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https://www.readbyqxmd.com/read/28735226/perinatal-fluoxetine-effects-on-social-play-the-hpa-system-and-hippocampal-plasticity-in-pre-adolescent-male-and-female-rats-interactions-with-pre-gestational-maternal-stress
#1
Mary Gemmel, Mariah Hazlett, Eszter Bögi, Sonsoles De Lacalle, Lesley A Hill, Nikolaos Kokras, Geoffrey L Hammond, Christina Dalla, Thierry D Charlier, Jodi L Pawluski
Selective serotonin reuptake inhibitor medications (SSRIs) are the first lines of treatment for maternal affective disorders, and are prescribed to up to 10% of pregnant women. Concern has been raised about how perinatal exposure to these medications affect offspring neurobehavioral outcomes, particularly those related to social interactions, as recent research has reported conflicting results related to autism spectrum disorder (ASD) risk in children prenatally exposed to SSRIs. Therefore, the aim of this work was to investigate the effects of perinatal exposure to the SSRI fluoxetine on social play behaviors and the hypothalamic pituitary adrenal system, using a model of pre-gestational maternal stress...
July 15, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28734351/capillary-electrophoresis-tandem-mass-spectrometry-as-a-highly-selective-tool-for-the-compositional-and-site-specific-assessment-of-multiple-peptide-deamidation
#2
Elena Dominguez-Vega, Thomas De Vijlder, Edwin P Romijn, Govert W Somsen
Site-specific mapping of multiple deamidations in peptides is a challenging analytical task. In this work, capillary electrophoresis-tandem mass spectrometry (CE-MS/MS) is presented as a high-resolution tool for the detailed characterization of these subtle modifications in peptides. The 4.5-kDa peptide drug TRI-1144, which contains five closely-positioned potential deamidation sites, was selected as model compound. TRI-1144 was exposed to acidic conditions and/or elevated temperatures for 1-14 h. Stressed samples were analyzed using a background electrolyte (BGE) of 150 mM ammonium formate (pH 6...
August 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28734133/physicians-self-reported-practice-behaviour-regarding-fertility-related-discussions-in-paediatric-oncology-in-sweden
#3
G M Armuand, J Nilsson, K A Rodriguez-Wallberg, J Malmros, J Arvidson, C Lampic, L Wettergren
OBJECTIVE: The aim of this study was to investigate practice behaviours of Swedish physicians with regard to discussing the impact of cancer treatment on fertility with paediatric oncology patients and their parents, and to identify factors associated with such discussions. METHODS: A cross-sectional survey study was conducted targeting all physicians in Sweden working in paediatric oncology care settings. Participants responded to a questionnaire measuring practice behaviour, attitudes, barriers, and confidence in knowledge...
July 22, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28733462/human-t-cell-immunosenescence-and-inflammation-in-aging
#4
REVIEW
Arsun Bektas, Shepherd H Schurman, Ranjan Sen, Luigi Ferrucci
The aging process is driven by a finite number of inter-related mechanisms that ultimately lead to the emergence of characteristic phenotypes, including increased susceptibility to multiple chronic diseases, disability, and death. New assays and analytical tools have become available that start to unravel some of these mechanisms. A prevailing view is that aging leads to an imbalance between stressors and stress-buffering mechanisms that causes loss of compensatory reserve and accumulation of unrepaired damage...
July 21, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28731073/-effect-of-stress-and-intesity-of-mobile-phone-using-on-the-health-and-subjective-symptoms-in-gsm-workers
#5
Agata Szyjkowska, Elżbieta Gadzicka, Wiesław Szymczak, Alicja Bortkiewicz
BACKGROUND: There are no available data on the health consequences that may result from the synergistic effects of electromagnetic fields (EMF) and stress. Understanding the mechanisms of the simultaneous exposure will make it possible to develop procedures to minimize adverse health effects in professionals using mobile phones. MATERIAL AND METHODS: A questionnaire survey was conducted in 600 randomly selected people to obtain data on their health status and the prevalence of subjective symptoms related to the mobile phones using...
July 12, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28730705/-those-who-care-much-understand-much-maternal-perceptions-of-children-s-appetite-perspectives-from-urban-and-rural-caregivers-of-diverse-parenting-experience-in-bangladesh
#6
Nurun Naila, Baitun Nahar, Monica Lazarus, Gaelen Ritter, Muttaquina Hossain, Mustafa Mahfuz, Tahmeed Ahmed, Donna Denno, Judd Walson, Scott Ickes
Appetite in children is an important determinant of nutritional intake and growth. The information used by caregivers to understand children's appetite can help inform infant and young child feeding promotion and appetite assessment. We conducted a qualitative study to (a) explore maternal perceptions and responses to children's appetite and (b) to identify how these factors differ by type of caregiver, level of maternal experience, and urban versus rural context. We used purposive sampling to recruit mothers and alternate caregivers into 14 total focus group discussions (six to eight participants in each group; N = 95) in both urban and rural settings in Bangladesh...
July 21, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28729870/plastid-nucleus-distance-alters-the-behavior-of-stromules
#7
Jessica L Erickson, Matthias Kantek, Martin H Schattat
Plastids send "retrograde" signals to the nucleus to deliver information regarding their physiological status. One open question concerning this signal transfer is how the signal bridges the cytoplasm. Based on individual reports of plastid derived tubular membrane extensions connecting to nuclei, these so-called stromules have been suggested to function as communication routes between plastids and nuclei in response to biotic stress. However, based on the data currently available it is unclear whether interactions between stromules and nuclei are truly intentional or observed as a result of an inflated stromule frequency throughout the cell, and are thus a random event...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28729651/combination-of-ginsenoside-rb1-and-rd-protects-the-retina-against-bright-light-induced-degeneration
#8
Minjuan Bian, Xiaoye Du, Peiwei Wang, Jingang Cui, Jing Xu, Jiangping Gu, Teng Zhang, Yu Chen
Photoreceptor degeneration is a central pathology of various retinal degenerative diseases which currently lack effective therapies. Antioxidant and anti-inflammatory activities are noted for Panax notoginsenoside saponins (PNS) and related saponin compound(s). However, the photoreceptor protective potentials of PNS or related saponin compound(s) remain unknown. The current study revealed that PNS protected against photoreceptor loss in bright light-exposed BALB/c mice. Combination of ginsenoside Rb1 and Rd, two major saponin compounds of PNS, recapitulated the retinal protection of PNS and attenuated retinal oxidative stress and inflammatory changes...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28728412/role-of-interfaces-in-the-elasticity-and-failure-of-clay-organic-nanocomposites-toughening-upon-interface-weakening
#9
Gyorgy Hantal, Laurent Brochard, Roland J-M Pellenq, Franz-Josef Ulm, Benoit Coasne
Synthetic organic-inorganic composites constitute a new class of engineering materials finding applications in an increasing range of fields. The interface between the constituting phases plays a pivotal role in the enhancement of mechanical properties. In exfoliated clay-organic nanocomposites, individual, high aspect ratio clay sheets are dispersed in the organic matrix providing large interfaces and hence efficient stress transfer. In this study, we aim at elucidating molecular-scale reinforcing mechanisms in a series of model clay-organic composite systems by means of reactive molecular simulations...
July 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28728063/factors-associated-with-non-return-to-work-in-the-severely-injured-victims-3-years-after-a-road-accident-a-prospective-study
#10
C Pélissier, E Fort, L Fontana, B Charbotel, M Hours
Road accidents may impact victims' physical and/or mental health and socio-occupational life, particularly the capacity to return to work. The purpose of our study is to assess modifiable medical and socio-occupational factors of non-return to work in the severely injured 3 years after a road accident. Among1,168 road accidents casualties in the Rhône administrative Département of France followed for five years, 141 of the 222 severely injured (Maximal Abbreviated Injury Scale ≥ 3) aged more than 16 years who were in work at the time of the accident, reported whether they had returned to work in the 3 years following the accident...
July 17, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28727992/how-does-emotional-exhaustion-influence-work-stress-relationships-between-stressor-appraisals-hedonic-tone-and-fatigue-in-nurses-daily-tasks-a-longitudinal-cohort-study
#11
Jordi Fernández-Castro, Fermín Martínez-Zaragoza, Tatiana Rovira, Silvia Edo, Ángel Solanes-Puchol, Beatriz Martín-Del-Río, Rosa García-Sierra, Gemma Benavides-Gil, Eduardo Doval
BACKGROUND: Work-related stress is a prevalent condition in the nursing profession, and its influence may vary according to changeable individual and situational factors. It is, therefore, important to investigate the real-time momentary changes in these factors and their relationship to emotional exhaustion experienced by nurses. OBJECTIVES: We aim to analyse how their perceptions of demand, control, effort and reward change according to the task performed through real-time assessment and interact with the emotional exhaustion level of ward nurses...
July 5, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28727115/the-microbiota-gut-brain-axis-as-a-key-regulator-of-neural-function-and-the-stress-response-implications-for-human-and-animal-health
#12
N C Wiley, T G Dinan, R P Ross, C Stanton, G Clarke, J F Cryan
The brain-gut-microbiota axis comprises an extensive communication network between the brain, the gut, and the microbiota residing there. Development of a diverse gut microbiota is vital for multiple features of behavior and physiology, as well as many fundamental aspects of brain structure and function. Appropriate early-life assembly of the gut microbiota is also believed to play a role in subsequent emotional and cognitive development. If the composition, diversity, or assembly of the gut microbiota is impaired, this impairment can have a negative impact on host health and lead to disorders such as obesity, diabetes, inflammatory diseases, and even potentially neuropsychiatric illnesses, including anxiety and depression...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726715/overexpression-of-the-osimp-gene-increases-the-accumulation-of-inositol-and-confers-enhanced-cold-tolerance-in-tobacco-through-modulation-of-the-antioxidant-enzymes-activities
#13
Rong-Xiang Zhang, Li-Jun Qin, De-Gang Zhao
Inositol is a cyclic polyol that is involved in various physiological processes, including signal transduction and stress adaptation in plants. l-myo-inositol monophosphatase (IMPase) is one of the metal-dependent phosphatase family members and catalyzes the last reaction step of biosynthesis of inositol. Although increased IMPase activity induced by abiotic stress has been reported in chickpea plants, the role and regulation of the IMP gene in rice (Oryza sativa L.) remains poorly understood. In the present work, we obtained a full-length cDNA sequence coding IMPase in the cold tolerant rice landraces in Gaogonggui, which is named as OsIMP...
July 20, 2017: Genes
https://www.readbyqxmd.com/read/28724592/vascular-development-in-very-young-conifer-seedlings-theoretical-hydraulic-capacities-and-potential-resistance-to-embolism
#14
Megan L Miller, Daniel M Johnson
PREMISE OF THE STUDY: Conifers have the highest rates of mortality during their first year, often attributed to water stress; yet, this tree life stage is the least studied in terms of hydraulic properties. Previous work has revealed correlations between xylem anatomy to both hydraulic transport capacity and resistance to hydraulic dysfunction. In this study, we compared xylem anatomical and plant functional traits of Pseudotsuga menziesii, Larix occidentalis, and Pinus ponderosa seedlings over the first 10 wk of growth to evaluate potential maximum hydraulic capabilities and resistance to drought-induced embolism...
July 19, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28721811/moving-to-the-rhythm-with-clock-circadian-genes-autophagy-mtor-and-sirt1-in-degenerative-disease-and-cancer
#15
Kenneth Maiese
BACKGROUND: The mammalian circadian clock and its associated clock genes are increasingly be recognized as critical components for a number of physiological and disease processes that extend beyond hormone release, thermal regulation, and sleep-wake cycles. New evidence suggests that clinical behavior disruptions that involve prolonged shift work and even space travel may negatively impact circadian rhythm and lead to multi-system disease. METHODS: In light of the significant role circadian rhythm can hold over the body's normal physiology as well as disease processes, we examined and discussed the impact circadian rhythm and clock genes hold over lifespan, neurodegenerative disorders, and tumorigenesis...
July 17, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28720029/the-effects-of-the-relaxation-response-on-nurses-level-of-anxiety-depression-well-being-work-related-stress-and-confidence-to-teach-patients
#16
Catherine Calder Calisi
PURPOSE: The purpose of this pilot study was threefold: to teach nurses the Relaxation Response ( RR), a relaxation technique created by Benson; to measure the effects of the RR on nurses' levels of anxiety, depression, well-being, and work-related stress; and to explore nurses' confidence in teaching their patients the RR. DESIGN: A wait-list, randomized-control quantitative study design was used. METHOD: Nurses in the intervention group were trained on the benefits and the technique of the RR and were then asked to practice the RR over an 8-week period...
July 1, 2017: Journal of Holistic Nursing: Official Journal of the American Holistic Nurses' Association
https://www.readbyqxmd.com/read/28718290/enhanced-long-term-and-thermal-stability-of-polymer-solar-cells-in-air-at-high-humidity-with-the-formation-of-unusual-quantum-dot-networks
#17
Long Tan, Fan Yang, Mee Rahn Kim, Pandeng Li, Deepak Thrithamarassery Gangadharan, Joelle Margot, Ricardo Izquierdo, Mohamed Chaker, Dongling Ma
Due to the practical applications of polymer solar cells (PSCs), their stability recently has received increasing attention. Herein, a new strategy was developed to largely enhance the long-term and thermal stability of PSCs in air with a relatively high humidity of 50-60% without any encapsulation. In this strategy, semiconductor PbS/CdS core/shell quantum dots (QDs) were incorporated into the photoactive blend of poly(3-hexylthiophene) (P3HT) and phenyl-C61-butyric acid methyl ester (PCBM). By replacing the initial ligands of oleic acid with halide ligands on the surface of PbS/CdS QDs via solution-phase-ligand-exchange, we were able to form unusual, continuous QD networks in the film of P3HT:PCBM, which effectively stabilized the photoactive layer...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28717750/fear-of-treatments-surpasses-demographic-and-socioeconomic-factors-in-affecting-patients-with-breast-cancer-in-urban-south-africa
#18
Sarah Rayne, Kathryn Schnippel, Cynthia Firnhaber, Kathryne Wright, Deirdre Kruger, Carol-Ann Benn
PURPOSE: Breast cancer is the most common cause of cancer in women in South Africa, and often patients present late. There is little understanding of the psychosocial stresses affecting women with breast cancer in Africa. METHODS: A questionnaire was distributed to 263 patients with breast cancer at two sites (one government and one private facility) in Johannesburg. Self-reported levels of fear were recorded on summative scales and their relationship to demographic variables assessed through univariable and multivariable modified Poisson regression...
April 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28716549/emotional-labour-and-aboriginal-maternal-infant-care-workers-the-invisible-load
#19
R Kirkham, A Rumbold, E Hoon, D Stuart-Butler, V Moore
BACKGROUND: The term 'emotional labour' has been used to describe the competing demands on midwives to empathize with clients whilst maintaining a level of professional detachment. Previous research indicates that when individuals experience difficulty managing these emotions, burnout may result. Aboriginal health care workers often have roles with large emotional demands, as they are relied upon heavily to engage clients in care. However, the concept of emotional labour has received little attention in relation to this group...
July 14, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28716466/chronic-low-back-pain-patients-walk-with-locally-altered-spinal-kinematics
#20
Guillaume Christe, François Kade, Brigitte M Jolles, Julien Favre
Various studies have reported alterations of spinal kinematics in patients with chronic low back pain (CLBP) during gait. However, while recent findings stressed the importance of multi-segment analysis, most of prior gait studies modelled the lumbar spine as one segment, when it was not the entire trunk that was considered as a single segment. Therefore, there is a need for comprehensive multi-segment research that could improve our understanding of CLBP pathomechanism and thus possibly contribute to better care for CLBP...
July 5, 2017: Journal of Biomechanics
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