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https://www.readbyqxmd.com/read/28338760/childhood-maltreatment-and-young-adulthood-hallucinations-delusional-experiences-and-psychosis-a-longitudinal-study
#1
Amanuel Alemu Abajobir, Steve Kisely, James G Scott, Gail Williams, Alexandra Clavarino, Lane Strathearn, Jake Moses Najman
Child maltreatment is a widespread public health problem associated with a range of mental health disorders later in life. In order to effectively address these disorders, there is a need to understand more about the mental health consequences of different types of child maltreatment. This study examines the associations between prospectively substantiated child maltreatment (ages 0-14 y) and reports of hallucinations and delusional experiences at 21 years after birth. As well, we examined 12-month and lifetime psychotic disorders using data from a longitudinal birth cohort...
January 30, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28334978/therapeutic-window-of-dopamine-d2-3-receptor-occupancy-to-treat-psychosis-in-alzheimer-s-disease
#2
Suzanne Reeves, Emma McLachlan, Julie Bertrand, Fabrizia D Antonio, Stuart Brownings, Akshay Nair, Suki Greaves, Alan Smith, David Taylor, Joel Dunn, Paul Marsden, Robert Kessler, Robert Howard
Antipsychotic drugs, originally developed to treat schizophrenia, are used to treat psychosis, agitation and aggression in Alzheimer's disease. In the absence of dopamine D2/3 receptor occupancy data to inform antipsychotic prescribing for psychosis in Alzheimer's disease, the mechanisms underpinning antipsychotic efficacy and side effects are poorly understood. This study used a population approach to investigate the relationship between amisulpride blood concentration and central D2/3 occupancy in older people with Alzheimer's disease by combining: (i) pharmacokinetic data (280 venous samples) from a phase I single (50 mg) dose study in healthy older people (n = 20, 65-79 years); (ii) pharmacokinetic, 18F-fallypride D2/3 receptor imaging and clinical outcome data on patients with Alzheimer's disease who were prescribed amisulpride (25-75 mg daily) to treat psychosis as part of an open study (n = 28; 69-92 years; 41 blood samples, five pretreatment scans, 19 post-treatment scans); and (iii) 18F-fallypride imaging of an antipsychotic free Alzheimer's disease control group (n = 10, 78-92 years), to provide additional pretreatment data...
February 4, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28331325/a-chinese-version-of-the-psychotic-symptom-rating-scales-psychometric-properties-in-recent-onset-and-chronic-psychosis
#3
Wai-Tong Chien, Isabella Yuet-Ming Lee, Li-Qun Wang
The purpose of this study was to test the reliability, validity, and factor structure of a Chinese version of the Psychotic Symptom Rating Scale (PSYRATS) in 198 and 202 adult patients with recent-onset and chronic psychosis, respectively. The PSYRATS has been translated into different language versions and has been validated for clinical and research use mainly in chronic psychotic patients but not in recent-onset psychosis patients or in Chinese populations. The psychometric analysis of the translated Chinese version included assessment of its content validity, semantic equivalence, interrater and test-retest reliability, reproducibility, sensitivity to changes in psychotic symptoms, internal consistency, concurrent validity (compared to a valid psychotic symptom scale), and factor structure...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28331324/update-on-the-treatment-of-parkinson-s-disease-psychosis-role-of-pimavanserin
#4
REVIEW
Brianna L Combs, Arthur G Cox
Parkinson's disease (PD) has a prevalence of nearly 1 million people in the USA, with increasing incidence in the elderly population. Generally, the age of presentation is between 55 and 65 years, with the likelihood of diagnosis increasing as patients reach the age of 80 years or above. Some of the common treatments for PD increase dopamine levels in the brain. Dopaminergic therapy helps to improve motor and non-motor symptoms, but it is not without risks. Dopaminergic therapy can cause confusion, delirium, and psychotic-like behavior...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28318911/cannabis-use-polysubstance-use-and-psychosis-spectrum-symptoms-in-a-community-based-sample-of-u-s-youth
#5
Jason D Jones, Monica E Calkins, J Cobb Scott, Emily C Bach, Raquel E Gur
PURPOSE: To examine how cannabis use and polysubstance use among cannabis users relate to psychosis spectrum (PS) symptoms in a large community-based sample of U.S. youth. METHODS: Four thousand one hundred seventy-one youths (aged 14-21 years; mean = 16.90 years, SD = 1.85; 55% female) from the Philadelphia Neurodevelopmental Cohort completed assessments of substance use, PS symptoms, and confounding variables (e.g., demographics, comorbid psychopathology, and trauma exposure)...
March 16, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28318838/do-paranoid-delusions-exist-on-a-continuum-with-subclinical-paranoia-a-multi-method-taxometric-study
#6
A Elahi, G Perez Algorta, F Varese, J C McIntyre, R P Bentall
BACKGROUND: There is widespread interest in whether psychosis exists on a continuum with healthy functioning. Previous research has implied that paranoia, a common symptom of psychosis, exists on a continuum but this has not been investigated using samples including both patients and non-patients and up-to-date taxometric methods. AIM: To assess the latent structure of paranoia in a diverse sample using taxometric methods. METHOD: We obtained data from 2836 participants, including the general population as well as at-risk mental state and psychotic patients using the P-scale of the Paranoia and Deservedness Scale...
March 17, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28318497/belief-bias-reasoning-in-non-clinical-delusion-prone-individuals
#7
T Anandakumar, E Connaughton, M Coltheart, R Langdon
BACKGROUND AND OBJECTIVES: It has been proposed that people with delusions have difficulty inhibiting beliefs (i.e., "doxastic inhibition") so as to reason about them as if they might not be true. We used a continuity approach to test this proposal in non-clinical adults scoring high and low in psychometrically assessed delusion-proneness. High delusion-prone individuals were expected to show greater difficulty than low delusion-prone individuals on "conflict" items of a "belief-bias" reasoning task (i...
March 15, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28317166/the-relationship-of-specific-items-on-the-neuropsychiatric-inventory-to-caregiver-burden-in-dementia-a-systematic-review
#8
REVIEW
Toril Marie Terum, John Roger Andersen, Arvid Rongve, Dag Aarsland, Ellen J Svendsboe, Ingelin Testad
OBJECTIVE: Neuropsychiatric symptoms (NPSs) are common in dementia, and they have been identified as important care-recipient variables in terms of their impact on caregiver burden. The aim of this review was to describe how individual NPSs in dementia, assessed using the Neuropsychiatric Inventory, are associated with caregiver burden. METHODS: We performed a systematic review of English language, peer-reviewed articles retrieved from MEDLINE, PSYCINFO, and EMBASE...
March 20, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28315846/risk-factors-for-early-psychosis-in-pd-insights-from-the-parkinson-s-progression-markers-initiative
#9
Dominic H Ffytche, Joana B Pereira, Clive Ballard, K Ray Chaudhuri, Daniel Weintraub, Dag Aarsland
BACKGROUND: Parkinson's Disease (PD) psychosis refers to the spectrum of illusions, formed hallucinations and delusions that occur in PD. Visual hallucinations and illusions are thought to be caused by specific cognitive and higher visual function deficits and patients who develop such symptoms early in the disease course have greater rates of cognitive decline and progression to dementia. To date, no studies have investigated whether such deficits are found prior to the onset of PD psychosis...
April 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28315577/altered-functional-connectivity-in-brain-networks-underlying-self-referential-processing-in-delusions-of-reference-in-schizophrenia
#10
Sara Larivière, Katie M Lavigne, Todd S Woodward, Philip Gerretsen, Ariel Graff-Guerrero, Mahesh Menon
Delusions of reference in schizophrenia are thought to result from misattributions of self-relevance to neutral events. Activation of regions within the cortical midline structures (CMS; e.g., medial prefrontal cortex, cingulate cortex, and precuneus) have been previously associated with self-referential processing in schizophrenia patients; however, the specificity of this pattern to individuals with current delusions of reference has yet to be determined. In the present study, we identified functional brain networks that underlie self-referential processing using task-based multivariate functional connectivity...
March 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28314070/long-lasting-effects-of-chronic-heavy-cannabis-abuse
#11
Joannis N Nestoros, Elena Vakonaki, Manolis N Tzatzarakis, Athanasios Alegakis, Markos D Skondras, Aristidis M Tsatsakis
BACKGROUND AND OBJECTIVES: The purpose of this study was to evaluate the extent of short-term memory impairment and schizophrenia-like symptoms in heavy and systematic cannabis users and the association between the severity of abuse and the longevity of its persistent symptoms after refraining from such use. METHODS: A complete psychiatric examination and a psychometric evaluation were performed in 48 solely cannabis users. Additionally, head hair samples were analyzed and the detected cannabinoids levels were correlated with the psychometric findings...
March 17, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28302577/methamphetamine-effects-on-the-brain-gut-and-immune-system
#12
REVIEW
Monica D Prakash, Kathy Tangalakis, Juliana Antonipillai, Lily Stojanovska, Kulmira Nurgali, Vasso Apostolopoulos
Methamphetamine (METH) is a powerful central nervous system stimulant which elevates mood, alertness, energy levels and concentration in the short-term. However, chronic use and/or at higher doses METH use often results in psychosis, depression, delusions and violent behavior. METH was formerly used to treat conditions such as obesity and attention deficit hyperactivity disorder, but now is primarily used recreationally. Its addictive nature has led to METH abuse becoming a global problem. At a cellular level, METH exerts a myriad of effects on the central and peripheral nervous systems, immune system and the gastrointestinal system...
March 13, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28290660/homogeneous-liquid-phase-transfer-of-graphene-oxide-into-epoxy-resins
#13
Lyaysan Amirova, Albina Surnova, Dinar Balkaev, Delus Musin, Rustem Amirov, Ayrat M Dimiev
Quality of polymer composite materials depends on the distribution of the filler in the polymer matrix. Due to the presence of the oxygen functional groups, graphene oxide (GO) has strong affinity to epoxy resins, providing potential opportunity for the uniform distribution of GO sheets in the matrix. Another advantage of GO over its non-oxidized counterpart is its ability to exfoliate to single-atomic-layer sheets in water and in some organic solvents. However, these advantages of GO has not yet been fully realized due to the lack of the methods efficiently introducing GO into epoxy resin...
March 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28285771/improvement-in-depression-is-associated-with-improvement-in-cognition-in-late-life-psychotic-depression
#14
Lindsay W Victoria, Ellen M Whyte, Meryl A Butters, Barnett S Meyers, George S Alexopoulos, Benoit H Mulsant, Anthony J Rothschild, Samprit Banerjee, Alastair J Flint
OBJECTIVE: To characterize cognitive function at baseline and investigate the relationship between change in cognition, depression, and psychosis after treatment among older adults with major depressive disorder with psychotic features. METHODS: This was a secondary analysis of a double-blind, randomized, controlled treatment trial at inpatient and outpatient settings at four academic health centers on "Young Old" (aged 60-71 years, N = 71) and "Older" (aged 72-86 years, N = 71) participants diagnosed with psychotic depression...
February 9, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28282630/differences-in-the-symptom-profile-of-methamphetamine-related-psychosis-and-primary-psychotic-disorders
#15
Rebecca McKetin, Amanda L Baker, Sharon Dawe, Alexandra Voce, Dan I Lubman
We examined the lifetime experience of hallucinations and delusions associated with transient methamphetamine-related psychosis (MAP), persistent MAP and primary psychosis among a cohort of dependent methamphetamine users. Participants were classified as having (a) no current psychotic symptoms, (n=110); (b) psychotic symptoms only when using methamphetamine (transient MAP, n=85); (c) psychotic symptoms both when using methamphetamine and when abstaining from methamphetamine (persistent MAP, n=37), or (d) meeting DSM-IV criteria for lifetime schizophrenia or mania (primary psychosis, n=52)...
May 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28277976/issues-in-consultation-for-treatments-with-distressed-activated-abuser-protector-self-states-in-dissociative-identity-disorder
#16
Richard A Chefetz
The identified "problem self-state" in a dissociative disorder consultation is like the identified patient in a family therapy; the one who is identified may have an assigned role to be blamed which serves the function of deflecting the activities of painful self-states in other family members. In consultation, the "family" includes the therapist in addition to the patient. When the state identified as a problem self-state is an abuser/protector self-state, complications often involve the profound nature of transference-countertransference enactments between patient and therapist, the delusion of separateness, chronic and acute threats of suicide, negative therapeutic reactions, and the evocation of intense negativity...
February 16, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28276863/when-synesthesia-and-savant-abilities-are-mistaken-for-hallucinations-and-delusions-contribution-of-a-cognitive-approach-for-their-differential-diagnosis
#17
Lucie Bouvet, Jacques-Edouard Barbier, Nia Cason, Serge Bakchine, Nathalie Ehrlé
OBJECTIVE: Schizophrenia is characterized by hallucinations, delusions, disorganized speech and behavior, and other symptoms that cause social or occupational dysfunction. However, some of these symptoms, such as hallucinations and delusions, can be indicative of other phenomena such as synesthesia and savant abilities. The aim of this paper is to highlight how neurological and psychiatric conditions can be confused and how formal neuropsychological evaluations can be necessary to distinguish them...
February 17, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28262177/clinical-characteristics-of-patients-with-non-affective-non-organic-late-onset-psychosis
#18
Sureshkumar Ramasamy, Srikala Bharath
OBJECTIVE: Schizophrenia and related psychotic disorders are predominantly studied in young population. However some individuals do develop psychotic disorder for the first time during their old age. The aim of this study is to look at the clinical characteristics of non-affective, non-organic, late onset psychosis. PARTICIPANTS AND METHODS: Retrospective chart review study, medical records of all patients registered between 1st of January 2006 and 31st May 2011 at geriatric clinic in NIMHANS, Bangalore was screened, 83 files with a diagnosis of late onset psychosis and meeting the study criteria were systematically analyzed...
February 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28262165/folie-%C3%A3-deux-and-fregoli-syndrome-with-greater-severity-in-the-secondary-a-case-report
#19
LETTER
David C L Teo, Abishek M Abraham, Andrew L H Peh
Folie à deux and Fregoli syndrome are rarely seen in clinical practice. We present a case in which these rare syndromes co-occur. Remarkably, in this case the 'secondary' develops a more serious illness course than the 'primary' and reciprocally induces a de novo Fregoli delusion in the 'primary'. This case discusses how socio-cultural factors, such as interdependent family dynamics, could have precipitated this rare variant of folie à deux. It also highlights the importance of making culturally-sensitive formulations for treatment...
February 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28262162/schizophrenia-like-symptoms-in-a-patient-with-leigh-syndrome
#20
Kazumi Satogami, Shun Takahashi, Asami Kose, Kazuhiro Shinosaki
Leigh syndrome is a mitochondrial disease characterized by subacute necrotizing encephalomyelopathy. Almost all cases of Leigh syndrome develop at infancy or early childhood and die within several years due to rapidly progressive muscle weakness and respiratory failure. Here, we present a rare case of a patient who developed Leigh syndrome associated with thiamine-responsive pyruvate dehydrogenase-complex deficiency at 2 years of age and has survived to adolescence through effective high dose thiamin therapy...
February 2017: Asian Journal of Psychiatry
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