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https://www.readbyqxmd.com/read/28463039/anti-ss-a-ro-antibody-positivity-as-a-risk-factor-for-relapse-in-patients-with-polymyositis-dermatomyositis
#1
Noriko Tatebe, Ken-Ei Sada, Yosuke Asano, Sonia Zeggar, Sumie Hiramatsu, Yoshia Miyawaki, Keiji Ohashi, Michiko Morishita, Takayuki Katsuyama, Eri Katsuyama, Haruki Watanabe, Mariko Narazaki, Katsue Watanabe, Tomoko Kawabata, Jun Wada
OBJECTIVE: The objective of this study is to elucidate predictors of relapse in patients with polymyositis and dermatomyositis (PM/DM). METHODS: Fifty PM/DM patients who achieved disease stabilization at Okayama University Hospital in 2004-2014 were enrolled retrospectively. Candidate predictors such as demographic factors, clinical symptoms, laboratory data, and treatment status were compared. RESULTS: The mean age of enrolled patients was 58 years; 34 were female...
May 2, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28413993/efficacy-of-sofosbuvir-plus-ribavirin-with-or-without-peginterferon-alfa-in-treatment-of-a-cohort-of-egyptian-patients-with-hepatitis-c-virus-infection
#2
Ossama Ashraf Ahmed, Hany Haroun Kaisar, Nehad Hawash, Hossam Samir, Sherif Sadek Taha Shabana, Mohamed Hassan Ahmed Fouad, Fatma Rizk, Sherief Abd-Elsalam
Background &Aims: Sofosbuvir is a powerful drug for treatment of hepatitis C virus (HCV) infection. In comparison to preceding remedies, sofosbuvir-based regimens provide a higher cure rate, fewer side effects, and much lower duration of treatment. The aim of the work was to assess the efficacy and safety of sofosbuvir plus ribavirin with or without peginterferon-alfa in treatment of a cohort of Egyptian patients with hepatitis C virus infection. METHODS: Two hundred treatment naive patients who were HCV-antibody positive and HCV RNA by PCR positive aged more than 18 years were enrolled in the study and patients were classified into two groups: Group I which included 100 patients who received dual therapy with sofosbuvir plus oral weight based ribavirin and Group II which included 100 patients triple therapy with sofosbuvir plus oral weight based ribavirin (as with the dual therapy) and a 180 mcg Peg-INF alpha 2a subcutaneous injection weekly for 12 weeks...
April 17, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28411110/impaired-wnt-signaling-and-the-spine-heterozygous-wnt1-mutation-causes-severe-age-related-spinal-pathology
#3
Riikka E Mäkitie, Tuukka Niinimäki, Miika T Nieminen, Camilla Schalin-Jäntti, Jaakko Niinimäki, Outi Mäkitie
BACKGROUND: WNT signaling plays a major role in bone and cartilage metabolism. Impaired WNT/β-catenin signaling leads to early-onset osteoporosis, but specific features in bone and other tissues remain inadequately characterized. We have identified two large Finnish families with early-onset osteoporosis due to a heterozygous WNT1 mutation c.652T>G, p.C218G. This study evaluated the impact of impaired WNT/β-catenin signaling on spinal structures. METHODS: Altogether 18 WNT1 mutation-positive (age range 11-76years, median 49years) and 14 mutation-negative subjects (10-77years, median 43years) underwent magnetic resonance imaging (MRI) of the spine...
April 11, 2017: Bone
https://www.readbyqxmd.com/read/28404528/alcohol-and-healthy-ageing-a-challenge-for-alcohol-policy
#4
D Nicholson, F McCormack, P Seaman, K Bell, T Duffy, M Gilhooly
OBJECTIVES: This paper presents findings of a qualitative study of older people's use of alcohol during retirement and identifies ways that an improved understanding of older people's drinking can inform policy approaches to alcohol and active and healthy ageing. STUDY DESIGN: Qualitative semi-structured interviews conducted with a self-selecting sample of retired people. METHODS: Participants were recruited from three geographical locations in the West of Scotland...
April 3, 2017: Public Health
https://www.readbyqxmd.com/read/28385571/aging-mobility-impairments-and-subjective-wellbeing
#5
Vicki A Freedman, Deborah Carr, Jennifer C Cornman, Richard E Lucas
BACKGROUND: Wellbeing is often described as U-shaped over the life course, suggesting an apparent paradox that wellbeing remains high at older ages despite increases in impairments. OBJECTIVE/HYPOTHESES: We explore associations among age, lower body impairments-one of the most common late-life impairments-and three measures of wellbeing: life satisfaction, emotional wellbeing and somatic wellbeing. We hypothesize that age effects are positive, become stronger once lower body impairments are controlled, and are concentrated among those who have maintained their mobility...
March 22, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28283491/factors-influencing-young-men-s-decision-to-undergo-health-screening-in-malaysia-a-qualitative-study
#6
Chin Hai Teo, Chirk Jenn Ng, Alan White
OBJECTIVES: Uptake of health screening is low in men, particularly among those aged <40 years. This study aimed to explore factors that influence health screening behaviour in younger men. DESIGN: This qualitative study employed an interpretive descriptive approach. Two trained researchers conducted in-depth interviews (IDIs) and focus group discussions (FGDs) using a semi-structured topic guide, which was developed based on literature review and behavioural theories...
March 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28277894/the-influence-of-comorbidities-on-the-aging-males-symptoms-scale-in-patients-with-erectile-dysfunction
#7
Jorge Panach-Navarrete, José María Martínez-Jabaloyas
OBJECTIVES: To investigate if certain common age-related comorbidities are related with a positive aging males' symptoms (AMS) test outcome. METHODS: This was a multicentric, transversal, observational study carried out in a male population with erectile dysfunction. Comorbidities and testosterone levels were registered. The relationship between comorbidities, testosterone levels, and the AMS test outcomes was studied using the global score and the sub-scale score components...
March 9, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28269108/human-static-postures-analysis-using-empirical-mode-decomposition
#8
Khaled Safi, Emilie Hutin, Samer Mohammed, Inke Marie Albertsen, Eric Delechelle, Yacine Amirat, Mohamad Khalil, Jean-Michel Gracies
The goal of this paper is to analyze the human stability during static postures using stabilometric signals. The effects of subject's visual input, feet position, age and gender are analyzed. Twenty eight healthy subjects have participated in this study. The center of pressure displacements were measured along the Medio-Lateral (ML) and Antero-Posterior (AP) directions. Empirical mode decomposition method is used to decompose the stabilometric signal into several elementary signals called Intrinsic Mode Functions (IMF)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227334/human-static-postures-analysis-using-empirical-mode-decomposition
#9
Khaled Safi, Emilie Hutin, Samer Mohammed, Inke Marie Albertsen, Eric Delechelle, Yacine Amirat, Mohamad Khalil, Jean-Michel Gracies, Khaled Safi, Emilie Hutin, Samer Mohammed, Inke Marie Albertsen, Eric Delechelle, Yacine Amirat, Mohamad Khalil, Jean-Michel Gracies, Eric Delechelle, Mohamad Khalil, Inke Marie Albertsen, Jean-Michel Gracies, Emilie Hutin, Khaled Safi, Yacine Amirat, Samer Mohammed
The goal of this paper is to analyze the human stability during static postures using stabilometric signals. The effects of subject's visual input, feet position, age and gender are analyzed. Twenty eight healthy subjects have participated in this study. The center of pressure displacements were measured along the Medio-Lateral (ML) and Antero-Posterior (AP) directions. Empirical mode decomposition method is used to decompose the stabilometric signal into several elementary signals called Intrinsic Mode Functions (IMF)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222807/validation-of-the-aging-perceptions-questionnaire-short-on-a-sample-of-community-dwelling-turkish-elderly-migrants
#10
Anne Slotman, Jane M Cramm, Anna P Nieboer
BACKGROUND: Aging perceptions have been found to be major contributors to health in old age. To quantitatively explore aging perceptions among elderly Turkish migrants, valid and reliable Turkish-language instruments are needed. The objective of the current study was to examine the construct validity and reliability of the Turkish-language version of the seven-dimension Aging Perceptions Questionnaire Short version (APQ-S) in a sample of community-dwelling elderly Turkish migrants in the Netherlands...
February 21, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28219631/condyle-excursion-angle-articular-eminence-inclination-and-temporomandibular-joint-morphologic-relations-with-disc-displacement
#11
Katharina Alves Rabelo, Saulo Leonardo Sousa Melo, Marianna Guanaes Gomes Torres, Paulo Sérgio F Campos, Patrícia Meira Bento, Daniela Pita de Melo
PURPOSE: The aim of this study was to evaluate the relations of the condyle excursion angle (CEA) and the morphology and morphometry of the articular eminence to disc displacement (DD) using magnetic resonance imaging (MRI) of symptomatic patients. MATERIALS AND METHODS: MRIs of 199 temporomandibular joints (TMJs) were evaluated. Qualitative and quantitative morphologic analyses were performed with tools available in PACS 11.0 (Carestream Health, Inc, Rochester, NY)...
January 29, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28176883/association-of-body-mass-index-with-the-tuberculosis-infection-a-population-based-study-among-17796-adults-in-rural-china
#12
Haoran Zhang, Xiangwei Li, Henan Xin, Hengjing Li, Mufei Li, Wei Lu, Liqiong Bai, Xinhua Wang, Jianmin Liu, Qi Jin, Lei Gao
Body mass index (BMI) has been shown to be associated with host susceptibility to several infections. However, the link between BMI and the risk of tuberculosis (TB) infection has been sparsely studied in China and in worldwide. Based on the baseline survey of a population-based, prospective study in rural China, the association between BMI and TB infection among adults was estimated by means of cross-sectional analysis. TB infection status was tested using QuantiFERON-TB Gold In-Tube (QFT), a commercial of interferon-γ release assay (IGRA)...
February 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28149209/performance-outcomes-after-metacarpal-fractures-in-national-basketball-association-players
#13
Michael S Guss, John P Begly, Austin J Ramme, Richard M Hinds, Raj J Karia, John T Capo
Background: The aim was to determine whether players in the National Basketball Association (NBA) who sustain metacarpal fractures demonstrate decreased performance upon return to competition when compared with their performance before injury and that of their control-matched peers. Methods: Data for 32 NBA players with metacarpal fractures incurred over 11 seasons (2002-2003 to 2012-2013) were obtained from injury reports, press releases, and player profiles (www.nba.com and www.basketballreference.com). Player age, body mass index (BMI), position, shooting hand, number of years in the league, and treatment (surgical vs nonsurgical) were recorded...
December 2016: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28127562/declining-physical-performance-associates-with-serum-fasl-mir-21-and-mir-146a-in-aging-sprinters
#14
Reeta Kangas, Timo Törmäkangas, Ari Heinonen, Markku Alen, Harri Suominen, Vuokko Kovanen, Eija K Laakkonen, Marko T Korhonen
Aging is associated with systemic inflammation and cellular apoptosis accelerating physiological dysfunctions. Whether physically active way of life affects these associations is unclear. This study measured the levels of serum inflammatory and apoptotic molecules, their change over 10 years, and their associations with physical performance in sprint-trained male athletes. HsCRP, cell counts, HGB, FasL, miR-21, and miR-146a were measured cross-sectionally (n = 67, 18-90 yrs) and serum FasL, miR-21, and miR-146a and their aging-related associations with physical performance were assessed over a 10-year follow-up (n = 49, 50-90 yrs)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28102544/nursing-perceptions-of-patient-safety-climate-in-the-gaza-strip-palestine
#15
A Elsous, A Akbari Sari, Y AlJeesh, M Radwan
AIMS: This study was undertaken to assess the perception of nurses about patient safety culture and to test whether it is significantly affected by the nurses' position, age, experience and working hours. BACKGROUND: Patient safety has sparked the interest of healthcare mangers, yet there is limited knowledge about the current patient safety culture among nurses in the Gaza Strip. METHODS: This was a descriptive cross-sectional study, administering the Arabic Safety Attitude Questionnaire (Short Form 2006) to 210 nurses in four public general hospitals...
January 19, 2017: International Nursing Review
https://www.readbyqxmd.com/read/28101309/patients-with-haemoglobinopathies-and-chronic-hepatitis-c-a-real-difficult-to-treat-population-in-2016
#16
Kalliopi Zachou, Pinelopi Arvaniti, Nikolaos K Gatselis, Kalliopi Azariadis, Georgia Papadamou, Eirini Rigopoulou, George N Dalekos
BACKGROUND & OBJECTIVES: In the past, patients with haemoglobinopathies were at high risk of acquiring hepatitis C virus (HCV) due to multiple transfusions before HCV screening. In these patients, the coexistence of haemochromatosis and chronic hepatitis C (CHC) often leads to more severe liver disease. We assessed the HCV prevalence, clinical characteristics and outcome in this setting with particular attention to the response to treatment including therapies with the new direct acting antivirals (DAAs)...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28077346/the-use-of-motion-based-technology-for-people-living-with-dementia-or-mild-cognitive-impairment-a-literature-review
#17
REVIEW
Erica Dove, Arlene J Astell
BACKGROUND: The number of people living with dementia and mild cognitive impairment (MCI) is increasing substantially. Although there are many research efforts directed toward the prevention and treatment of dementia and MCI, it is also important to learn more about supporting people to live well with dementia or MCI through cognitive, physical, and leisure means. While past research suggests that technology can be used to support positive aging for people with dementia or MCI, the use of motion-based technology has not been thoroughly explored with this population...
January 11, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28067612/is-there-a-paradox-of-aging-when-the-negative-aging-stereotype-meets-the-positivity-effect-in-older-adults
#18
Liqing Zhou, Jia Lu, Guopeng Chen, Li Dong, Yujia Yao
Background/Study Context: Socioemotional selectivity theory (SST) states that the positivity effect is a result of older adults' emotion regulation and that older adults derive more emotional satisfaction from prioritizing positive information processing. The authors explored whether the positivity effect appeared when the negative aging stereotype was activated in older adults and also whether the effect differed between mixed and unmixed valence conditions. METHODS: Sixty younger (18-23 years of age) and 60 older (60-87 years of age) adults were randomly assigned to a control group and a priming group, in which the negative aging stereotype was activated...
January 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28060953/what-do-men-want-from-a-health-screening-mobile-app-a-qualitative-study
#19
Chin Hai Teo, Chirk Jenn Ng, Alan White
There is a lack of mobile app which aims to improve health screening uptake developed for men. As part of the study to develop an effective mobile app to increase health screening uptake in men, we conducted a needs assessment to find out what do men want from a health screening mobile app. In-depth interviews and focus group discussions were conducted with 31 men from a banking institution in Kuala Lumpur. The participants were purposely sampled according to their job position, age, ethnicity and screening status...
2017: PloS One
https://www.readbyqxmd.com/read/28044003/fear-of-crime-in-old-age-a-sample-case-of-resilience
#20
Werner Greve, Bernhard Leipold, Cathleen Kappes
OBJECTIVES: Research on fear of crime (FOC) in adulthood has often shown a positive age relation, whereas the risk of criminal victimization decreases with age. The present study distinguishes three dimensions of FOC (affective, cognitive, and behavioral component) and attempts to investigate possible explanations for differential age correlations by referring to processes of adaptation and resilience. In particular, the functionality of FOC and its impact on the individual's well-being is assumed to be influenced by the individual's capacity to accommodate to adverse circumstances...
January 2, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
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