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Internal medicine

Peter R Shumaker
Over the last decade, the treatment of traumatic scars with lasers has emerged as a core component of multidisciplinary management. Military dermatologists have had a fundamental role in this shift by helping to develop new applications for existing technology and promulgate the techniques to reach additional providers and patients. International engagement is a prominent and highly attractive feature of military practice, and military dermatologists routinely participate in disaster response missions and ongoing planned operations...
August 2018: Cutis; Cutaneous Medicine for the Practitioner
Andrea Cortegiani, Federico Longhini, Filippo Sanfilippo, Santi Maurizio Raineri, Cesare Gregoretti, Antonino Giarratano
Predatory publishing is an exploitative fraudulent open-access publishing model that applies charges under the pretense of legitimate publishing operations without actually providing the editorial services associated with legitimate journals. The aim of this study was to analyze this phenomenon in the field of anesthesiology and related specialties (intensive care, critical and respiratory medicine, pain medicine, and emergency care). Two authors independently surveyed a freely accessible, constantly updated version of the original Beall lists of potential, possible, or probable predatory publishers and standalone journals...
September 18, 2018: Anesthesia and Analgesia
Gaëlle Richard Colmant, Laurent Kodjikian, Audrey De Parisot De Bernecourt, Martin Guillaud, Mathieu Gerfaud-Valentin, Philippe Denis, Christiane Broussolle, Yvan Jamilloux, Pascal Sève
PURPOSE: Despite the huge advance in diagnostic technics, about one-third of uveitis is still considered of unknown etiology. In this study, we aimed to report their clinical features and to describe how a diagnosis has been finally reached for some patients. METHODS: We retrospectively reviewed all patients with uveitis referred to our tertiary center between 2002 and 2016. The unknown etiology was admitted after a new ophthalmologic examination and a full work-up in internal medicine in our tertiary center...
September 20, 2018: Ocular Immunology and Inflammation
Salma Hussain Abu-Grain, Sanaa Sadiq Alsaad, Dalia Yahia El Kheir
Background: Being the first in-line care providers, primary health-care (PHC) physicians may encounter all forms of emergencies, ranging from minor complaints to life-threatening events. This wide variation of cases challenges the physicians to be competent in emergency medicine. Informative literature describing and assessing the factors affecting PHC physicians' emergency medical services (EMS)-related practice is deficient (nationally and internationally). The aim of this study is to assess PHC physicians' practice related to EMS, the factors affecting it, as well as their learning needs and preferred methods of continuous training in emergency medicine...
July 2018: Journal of Family Medicine and Primary Care
Thomas M Drake, Stephen R Knight, Ewen M Harrison, Kjetil Søreide
Precision medicine based upon molecular testing is heralded as a revolution in how cancer is prevented, diagnosed, and treated. Large efforts across the world aim to conduct comprehensive molecular profiling of disease to inform preclinical models, translational research studies and clinical trials. However, most studies have only been performed in patients from high-income countries. As the burden on non-communicable diseases increases, cancer will become a pressing burden across the world, disproportionately affecting low-middle income settings...
2018: Frontiers in Oncology
Andrea Peloso, Antonio Citro, Tamara Zoro, Lorenzo Cobianchi, Arianna Kahler-Quesada, Carlo M Bianchi, Axel Andres, Ekaterine Berishvili, Lorenzo Piemonti, Thierry Berney, Christian Toso, Graziano Oldani
According to the Juvenile Diabetes Research Foundation (JDRF), almost 1. 25 million people in the United States (US) have type 1 diabetes, which makes them dependent on insulin injections. Nationwide, type 2 diabetes rates have nearly doubled in the past 20 years resulting in more than 29 million American adults with diabetes and another 86 million in a pre-diabetic state. The International Diabetes Ferderation (IDF) has estimated that there will be almost 650 million adult diabetic patients worldwide at the end of the next 20 years (excluding patients over the age of 80)...
2018: Frontiers in Endocrinology
Sandor Kerpel-Fronius, Sander Becker, Jane Barrett, Johan Brun, Roberto Carlesi, Anthony Chan, Luis F Collia, Dominique J Dubois, Peter Kleist, Greg Koski, Chieko Kurihara, Luis F Laranjeira, Johanna Schenk, Honorio Silva
The complexity of developing and applying increasingly sophisticated new medicinal products has led to the participation of many non-medically qualified scientists in multi-disciplinary non-clinical and clinical drug development teams world-wide. In this introductory paper to the "IFAPP International Ethics Framework for Pharmaceutical Physicians and Medicines Development Scientists" it is argued that all members of such multidisciplinary teams must share the scientific and ethical responsibilities since they all influence directly or indirectly both the outcome of the various phases of the medicines development projects and the safety of the research subjects involved...
2018: Frontiers in Pharmacology
Li-Chun Li, Hai-Jiao Xing, Yan Liang, Yong-Hong Hu, Xin An, Xue-Xin He, Chun-Sheng Jia
OBJECTIVE: To compare the therapeutic effect of thermosensitive moxibustion (TSM) and medication in the treatment of insomnia patients with the syndrome of stagnation of liver- qi . METHODS: A total of 60 insomnia patients with the syndrome of liver-qi stagnation were randomly divided into TSM group and medication group ( n = 30 in each). Mild moxibustion was applied to bilateral Taichong (LR 3) and Qiuxu (GB 40) alternatively till the patient experienced an intense warmth (diathermic, heat transmission, etc...
September 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Hermine I Brunner, Alberto Martini, Daniel J Lovell, Nicolino Ruperto
Childhood-onset systemic lupus erythematosus (cSLE) is rare in many regions of the world, including Europe. Access to approved medications for cSLE is currently limited, among others, due to a lack of high-quality evidence from clinical trials. The objectives of the study were to evaluate the current regulatory framework regarding medication approvals, delineate barriers to clinical trial conduct, and strategies to improve access to new medications for cSLE. Relevant methodological and regulatory aspects, epidemiological data, study designs and outcome measures are reviewed, and the results of a survey among Paediatric Rheumatology International Trials Organisation/Pediatric Rheumatology Collaborative Study Group investigators are presented...
September 19, 2018: Annals of the Rheumatic Diseases
Imre Bihari, George Ayoub, Szilvia Bokros, Péter Bihari
INTRODUCTION: With the development of medicine, technical inventions have been intoduced into the therapy of varicose veins, such as ultrasound examination and laser treatment. PATIENTS AND METHODS: Over 11 years 1729 laser surgery were performed on varicose veins. Junctions of saphenous veins, saphenous stems and perforator veins were treated with lasers, but reticular and spider veins were treated with other methods. The most important elements of laser surgery are the introduction of the laser fibre into the lumen of the vein and delivering the laser energy...
September 2018: Magyar Sebészet
Frances Collichio, Elaine A Muchmore
The American Society of Hematology (ASH)/ASCO Curricular Milestones is a tool for assessment and teaching for fellows in hematology/oncology. The expectations of the Next Accreditation System of the Accreditation Council of Graduate Medical Education (ACGME) was developed over years from the creation of the six core competencies in 1999 to the current data-driven outcomes-based system. The current internal medicine subspecialty milestones (ACGME reporting milestones) follow the general rubric of the general internal medicine milestones...
May 23, 2018: American Society of Clinical Oncology Educational Book
Winfried Häuser, Matthias Schuler
Chronic pain is a main symptom of many diseases in internal medicine. The symptomatic treatment of pain in medical diseases is the task of the internist. Errors in drug therapy of pain can be reduced by a systematic approach of selection, application and monitoring of used medicine, taking effectiveness, duration, dose, comedication and safety into account.
September 2018: Deutsche Medizinische Wochenschrift
Joaquim J Ferreira, Claudia Trenkwalder, Tiago A Mestre
Among movement disorders and medicine in general, PD is one of the conditions for which there is a greater knowledge of the placebo and nocebo responses. In other movement disorders, the knowledge of placebo and nocebo responses is less. An advance in this field is expected to contribute to a better understanding of the nature of a therapeutic benefit in clinical research and clinical practice, and mechanisms of placebo and nocebo. We conducted a review on placebo and nocebo responses in other movement disorders besides PD by primarily examining meta-analyses of clinical trials assessing specifically the placebo and/or nocebo responses...
August 2018: Movement Disorders: Official Journal of the Movement Disorder Society
Marco Di Pascoli, Silvano Fasolato, Salvatore Piano, Massimo Bolognesi, Paolo Angeli
BACKGROUND AND AIMS: In patients with liver cirrhosis, the clinical benefit of the treatment with human albumin for ascites is debated, and no data are available regarding refractory ascites. In this study, in patients with cirrhosis and refractory ascites, we assessed the effect of long-term albumin administration on emergent hospitalization and mortality. METHODS: Seventy patients with cirrhosis and refractory ascites, followed at the Unit of Internal Medicine and Hepatology, University and General Hospital of Padova, Italy, were included into the study...
September 19, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Rachel Cross, Julie Considine, Judy Currey
AIM: To examine nursing handover of vital signs during patient care transition from the emergency department (ED) to inpatient wards. BACKGROUND: Communication failures are a leading cause of patient harm making communication through clinical handover an international healthcare priority. The transition of care from ED to ward settings is informed by nursing handover. Vital sign abnormalities in the ED are associated with clinical deterioration following hospital admission...
September 19, 2018: Journal of Clinical Nursing
Zheng Xiao, Chengqiong Wang, Zhouke Tan, Shanshan Hu, Yali Chen, Minghua Zhou, Jihong Feng, Shiyu Liu, Ling Chen, Jie Ding, Qihai Gong, Fushan Tang, Hui Liu, Xiaofei Li
WHAT IS KNOWN AND OBJECTIVE: Sodium cantharidinate has been widely used in lung cancer treatment in China. To investigate whether sodium cantharidinate improves clinical effectiveness in non-small-cell lung cancer, we systematically re-evaluated all related studies. METHODS: All studies of cantharidinate for non-small-cell lung cancers (NSCLC) were selected from the MEDLINE, EMBASE, Web of Science (ISI), China National Knowledge Infrastructure Database (CNKI), Chinese Scientific Journals Full-Text Database (VIP), Wanfang, China Biological Medicine Database (CBM), Cochrane Central Register of Controlled Trials (CENTRAL), Chinese clinical trial registry (Chi-CTR), WHO International Clinical Trials Registry Platform (WHO-ICTRP) and US-clinical trials databases (established to September 2017)...
September 19, 2018: Journal of Clinical Pharmacy and Therapeutics
N M Uzunov, L Melendez-Alafort, M Bello, G Cicoria, F Zagni, L De Nardo, A Selva, L Mou, C Rossi-Alvarez, G Pupillo, G Di Domenico, L Uccelli, A Boschi, F Groppi, A Salvini, A Taibi, A Duatti, P Martini, M Pasquali, M Loriggiola, M Marengo, L Strada, S Manenti, A Rosato, J Esposito
Evaluation of the radioisotopic purity of technetium-99m (99m Tc) produced in GBq amounts by proton bombardment of enriched molibdenum-100 (100 Mo) metallic targets at low proton energies (i.e. within 15-20 MeV) is conducted. This energy range was chosen since it is easily achievable by many conventional medical cyclotrons already available in the nuclear medicine departments of hospitals. The main motivation for such a study is in the framework of the research activities at the international level that have been conducted over the last few years to develop alternative production routes for the most widespread radioisotope used in medical imaging...
September 19, 2018: Physics in Medicine and Biology
Takenobu Katagiri, Sho Tsukamoto, Yutaka Nakachi, Mai Kuratani
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease that is characterized by the formation of heterotopic bone tissues in soft tissues, such as skeletal muscle, ligament, and tendon. It is difficult to remove such heterotopic bones via internal medicine or invasive procedures. The identification of activin A receptor, type I (ACVR1)/ALK2 gene mutations associated with FOP has allowed the genetic diagnosis of FOP. The ACVR1/ALK2 gene encodes the ALK2 protein, which is a transmembrane kinase receptor in the transforming growth factor-β family...
September 2018: Endocrinology and Metabolism
Eva Bermejo-Sánchez, Lorenzo D Botto, Marcia L Feldkamp, Boris Groisman, Pierpaolo Mastroiacovo
Birth defects (BD), also known as congenital anomalies, are structural or functional abnormalities present at birth as a result of abnormal prenatal development. Their cause can be broadly categorized as genetic, environmental, or a combination of both. It is estimated that approximately 3-6% of newborn infants worldwide are affected by BD, many of which are associated with serious morbidity, mortality, and lifelong disabilities. The International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR), founded in 1974, promotes worldwide birth defect surveillance, research, and prevention through the ongoing sharing of data, expertise, and training...
September 18, 2018: Journal of Community Genetics
Bengt Jönsson, Grace Hampson, Jonathan Michaels, Adrian Towse, J-Matthias Graf von der Schulenburg, Olivier Wong
BACKGROUND: Advanced therapy medicinal products (ATMPs) are beginning to reach European markets, and questions are being asked about their value for patients and how healthcare systems should pay for them. OBJECTIVES: To identify and discuss potential challenges of ATMPs in view of current health technology assessment (HTA) methodology-specifically economic evaluation methods-in Europe as it relates to ATMPs, and to suggest potential solutions to these challenges...
September 18, 2018: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
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