese-adult-males
#18
Xinyu Zhang, Bin Yang, Ni Li, Hongjun Li
BACKGROUND: There is a lack of nationwide epidemiologic survey data on the prevalence estimate of erectile dysfunction (ED) in Chinese men living on the mainland China. AIM: To attain the representative prevalence estimate of ED in the Chinese male population and to analyze potential risk factors associated with ED by demographics, socioeconomic status, and medical comorbidities. METHODS: The study was community based. The five-item Internation Index of Erectile Function questionnaire and in-person interview were used to obtain data...
October 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28814813/sexual-dysfunction-among-diabetics-and-its-impact-on-the-sqol-of-their-partners
#19
W K B A Owiredu, H Alidu, N Amidu, C Obirikorang, C K Gyasi-Sarpong, A T Bawah, P P M Dapare, A T Luuse
Sexual dysfunction (SD) has long been known to affect a significant number of people worldwide with serious implications and limitations on sexual expression and fulfillment. This may affect the sexual quality of life (SQoL) of individuals and their partners. A cross-sectional study was conducted among diabetic patients and their partners who visited the Tema General Hospital. A total of 130 and 116 diabetic males and females and their partners were interviewed. Male and female diabetic participants and partners were evaluated using the Golombuk Rust Inventory for Sexual Satisfaction-Male (GRISS-M)/SQoL-M and GRISS-Female/SQoL-F, respectively...
November 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28807505/delayed-ejaculation-and-associated-complaints-relationship-to-ejaculation-times-and-serum-testosterone-levels
#20
Abraham Morgentaler, Paula Polzer, Stanley Althof, Alexander Bolyakov, Craig Donatucci, Xiao Ni, Ankur B Patel, Shehzad Basaria
BACKGROUND: Although delayed ejaculation (DE) is typically characterized as a persistently longer than anticipated or desired time to ejaculation (or orgasm) during sexual activity, a timing-based definition of DE and its association with serum testosterone has not been established in a large cohort. AIM: To examine in an observational study estimated intravaginal ejaculatory latency time (IELT) and masturbatory ejaculation latency time (MELT) in men self-reporting DE, assess the association of IELT and MELT with serum testosterone levels, and determine whether correlation with demographic and sexual parameters exist...
September 2017: Journal of Sexual Medicine
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