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Varicocele and sexual function

Bobby B Najari, Leonard Introna, Darius A Paduch
OBJECTIVE: To evaluate whether varicocelectomy improves both serum testosterone and sexual function, as assessed by the Male Sexual Health Questionnaire (MSHQ). METHODS: A retrospective chart review of patients who have undergone varicocelectomy and had both pre- and post-operative MSHQ was performed. The MSHQ is a clinically validated questionnaire that assesses erectile function, ejaculatory function, and sexual satisfaction, with higher scores indicating better function...
May 16, 2016: Urology
Ty Higuchi, Gundela Holmdahl, Martin Kaefer, Martin Koyle, Hadley Wood, Christopher Woodhouse, Dan Wood
OBJECTIVE: To provide a comprehensive overview of genital anomalies encountered among adolescents, including late effects of problems addressed earlier in childhood. MATERIALS AND METHODS: The major congenital genital anomalies encountered in pediatric urology were identified. They include hypospadias, exstrophy-epispadias, cloacal malformations, disorders of sexual development, undescended testes, and some acquired penile anomalies seen in adolescence (priapism, adolescent varicocele)...
August 2016: Urology
Sarah M Lambert
The transition from childhood to adolescence and into adulthood occurs as a natural component of human development. As children progress through school and gain independence, health care practitioners must facilitate a parallel transition from pediatric to adult providers. Modern medicine has succeeded in extending the life expectancy for many children with complex conditions, and adult providers are participating in their medical care through adulthood. Transitioning pediatric urology care to adult urology care is unique to every individual and his or her underlying condition, while the transition process is universal...
April 2015: Seminars in Pediatric Surgery
He-Cheng Li, Lian-Dong Zhang, Ming Gao, Tie Chong, Qian Deng, Jian Yin, Zi-Ming Wang
OBJECTIVE: To investigate the intra-vaginal ejaculation latency time (IELT) of varicocele patients, the influence of spermatic vein ligation on IELT, and the relationship of Visual Analogue Score (VAS) with IELT. METHODS: We selected 112 males who had regular sexual life after spermatic vein ligation and conducted follow-up visits for 6 months. According to preoperative IELT, we divided the patients into an IELT < or = 2 min group and an IELT > 2 min group, and compared their IELT, VAS and Chinese Index of Sexual Function for Premature Ejaculation-5 (CIPE-5) scores before and 6 months after operation...
June 2014: Zhonghua Nan Ke Xue, National Journal of Andrology
Renata Walczak-Jedrzejowska, Jan Karol Wolski, Jolanta Slowikowska-Hilczer
Oxidative stress results from the imbalance between production of the reactive oxygen species (ROS) and the protective effect of the antioxidant system responsible for their neutralization and removal. An excess of ROS causes a pathological reaction resulting in damage to cells and tissues. Spermatozoa are particularly vulnerable to the harmful effects of ROS. Oxidative stress affects their activity, damages DNA structure, and accelerates apoptosis, all of which consequently decrease their numbers, hinders motility and development of normal morphology, and impairs function...
2013: Central European Journal of Urology
E Nieschlag
Although male reproductive functions are impaired in about half of the infertile couples seeking offspring, even today the examination and treatment of the male partner continues to be neglected. Despite the lack of evidence for a "sperm crisis", so highly touted in the press, the public remains worried, while the fact that male fertility declines beyond the age of 40 years and is accompanied by increasing genetic risks for the offspring goes largely unnoticed. In addition to a thorough physical examination supplemented by imaging techniques such as ultrasonography of the scrotal organs, semen analysis according to WHO guidelines, hormone determinations, and cyto- and molecular genetic analyses form part of the routine investigation of the infertile male...
December 2013: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Ewa Matuszczak, Adam Hermanowicz, Marta Komarowska, Wojciech Debek
AMH is secreted by immature Sertoli cells (SC) and is responsible for the regression of Müllerian ducts in the male fetus as part of the sexual differentiation process. AMH is also involved in testicular development and function. AMHs are at their lowest levels in the first days after birth but increase after the first week, likely reflecting active SC proliferation. AMH rises rapidly in concentration in boys during the first month, reaching a peak level at about 6 months of age, and then slowly declines during childhood, falling to low levels in puberty...
2013: International Journal of Endocrinology
Eberhard Nieschlag, Andrea Lenzi
Although the male reproductive function is impaired in about half of infertile couples, the evaluation of male infertility is underrated or neglected even today. In addition to a physical examination and imaging techniques, semen analysis as well as endocrine and genetic analyses should be part of the routine investigation. Few disorders have become subjects of rational treatment of the infertile male, even though, as examples, hypogonadotropic hypogonadism is treatable by gonadotropins and obstructive azoospermia by reconstructive surgery...
December 2013: International Journal of Gynaecology and Obstetrics
Hakan Bulus, Mustafa Dogan, Adnan Tas, Kadir Agladıoglu, Ali Coskun
INTRODUCTION AND AIM: Lichtenstein tension-free mesh hernia repair has been gold standard for treatment of inguinal hernia. Studies have demonstrated that the complication rate is low. However, because the structures in spermatic cord pass through a narrow space, there has been concern about injury to testicular artery, vein, and vas deferens. The aim of this study was to evaluate the effects of Lichtenstein tension-free mesh hernia repair on testicular arterial perfusion and sexual functions in early phase after the operation...
February 2013: Wiener Klinische Wochenschrift
Eric Chung
BACKGROUND: In recent years, significant advances have been made in our knowledge of the role of testosterone in male fertility and sexual function. In addition, new microsurgical techniques have improved outcomes in testicular biopsy for sperm retrieval, varicocoele treatment and vasectomy reversal. OBJECTIVE: This article provides an update on the assessment and treatment of male infertility, and the role of testosterone replacement therapy and erectile dysfunction...
October 2012: Australian Family Physician
Adel A Zalata, Naglaa Mokhtar, Abd El-Naser Badawy, Gamal Othman, Moheiddin Alghobary, Taymour Mostafa
PURPOSE: Androgen receptor, a member of the nuclear receptor superfamily, has important roles in male reproductive function. It is required for sexual differentiation, pubertal development, spermatogenesis regulation, meiosis completion and spermatocyte transition to haploid round spermatids. We assessed the association of androgen receptor expression and semen variables in infertile men with varicocele. MATERIALS AND METHODS: A total of 299 men were grouped into healthy, fertile controls, infertile men without varicocele and men with infertility associated with varicocele...
June 2013: Journal of Urology
Francesco Lotti, Giovanni Corona, Mario Mancini, Carlo Biagini, Giovanni M Colpi, Selene Degli Innocenti, Erminio Filimberti, Mauro Gacci, Csilla Krausz, Alessandra Sforza, Gianni Forti, Edoardo Mannucci, Mario Maggi
INTRODUCTION: No study has ever systematically evaluated the impact of varicocele on sexual function. AIM: Two cross-sectional studies were performed in patients attending an andrology unit either for male sexual dysfunction (study 1) or couple infertility (study 2). In study 1, we evaluated the impact of varicocele on sexual function. In study 2, we retrospectively evaluated a possible association between varicocele and prostatitis signs and symptoms. METHODS: Study 1 refers to a consecutive series of 2,448 (mean age 52...
October 2009: Journal of Sexual Medicine
Pikee Saxena, M M Misro, Somnath Roy, K Chopra, D Sinha, Deoki Nandan, Shubha Sagar Trivedi
To evaluate various causes possibly contributing towards recurrent pregnancy loss (RPL), particularly male factors. Prospective study of 75 couples with history of RPL who were investigated for genetic, anatomic, immunological, infective and systemic causes in both partners. Functional sperm capacity was assessed by the Hypo-osmotic swelling test (HOS), Acrosomal Reaction (AR), Nuclear condensation-decondensation test (NCD) and Seminal Total Leukocyte Count (TLC) along with semen analysis. Twenty male volunteers with recently proven fertility were also included for detailed sperm morphology and sperm functions test as controls...
July 2008: Indian Journal of Physiology and Pharmacology
Hisanori Taniguchi, Koei Muguruma, Yoshito Hiura, Takaaki Inoue, Gen Kawa, Hidefumi Kinoshita, Tadashi Matsuda, Shinichi Yoshimura
A 40-year-old unmarried male was referred to our hospital with anejaculation. His secondary sex characteristics, sexual function and ejaculation were previously normal but for the last 5 years he found it impossible to ejaculate even though he could achieve an erection. His genital stage was Tanner V, and pubic hair stage was Tanner III. There were no varicoceles or chromosomal aberrations. His testis volume was 10 ml on the right side and 12 ml on the left. His hormonal data were luleinizing hormone (LH) 0...
December 2008: Hinyokika Kiyo. Acta Urologica Japonica
M U De Martino, R Pastore, M Caprio, G Frajese, A Fabbri
The maturation and physiologic functions of male sexual apparatus are under the control of the hypothalamic-pituitary-gonadal (HPG) axis. The determination of gonadotropins and testosterone as secretory products of pituitary and gonads, respectively, represents the first step in the evaluation of male sexual function and the diagnosis of disorders in male reproductive axis. However, there are several clinical situations that require a dynamic evaluation of this system and the measurement of basal gonadotropins and testosterone must be combined with specific dynamic tests...
2003: Journal of Endocrinological Investigation
L S Zuckier
The genital tract is a complex anatomic region with overlapping endocrinologic, anatomic, and functional features. Nuclear medicine has value in examining functional aspects of reproductive and sexual function, ranging from testicular or cavernosal perfusion in the male, to fallopian tube transport in the female. Blood pool imaging has been helpful in detecting subclinical varicoceles. Proper understanding of the role that these tests play is important for their success and credibility.
September 1999: Quarterly Journal of Nuclear Medicine
Y Sato
Sexual disorders include the disorder of sexual differntiation and male infertility and sexual dysfunction. Sex determination is concerned with the control of the development of the primary and or gonadal sex, sex differentiation encompasses the events subsequent to gonadal organogenesis. Classification of anomalous sexual development are recognized as disorders of gonadal differentiation, female pseudhermaphroditism, male pseudhermaphroditism and unclassified form. Upon completion of a history and physical examination and evaluation of semen parameters, the male infertility can usually classified into one of nine categories: azoospermia, ejaculatory dysfunction, varicocele, gonadotoxins, antisperm antibodies, infections, endocrinopathy, idiopathic infertility, or miscellaneous...
November 1997: Nihon Rinsho. Japanese Journal of Clinical Medicine
M L Dufau, J C Tinajero, A Fabbri
Corticotropin-releasing factor (CRF), the key neuropeptide in the stress cascade, has major inhibitory actions on testicular function in addition to its known antireproductive effects at the central level (inhibition of sexual behavior and LH secretion). CRF is secreted by the Leydig cells of the testis and acts through high-affinity receptors at the Leydig cell membrane as a potent negative regulator of LH action, inhibiting gonadotropin-induced cAMP generation and androgen production. CRF is also a primary stimulus of beta-endorphin secretion by the Leydig cells, which in turn exerts paracrine inhibition of FSH action in the tubular compartment of the testis through high-affinity receptors in the Sertoli cells...
February 1, 1993: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
C Foresta, R Mioni, P Bordon, D Miotto, G Montini, A Varotto
Human recombinant erythropoietin (rHuEPO) treatment improves sexual function in end-stage renal failure patients with a still-debated mechanism. Experimental data suggested that rHuEPO was able to stimulate rat Leydig steroidogenesis; therefore, it has been suggested that rHuEPO may induce its effects in humans by acting on gonadal steroid production. Thirteen young adult males (age range, 16-28 yr) catheterized at peripheral and left internal spermatic venous levels during a contrast study for varicocele, were studied...
March 1994: Journal of Clinical Endocrinology and Metabolism
E V Shakhov, S B Artifeksov, Iu D Ryzhakov
The paper provides the evidence on interaction of the endocrine system hypophysis-gonads with varicocele. Gonadotropic hormones and sexual steroids were measured in the blood of varicocele males (47 cases) and of fertile healthy males (17 cases), testosterone in the tissue of the sexual glands and blood of white noninbred rats (40 test against 20 control animals). It was found that in 18% of varicocele patients high levels of FSH were associated with oligo-, pathospermia and changes in spermatogenic epithelium...
May 1993: Urologii︠a︡ i Nefrologii︠a︡
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