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https://www.readbyqxmd.com/read/28634108/disturbances-of-novel-object-exploration-and-recognition-in-a-chronic-ketamine-mouse-model-of-schizophrenia
#1
Maria Jelena Hauser, Dirk Isbrandt, Jochen Roeper
Schizophrenia is a chronic and devastating disease with an overall lifetime risk of 1%. While positive symptoms of schizophrenia such as hallucinations and delusions are reduced by antipsychotic medication based on the inhibition of type 2 dopaminergic receptors (D2R), negative symptoms (e.g. reduced motivation) and cognitive symptoms (e.g. impaired working memory) of schizophrenia are not effectively treated by current medication. This dichotomy might arise in part because of our limited understanding of the pathophysiology of negative and cognitive symptoms in schizophrenia...
June 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28630746/delusional-parasitosis-on-the-psychiatric-consultation-service-a-longitudinal-perspective-case-study
#2
Adam Trenton, Neha Pansare, Anthony Tobia, Viwek Bisen, Kenneth R Kaufman
BACKGROUND: Delusional parasitosis is infrequently seen in hospital-based consultation-liaison psychiatry. AIMS: Although there are many publications on delusional parasitosis, this report reviews a unique case that was diagnosed during a hospital admission and treated over the next 36 months. METHOD: Case report and literature review. RESULTS: This case report describes a 65-year-old man who was diagnosed with delusional parasitosis during a hospital admission for congestive heart failure and acute kidney injury...
May 2017: BJPsych Open
https://www.readbyqxmd.com/read/28626392/sensing-the-worst-neurophenomenological-perspectives-on-neutral-stimuli-misperception-in-schizophrenia-spectrum
#3
Mariateresa Sestito, Josef Parnas, Carlo Maggini, Vittorio Gallese
While investigating social cognitive impairments in schizophrenia, prominent evidence has been found that patients with schizophrenia show a tendency to misclassify neutral stimuli as negatively valenced. Within this population, patients presenting delusions are more prone to this phenomenon. In a previous study, Schizophrenia spectrum (SzSp) patients rated positive, negative and neutral stimuli that were multimodally presented, while assessed with a checklist exploring anomalous subjective experiences and evaluated for positive and negative symptomatology...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28623009/s%C3%A3-ntomas-neuropsiqui%C3%A3-tricos-como-factor-de-confusi%C3%A3-n-en-la-detecci%C3%A3-n-de-la-demencia
#4
David Córcoles, Angeles Malagón, Magdalena Bellsolà, Ana Gonzalez, Romina Cortizo, Jordi Leon, Antoni Bulbena, Victor Pérez, Luis M Martín
OBJECTIVE: The aim of the study was to evaluate whether the neuropsychiatric symptoms interfere with cognitive impairment detection in primary care and to describe which of them generate more confusion. DESIGN: Descriptive and observational study. LOCATION: Mobile psychiatric unit in collaboration with primary healthcare centers in Barcelona. PARTICIPANTS: A total of 104 patients over 65years referred to mobile psychiatric unit from primary healthcare clinicians suspecting mental disease...
June 13, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28622335/psychotic-symptoms-in-older-people-without-dementia-from-a-brazilian-community-based-sample-a-seven-years-follow-up
#5
Walter Barbalho Soares, Eriton Barros Dos Santos, Cássio Machado de Campos Bottino, Helio Elkis
BACKGROUND: Studies of the incidence of psychotic symptoms in elderly people at risk of dementia are scarce. This is a seven year follow up study aiming to determine the incidence of psychotic symptoms and their correlation with other clinical aspects, in particular the rate of development of cognitive impairment. METHODS: Cohort study of a community-based sample of elderly subjects. At study entry in 2004, the sample was composed of 1,125 individuals aged 60 years and older...
2017: PloS One
https://www.readbyqxmd.com/read/28620323/integrated-trauma-focused-cognitive-behavioural-therapy-for-post-traumatic-stress-and-psychotic-symptoms-a-case-series-study-using-imaginal-reprocessing-strategies
#6
Nadine Keen, Elaine C M Hunter, Emmanuelle Peters
Despite high rates of trauma in individuals with psychotic symptoms, post-traumatic stress symptoms are frequently overlooked in clinical practice. There is also reluctance to treat post-traumatic symptoms in case the therapeutic procedure of reprocessing the trauma exacerbates psychotic symptoms. Recent evidence demonstrates that it is safe to use reprocessing strategies in this population. However, most published studies have been based on treating post-traumatic symptoms in isolation from psychotic symptoms...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28618899/development-of-a-caregiver-reported-measure-to-support-systematic-assessment-of-people-with-dementia-in-long-term-care-the-integrated-palliative-care-outcome-scale-for-dementia
#7
Clare Ellis-Smith, Catherine J Evans, Fliss Em Murtagh, Lesley A Henson, Alice M Firth, Irene J Higginson, Barbara A Daveson
BACKGROUND: Symptom burden is common for long-term care residents with dementia which if untreated compromises quality of life. Measurement tools can support assessment of symptoms and problems but are not widely used in long-term care settings. We developed the Integrated Palliative care Outcome Scale for Dementia derived from the Palliative care Outcome Scale, Palliative care Outcome Scale-Symptom and Integrated Palliative care Outcome Scale. AIM: To examine the content validity, acceptability and comprehension of Integrated Palliative care Outcome Scale for Dementia for routine use in long-term care settings for people with dementia and to refine Integrated Palliative care Outcome Scale for Dementia...
July 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28618123/-pain-relieved-but-still-struggling-critically-ill-patients-experiences-of-pain-and-other-discomforts-during-analgosedation
#8
Helene Berntzen, Ida Torunn Bjørk, Hilde Wøien
AIM & OBJECTIVE: To explore how critically ill patients treated according to a strategy of analgosedation experience and handle pain, other discomforts, and wakefulness. BACKGROUND: Patients experience both pain and discomfort while in the intensive care unit (ICU). International guidelines recommend focused pain treatment and light sedation. An analgosedation protocol favoring pain management, light sedation and early mobilization was implemented in our university hospital medical and surgical ICU in Norway in 2014...
June 15, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28617822/intronic-snp-in-esr1-encoding-human-estrogen-receptor-alpha-is-associated-with-brain-esr1-mrna-isoform-expression-and-behavioral-traits
#9
Julia K Pinsonneault, John T Frater, Benjamin Kompa, Roshan Mascarenhas, Danxin Wang, Wolfgang Sadee
Genetic variants of ESR1 have been implicated in multiple diseases, including behavioral disorders, but causative variants remain uncertain. We have searched for regulatory variants affecting ESR1 expression in human brain, measuring allelic ESR1 mRNA expression in human brain tissues with marker SNPs in exon4 representing ESR1-008 (or ESRα-36), and in the 3'UTR of ESR1-203, two main ESR1 isoforms in brain. In prefrontal cortex from subjects with bipolar disorder, schizophrenia, and controls (n = 35 each; Stanley Foundation brain bank), allelic ESR1 mRNA ratios deviated from unity up to tenfold at the exon4 marker SNP, with large allelic ratios observed primarily in bipolar and schizophrenic subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28617374/-positive-changes-in-the-severity-of-residual-psychotic-symptoms-in-schizophrenic-patients-switched-to-treatment-with-risperidone
#10
D S Burminskiy, M A Morozova
AIM: To evaluate the effect of changing therapy from typical antipsychotics to the atypical antipsychotic risperidone in the treatment of difficult-to-treat residual psychotic symptoms. MATERIAL AND METHODS: The study included 15 patients, 8 men and 7 women, mean age 49.1±10.25 years, diagnosed with paranoid schizophrenia, partial remission (ICD-10 F20.04). At the beginning all participants received regular maintenance antipsychotic therapy with typical antipsychotics...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28615772/postherpetic-neuralgia-presenting-as-delusional-parasitosis-a-case-series
#11
Shailendra Mohan Tripathi, Priti Singh, Nisha Mani Pandey
Delusional parasitosis (DP) or Ekbom's disease is a rare psychiatric condition where the sufferers have a firm-fixed belief of insects crawling over their skin. The condition may be primary monosymptomatic hypochrondrical delusion or secondary to an underlying psychiatric or organic condition. We present two cases of elderly men presenting with classical symptomatology of DP, which is found to be secondary to postherpetic neuralgia following an acute episode of shingles or herpes zoster infection. One patient responded to a combination of antipsychotic, olanzapine, and pregabalin, used for neuropathic pain, and the other patient responded completely with medications used for neuropathic pain only without any antipsychotic use...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28613395/clozapine-dose-for-schizophrenia
#12
REVIEW
Selvizhi Subramanian, Birgit A Völlm, Nick Huband
BACKGROUND: Schizophrenia and related disorders such as schizophreniform and schizoaffective disorder are serious mental illnesses characterised by profound disruptions in thinking and speech, emotional processes, behaviour and sense of self. Clozapine is useful in the treatment of schizophrenia and related disorders, particularly when other antipsychotic medications have failed. It improves positive symptoms (such as delusions and hallucinations) and negative symptoms (such as withdrawal and poverty of speech)...
June 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28605242/sexual-behavior-in-patients-with-psychosis-admitted-to-a-hospital-unit
#13
María Del Mar Baños-Martín, Verónica V Márquez-Hernández, Lorena Gutiérrez-Puertas, Gabriel Aguilera-Manrique, Vanesa Gutiérrez-Puertas, Genoveva Granados-Gámez
The sexual dimension is part of a person's functionality. Patients with mental disorders have the same sexual needs as any other person, although they may not always be recognized. This is a retrospective observational study to describe the information on sexuality of patients with mental disorders, admitted to an acute short-stay inpatient unit between 2011 and 2015. We analyzed 293 clinical histories of patients, comprising diagnoses in the ICD-10 (International Classification of Diseases) between F20 and F29, inclusively...
June 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28601666/a-conditioning-model-of-delusion
#14
REVIEW
Douglas John Roy
"Delusions" are beliefs that are false and persistent. It is suggested here that these characteristics can emerge from interplays between two fundamental learning processes: (1) the allocation of attentional resources among stimuli; and (2) the effects of feedback on learning. The former of these has been operationalized in the learned irrelevance and latent inhibition paradigms; the latter in studies of the effects of persistence-training. Normally, the attentional process functions to constrain persistence-training effects so that only valid associations acquire persistence...
June 7, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28600444/deconstructing-psychosis-and-misperception-symptoms-in-parkinson-s-disease
#15
Yoshiyuki Nishio, Kayoko Yokoi, Makoto Uchiyama, Yasuyuki Mamiya, Hiroyuki Watanabe, Miyeong Gang, Toru Baba, Atsushi Takeda, Kazumi Hirayama, Etsuro Mori
OBJECTIVE: Patients with Lewy body disease develop a variety of psychotic and misperception symptoms, including visual hallucinations and delusions, as well as 'minor hallucinations', that is, a sense of presence, passage hallucinations and visual illusions. Although these symptoms have been suggested to have common underlying mechanisms, the commonalities and differences among them have not been systematically investigated at the neural level. METHODS: Sixty-seven patients with Parkinson's disease underwent neuropsychological and behavioural assessments, volumetric MRI and 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET)...
June 9, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28599949/quetiapine-extended-release-versus-aripiprazole-in-children-and-adolescents-with-first-episode-psychosis-the-multicentre-double-blind-randomised-tolerability-and-efficacy-of-antipsychotics-tea-trial
#16
Anne Katrine Pagsberg, Pia Jeppesen, Dea Gowers Klauber, Karsten Gjessing Jensen, Ditte Rudå, Marie Stentebjerg-Olesen, Peter Jantzen, Simone Rasmussen, Eva Ann-Sofie Saldeen, Maj-Britt Glenn Lauritsen, Niels Bilenberg, Anne Dorte Stenstrøm, Louise Nyvang, Sarah Madsen, Thomas M Werge, Theis Lange, Christian Gluud, Maria Skoog, Per Winkel, Jens Richardt M Jepsen, Birgitte Fagerlund, Christoph U Correll, Anders Fink-Jensen
BACKGROUND: Head-to-head trials to guide antipsychotic treatment choices for paediatric psychosis are urgently needed because extrapolations from adult studies might not be implementable. In this superiority trial with two-sided significance testing, we aimed to compare the efficacy and safety of quetiapine-extended release (quetiapine-ER) versus aripiprazole in children and adolescents with first-episode psychosis, to determine whether differences between the two treatments were sufficient to guide clinicians in their choice of one drug over the other...
June 6, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28598957/childhood-adversity-cortisol-levels-and-psychosis-a-retrospective-investigation
#17
Carlo Faravelli, Giovanni Mansueto, Sara Palmieri, Carolina Lo Sauro, Francesco Rotella, Francesco Pietrini, Giulia Fioravanti
Although it has been proposed that the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis may act as a possible pathway linking early life stress to psychosis, this relationship has not yet been fully confirmed. This study aimed to investigate the relationship between childhood adversity (CA), cortisol levels, and psychosis. Eighty-five patients with psychosis and 170 control subjects were enrolled in the study. CA was evaluated using the Florence Psychiatric Interview, and Childhood Experience of Care and Abuse Questionnaire...
June 8, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28596465/-somatoparaphrenia
#18
Satoka Akita, Tomoko Akiyama, Masaru Mimura
Somatoparaphrenia (SP) typically occurs after a right-hemisphere stroke, where the patient refers to his/her hemiplegic left hand as belonging to someone else. In this report, we review the literature for the brain structures affected in SP. We also report three cases with varying degrees of SP: a typical case, one case where SP affected the visceral sensations, and one case where a concurring psychiatric condition lead to a very complex, bizarre delusion.
June 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28593624/-the-othello-syndrome-in-parkinson-s-disease-an-example-of-a-lesser-known-delusion
#19
E C Potters, J T H van Asseldonk, J J D Tilanus
Delusions are fairly common features of Parkinson's disease. Some delusions are easily recognised, but others are less well-known and can be missed by health professionals. We describe the case of a female patient with Parkinson's disease who believed, erroneously, that her partner was being unfaithful; this type of delusion is also called the Othello syndrome. After psychoeducation and the start of clozapine, the delusion faded and the relationship became more peaceful.
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28588507/neurovascular-unit-dysfunction-and-blood-brain-barrier-hyperpermeability-contribute-to-schizophrenia-neurobiology-a-theoretical-integration-of-clinical-and-experimental-evidence
#20
REVIEW
Souhel Najjar, Silky Pahlajani, Virginia De Sanctis, Joel N H Stern, Amanda Najjar, Derek Chong
Schizophrenia is a psychotic disorder characterized by delusions, hallucinations, negative symptoms, as well as behavioral and cognitive dysfunction. It is a pathoetiologically heterogeneous disorder involving complex interrelated mechanisms that include oxidative stress and neuroinflammation. Neurovascular endothelial dysfunction and blood-brain barrier (BBB) hyperpermeability are established mechanisms in neurological disorders with comorbid psychiatric symptoms such as epilepsy, traumatic brain injury, and Alzheimer's disease...
2017: Frontiers in Psychiatry
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