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Hand-foot-mouth disease

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https://www.readbyqxmd.com/read/29029128/evolution-and-spatio-temporal-dynamics-of-enterovirus-a71-subgenogroups-in-vietnam
#1
Nguyen Thi Thanh Thao, Celeste Donato, Vu Thi Huyen Trang, Nguyen Trung Kien, Ph M Mai Thuy Trang, Tran Quoc Khanh, Dang Thi Nguyet, October Sessions, Hoang Quoc Cuong, Phan Trong Lan, Vu Thi Que Huong, H Rogier van Doorn, Vijaykrishna Dhanasekaran
Background: Enterovirus A71 (EV-A71) is the major cause of severe hand, foot and mouth disease and viral encephalitis in children across the Asia-Pacific region, including in Vietnam which has experienced a high burden of disease in recent years. Multiple subgenogroups (C1, C4, C5 and B5) concurrently circulate in the region with a large variation in epidemic severity. The relative differences in their evolution and epidemiology were examined within Vietnam and globally. Methods: A total of 752 VP1 gene sequences were analysed (413 generated in this study combined with 339 obtained from GenBank), collected from patients in 36 provinces in Vietnam during 2003-2013 along with epidemiological metadata...
September 23, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29028076/intestinal-probiotics-in-relieving-clinical-symptoms-of-severe-hand-foot-and-mouth-disease-and-potential-mechanism-analysis
#2
F Zhu, Z Jiang, H-W Li
OBJECTIVE: In this prospective cohort study, the efficacy and action mechanism of an intestinal probiotic formulation, Golden Bifid, in severe hand, foot, and mouth disease (HFMD) were determined in 63 consecutively admitted patients successfully treated in the Pediatrics Emergency Department of our hospital. PATIENTS AND METHODS: All patients had a persistent fever; 43 patients had rashes on hands, feet, crissum, and hips; and 45 patients had neurological signs and symptoms...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29024766/protective-effect-of-an-alpha-7-nicotinic-acetylcholine-receptor-agonist-against-enterovirus-71-infection-in-neuronal-cells
#3
FengXia Song, LinQin Zhao, RuNan Zhu, QinWei Song, Jie Deng, Run Tian, Fang Wang, Yuan Qian
Enterovirus 71, as one of the dominant pathogens associated with severe hand, foot, and mouth disease, has been well reported to trigger severe neurological symptoms among young children over the last decade, particularly among children in the Asia-Pacific region. To date, no effective antiviral agent has been developed for the treatment of severe enterovirus 71 infection. PNU-282987, a selective alpha 7 nicotinic acetylcholine receptor (α7nAChR) agonist, has been reported to have a neuroprotective effect by participating in inflammatory regulation in previous studies...
October 9, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28993196/long-non-coding-rna-expression-profiles-in-different-severity-ev71-infected-hand-foot-and-mouth-disease-patients
#4
Jun Meng, Zhenyu Yao, Yaqing He, Renli Zhang, Hong Yang, Xiangjie Yao, Long Chen, Hailong Zhang, Jinquan Cheng
Enterovirus 71 (EV71) is associated with the severe hand foot and mouth disease (HFMD) outcomes, however the host-virus interaction mechanism and the pathogenesis remain poorly understood. Long non-coding RNAs (lncRNAs) are involved in variety physiological and pathological processes, but the functions of lncRNAs in EV71 infection remain elusive. Here we profiled the expression of lncRNAs in peripheral blood mononuclear cells (PBMCs) from EV71-infected mild patients, severe patients as well as the healthy controls, and identified 8541 lncRNAs were differentially expressed...
October 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28988169/predicting-the-hand-foot-and-mouth-disease-incidence-using-search-engine-query-data-and-climate-variables-an-ecological-study-in-guangdong-china
#5
Zhicheng Du, Lin Xu, Wangjian Zhang, Dingmei Zhang, Shicheng Yu, Yuantao Hao
OBJECTIVES: Hand, foot, and mouth disease (HFMD) has caused a substantial burden in China, especially in Guangdong Province. Based on the enhanced surveillance system, we aimed to explore whether the addition of temperate and search engine query data improves the risk prediction of HFMD. DESIGN: Ecological study. SETTING AND PARTICIPANTS: Information on the confirmed cases of HFMD, climate parameters and search engine query logs was collected...
October 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28982663/hand-foot-mouth-disease-mimicking-diaper-dermatitis
#6
Iria Neri, Andrea Sechi, Miriam Leuzzi, Marco Adriano Chessa, Annalucia Virdi, Annalisa Patrizi
No abstract text is available yet for this article.
October 5, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28979010/hand-foot-and-mouth-disease-in-west-bengal-india-a-preliminary-report-on-clinicovirological-trend-over-3-successive-years-2013-2015
#7
Nilendu Sarma, Sayantani Chakraborty, Abira Dutta, Provash Chandra Sadhukhan
INTRODUCTION: Hand, foot, and mouth disease (HFMD), an enteroviral disease has emerged as a major emerging infection in India. This is caused most commonly by enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) but can also be due to CVA4-10, CVA24, CVB2-5, and echovirus 18 (Echo18). Virological analysis of the cases of HFMD has been infrequently done in India. West Bengal is one of the worst affected states in India. OBJECTIVE: To document the clinical and etiological aspect, the changing patterns and clinic-virological correlation...
September 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28970483/epitope-associated-and-specificity-focused-features-of-ev71-neutralizing-antibody-repertoires-from-plasmablasts-of-infected-children
#8
Kuan-Ying Arthur Huang, Mei-Feng Chen, Yhu-Chering Huang, Shin-Ru Shih, Cheng-Hsun Chiu, Jainn-Jim Lin, Jen-Ren Wang, Kuo-Chien Tsao, Tzou-Yien Lin
Protective antibody levels are critical for protection from severe enterovirus 71 infection. However, little is known about the specificities and functional properties of the enterovirus 71-specific antibodies induced by natural infection in humans. Here we characterize 191 plasmablast-derived monoclonal antibodies from three enterovirus 71-infected children, each of whom shows a distinct serological response. Of the 84 enterovirus 71-specific antibodies, neutralizing antibodies that target the rims and floor of the capsid canyon exhibit broad and potent activities at the nanogram level against viruses isolated in 1998-2016...
October 2, 2017: Nature Communications
https://www.readbyqxmd.com/read/28970089/risk-factors-of-neurogenic-pulmonary-edema-in-patients-with-severe-hand-foot-mouth-diseases-a-meta-analysis
#9
Lijun Peng, Ruping Luo, Zhisheng Jiang
BACKGROUND: To investigate the risk factors of neurogenic pulmonary edema (NPE) on patients with severe hand-foot-mouth disease (HFMD) and to provide evidence for prevention and treatment of NPE. METHODS: Several databases (from inception to 2017) were searched to identify case-control studies on risk factors of NPE among severe HFMD patients. Data were analyzed via meta-analysis. We calculated combined odds ratio (OR) and 95% confidence interval (CI) using fixed models and random models, and performed sensitivity analysis and publication bias evaluation...
September 29, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28962547/b-type-brain-natriuretic-peptide-as-a-measure-of-the-severity-of-hand-foot-mouth-disease-a-case-control-study
#10
AYuan Zhang, Lin Yang, Pengfei Guo, Shaojun Li, Xiaoxiao Ao, Feng Xu, Liping Tan
BACKGROUND: Hand-foot-mouth disease (HFMD) is an acute infectious disease caused by enteroviruses, and HFMD complicated by cardiopulmonary failure has a high mortality. B type natriuretic peptide (BNP) is widely applied in monitoring cardiovascular disorders, and thus, we investigated whether this index was associated with the severity of HFMD and the outcome in severe HFMD. METHODS: Serum BNP, lactate, and glucose levels as well as white blood cell (WBC) count, PaO2/FiO2, and cardiac output (CO) were analyzed in the 83 enrolled HFMD patients according to different conditions (common, severe, and critical; with and without complication; and survivors and non-survivors)...
September 29, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28956547/acute-localized-exanthem-due-to-coxsackievirus-a4
#11
Francesco Drago, Giulia Ciccarese, Lodovica Gariazzo, Margherita Cioni, Aurora Parodi
Enteroviruses are the leading cause of exanthems in children, especially during summer and autumn. Enterovirus infections may occur in epidemics or small outbreaks. A 30-year-old woman presented with a three-day history of an erythematous maculopapular skin rash with petechiae localized exclusively under the nipple of the right breast. The skin eruption was associated with an erythematous-petechial enanthem. The patient complained of low-grade fever, headache, asthenia, sore throat and arthromyalgias. IgM (1:128) and IgG (1:640) antibodies against Coxsackievirus A4 were detected by the virus neutralization test...
September 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28954889/herp-binds-tbk1-to-activate-innate-immunity-and-repress-virus-replication-in-response-to-endoplasmic-reticulum-stress
#12
Maolin Ge, Zhen Luo, Zhi Qiao, Yao Zhou, Xin Cheng, Qibin Geng, Yanyan Cai, Pin Wan, Ying Xiong, Fang Liu, Kailang Wu, Yingle Liu, Jianguo Wu
Host innate immunity is crucial for cellular responses against viral infection sensed by distinct pattern recognition receptors and endoplasmic reticulum (ER) stress. Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease and neurological diseases. However, the exact mechanism underlying the link between ER stress induced by EV71 infection and host innate immunity is largely unknown. In this study, we demonstrated that EV71 infection induces the homocysteine-induced ER protein (HERP), a modulator of the ER stress response which is dependent on the participation of MAVS...
September 27, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28948918/hand-foot-and-mouth-disease-in-mainland-china-before-it-was-listed-as-category-c-disease-in-may-2008
#13
Jie Li, Jinfeng Wang, Chengdong Xu, Qian Yin, Maogui Hu, Zhaojun Sun, Dewang Shao
No abstract text is available yet for this article.
October 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28946852/spatio-temporal-clustering-analysis-and-its-determinants-of-hand-foot-and-mouth-disease-in-hunan-china-2009-2015
#14
Xinrui Wu, Shixiong Hu, Abuaku Benjamin Kwaku, Qi Li, Kaiwei Luo, Ying Zhou, Hongzhuan Tan
BACKGROUND: Hand, foot and mouth disease (HFMD) is one of the highest reported infectious diseases with several outbreaks across the world. This study aimed at describing epidemiological characteristics, investigating spatio-temporal clustering changes, and identifying determinant factors in different clustering areas of HFMD. METHODS: Descriptive statistics was used to evaluate the epidemic characteristics of HFMD from 2009 to 2015. Spatial autocorrelation and spatio-temporal cluster analysis were used to explore the spatial temporal patterns...
September 25, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28943436/vitamin-d-receptor-protects-glioblastoma-a172%C3%A2-cells-against-coxsackievirus-a16-infection-induced-cell-death-in-the-pathogenesis-of-hand-foot-and-mouth-disease
#15
Meiling Qu, Shunxiang Di, Shuyun Zhang, Zhiqun Xia, Guohong Quan
Hand, foot, and mouth disease (HFMD) was one of the most common children illnesses. Coxsackievirus A16 was one of the major pathogens that cause HFMD. However, the role of vitamin D underlying this common illness has not been elucidated. Our study examined that vitamin D levels was significantly lower in 33 HFMD patients, compared to 36 healthy children. Unexpectedly, both mRNA and protein expression of VDR were significantly decreased in CA16 infected glioblastoma A172 cells. And overexpression of VDR or vitamin D treatment in CA16 infected glioblastoma A172 cells could reverse the CA16 infection induced cell death, apoptosis or mitochondrial membrane rupture...
November 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28942015/multiple-transmission-chains-of-coxsackievirus-a4-co-circulating-in-china-and-neighboring-countries-in-recent-years-phylogenetic-and-spatiotemporal-analyses-based-on-virological-surveillance
#16
Peng Chen, Haiyan Wang, Zexin Tao, Aiqiang Xu, Xiaojuan Lin, Nan Zhou, Pei Wang, Qian Wang
Coxsackievirus A4 (CV-A4) has been reported frequently in association with many infectious diseases and cases of hand, foot, and mouth disease potentially associated with CV-A4 infection are also identified. This study summarized the Shandong CV-A4 strains isolated from 25years acute flaccid paralysis surveillance, with an emphasis on exploring the phylogenetic analyses and spatiotemporal dynamics of CV-A4 at the global scale. We sampled 43 CV-A4 isolates and utilized VP1 gene to construct phylogenetic trees...
September 20, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28941133/comparative-analysis-of-serum-proteins-from-patients-with-severe-and-mild-ev-a71-induced-hfmd-using-itraq-coupled-lc-ms-ms-screening
#17
Peihu Fan, Wei Chen, Pin Yu, Linlin Bao, Lili Xu, Chuan Qin
PURPOSE: This study was designed to provide a rationale for monitoring the development of severe hand, foot, and mouth disease (HFMD) and predicting the onset of this disease via global comparative analysis between patients with severe and mild HFMD. EXPERIMENTAL DESIGN: We collected serum from five groups: mild (E-M) and severe (E-S) EV-A71-induced HFMD; mild (NE-M) and severe (NE-S) non-EV-A71-induced HFMD; and healthy control subjects (CON). We then performed comparative analysis and identified specific differentially expressed proteins (DEPs) of E-S using isobaric mass tag (isobaric tags for relative and absolute quantitation, iTRAQ) labeling coupled with multidimensional liquid chromatography-mass spectrometry (LC-MS/MS)...
September 20, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28938017/a-highly-conserved-amino-acid-in-vp1-regulates-maturation-of-enterovirus-71
#18
Yong-Xin Zhang, Yu-Ming Huang, Quan-Jie Li, Xiao-Yu Li, Yong-Dong Zhou, Fei Guo, Jin-Ming Zhou, Shan Cen
Enterovirus 71 (EV71) is the major causative agent of hand, foot and mouth disease (HFMD) in children, causing severe clinical outcomes and even death. Here, we report an important role of the highly conserved alanine residue at position 107 in the capsid protein VP1 (VP1A107) in the efficient replication of EV71. Substitutional mutations of VP1A107 significantly diminish viral growth kinetics without significant effect on viral entry, expression of viral genes and viral production. The results of mechanistic studies reveal that VP1A107 regulates the efficient cleavage of the VP0 precursor during EV71 assembly, which is required, in the next round of infection, for the transformation of the mature virion (160S) into an intermediate or A-particle (135S), a key step of virus uncoating...
September 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28937791/web-based-surveillance-of-illness-in-childcare-centers
#19
Natalie Schellpfeffer, Abaigeal Collins, David C Brousseau, Emily T Martin, Andrew Hashikawa
School absenteeism is an inefficient and unspecific metric for measuring community illness and does not provide surveillance during summertime. Web-based biosurveillance of childcare centers may represent a novel way to efficiently monitor illness outbreaks year-round. A web-based biosurveillance program ( sickchildcare.org ) was created and implemented in 4 childcare centers in a single Michigan county. Childcare providers were trained to report sick children who required exclusion or had parent-reported absences due to illness...
September 22, 2017: Health Security
https://www.readbyqxmd.com/read/28936831/-real-world-analysis-to-explore-xiyanping-injection-combined-with-other-drugs-for-hand-foot-mouth-disease
#20
Zhi-Fei Wang, Hai-Wei Fan, Yan-Ming Xie
Integrated network analysis was used in this paper to analyze Xiyanping injection combined therapy for hand-foot-mouth disease based on the registered research data of 3 204 cases. It was found that the drug combination therapy was almost consistent with the guidelines for the diagnosis and treatment of hand foot mouth disease, but there were some problems to be noticed: there were too many applications of antibiotics, more than the need in preventing secondary infection; and ribavirin was not necessary for use...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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