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Gulf war illness

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https://www.readbyqxmd.com/read/28328972/altered-gut-microbiome-in-a-mouse-model-of-gulf-war-illness-causes-neuroinflammation-and-intestinal-injury-via-leaky-gut-and-tlr4-activation
#1
Firas Alhasson, Suvarthi Das, Ratanesh Seth, Diptadip Dattaroy, Varun Chandrashekaran, Caitlin N Ryan, Luisa S Chan, Traci Testerman, James Burch, Lorne J Hofseth, Ronnie Horner, Mitzi Nagarkatti, Prakash Nagarkatti, Stephen M Lasley, Saurabh Chatterjee
Many of the symptoms of Gulf War Illness (GWI) that include neurological abnormalities, neuroinflammation, chronic fatigue and gastrointestinal disturbances have been traced to Gulf War chemical exposure. Though the association and subsequent evidences are strong, the mechanisms that connect exposure to intestinal and neurological abnormalities remain unclear. Using an established rodent model of Gulf War Illness, we show that chemical exposure caused significant dysbiosis in the gut that included increased abundance of phylum Firmicutes and Tenericutes, and decreased abundance of Bacteroidetes...
2017: PloS One
https://www.readbyqxmd.com/read/28303641/myalgic-encephalomyelitis-chronic-fatigue-syndrome-and-gulf-war-illness-patients-exhibit-increased-humoral-responses-to-the-herpesviruses-encoded-dutpase-implications-in-disease-pathophysiology
#2
Peter Halpin, Marshall Vance Williams, Nancy G Klimas, Mary Ann Fletcher, Zachary Barnes, Maria Eugenia Ariza
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI) are debilitating diseases with overlapping symptomology and there are currently no validated tests for definitive diagnosis of either syndrome. While there is evidence supporting the premise that some herpesviruses may act as possible triggers of ME/CFS, the involvement of herpesviruses in the pathophysiology of GWI has not been studied in spite of a higher prevalence of ME/CFS in these patients. We have previously demonstrated that the deoxyuridine triphosphate nucleotidohydrolases (dUTPase) encoded by Epstein-Barr virus (EBV), human herpesvirus-6 (HHV-6), and varicella-zoster virus (VZV) possess novel functions in innate and adaptive immunity...
March 17, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28286177/screening-for-novel-central-nervous-system-biomarkers-in-veterans-with-gulf-war-illness
#3
Mohamed B Abou-Donia, Lisa A Conboy, Efi Kokkotou, Eric Jacobson, Eman M Elmasry, Passent Elkafrawy, Megan Neely, Cameron R 'Dale' Bass, Kimberly Sullivan
Gulf War illness (GWI) is primarily diagnosed by symptom report; objective biomarkers are needed that distinguish those with GWI. Prior chemical exposures during deployment have been associated in epidemiologic studies with altered central nervous system functioning in veterans with GWI. Previous studies from our group have demonstrated the presence of autoantibodies to essential neuronal and glial proteins in patients with brain injury and autoantibodies have been identified as candidate objective markers that may distinguish GWI...
March 9, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28131230/electrophysiological-correlates-of-semantic-memory-retrieval-in-gulf-war-syndrome-2-patients
#4
Gail D Tillman, Clifford S Calley, Virginia I Buhl, Hsueh-Sheng Chiang, Robert W Haley, John Hart, Michael A Kraut
Gulf War veterans meeting criteria for Haley Syndrome 2 of Gulf War illness endorse a particular constellation of symptoms that include difficulty with processing information, word-finding, and confusion. To explore the neural basis of their word-finding difficulty, we assessed event-related potentials (ERPs) associated with semantic memory retrieval in 22 veterans classified as Syndrome 2 and 28 veterans who served as controls. We recorded EEGs while subjects judged whether pairs of words that represented object features combined to elicit a retrieval of an object memory or no retrieval...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28073904/comparability-of-health-service-use-by-veterans-with-multisymptom-illness-and-those-with-chronic-diseases
#5
Stella M Gwini, Andrew B Forbes, Malcolm R Sim, Helen L Kelsall
OBJECTIVE: To compare health service utilization and disability claims among military personnel with multisymptom illness (MSI) (but no chronic diseases), those with chronic disease(s) and those without MSI or chronic diseases. MSI is also known as Gulf War illness. DESIGN: Cohort study. SETTING: Australia. PARTICIPANTS: In total, 1288 participants of a Gulf War veterans' study conducted in 2000-2003 (Wave-1) were followed up in 2011-2012 (Wave-2), aged on average 40 years...
January 9, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28051953/gulf-war-and-health-treatment-for-chronic-multisymptom-illness
#6
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28025109/deet-potentiates-the-development-and-persistence-of-anticholinesterase-dependent-chronic-pain-signs-in-a-rat-model-of-gulf-war-illness-pain
#7
L K Flunker, T J Nutter, R D Johnson, B Y Cooper
Exposure to DEET (N,N-diethyl-meta-toluamide) may have influenced the pattern of symptoms observed in soldiers with GWI (Gulf War Illness; Haley and Kurt, 1997). We examined how the addition of DEET (400mg/kg; 50% topical) to an exposure protocol of permethrin (2.6mg/kg; topical), chlorpyrifos (CP; 120mg/kg), and pyridostigmine bromide (PB;13mg/kg) altered the emergence and pattern of pain signs in an animal model of GWI pain (Nutter et al., 2015). Rats underwent behavioral testing before, during and after a 4week exposure: 1) hindlimb pressure withdrawal threshold; 2) ambulation (movement distance and rate); and 3) resting duration...
December 23, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28001756/transcranial-red-near-infrared-light-emitting-diode-therapy-to-improve-cognition-in-chronic-traumatic-brain-injury
#8
Margaret A Naeser, Paula I Martin, Michael D Ho, Maxine H Krengel, Yelena Bogdanova, Jeffrey A Knight, Megan K Yee, Ross Zafonte, Judith Frazier, Michael R Hamblin, Bang-Bon Koo
We review the general topic of traumatic brain injury (TBI) and our research utilizing transcranial photobiomodulation (tPBM) to improve cognition in chronic TBI using red/near-infrared (NIR) light-emitting diodes (LEDs) to deliver light to the head. tPBM improves mitochondrial function increasing oxygen consumption, production of adenosine triphosphate (ATP), and improving cellular energy stores. Nitric oxide is released from the cells increasing regional blood flow in the brain. Review of published studies: In our previously published study, 11 chronic TBI patients with closed-head TBI caused by different accidents (motor vehicle accident, sports-related, improvised explosive device blast injury) and exhibiting long-lasting cognitive dysfunction received 18 outpatient treatments (Monday, Wednesday, Friday for 6 weeks) starting at 10 months to 8 years post-TBI...
December 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27984134/long-title-translational-potential-of-long-term-decreases-in-mitochondrial-lipids-in-a-mouse-model-of-gulf-war-illness
#9
Laila Abdullah, James E Evans, Utsav Joshi, Gogce Crynen, John Reed, Benoit Mouzon, Stephan Baumann, Hannah Montague, Zuchra Zakirova, Tanja Emmerich, Corbin Bachmeier, Nancy Klimas, Kimberly Sullivan, Michael Mullan, Ghania Ait-Ghezala, Fiona Crawford
Gulf War Illness (GWI) affects 25% of veterans from the 1990-1991 Gulf War (GW) and is accompanied by damage to the brain regions involved in memory processing. After twenty-five years, the chronic pathobiology of GWI is still unexplained. To address this problem, we examined the long-term consequences of GW exposures in an established GWI mouse model to identify biological processes that are relevant to the chronic symptoms of GWI. Three-month old male C57BL6 mice were exposed for 10days to GW agents (pyridostigmine bromide and permethrin)...
October 29, 2016: Toxicology
https://www.readbyqxmd.com/read/27931520/translational-potential-of-long-term-decreases-in-mitochondrial-lipids-in-a-mouse-model-of-gulf-war-illness
#10
Laila Abdullah, James E Evans, Utsav Joshi, Gogce Crynen, Jon Reed, Benoit Mouzon, Stephan Baumann, Hannah Montague, Zuchra Zakirova, Tanja Emmerich, Corbin Bachmeier, Nancy Klimas, Kimberly Sullivan, Michael Mullan, Ghania Ait-Ghezala, Fiona Crawford
Gulf War Illness (GWI) affects 25% of veterans from the 1990-1991 Gulf War (GW) and is accompanied by damage to the brain regions involved in memory processing. After twenty-five years, the chronic pathobiology of GWI is still unexplained. To address this problem, we examined the long-term consequences of GW exposures in an established GWI mouse model to identify biological processes that are relevant to the chronic symptoms of GWI. Three-month old male C57BL6 mice were exposed for 10days to GW agents (pyridostigmine bromide and permethrin)...
November 30, 2016: Toxicology
https://www.readbyqxmd.com/read/27901559/extension-of-the-presumptive-period-for-compensation-for-gulf-war-veterans-interim-final-rule
#11
(no author information available yet)
The Department of Veterans Affairs (VA) is issuing this interim final rule to amend its adjudication regulations regarding compensation for disabilities resulting from undiagnosed illnesses suffered by veterans who served in the Persian Gulf War. This amendment is necessary to extend the presumptive period for qualifying chronic disabilities resulting from undiagnosed illnesses that must become manifest to a compensable degree in order that entitlement for compensation be established. The intended effect of this amendment is to provide consistency in VA adjudication policy and preserve certain rights afforded to Persian Gulf War veterans and ensure fairness for current and future Persian Gulf War veterans...
October 17, 2016: Federal Register
https://www.readbyqxmd.com/read/27860470/physical-activity-and-chronic-illnesses-among-gulf-war-veterans
#12
S S Coughlin
No abstract text is available yet for this article.
2016: Annals of Translational Medicine & Epidemiology
https://www.readbyqxmd.com/read/27806904/supporting-a-neuroimmune-basis-of-gulf-war-illness
#13
James P O'Callaghan, Lindsay T Michalovicz, Kimberly A Kelly
No abstract text is available yet for this article.
November 2016: EBioMedicine
https://www.readbyqxmd.com/read/27765642/brain-correlates-of-human-leukocyte-antigen-hla-protection-in-gulf-war-illness-gwi
#14
Lisa M James, Brian E Engdahl, Arthur C Leuthold, Apostolos P Georgopoulos
BACKGROUND: We recently reported that six alleles from class II genes of the Human Leukocyte Antigen (HLA) confer protection from Gulf War Illness (GWI) (Georgopoulos et al., 2015). The most significant effect is exerted on Neurological-Cognitive-Mood (NCM), Pain, and Fatigue symptoms, such that higher number of copies of the protective alleles are associated with lower symptom severity. Here we tested the hypothesis that this effect is exerted by modulating the strength of neural synchronicity...
November 2016: EBioMedicine
https://www.readbyqxmd.com/read/27672557/cognitive-slowing-in-gulf-war-illness-predicts-executive-network-hyperconnectivity-study-in-a-population-representative-sample
#15
Monroe P Turner, Nicholas A Hubbard, Lyndahl M Himes, Shawheen Faghihahmadabadi, Joanna L Hutchison, Ilana J Bennett, Michael A Motes, Robert W Haley, Bart Rypma
Cognitive slowing is a prevalent symptom observed in Gulf War Illness (GWI). The present study assessed the extent to which functional connectivity between dorsolateral prefrontal cortex (DLPFC) and other task-relevant brain regions was predictive of GWI-related cognitive slowing. GWI patients (n = 54) and healthy veteran controls (n = 29) were assessed on performance of a processing speed task (the Digit Symbol Substitution Task; DSST) while undergoing functional magnetic resonance imaging (fMRI). GWI patients were slower on the DSST relative to controls...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27612364/insomnia-severity-subjective-sleep-quality-and-risk-for-obstructive-sleep-apnea-in-veterans-with-gulf-war-illness
#16
Linda L Chao, Linda R Abadjian, Iva L Esparza, Rosemary Reeb
Despite the fact that sleep disturbances are common in veterans with Gulf War Illness (GWI), there has been a paucity of published sleep studies in this veteran population to date. Therefore, the present study examined subjective sleep quality (assessed with the Pittsburgh Sleep Quality Index), insomnia severity (assessed with the Insomnia Severity Index), and risk for obstructive sleep apnea (assessed with the STOP questionnaire) in 98 Gulf War veterans. Veterans with GWI, defined either by the Kansas or Centers for Disease Control and Prevention criteria, had greater risk for obstructive sleep apnea (i...
September 2016: Military Medicine
https://www.readbyqxmd.com/read/27592598/a-magnetoencephalographic-meg-study-of-gulf-war-illness-gwi
#17
Brian E Engdahl, Lisa M James, Ryan D Miller, Arthur C Leuthold, Scott M Lewis, Adam F Carpenter, Apostolos P Georgopoulos
BACKGROUND: Gulf War Illness (GWI) has affected many Gulf War veterans. It involves several organs, most notably the brain. Neurological-cognitive-mood-related symptoms frequently dominate and are at the root of chronic ill-health and disability in GWI. Here we investigated the neural mechanisms underlying brain dysfunction in GWI in the absence of mental health disorders. METHODS: Eighty-six veterans completed diagnostic interviews to establish the presence of GWI and assess mental health status...
October 2016: EBioMedicine
https://www.readbyqxmd.com/read/27389793/multisymptom-illness-in-gulf-war-veterans-a-systematic-review-and-meta-analysis
#18
Stella M Gwini, Andrew B Forbes, Malcolm R Sim, Helen L Kelsall
OBJECTIVE: The aim of this study was to conduct a systematic review and meta-analysis of multisymptom illness (MSI) in 1990 to 1991 Gulf/Afghanistan/Iraq War veterans. METHODS: Electronic databases were searched from January 1990, June 2014 for studies on MSI prevalence in Gulf/Afghanistan/Iraq War veterans, based on the Centers for Disease Control and Prevention MSI case definition, and which included a military comparison group. RESULTS: Seven studies were identified among US, UK, and Australian Gulf War veterans; no studies were identified in Afghanistan/Iraq War veterans...
July 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27362013/effort-dependent-and-independent-cardiopulmonary-measures-for-assessing-gulf-war-illness-3647-board-86-june-4-9-30-am-11-00-am
#19
Jacob B Lindheimer
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27352030/blood-biomarkers-of-chronic-inflammation-in-gulf-war-illness
#20
Gerhard J Johnson, Billie C S Slater, Linda A Leis, Thomas S Rector, Ronald R Bach
BACKGROUND: More than twenty years following the end of the 1990-1991 Gulf War it is estimated that approximately 300,000 veterans of this conflict suffer from an unexplained chronic, multi-system disorder known as Gulf War Illness (GWI). The etiology of GWI may be exposure to chemical toxins, but it remains only partially defined, and its case definition is based only on symptoms. Objective criteria for the diagnosis of GWI are urgently needed for diagnosis and therapeutic research. OBJECTIVE: This study was designed to determine if blood biomarkers could provide objective criteria to assist diagnosis of GWI...
2016: PloS One
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