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https://www.readbyqxmd.com/read/29681460/kremen1-is-a-host-entry-receptor-for-a-major-group-of-enteroviruses
#1
Jacqueline Staring, Lisa G van den Hengel, Matthijs Raaben, Vincent A Blomen, Jan E Carette, Thijn R Brummelkamp
Human type A Enteroviruses (EV-As) cause diseases ranging from hand-foot-and-mouth disease to poliomyelitis-like disease. Although cellular receptors are identified for some EV-As, they remain elusive for the majority of EV-As. We identify the cell surface molecule KREMEN1 as an entry receptor for coxsackievirus A10 (CV-A10). Whereas loss of KREMEN1 renders cells resistant to CV-A10 infection, KREMEN1 overexpression enhances CV-A10 binding to the cell surface and increases susceptibility to infection, indicating that KREMEN1 is a rate-limiting factor for CV-A10 infection...
April 18, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29681142/modeling-the-present-and-future-incidence-of-pediatric-hand-foot-and-mouth-disease-associated-with-ambient-temperature-in-mainland-china
#2
Qi Zhao, Shanshan Li, Wei Cao, De-Li Liu, Quan Qian, Hongyan Ren, Fan Ding, Gail Williams, Rachel Huxley, Wenyi Zhang, Yuming Guo
BACKGROUND: There is limited evidence about the association between ambient temperature and the incidence of pediatric hand, foot, and mouth disease (HFMD) nationwide in China. OBJECTIVES: We examined the childhood temperature-HFMD associations across mainland China, and we projected the change in HFMD cases due to projected temperature change by the 2090s. METHODS: Data on daily HFMD (children 0-14 y old) counts and weather were collected from 362 sites during 2009-2014...
April 20, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29651498/hand-foot-and-mouth-disease-and-echovirus-3-a-comment-to-h%C3%A3-gsberg-and-bygum
#3
Pascal Del Giudice, Thomas Hubiche
No abstract text is available yet for this article.
April 12, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29650033/enterovirus-serotypes-in-patients-with-central-nervous-system-and-respiratory-infections-in-viet-nam-1997-2010
#4
Nguyen Thi Thuy Chinh B'Krong, Ngo Ngoc Quang Minh, Phan Tu Qui, Tran Thi Hong Chau, Ho Dang Trung Nghia, Lien Anh Ha Do, Nguyen Ngoc Nhung, Nguyen Van Vinh Chau, Guy Thwaites, Le Van Tan, H Rogier van Doorn, Tran Tan Thanh
BACKGROUND: Enteroviruses are the most common causative agents of human illness. Enteroviruses have been associated with regional and global epidemics, recently, including with severe disease (Enterovirus A71 and D68), and are of interest as emerging viruses. Here, we typed Enterovirus A-D (EV) from central nervous system (CNS) and respiratory infections in Viet Nam. METHODS: Data and specimens from prospective observational clinical studies conducted between 1997 and 2010 were used...
April 12, 2018: Virology Journal
https://www.readbyqxmd.com/read/29626210/the-life-cycle-of-non-polio-enteroviruses-and-how-to-target-it
#5
REVIEW
Jim Baggen, Hendrik Jan Thibaut, Jeroen R P M Strating, Frank J M van Kuppeveld
The genus Enterovirus (EV) of the family Picornaviridae includes poliovirus, coxsackieviruses, echoviruses, numbered enteroviruses and rhinoviruses. These diverse viruses cause a variety of diseases, including non-specific febrile illness, hand-foot-and-mouth disease, neonatal sepsis-like disease, encephalitis, paralysis and respiratory diseases. In recent years, several non-polio enteroviruses (NPEVs) have emerged as serious public health concerns. These include EV-A71, which has caused epidemics of hand-foot-and-mouth disease in Southeast Asia, and EV-D68, which recently caused a large outbreak of severe lower respiratory tract disease in North America...
April 6, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/29619599/inactivated-enterovirus-71-with-poly-%C3%AE-glutamic-acid-chitosan-nano-particles-pc-nps-induces-high-cellular-and-humoral-immune-responses-in-balb-c-mice
#6
Prabuddha S Pathinayake, W A Gayan Chathuranga, Hyun-Cheol Lee, Mohammed Y E Chowdhury, Moon-Hee Sung, Jong-Soo Lee, Chul-Joong Kim
Enterovirus 71 (EV71) is the major causative agent of hand-foot-and-mouth disease (HFMD) and many neurological manifestations. Recently, this virus has become a serious concern because of consecutive epidemics in the Asia-Pacific region. However, no effective vaccine for EV71 has been discovered except two EV71 vaccines which are being used in local communities of China. To develop a safe and efficient EV71 vaccine candidate, we generated inactivated EV71 and evaluated its efficacy with γ-PGA/Chitosan nanoparticles (PC NPs), which are safe, biodegradable and effective as an adjuvant...
April 4, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29617579/hand-foot-and-mouth-disease-in-an-adult
#7
Chiaki Murase, Masashi Akiyama
New England Journal of Medicine, Volume 378, Issue 14, April 2018.
April 5, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29614964/spatio-temporal-analysis-of-the-relationship-between-meteorological-factors-and-hand-foot-mouth-disease-in-beijing-china
#8
Lin Tian, Fengchao Liang, Meimei Xu, Lei Jia, Xiaochuan Pan, Archie C A Clements
BACKGROUND: Hand-foot-mouth disease (HFMD) is a common infectious disease in China and occurs mostly in infants and children. Beijing is a densely populated megacity, in which HFMD has been increasing in the last decade. The aim of this study was to quantify spatio-temporal characteristics of HFMD and the relationship between meteorological factors and HFMD incidence in Beijing, China. METHODS: Daily counts of HFMD cases from January 2010 to December 2012 were obtained from the Beijing Center for Disease Prevention and Control (CDC)...
April 3, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29609253/-study-on-early-warning-threshold-values-for-7-common-communicable-diseases-in-gansu-province-2016
#9
Y Cheng, X F Liu, L Meng, X T Yang, D P Liu, K F Wei, X J Jiang, H X Liu, Y H Zheng
Objective: To optimize the warning threshold values of common communicable diseases in Gansu province, and improve the early warning effect. Method: An early warning model was set up for influenza, scarlet fever, other infectious diarrheal diseases, dysentery, typhoid and paratyphoid, viral hepatitis type E and hand foot and mouth disease (HFMD) respectively in Gansu by using the moving percentile method and cumulative sum method. By calculating the sensitivity, specificity, predictive value of positive test, predictive value of negative test, Youden' index and receiver-operating characteristic curve, the optimum early warning threshold values for communicable diseases in Gansu were selected...
March 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29609251/-epidemiological-characteristics-of-coxsackie-virus-a16-caused-hand-foot-and-mouth-disease-cases-in-guangdong-province-2012-2016
#10
L M Sun, S L Wu, X H Tan, H Li, F Yang, H R Zeng, H Y Zheng, L Liu, J F He
Objective: To analyze the epidemiological characteristics of hand foot and mouth disease (HFMD) cases caused by Coxsackie virus A16 (Cox A16) in Guangdong province from 2012 to 2016. Methods: The data of mild HFMD cases caused by Cox A16 were collected from 8 sentinel hospitals in 8 prefecture-level cities in Guangdong to estimate Cox A16 infection status and its population and time distribution characteristics. Results: (1) The highest estimated incidence of Cox A16 infection was in 2014 (113.0/100 000), followed by 2016 (86...
March 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29603282/sequence-analysis-based-characterization-and-identification-of-neurovirulence-associated-variants-of-36-ev71-strains-from-china
#11
Jun Xu, Fang Wang, Desheng Zhao, Jiang Liu, Hong Su, Baolong Wang
Enterovirus 71 (EV71) is the main pathogen of hand-foot-mouth disease (HFMD) and causes several neurological complications. As new strains of EV71 are constantly discovered, it is important to understand the genomic characteristics of the viruses and the mechanism of virulence. Herein, we isolated five strains of EV71 from HFMD patients with or without neurovirulence and sequenced their whole genomes. We then performed whole genome sequence analysis of totally 36 EV71 strains. The phylogenetic analysis of the VP1 region revealed all five isolated strains are clustered into C4a of C4 subgenotype...
March 30, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29597291/antiviral-and-inflammatory-cellular-signaling-associated-with-enterovirus-71-infection
#12
REVIEW
Yuefei Jin, Rongguang Zhang, Weidong Wu, Guangcai Duan
Enterovirus 71 (EV71) infection has become a major threat to global public health, especially in infants and young children. Epidemiological studies have indicated that EV71 infection is responsible for severe and even fatal cases of hand, foot, and mouth disease (HFMD). Accumulated evidence indicates that EV71 infection triggers a plethora of interactive signaling pathways, resulting in host immune evasion and inflammatory response. This review mainly covers the effects of EV71 infection on major antiviral and inflammatory cellular signal pathways...
March 28, 2018: Viruses
https://www.readbyqxmd.com/read/29587191/an-emerging-and-expanding-clade-accounts-for-the-persistent-outbreak-of-coxsackievirus-a6-associated-hand-foot-and-mouth-disease-in-china-since-2013
#13
Shuizhen He, Mengyuan Chen, Wenhui Wu, Qiang Yan, Zhihao Zhuo, Xiaosong Su, Shiyin Zhang, Shengxiang Ge, Ningshao Xia
Enterovirus (EV)-A71 and Coxsackievirus (CV)-A16 have historically been the major pathogens of hand, foot, and mouth disease (HMFD) in China; however, CV-A6, which had previously received little attention, became the predominant pathogen in 2013, and has remained one of the common pathogens since then. In this work, we conducted a molecular epidemiology study of CV-A6-associated HFMD in Xiamen from 2009 to 2015. The data showed CV-A6 pandemics had a certain periodicity rather than occurring randomly. Evolution analysis based on near-complete VP1 nucleotide sequences showed subgenotype D5 lineage 4 strains account for the persistent outbreak of CV-A6-associated HFMD in China since 2013...
March 24, 2018: Virology
https://www.readbyqxmd.com/read/29582164/induction-of-a-high-titered-antibody-response-using-hiv-gag-ev71-vp1-based-virus-like-particles-with-the-capacity-to-protect-newborn-mice-challenged-with-a-lethal-dose-of-enterovirus-71
#14
Xi Wang, Ke Dong, Min Long, Fang Lin, Zhaowei Gao, Lin Wang, Zhe Zhang, Xi Chen, Ying Dai, Huiping Wang, Huizhong Zhang
Enterovirus 71 (EV71) is the most frequently detected causative agent in hand, foot, and mouth disease (HFMD) and is a serious threat to public health in the Asia-Pacific region. Many EV71 vaccines are under development worldwide, and although both inactivated virus vaccines and virus-like particles (VLPs) are considered to be effective, the main focus has been on inactivated EV71vaccines. There have been very few studies on EV71 VLPs. In this study, using a strategy based on HIV gag VLPs, we constructed a gag-VP1 fusion gene to generate a recombinant baculovirus expressing the EV71 structural protein VP1 together with gag, which was then used to infect TN5 cells to form VLPs...
March 27, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29572108/establishment-of-the-1st-who-international-standard-for-anti-ev71-serum-human
#15
Gillian Cooper, Qunying Mao, Laura Crawt, Yiping Wang, Thomas Dougall, Peter Rigsby, Zhenglun Liang, Miao Xu, Philip Minor, Junzhi Wang, Javier Martin
Enterovirus A71 (EV71) is the major causative agent of severe and fatal hand, foot and mouth disease. There is plenty of evidence that EV71 has circulated widely in the Western Pacific Region for the last twenty years. Vaccines against EV71 are already available or under development. A collaborative study to establish the 1st WHO International Standard for anti-EV71 serum (Human) was conducted to ensure that methods used to measure the serum neutralizing activity or antibody levels against EV71 are accurate, sensitive and reproducible...
March 20, 2018: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/29564154/severity-and-burden-of-hand-foot-and-mouth-disease-in-asia-a-modelling-study
#16
Wee Ming Koh, Hishamuddin Badaruddin, Hanh La, Mark I-Cheng Chen, Alex R Cook
Background: Hand, foot and mouth disease (HFMD) affects millions of children across Asia annually, leading to an increase in implemented control policies such as surveillance, isolation and social distancing in affected jurisdictions. However, limited knowledge of disease burden and severity causes difficulty in policy optimisation as the associated economic cost cannot be easily estimated. We use a data synthesis approach to provide a comprehensive picture of HFMD disease burden, estimating infection risk, symptomatic rates, the risk of complications and death, and overall disability-adjusted life-year (DALY) losses, along with associated uncertainties...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29563294/divergent-pathogenic-properties-of-circulating-coxsackievirus-a6-associated-with-emerging-hfmd
#17
Shao-Hua Wang, Ao Wang, Pan-Pan Liu, Wen-Yan Zhang, Juan Du, Shuang Xu, Guan-Chen Liu, Bai-Song Zheng, Chen Huan, Ke Zhao, Xiao-Fang Yu
Coxsackievirus A6 (CV-A6) is an emerging pathogen associated with hand, foot, and mouth disease (HFMD). Its genetic characterization and pathogenic properties are largely unknown. Here, we report 39 circulating CV-A6 strains isolated in 2013 from HFMD patients in Northeast China. Three major clusters of CV-A6 were identified and related to CV-A6 mostly from Shanghai, indicating that domestic CV-A6 strains were responsible for HFMD emerging in Northeast China. Four full-length CV-A6 genomes representing each cluster were sequenced and analyzed further...
March 21, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29559626/epidemiological-surveillance-of-hand-foot-and-mouth-disease-in-shanghai-in-2014-2016-prior-to-the-introduction-of-the-enterovirus-71-vaccine
#18
Jingjing Li, Hao Pan, Xiangshi Wang, Qirong Zhu, Yanling Ge, Jiehao Cai, Yuefang Li, Aimei Xia, Jiayu Hu, Mei Zeng
Hand, foot, and mouth disease (HFMD) is mainly epidemic in China and Southeast Asian countries. A novel enterovirus 71 vaccine has been available in China for preventing severe HFMD since 2016. Knowledge of the dynamic epidemiology of HFMD in different regions is necessary for appropriate intervention strategies. This study focused on the citywide surveillance data on the epidemiology and etiology of HFMD in Shanghai during 2014-2016. In these 3 years, the total numbers of reported HFMD cases were 65,018, 39,702, and 57,548, respectively; the numbers of severe cases (case-severity ratios) were 248 (0...
March 21, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29553326/emerging-coxsackievirus-a6-causing-hand-foot-and-mouth-disease-vietnam
#19
Nguyen To Anh, Le Nguyen Truc Nhu, Hoang Minh Tu Van, Nguyen Thi Thu Hong, Tran Tan Thanh, Vu Thi Ty Hang, Nguyen Thi Han Ny, Lam Anh Nguyet, Tran Thi Lan Phuong, Le Nguyen Thanh Nhan, Nguyen Thanh Hung, Truong Huu Khanh, Ha Manh Tuan, Ho Lu Viet, Nguyen Tran Nam, Do Chau Viet, Phan Tu Qui, Bridget Wills, Sarawathy Sabanathan, Nguyen Van Vinh Chau, Louise Thwaites, H Rogier van Doorn, Guy Thwaites, Maia A Rabaa, Le Van Tan
Hand, foot and mouth disease (HFMD) is a major public health issue in Asia and has global pandemic potential. Coxsackievirus A6 (CV-A6) was detected in 514/2,230 (23%) of HFMD patients admitted to 3 major hospitals in southern Vietnam during 2011-2015. Of these patients, 93 (18%) had severe HFMD. Phylogenetic analysis of 98 genome sequences revealed they belonged to cluster A and had been circulating in Vietnam for 2 years before emergence. CV-A6 movement among localities within Vietnam occurred frequently, whereas viral movement across international borders appeared rare...
April 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29549443/association-of-interleukin-17f-gene-polymorphisms-with-susceptibility-to-severe-enterovirus-71-infection-in-chinese-children
#20
Fei Li, Peipei Liu, Ya Guo, Zhenliang Han, Yedan Liu, Yuanyuan Wang, Long Song, Jianguo Cheng, Zongbo Chen
Enterovirus 71 (EV71) is a single-strand RNA virus that causes hand, foot and mouth disease (HFMD) in infants and young children, leading to neurological complications with significant morbidity and mortality. Unfortunately, the pathogenesis of EV71 infection is not well understood. In this study, we investigated the IL-17F rs1889570 and rs4715290 gene polymorphisms in a Chinese Han population. Severe cases and cases with EV71 encephalitis had a significantly higher frequency of the rs1889570 T/T genotype and T allele...
March 16, 2018: Archives of Virology
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