keyword
MENU ▼
Read by QxMD icon Read
search

pneumonia antibiotic adult

keyword
https://www.readbyqxmd.com/read/29149338/multiplex-respiratory-virus-testing-for-antimicrobial-stewardship-a-prospective-assessment-of-antimicrobial-use-and-clinical-outcomes-among-hospitalized-adults
#1
Makeda Semret, Ian Schiller, Barbara Ann Jardin, Charles Frenette, Vivian G Loo, Jesse Papenburg, Shelly A McNeil, Nandini Dendukuri
Background: Respiratory tract infections are frequent causes of hospitalization and initiation of empirical antimicrobial therapy. Testing for a broad panel of respiratory viruses has been advocated as a useful tool for antibiotic stewardship. We conducted a prospective observational study to assess the impact of rapid viral test results on antimicrobial prescriptions and clinical outcomes among hospitalized adults. Methods: Eight hundred patients admitted with respiratory symptoms were tested by a 12-virus respiratory panel (RVP) during 3 consecutive winters in Montreal, Canada...
November 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29149019/incidence-and-consequences-of-near-drowning-related-pneumonia-a-descriptive-series-from-martinique-french-west-indies
#2
Laura Cerland, Bruno Mégarbane, Hatem Kallel, Yanick Brouste, Hossein Mehdaoui, Dabor Resiere
Drowning represents one major cause of accidental death. Near-drowning patients are exposed to aspiration that may result in pneumonia with life-threatening consequences. We designed this descriptive study to investigate the frequency, nature, and consequences of post-drowning pneumonia. One hundred and forty-four near-drowning patients (33 children and 111 adults) admitted during four years to the University Hospital of Martinique, French Indies, were included. Patients presented pre-hospital cardiac arrest (41%) and exhibited acute respiratory failure (54%), cardiovascular failure (27%), and lactic acidosis (75%) on admission...
November 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29138886/clinical-predictors-of-stenotrophomonas-maltophilia-bacteremia-in-adult-patients-with-hematologic-malignancy
#3
Si-Ho Kim, Sun Young Cho, Cheol-In Kang, Hyeri Seok, Kyungmin Huh, Young Eun Ha, Doo Ryeon Chung, Nam Yong Lee, Kyong Ran Peck, Jae-Hoon Song
Stenotrophomonas maltophilia (SM) has emerged as an important nosocomial pathogen with high morbidity and mortality. Because of its unique antimicrobial susceptibility pattern, appropriate antimicrobial therapy for SM bacteremia is still challenging, especially in immunocompromised patients. The present study was performed to assess clinical predictors of SM bacteremia in adult patients with hematologic malignancy. From 2006 through 2016, a case-control study was performed at a tertiary-care hospital. Case patients were defined as SM bacteremia in patients with hematologic malignancy...
November 14, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29126268/duration-of-antibiotic-use-among-adults-with-uncomplicated-community-acquired-pneumonia-requiring-hospitalization-in-the-united-states
#4
Sarah H Yi, Kelly M Hatfield, James Baggs, Lauri A Hicks, Arjun Srinivasan, Sujan Reddy, John A Jernigan
Background: Previous studies suggest duration of antibiotic therapy for community-acquired pneumonia (CAP) often exceeds national recommendations and might represent an important opportunity to improve antibiotic stewardship nationally. The objective of this study was to determine average length of antibiotic therapy (LOT) for patients treated for uncomplicated CAP in US hospitals and proportion of patients with excessive durations. Methods: Records of retrospective cohorts of patients 18-64 years with private insurance and ≥65 years with Medicare hospitalized for CAP in 2012-13 were utilized...
November 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29117669/late-diagnosis-of-influenza-in-adult-patients-during-a-seasonal-outbreak
#5
Seong-Ho Choi, Jin-Won Chung, Tark Kim, Ki-Ho Park, Mi Suk Lee, Yee Gyung Kwak
Background/Aims: Due to advances in diagnostic techniques, clinicians are more frequently performing influenza diagnostic tests and referring to their test results ahead of the administration of neuraminidase inhibitors (NAIs). To investigate the clinical significance of the time from symptom onset to laboratory diagnosis, we reviewed the clinical characteristics of adult patients with influenza who had an early laboratory diagnosis (ED) or a late laboratory diagnosis (LD) at one of four tertiary care centers during a seasonal outbreak of influenza...
November 10, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29111412/serotype-distribution-and-antibiotic-susceptibility-of-streptococcus-pneumoniae-strains-in-the-south-of-tunisia-a-five-year-study-2012-2016-of-pediatric-and-adult-populations
#6
Sonia Ktari, Ikram Jmal, Manel Mroua, Sonda Maalej, Nour El Houda Ben Ayed, Basma Mnif, Faouzia Rhimi, Adnene Hammami
OBJECTIVES: To analyze the serotype distribution of S. pneumoniae clinical isolates collected in the South of Tunisia over a 5-year period in different age groups and assess their antimicrobial susceptibility pattern. METHODS: A total of 305 non duplicate S. pneumoniae isolates were collected from January 2012 to December 2016 at University Hospital of Sfax,Tunisia. All isolates were serotyped by multiplex polymerase chain reaction. Antibiotic susceptibility of all isolates was determined using the disk diffusion or E-test assays...
October 27, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29108950/amoxicillin-for-acute-lower-respiratory-tract-infection-in-primary-care-subgroup-analysis-by-bacterial-and-viral-etiology
#7
Robin Bruyndonckx, Beth Stuart, Paul Little, Niel Hens, Margareta Ieven, Christopher C Butler, Theo Verheij, Herman Goossens, Samuel Coenen
OBJECTIVE: We aimed to assess the effects of amoxicillin treatment in adult patients presenting to primary care with a lower respiratory tract infection (LRTI) who are infected with a potential bacterial, viral, or mixed bacterial/viral infection. METHODS: The multicenter randomized controlled trial focused on adults with LRTI not suspected for pneumonia. Patients were randomized to receive either antibiotic (amoxicillin 1g) or placebo three times daily for seven consecutive days using computer-generated random numbers (follow-up 28 days)...
November 3, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29108947/antibiotic-strategies-and-clinical-outcomes-in-critically-ill-patients-with-pneumonia-caused-by-carbapenem-resistant-acinetobacter-baumannii
#8
Chun-An Liang, Ying-Chi Lin, Po-Liang Lu, Huang-Chi Chen, Hsu-Liang Chang, Chau-Chyun Sheu
OBJECTIVES: This study aimed to investigate antibiotic prescribing patterns and effectiveness of different anti-carbapenem-resistant Acinetobacter baumannii (CRAB) strategies for CRAB pneumonia. METHODS: We conducted a multicenter, retrospective study in three hospitals. During 2010-2015, adult ICU patients with CRAB pneumonia treated with at least one antimicrobial agent covering the CRAB isolate in vitro for more than two days were included. We used multivariate logistic regression to analyze the associations of anti-CRAB strategies with ICU mortality and other clinical outcomes...
November 3, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29096171/considerations-for-effect-site-pharmacokinetics-to-estimate-drug-exposure-concentrations-of-antibiotics-in-the-lung
#9
REVIEW
Keith A Rodvold, William W Hope, Sara E Boyd
Bronchoalveolar lavage (BAL) and microdialysis have become the most reliable and relevant methods for measuring lung concentrations of antibiotics, with the majority of BAL studies involving either healthy adult subjects or patients undergoing diagnostic bronchoscopy. Emphasis on the amount of drug that reaches the site of infection is increasingly recognized as necessary to determine whether a dose selection will translate to good clinical outcomes in the treatment of patients with pneumonia. Observed concentrations and/or parameters of exposure (e...
October 30, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29096010/macrolides-in-children-with-community-acquired-pneumonia-panacea-or-placebo
#10
Christopher C Blyth, Jeffrey S Gerber
Pneumonia, most often caused by a respiratory virus, is common in childhood. Mycoplasma pneumoniae also is detected frequently, particularly in older children in the era of pneumococcal conjugate vaccination. Despite recommendations for β-lactam antibiotics, macrolide antibiotics, including erythromycin, clarithromycin, and azithromycin, are prescribed frequently to children with acute lower respiratory infection. However, the significance of detecting "atypical" pathogens, including M pneumoniae, in children remains contentious...
October 31, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29093233/optimal-amikacin-levels-for-patients-with-sepsis-in-intensive-care-unit-of-cipto-mangunkusumo-hospital-jakarta-indonesia
#11
Gestina Aliska, Rianto Setiabudy, Purwantyastuti Purwantyastuti, Anis Karuniawati, Rudyanto Sedono, Trisni U Dewi, Muhammad K Azwar
BACKGROUND: Amikacin is one of the antibiotics of choice for sepsis and septic shock. Pharmacokinetic of amikacin can be influenced by septic condition with subsequent effect on its pharmacodynamic. At Cipto Mangunkusumo Hospital (RSCM), Jakarta, adult patients in the ICU were given standard amikacin dose of 1 g/day, however the achievement of optimal plasma level had never been evaluated. This study aimed to evaluate whether the optimal plasma level of amikacin was achieved with the use of standard dose in septic conditions...
July 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29077003/antibiotic-prescribing-for-uncomplicated-acute-bronchitis-is-highest-in-younger-adults
#12
Larissa Grigoryan, Roger Zoorob, Jesal Shah, Haijun Wang, Monisha Arya, Barbara W Trautner
Reducing inappropriate antibiotic prescribing is currently a global health priority. Current guidelines recommend against antibiotic treatment for acute uncomplicated bronchitis. We studied antibiotic prescribing patterns for uncomplicated acute bronchitis and identified predictors of inappropriate antibiotic prescribing. We used the Epic Clarity database (electronic medical record system) to identify all adult patients with acute bronchitis in family medicine clinics from 2011 to 2016. We excluded factors that could justify antibiotic use, such as suspected pneumonia, COPD or immunocompromising conditions...
October 27, 2017: Antibiotics
https://www.readbyqxmd.com/read/29068158/development-of-an-adult-physiologically-based-pharmacokinetic-model-of-solithromycin-in-plasma-and-epithelial-lining-fluid
#13
Sara N Salerno, Andrea Edginton, Michael Cohen-Wolkowiez, Christoph P Hornik, Kevin M Watt, Brian D Jamieson, Daniel Gonzalez
Solithromycin is a fluoroketolide antibiotic under investigation for community-acquired bacterial pneumonia (CABP). We developed a whole-body physiologically based pharmacokinetic (PBPK) model for solithromycin in adults using PK-Sim and MoBi version 6.2, which incorporated time-dependent CYP3A4 auto-inhibition. The model was developed and evaluated using plasma and epithelial lining fluid (ELF) concentration data from 100 healthy subjects and 22 patients with CABP (1,966 plasma, 30 ELF samples). We performed population simulations and calculated the number of observations falling outside the 90% prediction interval...
October 25, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/29043150/community-acquired-pneumonia-in-the-united-kingdom-a-call-to-action
#14
EDITORIAL
James Chalmers, James Campling, Gillian Ellsbury, Peter M Hawkey, Harish Madhava, Mary Slack
Pneumococcal disease has a high burden in adults in the United Kingdom (UK); however, the total burden is underestimated, principally because most cases of community-acquired pneumonia (CAP) are non-invasive. Research into pneumonia receives poor funding relative to its disease burden (global mortality, disability-adjusted life years, and years lived with disability), ranking just 20 out of 25 for investment in infectious diseases in the UK. The current accuracy of data for establishing incidence rates is questionable, and it is a reflection of the paucity of research that much of the background information available derives from nearly 30 years ago...
2017: Pneumonia
https://www.readbyqxmd.com/read/29028977/evolving-understanding-of-the-causes-of-pneumonia-in-adults-with-special-attention-to-the-role-of-pneumococcus
#15
Daniel M Musher, Michael S Abers, John G Bartlett
Before 1945, Streptococcus pneumoniae caused more than 90% of cases of pneumonia in adults. After 1950, the proportion of pneumonia caused by pneumococcus began to decline. Pneumococcus has continued to decline; at present, this organism is identified in fewer than fewer10%-15% of cases. This proportion is higher in Europe, a finding likely related to differences in vaccination practices and smoking. Gram-negative bacilli, Staphylococcus aureus, Chlamydia, Mycoplasma, and Legionella are each identified in 2%-5% of patients with pneumonia who require hospitalization...
September 27, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29025364/pharmacokinetic-pharmacodynamic-parameters-for-treatment-optimization-of-infection-due-to-antibiotic-resistant-bacteria-a-summary-for-practical-purposes-in-children-and-adults
#16
Giulia Gustinetti, Giuliana Cangemi, Roberto Bandettini, Elio Castagnola
In the last years, there has been a tremendous increase in the incidence of bacterial infections due to resistant strains, especially multi-drug resistant Gram-negative bacilli. In Europe, a north to south and a west to east gradient was noticed, with more than one third of the K. pneumonia isolates being resistant to carbapenems in few countries. New antibiotics are lacking and, as a consequence, pharmacokinetic/pharmacodynamic parameters, normalized to pathogen minimal inhibitory concentration, are used with increased frequency to treat infections due to difficult-to-treat pathogens...
October 13, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28982676/prediction-score-for-anticoagulation-control-quality-among-older-adults
#17
REVIEW
Kueiyu Joshua Lin, Daniel E Singer, Robert J Glynn, Suzanne Blackley, Li Zhou, Jun Liu, Gina Dube, Lynn B Oertel, Sebastian Schneeweiss
BACKGROUND: Time in the therapeutic range (TTR) is associated with the effectiveness and safety of vitamin K antagonist (VKA) therapy. To optimize prescribing of VKA, we aimed to develop and validate a prediction model for TTR in older adults taking VKA for nonvalvular atrial fibrillation and venous thromboembolism. METHODS AND RESULTS: The study cohort comprised patients aged ≥65 years who were taking VKA for atrial fibrillation or venous thromboembolism and who were identified in the 2 US electronic health record databases linked with Medicare claims data from 2007 through 2014...
October 5, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28981235/-lower-respiratory-tract-infections-in-immunocompetent-adult
#18
F Jacobs
Lower respiratory tract infections represent one of the main causes of mortality in the world. They essentially consist of bronchitis, acute exacerbations of chronic obstructive bronchopulmonary diseases (COPD) and acute pneumonia. If acute bronchitis is mainly of viral origin, acute exacerbations of COPD and pneumonia are mainly due to a trio of bacteria (Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis). Other pathogens as many viruses and atypical bacteria such as Mycoplasma pneumoniae, Legionella, some Enterobacteriaceae and very rarely Pseudomonas aeruginosa are also implicated...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28970157/initial-empiric-antibiotic-therapy-for-community-acquired-pneumonia-in-chinese-hospitals
#19
Xiaomeng Nie, Yesheng Li, Zhangwei Yang, Hui Wang, Sanyong Jin, Yang Jiao, Mark L Metersky, Yi Huang
OBJECTIVES: Studies on treatment of community-acquired pneumonia (CAP) in China are very scarce. This study was performed to investigate empirical antibiotic practices for patients hospitalized with CAP in China and the risk factors for treatment failure. METHODS: Data was collected from a national Chinese hospitalization database. Adult patients who were diagnosed as CAP between October 1st, 2014, and September 30th, 2015 were identified. We studied initial empiric antibiotic regimens, microbiologic sampling, treatment failure, in hospital mortality, and length of hospital stay (LOS)...
September 29, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28968012/-antimicrobial-susceptibility-profile-in-urinary-pathogens-causing-community-acquired-infections-in-diabetic-patients-in-colombia
#20
Laura Cristina Nocua-Báez, Jorge Alberto Cortés, Aura Lucía Leal, Gerson Fitzgerald Arias, María Victoria Ovalle-Guerro, Sandra Yamile Saavedra-Rojas, Giancarlo Buitrago, Javier Antonio Escobar-Pérez, Betsy Castro-Cardozo
INTRODUCTION: Urinary tract infection is the most common pathology in diabetic patients, and an important determinant of morbidity and mortality among them. The increasing resistance of uropathogens acquired in the community to commonly used antibiotics is alarming. OBJECTIVE: To identify the profile of antibiotic susceptibility of uropathogens responsible for communityacquired infections among diabetic patients in hospitals in Colombia. MATERIALS AND METHODS: We conducted a descriptive study in a subgroup of diabetic patients in the framework of a larger study in adults with urinary tract infection acquired in the community...
September 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
keyword
keyword
120987
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"