Yuhao Chen, Tiantian Zhao, Zhuang Miao, Tianguang Huang, Meiyuan Chen, Yi Zhao, Ao Hai, Qingrong Qi, Ping Feng, Minyong Li, Bowen Ke
Carboxylesterase (CES), a main hydrolysis enzyme family in the human body, plays a crucial role in drug metabolism. Among them, CES1 and CES2 are the primary subtypes, and each exhibits distinct distribution and functions. However, convenient and non-invasive methods for distinguishing them and the real-time monitoring of CES2 are relatively rare, hindering the further understanding of physiological functions and underlying mechanisms. In this study, we have designed, synthesized, and evaluated the first selective bioluminescent probe (CBP 1) for CES2 with high sensitivity, high specificity and rapid reactivity...
December 11, 2023: Analyst