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Parkinson's disease cognition

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https://www.readbyqxmd.com/read/29787739/apathy-in-individuals-with-parkinson-s-disease-associated-with-mild-cognitive-impairment-a-neuropsychological-investigation
#1
Alberto Costa, Antonella Peppe, Silvia Zabberoni, Francesco Scalici, Carlo Caltagirone, Giovanni Augusto Carlesimo
Apathy is frequently reported in individuals with Parkinson's disease (PD) and is hypothesized to be associated with frontal-striatal related cognitive functions. Available data, however, do not provide univocal results. Moreover, this relationship has been poorly investigated in PD patients with mild cognitive impairment (MCI). This study was aimed at investigating the association between severity of apathy of PD patients and their performance on neuropsychological tests investigating executive abilities. Individuals with PD (i...
May 19, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29786895/deep-brain-stimulation-treated-dystonia-trajectory-via-status-dystonicus
#2
Elodie Nerrant, Victoria Gonzalez, Christophe Milesi, Xavier Vasques, Diane Ruge, Thomas Roujeau, Isabel De Antonio Rubio, Fabienne Cyprien, Emilie Chan Seng, Diane Demailly, Agathe Roubertie, Alain Boularan, Fréderic Greco, Pierre-François Perrigault, Gilles Cambonie, Philippe Coubes, Laura Cif
BACKGROUND: Status dystonicus (SD) is a life-threatening condition. OBJECTIVE AND METHODS: In a dystonia cohort who developed status dystonicus, we analyzed demographics, background dystonia phenomenology and complexity, trajectory previous to-, via status dystonicus episodes, and evolution following them. RESULTS: Over 20 years, 40 of 328 dystonia patients who were receiving DBS developed 58 status dystonicus episodes. Dystonia was of pediatric onset (95%), frequently complex, and had additional cognitive and pyramidal impairment (62%) and MRI alterations (82...
May 22, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29785679/drooling-in-parkinson-s-disease-evidence-of-a-role-for-divided-attention
#3
Hannah Reynolds, Nick Miller, Richard Walker
Drooling is a frequently reported symptom in Parkinson's Disease (PD) with significant psychosocial impact and negative health consequences including silent aspiration of saliva with the associated risk of respiratory infections. It is suggested that in PD drooling is associated with inefficient oropharyngeal swallowing which reduces the effective clearance of saliva rather than hyper-salivation. This is compounded by unintended mouth opening and flexed posture increasing anterior loss of saliva. It is reported to occur most frequently during cognitively distracting concurrent tasks suggesting an impact from divided attention in a dual-task situation...
May 21, 2018: Dysphagia
https://www.readbyqxmd.com/read/29785199/physical-exercise-for-parkinson-s-disease-clinical-and-experimental-evidence
#4
REVIEW
Alessandro Oliveira de Carvalho, Alberto Souza Sá Filho, Eric Murillo-Rodriguez, Nuno Barbosa Rocha, Mauro Giovanni Carta, Sergio Machado
Background: National projections about the increase in the elderly population over 60 years bring with it an increase in the number of people affected by Parkinson's Disease (PD), making it an important public health problem. Therefore, the establishment of effective strategies for intervention in people with PD needs to be more clearly investigated. Objective: The study aimed to report the effectiveness of exercise on functional capacity and neurobiological mechanisms in people with PD...
2018: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/29784561/parkinson-s-disease-phenotype-is-influenced-by-the-severity-of-the-mutations-in-the-gba-gene
#5
Avner Thaler, Noa Bregman, Tanya Gurevich, Tamara Shiner, Yonatan Dror, Ofir Zmira, Ziv Gan-Or, Anat Bar-Shira, Mali Gana-Weisz, Avi Orr-Urtreger, Nir Giladi, Anat Mirelman
OBJECTIVE: Mutations in the glucocerebrosidase (GBA) gene are divided into mild and severe (mGBA, sGBA) based on their contribution to the phenotype of Gaucher disease (GD) among homozygotes. We conducted a longitudinal analysis of Parkinson's disease (PD) patients carrying mutations in the GBA gene to better characterize genotype-phenotype correlations. METHODS: Patients underwent a comprehensive assessment of medical, neurological, cognitive and non-motor functions...
May 17, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29783725/polyphenols-in-parkinson-s-disease-a-systematic-review-of-in-vivo-studies
#6
REVIEW
Małgorzata Kujawska, Jadwiga Jodynis-Liebert
Parkinson's disease (PD) is the second most common neurodegenerative disorder. However, therapeutic options treating only its symptoms are very disappointing. Therefore there is an ongoing search for compounds capable of tackling the multi-dimensional features of PD. Recently natural polyphenols have gained great interest as potential therapeutic agents. Herein, we have attempted to summarize results obtained in different animal models demonstrating their neuroprotective effects. The in vivo findings presented below are supported by human subject data and reports regarding the ability of polyphenols to cross the blood-brain barrier...
May 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29782882/prolonged-increase-in-ser31-tyrosine-hydroxylase-phosphorylation-in-substantia-nigra-following-cessation-of-chronic-methamphetamine
#7
Michael F Salvatore, Vicki A Nejtek, Habibeh Khoshbouei
Methamphetamine (MA) exposure may increase the risk of motor or cognitive impairments similar to Parkinson's disease (PD) by middle age. Although damage to nigrostriatal or mesoaccumbens dopamine (DA) neurons may occur during or early after MA exposure, overt PD-like symptoms at a younger age may not manifest due to compensatory mechanisms to maintain DA neurotransmission. One possible compensatory mechanism is increased tyrosine hydroxylase (TH) phosphorylation. In the rodent PD 6-OHDA model, nigrostriatal lesion decreases TH protein in both striatum and substantia nigra (SN)...
May 18, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29780572/cognitive-training-and-transcranial-direct-current-stimulation-for-mild-cognitive-impairment-in-parkinson-s-disease-a-randomized-controlled-trial
#8
Blake J Lawrence, Natalie Gasson, Andrew R Johnson, Leon Booth, Andrea M Loftus
This study examined whether standard cognitive training, tailored cognitive training, transcranial direct current stimulation (tDCS), standard cognitive training + tDCS, or tailored cognitive training + tDCS improved cognitive function and functional outcomes in participants with PD and mild cognitive impairment (PD-MCI). Forty-two participants with PD-MCI were randomized to one of six groups: (1) standard cognitive training, (2) tailored cognitive training, (3) tDCS, (4) standard cognitive training + tDCS, (5) tailored cognitive training + tDCS, or (6) a control group...
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/29779721/evaluation-of-an-ontology-based-system-for-computerized-cognitive-rehabilitation
#9
Anna Alloni, Silvana Quaglini, Silvia Panzarasa, Elena Sinforiani, Sara Bernini
OBJECTIVES: This paper describes the results of a randomized clinical trial about the effectiveness of a computerized rehabilitation treatment on a sample of 31 patients affected by Parkinson disease. METHODS: Computerized exercises were administered by the therapists to the intervention group (n = 17) through the CoRe tool, which automatically generates a big variety of exercises leveraging on a stimuli set (words, sounds and images) organized into a dedicated ontology...
July 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29779045/clinical-utility-of-fdg-pet-in-parkinson-s-disease-and-atypical-parkinsonism-associated-with-dementia
#10
REVIEW
Zuzana Walker, Federica Gandolfo, Stefania Orini, Valentina Garibotto, Federica Agosta, Javier Arbizu, Femke Bouwman, Alexander Drzezga, Peter Nestor, Marina Boccardi, Daniele Altomare, Cristina Festari, Flavio Nobili
PURPOSE: There are no comprehensive guidelines for the use of FDG PET in the following three clinical scenarios: (1) diagnostic work-up of patients with idiopathic Parkinson's disease (PD) at risk of future cognitive decline, (2) discriminating idiopathic PD from progressive supranuclear palsy, and (3) identifying the underlying neuropathology in corticobasal syndrome. METHODS: We therefore performed three literature searches and evaluated the selected studies for quality of design, risk of bias, inconsistency, imprecision, indirectness and effect size...
May 19, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29778803/age-affects-reinforcement-learning-through-dopamine-based-learning-imbalance-and-high-decision-noise-not-through-parkinsonian-mechanisms
#11
Ravi B Sojitra, Itamar Lerner, Jessica R Petok, Mark A Gluck
Probabilistic reinforcement learning declines in healthy cognitive aging. While some findings suggest impairments are especially conspicuous in learning from rewards, resembling deficits in Parkinson's disease, others also show impairments in learning from punishments. To reconcile these findings, we tested 252 adults from 3 age groups on a probabilistic reinforcement learning task, analyzed trial-by-trial performance with a Q-reinforcement learning model, and correlated both fitted model parameters and behavior to polymorphisms in dopamine-related genes...
April 19, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29777676/cognitive-effects-of-rhythmic-auditory-stimulation-in-parkinson-s-disease-a-p300-study
#12
Juan Lei, Nadine Conradi, Cornelius Abel, Stefan Frisch, Alla Brodski-Guerniero, Marcel Hildner, Christian A Kell, Jochen Kaiser, Maren Schmidt-Kassow
Rhythmic auditory stimulation (RAS) may compensate dysfunctions of the basal ganglia (BG), involved with intrinsic evaluation of temporal intervals and action initiation or continuation. In the cognitive domain, RAS containing periodically presented tones facilitates young healthy participants' attention allocation to anticipated time points, indicated by better performance and larger P300 amplitudes to periodic compared to random stimuli. Additionally, active auditory-motor synchronization (AMS) leads to a more precise temporal encoding of stimuli via embodied timing encoding than stimulus presentation adapted to the participants' actual movements...
May 16, 2018: Brain Research
https://www.readbyqxmd.com/read/29777524/mercury-involvement-in-neuronal-damage-and-in-neurodegenerative-diseases
#13
REVIEW
Veronica Lanza Cariccio, Annalisa Samà, Placido Bramanti, Emanuela Mazzon
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis are characterized by a chronic and selective process of neuronal cell death. Although the causes of neurodegenerative diseases remain still unknown, it is now a well-established idea that more factors, such as genetic, endogenous, and environmental, are involved. Among environmental causes, the accumulation of mercury, a heavy metal considered a toxic agent, was largely studied as a probable factor involved in neurodegenerative disease course...
May 18, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29776682/the-impact-of-apolipoprotein-e-alleles-on-cognitive-performance-in-patients-with-parkinson-s-disease
#14
Anna Pierzchlińska, Monika Białecka, Mateusz Kurzawski, Jarosław Sławek
Apolipoprotein E (ApoE) is a vital component of several lipoproteins and plays a major role in lipid metabolism. APOE gene comprises of three alleles determined by two single nucleotide polymorphisms (rs429358 and rs7412) resulting in the protein isoforms, among which ApoE4 is a confirmed risk factor for Alzheimer's Disease. However, the impact of APOE genotypes on Parkinson's Disease Dementia (PDD) is still inconclusive. The PDD diagnostic criteria are very inconsistent, and could be complemented with genetic factors...
May 5, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29773512/increased-foot-strike-variability-in-parkinson-s-disease-patients-with-freezing-of-gait
#15
Jesal Shah, Lakshmi Pillai, David K Williams, Shannon M Doerhoff, Linda Larson-Prior, Edgar Garcia-Rill, Tuhin Virmani
INTRODUCTION: Freezing of gait (FOG) is a debilitating, late motor complication of Parkinson's disease (PD) that occurs in 50-80% of patients. Gait freezing significantly worsens quality of life by decreasing mobility and increasing falls. Studies have shown that patients with episodic freezing episodes also have deficits in continuous gait. We evaluated whether there was an objective gait correlate to the increased stumbling reported by many patients with gait freezing. METHODS: PD subjects and healthy controls (HC) were enrolled after IRB approval...
May 1, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29772521/myricetin-attenuates-neurodegeneration-and-cognitive-impairment-in-parkinsonism
#16
Vijayraja Dhanraj, Jeyaprakash Karuppaiah, Rengasamy Balakrishnan, Namasivayam Elangovan
Parkinson's disease (PD) is a progressive neurodegenerative disease due to dopaminergic neuron degeneration. It mostly affects the aged population, leads to memory decline and loss of motor coordination. The present study investigates the neuroprotective role of myricetin a flavonol isolated from the brown seaweed Turbinaria ornata in rotenone induced Drosophila model of PD. Rotenone administration led to dopaminergic neuronal degeneration, dopamine depletion, impaired muscular coordination, gait disturbances, memory decline oxidative stress and apoptosis...
June 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/29769626/the-cholinergic-contribution-to-the-resting-state-functional-network-in-non-demented-parkinson-s-disease
#17
Yoonju Lee, Jee Hyun Ham, Jungho Cha, Yeong-Hun Park, Jae Jung Lee, Mun Kyung Sunwoo, Jin Yong Hong, Young H Sohn, Jong-Min Lee, Phil Hyu Lee
The cholinergic system arising from the basal forebrain plays an important role in cognitive performance in Parkinson's disease (PD). Here, we analyzed cholinergic status-dependent cortical and subcortical resting-state functional connectivity in PD. A total of 61 drug-naïve PD patients were divided into tertiles based on normalized substantia innominata (SI) volumes. We compared the resting-state network from seed region of interest in the caudate, posterior cingulate cortex (PCC), and SI between the lowest (PD-L) and highest tertile (PD-H) groups...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769545/short-term-temporal-memory-in-idiopathic-and-parkin-associated-parkinson-s-disease
#18
Bertrand Degos, Ilhame Ameqrane, Sophie Rivaud-Péchoux, Pierre Pouget, Marcus Missal
In a rapidly changing environment, we often know when to do something before we have to do it. This preparation in the temporal domain is based on a 'perception' of elapsed time and short-term memory of previous stimulation in a similar context. These functions could be perturbed in Parkinson's disease. Therefore, we investigated their role in eye movement preparation in sporadic Parkinson's disease and in a very infrequent variant affecting the Parkin gene. We used a simple oculomotor task where subjects had to orient to a visual target and movement latency was measured...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768473/impaired-serial-ordering-in-nondemented-patients-with-mild-parkinson-s-disease
#19
Jinghong Ma, Shaoyang Ma, Haiqiang Zou, Yizhi Zhang, Piu Chan, Zheng Ye
The ability to arrange thoughts and actions in an appropriate serial order (the problem of serial order) is essential to complex behaviors such as language, reasoning and cognitive planning. Patients with Parkinson's disease (PD) perform poorly in tasks that rely on the successful rearrangement of working memory representations. We hypothesized that serial ordering is impaired in nondemented patients with mild PD. We recruited 49 patients with mild idiopathic PD (Hoehn and Yahr Scale 1-2.5) and 51 matched healthy adults...
2018: PloS One
https://www.readbyqxmd.com/read/29767379/individual-cognitive-change-after-dbs-surgery-in-parkinson-s-disease-patients-using-reliable-change-index-methodology
#20
Thomas Foki, Daniela Hitzl, Walter Pirker, Klaus Novak, Gisela Pusswald, Johann Lehrner
Long-term therapy of Parkinson's disease (PD) with levodopa (L-DOPA) is associated with a high risk of developing motor fluctuations and dyskinesia. Deep brain stimulation (DBS) in PD patients of the subthalamic nucleus can improve these motor complications. Although the positive effect on motor symptoms has been proven, postoperative cognitive decline has been documented. To tackle the impact of PD-DBS on cognition, 18 DBS patients were compared to 25 best medically treated Parkinson's patients, 24 Mild Cognitive Impairment (MCI) patients and 12 healthy controls using the Neuropsychological Test Battery Vienna-long (NTBV-long) for cognitive outcome 12 months after first examination...
May 16, 2018: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
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