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https://www.readbyqxmd.com/read/28748485/early-onset-first-episode-psychosis-dimensional-structure-of-symptoms-clinical-subtypes-and-related-neurodevelopmental-markers
#1
Maria Giuseppina Petruzzelli, Lucia Margari, Andrea Bosco, Francesco Craig, Roberto Palumbi, Francesco Margari
Despite the growing interest in a dimensional approach to the assessment of symptoms and clinically relevant phenomena in schizophrenia spectrum disorders, very few studies, to date, have examined the dimensional structure of symptoms in early onset first episode psychosis. In the present study, we assessed a sample of 60 children and adolescents of both sexes with first episode schizophrenia spectrum psychosis. A principal component analysis (PCA) of the Positive and Negative Syndrome Scale (PANSS) was performed and the factors obtained were used to carry out a cluster analysis...
July 26, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28748060/a-case-of-attempted-bilateral-self-enucleation-in-a-patient-with-bipolar-disorder
#2
Hannah Muniz Castro, John Alvarez, Robert G Bota, Marc Yonkers, Jeremiah Tao
Attempted and completed self-enucleation, or removal of one's own eyes, is a rare but devastating form of self-mutilation behavior. It is often associated with psychiatric disorders, particularly schizophrenia, substance induced psychosis, and bipolar disorder. We report a case of a patient with a history of bipolar disorder who gouged his eyes bilaterally as an attempt to self-enucleate himself. On presentation, the patient was manic with both psychotic features of hyperreligous delusions and command auditory hallucinations of God telling him to take his eyes out...
March 22, 2017: Mental Illness
https://www.readbyqxmd.com/read/28748014/-a-typical-shared-psychotic-disorder-about-a-case
#3
Marcellin Bugeme, Papa Alioune Seck, Paul Makinko Ilunga, Olivier Mukuku
Shared psychotic disorder is a rare entity characterized by the transmission of delusional symptoms from one patient ("inducer") to another ("induced" partner). We here report a clinical observation of atypical shared psychotic disorder involving delusion of persecution and of grandeur in a teenager induced by two subjects (grand-father and paternal uncle) with two different types of psychiatric disorders, all of which present in the same subject (third-party). The nature of the content transmitted to the third subject was the sum of the ideas of the first two subjects...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28747115/where-pseudo-hallucinations-meet-dissociation-a-cluster-analysis
#4
Deborah Wearne, Guy J Curtis, Amanda Genetti, Mathew Samuel, Justin Sebastian
OBJECTIVES: The possible link between cognitive areas of perception and integration of consciousness was examined using assessments of hallucinations and derealisation/depersonalization. METHODS: Sixty-five subjects in three main diagnostic groups - posttraumatic stress disorder (PTSD), borderline personality disorder (BPD) and schizophrenia - identified by their treating psychiatrist as hearing voices were surveyed regarding characteristics of hallucinations, derealisation/depersonalization, delusions and childhood/adult trauma...
August 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28745673/-doctrine-of-psychopathy-typology-e-kretschmer-s-concept-of-key-experience-and-inherited-defect
#5
N Yu Pyatnitskyi
The author analyzes the first concept of E. Kretschmer which preceded his famous concept of cycloid and schizoid temperaments: specific 'root' or 'key' experience characteristic of the personality type. This concept was built on the clinical data of patients with delusions but E. Kretschmer assumed that the difference in the degree of disease was not essential ('neurosis of reference' and 'sensitive delusion of reference' were more close than 'sensitive delusion of reference' and 'expansive delusion'). For a sensitive psychopath, the key and specific experience is 'shameful defeat', for expansive psychopath - 'the violence over will by the common will'...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28741694/reduced-parahippocampal-volume-and-psychosis-symptoms-in-alzheimer-s-disease
#6
Emma McLachlan, Jennifer Bousfield, Robert Howard, Suzanne Reeves
OBJECTIVE: Establishing structural imaging correlates of psychosis symptoms in Alzheimer's disease (AD) could localise pathology and target symptomatic treatment. This study investigated whether psychosis symptoms are associated with visuoperceptual or frontal networks, and whether regional brain volume differences could be linked with the paranoid (persecutory delusions) or misidentification (misidentification phenomena and/or hallucinations) subtypes. METHODS: A total of 104 patients with probable AD (AddNeuroMed; 47 psychotic, 57 non-psychotic), followed up for at least one year with structural MRI at baseline...
July 25, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28740829/no-association-between-symptom-severity-and-mmn-impairment-in-schizophrenia-a-meta-analytic-approach
#7
Molly A Erickson, Matthew Albrecht, Abigail Ruffle, Leah Fleming, Philip Corlett, James Gold
The mismatch negativity (MMN) is an event-related potential that is consistently attenuated in people with schizophrenia. Within the predictive coding model of psychosis, MMN impairment is thought to reflect the same prediction failures that are also thought to underlie the development and crystallization of delusions and hallucinations. However, the true relationship between symptom severity and MMN impairment across studies has not yet been established. The present meta-analysis used meta-regressions to examine the relationship between MMN impairment (quantified as Hedges' g) and PANSS positive and negative symptom totals across 62 and 68 samples, respectively...
September 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28739291/pancreatic-cancer-screening-still-a-delusion
#8
REVIEW
Pedro Moutinho-Ribeiro, Rosa Coelho, Marc Giovannini, Guilherme Macedo
Pancreatic adenocarcinoma represents the fourth most common cause of cancer mortality and death due to pancreatic cancer (PC) have increased since 2003. Its incidence has also raised about 30% in the past decade and it is expected to become the second cause of cancer mortality by 2020 in the USA. Most PC present with metastatic disease and improvements in treatment outcomes for this group have been disappointing. These observations support the idea that screening to identify patients at an earlier stage might be an important strategy in improving overall PC outcomes...
July 13, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28728118/threatening-events-theme-of-cognitive-biases-mediates-the-relationship-between-fear-of-social-situations-and-delusion-like-experiences-among-healthy-adults
#9
Katarzyna Prochwicz, Joanna Kłosowska, Milena Karpowska
Social anxiety (SA) is frequently observed among patients diagnosed with psychosis as well as among individuals with delusion-like experiences (DLEs). A heightened level of SA has been recognized to precede the development of psychotic symptoms; however, the detailed mechanisms that link SA to delusional ideation remain unrecognized. Since social anxiety is associated with the presence of cognitive biases and biased cognitive processes have been found to play a role in the development and maintenance of delusions, we hypothesized that cognitive biases may mediate in the relationship between social anxiety and DLEs...
July 5, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28715903/parkinson-s-disease-and-parkinson-s-disease-psychosis-a-perspective-on-the-challenges-treatments-and-economic-burden
#10
Doral Fredericks, James C Norton, Carolyn Atchison, Robert Schoenhaus, Michael W Pill
Parkinson's disease (PD) is a progressive neurodegenerative disease associated with a decrease in the neurotransmitter dopamine and characterized by the cardinal motor hallmarks of resting tremor, rigidity, bradykinesia/akinesia, and postural instability. Lesser-known features of PD revolve around nonmotor concerns including psychosis, dementia, sleep disturbances, autonomic dysfunction, and sensory abnormalities. Parkinson's disease psychosis (PDP) contributes significantly to morbidity, mortality, nursing home placement, and quality of life (QOL)...
April 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28715666/cognitive-affective-and-social-factors-maintaining-paranoia-in-adolescents-with-mental-health-problems-a-longitudinal-study
#11
Jessica C Bird, Felicity Waite, Eleanor Rowsell, Emma C Fergusson, Daniel Freeman
Paranoia may be a significant concern during adolescence, but there has been little research on excessive mistrust in young people. In this longitudinal study we set out to test the predictive ability of a number of cognitive, affective, and social factors in the early development of paranoia in a clinical adolescent population. Thirty four help-seeking adolescents, aged 11-16 years, reporting paranoid thoughts and attending mental health services were recruited. Self-report and interview assessments of paranoia were conducted at baseline...
July 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28708753/effectiveness-of-preoperative-intranasal-dexmedetomidine-compared-with-oral-midazolam-for-the-prevention-of-emergence-delirium-in-the-pediatric-patient-undergoing-general-anesthesia-a-systematic-review
#12
James FitzSimons, Laura S Bonanno, Stephanie Pierce, Jennifer Badeaux
BACKGROUND: Emergence delirium is defined as a cognitive disturbance during emergence from general anesthesia resulting in hallucinations, delusions and confusion manifested by agitation, restlessness, involuntary physical movement and extreme flailing in bed. Postoperative emergence delirium develops in 12% to 18% of all children undergoing general anesthesia for surgery. This post-anesthetic phenomenon changes cognitive and psychomotor behavior, and puts pediatric patients and health care personnel at risk of injury...
July 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28705297/the-diagnosis-and-treatment-of-behavioral-disorders-in-dementia
#13
Torsten Kratz
BACKGROUND: Behavioral disorders such as aggressiveness, agitation, delusions, disinhibition, affect lability, and apathy arise in more than 90% of patients with dementia. Behavioral disorders are a major challenge and the greatest stress factor in everyday life for nursing personnel and for family members caring for the patient. METHODS: This review is based on relevant publications retrieved by a selective literature search in the PubMed, Cochrane Library, and German S3 guideline databases with the search terms "behavioral disorders," "non-cognitive disorders," and "challenging behavior," in conjunction with "dementia" and "behavioral and psychological symptoms of dementia...
June 30, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28705022/evaluation-of-dose-and-outcomes-for-pediatric-vilazodone-ingestions
#14
Christopher E Gaw, Henry A Spiller, Jason L Russell, Thiphalak Chounthirath, Gary A Smith
BACKGROUND: Selective serotonin reuptake inhibitor (SSRI) exposures among children younger than 6 years of age are generally well tolerated. Vilazodone is an SSRI with partial agonism at the 5-HT1A receptor with demonstrated clinical efficacy for depression whose off-label usage is likely to increase. Recent evidence suggests that unintentional ingestion of vilazodone in children under 6 years old is associated with more severe clinical effects than other SSRIs. We chose to evaluate dose and outcomes for pediatric vilazodone ingestions...
July 14, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28702665/structural-switch-from-a-multistranded-g-quadruplex-to-single-strands-as-a-consequence-of-point-mutation-in-the-promoter-of-the-human-grin1-gene
#15
Swati Chaudhary, Mahima Kaushik, Ritushree Kukreti, Shrikant Kukreti
A huge number of G-rich sequences forming quadruplexes are found in the human genome, especially in telomeric regions, UTRs, and the promoter regions of a number of genes. One such gene is GRIN1 encoding the NR1 subunit of the N-methyl-d-aspartate receptor (NMDA). Several lines of reports have implicated that attenuated function of NMDA results in schizophrenia, a genetic disorder characterized by hallucinations, delusions, and psychosis. Involvement of the GRIN1 gene in the pathogenesis of schizophrenia has been extensively analysed...
July 12, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28699248/phenotypical-characteristics-of-postpartum-psychosis-a-clinical-cohort-study
#16
Astrid M Kamperman, Marian J Veldman-Hoek, Richard Wesseloo, Emma Robertson Blackmore, Veerle Bergink
OBJECTIVES: Postpartum psychosis (PP) is known for its clear onset but its phenotype has never been clearly described in a cohort. The aim of this study was to describe PP symptomatology, and to identify subgroups of patients based on symptom profiles. METHODS: We prospectively assessed a wide range of symptoms in cases of PP in a cohort of women (N=130) admitted to the Mother-Baby inpatient unit. Using a person-centered analytic approach, we distinguished mutually exclusive subgroups of women...
July 12, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28689196/love-as-delusion-delusions-of-love-erotomania-narcissism-and-shame
#17
Brendan D Kelly
Erotomania has a long, colourful history in psychiatry. It is a rare condition in which the patient ('subject') develops the belief that he or she is loved from afar by another person ('object'). The subject is generally female, though men predominate in forensic samples. The object is generally perceived to belong to a higher social class, reflecting a sociopolitical element in the construction of love. Erotomania requires active treatment and risk management as it can be associated with stalking and other offending behaviour...
July 8, 2017: Medical Humanities
https://www.readbyqxmd.com/read/28680405/cannabinoids-and-vanilloids-in-schizophrenia-neurophysiological-evidence-and-directions-for-basic-research
#18
REVIEW
Rafael N Ruggiero, Matheus T Rossignoli, Jana B De Ross, Jaime E C Hallak, Joao P Leite, Lezio S Bueno-Junior
Much of our knowledge of the endocannabinoid system in schizophrenia comes from behavioral measures in rodents, like prepulse inhibition of the acoustic startle and open-field locomotion, which are commonly used along with neurochemical approaches or drug challenge designs. Such methods continue to map fundamental mechanisms of sensorimotor gating, hyperlocomotion, social interaction, and underlying monoaminergic, glutamatergic, and GABAergic disturbances. These strategies will require, however, a greater use of neurophysiological tools to better inform clinical research...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28675999/subduing-the-green-eyed-monster-bridging-the-psychopharmacological-and-psychosocial-treatment-perspective-in-understanding-pathological-jealousy
#19
Farah Deena Abdul Samad, Hatta Sidi, Jaya Kumar, Srijit Das, Marhani Midin, Nurul Hazwani Hatta
Human being is not spared from a broad-ranged emotional state, including being jealous. Jealousy has both affective-cognitive and behavioural-evaluative dimension where the person perceives, or experiences a real threat on a valued relationship. As this complex emotion becomes irrational and not amenable to reason, it later transforms into a dangerously 'green-eyed monster'. This perilous situation which is viewed as pathological jealousy is a form of delusion, which is maintained by a fixed and false reasoning in an originally entrusted intimate relationship...
July 4, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28675258/narcolepsy-cataplexy-and-psychosis-a-case-study
#20
F Canellas-Dols, C Delgado, C Arango-Lopez, R Peraita-Adrados
AIMS: To report a challenging patient a girl who developed narcolepsyy with cataplexy (NT1) and a psychosis during adolescence. To discuss diagnostic and therapeutic challenges of the comorbid cases. CASE REPORT: A 14-year-old girl was referred to Sleep and Epilepsy Unit for excessive daytime sleepiness, impaired nocturnal sleep, binge eating and weight gain, over the last year. After being diagnosed with a NT1 the patient was treated with modafinil and sodium oxybate...
July 16, 2017: Revista de Neurologia
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