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E. o'loughlin

A O'Loughlin, E Kellegher, C McCusker, R Canavan
BACKGROUND: Diabetic Charcot neuroarthropathy (DCN) is a devastating complication for people with diabetes mellitus. The failure to diagnose DCN and institute treatment in the acute phase leads to permanent deformity and significant morbidity. There is a paucity of data on the prevalence and characteristics of patients who have developed this complication of diabetes. AIMS: To determine the prevalence, clinical characteristics and outcomes of patients with DCN from 2006 to 2012...
October 6, 2016: Irish Journal of Medical Science
Emer O'Loughlin, Susan Hourihan, Jeremy Chataway, E Diane Playford, Afsane Riazi
PURPOSE: The majority of people with multiple sclerosis (pwMS) initially present with discreet periods of relapses followed by partial remission of symptoms (RRMS). Over time, most pwMS transition to secondary progressive MS (SPMS), characterized by a gradual accumulation of disability. This study aimed to explore the experiences, coping and needs associated with transitioning from RRMS to SPMS. METHOD: Data were collected via semi-structured interviews with nine pwMS and seven specialist MS health professionals (HPs)...
August 16, 2016: Disability and Rehabilitation
C Raina MacIntyre, Peter Shaw, Fiona E Mackie, Christina Boros, Helen Marshall, Michelle Barnes, Holly Seale, Sean E Kennedy, Aye Moa, Andrew Hayen, Abrar Ahmad Chughtai, Edward V O'Loughlin, Michael Stormon
AIM: The aim of this study was to determine the immunogenicity and reactogenicity of HPV vaccine in immunocompromised children. METHODS: A multi-centre clinical trial was conducted in three paediatric hospitals in Australia. Unvaccinated children 5-18years of age attending one of three paediatric hospitals with a range of specified conditions associated with immunosuppression were included. Quadrivalent HPV vaccine (Gardasil) was given to the participants and serum anti-HPV antibody levels were measured at baseline (before first dose), 7 and 24months after the first dose of vaccine...
August 5, 2016: Vaccine
Yiran Dong, Robert A Sanford, Maxim I Boyanov, Kenneth M Kemner, Theodore M Flynn, Edward J O'Loughlin, Randall A Locke Ii, Joseph R Weber, Sheila M Egan, Bruce W Fouke
A Gram-stain-negative, microaerophilic rod-shaped organism designated as strain Z9T was isolated from groundwater of 1.7 km in depth from the Mt. Simon Sandstone of the Illinois Basin, IL, USA. The cells of strain Z9T were rod shaped with the dimensions (0.3×(1-10)) μm and stained Gram-negative. Strain Z9T grew within the temperature range 20-60 °C (optimum at 30-40 °C), between pH 5-8 (optimum 5.2-5.8), and under salt concentrations 1-5% NaCl (optimum 2.5 % NaCl). In addition to growth by fermentation and nitrate reduction, this strain was able to reduce Fe(III), Mn(IV), Co(III) and Cr(VI) when H2 or organic carbon was available as the electron donor, but did not actively reduce oxidized sulfur compounds (e...
July 11, 2016: International Journal of Systematic and Evolutionary Microbiology
Tomas B Corcoran, Emilie Mas, Anne E Barden, L Jackson Roberts, Trevor A Mori, Edmond O'Loughlin
Hypovolaemia can be associated with substantial morbidity, particularly when it occurs in the setting of trauma and in patients with comorbid diseases. Hypovolaemia and inflammation such as occur in the setting of trauma and surgery, are associated with systemic oxidative stress and free-radical injury. Free-radical injury that results from hypovolaemia-induced organ reperfusion may further augment inflammatory processes. It is unknown exactly what proportion of free-radical injury is associated with isolated hypovolaemia as opposed to the contribution from inflammation from surgery or trauma...
July 2016: Prostaglandins & Other Lipid Mediators
Robert J Wellman, Erika N Dugas, Hartley Dutczak, Erin K O'Loughlin, Geetanjali D Datta, Béatrice Lauzon, Jennifer O'Loughlin
CONTEXT: The onset of cigarette smoking typically occurs during childhood or early adolescence. Nicotine dependence symptoms can manifest soon after onset, contributing to sustained, long-term smoking. Previous reviews have not clarified the determinants of onset. EVIDENCE ACQUISITION: In 2015, a systematic review of the literature in PubMed and EMBASE was undertaken to identify peer-reviewed prospective longitudinal studies published between January 1984 and August 2015 that investigated predictors of cigarette smoking onset among youth aged <18 years who had never smoked...
May 11, 2016: American Journal of Preventive Medicine
Jennifer O'Loughlin, Robert J Wellman, Louise Potvin
No abstract text is available yet for this article.
March 2016: International Journal of Public Health
Robert J Wellman, Jennifer O'Loughlin
No abstract text is available yet for this article.
March 2016: International Journal of Public Health
Robert J Wellman, John A Vaughn, Marie-Pierre Sylvestre, Erin K O'Loughlin, Erika N Dugas, Jennifer L O'Loughlin
PURPOSE: Heavy episodic (i.e., "binge") drinking (i.e., ≥five drinks/occasion) is highly prevalent among young adults; those who binge do so four times per month on average, consuming nine drinks on average on each occasion. Although it is well established that chronic heavy drinking (≥two alcoholic beverages per day) increases the risk of hypertension, the relationship between binge drinking and blood pressure is not well described. Our aim was to describe the relationship between frequency of binge drinking, both current (at age 24 years) and past (at age 20 years), and systolic blood pressure (SBP) at age 24 years...
March 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
Louisa Degenhardt, Helena Romaniuk, Carolyn Coffey, Wayne D Hall, Wendy Swift, John B Carlin, Christina O'Loughlin, George C Patton
BACKGROUND: There are limited longitudinal data on the associations between different social contexts of alcohol use and risky adolescent drinking. METHODS: Australian prospective longitudinal cohort of 1943 adolescents with 6 assessment waves at ages 14-17 years. Drinkers were asked where and how frequently they drank. Contexts were: at home with family, at home alone, at a party with friends, in a park/car, or at a bar/nightclub. The outcomes were prevalence and incidence of risky drinking (≥5 standard drinks (10g alcohol) on a day, past week) and very risky drinking (>20 standard drinks for males and >11 for females) in early (waves 1-2) and late (waves 3-6) adolescence...
2015: BMC Public Health
Sean Martin, Andrew Vincent, Anne W Taylor, Evan Atlantis, Alicia Jenkins, Andrzej Januszewski, Peter O'Loughlin, Gary Wittert
BACKGROUND: The relationship between lower urinary tract symptoms (LUTS) and common mental health disorders such as depression and anxiety in men remains unclear. Inflammation has recently been identified as an independent risk factor for LUTS and depression. This study aimed to assess the association between depression, anxiety and LUTS, and the moderating influence of systemic inflammation, in the presence of other biopsychosocial confounders. METHODS: Participants were randomly-selected from urban, community-dwelling males aged 35-80 years at recruitment (n = 1195; sample response rate:67...
2015: PloS One
Charles L Larson, Derrick R Samuelson, Tyson P Eucker, Jason L O'Loughlin, Michael E Konkel
Campylobacter jejuni is a gram-negative, curved and rod-shaped bacterium that causes human gastroenteritis. Acute disease is associated with C. jejuni invasion of the intestinal epithelium. Epithelial cells infected with C. jejuni strains containing mutations in the FlpA and CadF fibronectin (Fn)-binding proteins exhibit reduced invasion of host cells and a C. jejuni CadF FlpA double mutant is impaired in the activation of epidermal growth factor receptor (EGFR) and Rho GTPase Rac1. Although these observations establish a role for Fn-binding proteins during C...
October 2013: Emerging Microbes & Infections
Jason L O'Loughlin, Derrick R Samuelson, Andrea G Braundmeier-Fleming, Bryan A White, Gary J Haldorson, Jennifer B Stone, Jeremy J Lessmann, Tyson P Eucker, Michael E Konkel
Campylobacter jejuni is a leading cause of human foodborne gastroenteritis worldwide. The interactions between this pathogen and the intestinal microbiome within a host are of interest as endogenous intestinal microbiota mediates a form of resistance to the pathogen. This resistance, termed colonization resistance, is the ability of commensal microbiota to prevent colonization by exogenous pathogens or opportunistic commensals. Although mice normally demonstrate colonization resistance to C. jejuni, we found that mice treated with ampicillin are colonized by C...
July 2015: Applied and Environmental Microbiology
Wanda Vélez-Carrasco, Carol E Green, Paul Catz, Anna Furimsky, Kathleen O'Loughlin, Vesna A Eterović, P A Ferchmin
4R-cembranoid (4R) is a natural cyclic diterpenoid found in tobacco leaves that displays neuroprotective activity. 4R protects against NMDA, paraoxon (POX), and diisopropylfluorophosphate (DFP) damage in rat hippocampal slices and against DFP in rats in vivo. The purpose of this study was to examine the metabolism and pharmacokinetics of 4R as part of its preclinical development as a neuroprotective drug. 10 µM 4R was found to be very stable in plasma for up to 1 hr incubation. 4R metabolism in human microsomes was faster than in the rat...
2015: PloS One
Jason L O'Loughlin, Tyson P Eucker, Juan D Chavez, Derrick R Samuelson, Jason Neal-McKinney, Christopher R Gourley, James E Bruce, Michael E Konkel
Campylobacter jejuni is a leading bacterial cause of human gastroenteritis. The goal of this study was to analyze the C. jejuni F38011 strain, recovered from an individual with severe enteritis, at a genomic and proteomic level to gain insight into microbial processes. The C. jejuni F38011 genome is comprised of 1,691,939 bp, with a mol.% (G+C) content of 30.5%. PacBio sequencing coupled with REBASE analysis was used to predict C. jejuni F38011 genomic sites and enzymes that may be involved in DNA restriction-modification...
2015: PloS One
Laura C Miller, Colleen T O'Loughlin, Zinan Zhang, Albert Siryaporn, Justin E Silpe, Bonnie L Bassler, Martin F Semmelhack
The development of new approaches for the treatment of antimicrobial-resistant infections is an urgent public health priority. The Pseudomonas aeruginosa pathogen, in particular, is a leading source of infection in hospital settings, with few available treatment options. In the context of an effort to develop antivirulence strategies to combat bacterial infection, we identified a series of highly effective small molecules that inhibit the production of pyocyanin, a redox-active virulence factor produced by P...
February 12, 2015: Journal of Medicinal Chemistry
Gaetano D Gargiulo, Aiden O'Loughlin, Paul P Breen
Continuous unobtrusive monitoring of tidal volume, particularly for critical care patients (i.e. neonates and patients in intensive care) during sleep studies and during daily activities, is still an unresolved monitoring need. Also a successful monitoring solution is yet to be proposed for continuous non-invasive cardiac stroke volume monitoring that is a novel clinical need.In this paper we present the feasibility study for a wearable, non-invasive, non-contact and unobtrusive sensor (embedded in a standard T-shirt) based on four electro-resistive bands that simultaneously monitors tidal volume and cardiac stroke volume changes...
February 2015: Physiological Measurement
E O'Loughlin, M Ward, A Crossley, R Hughes, A P Bremner, T Corcoran
It is important to detect and treat hypovolaemia; however, detection is particularly challenging in the conscious, spontaneously breathing patient. Eight healthy male volunteers were monitored using four minimally invasive monitors: Vigileo FloTrac(™) ; LiDCOrapid(™) ; USCOM 1A; and CardioQ(™) oesophageal Doppler. Monitor output and clinical signs were recorded during incremental venesection of 2.5% estimated blood volume aliquots to a total of 20% blood volume removed. A statistically significant difference from baseline stroke volume was detected after 2...
February 2015: Anaesthesia
Daniel E Neafsey, Robert M Waterhouse, Mohammad R Abai, Sergey S Aganezov, Max A Alekseyev, James E Allen, James Amon, Bruno Arcà, Peter Arensburger, Gleb Artemov, Lauren A Assour, Hamidreza Basseri, Aaron Berlin, Bruce W Birren, Stephanie A Blandin, Andrew I Brockman, Thomas R Burkot, Austin Burt, Clara S Chan, Cedric Chauve, Joanna C Chiu, Mikkel Christensen, Carlo Costantini, Victoria L M Davidson, Elena Deligianni, Tania Dottorini, Vicky Dritsou, Stacey B Gabriel, Wamdaogo M Guelbeogo, Andrew B Hall, Mira V Han, Thaung Hlaing, Daniel S T Hughes, Adam M Jenkins, Xiaofang Jiang, Irwin Jungreis, Evdoxia G Kakani, Maryam Kamali, Petri Kemppainen, Ryan C Kennedy, Ioannis K Kirmitzoglou, Lizette L Koekemoer, Njoroge Laban, Nicholas Langridge, Mara K N Lawniczak, Manolis Lirakis, Neil F Lobo, Ernesto Lowy, Robert M MacCallum, Chunhong Mao, Gareth Maslen, Charles Mbogo, Jenny McCarthy, Kristin Michel, Sara N Mitchell, Wendy Moore, Katherine A Murphy, Anastasia N Naumenko, Tony Nolan, Eva M Novoa, Samantha O'Loughlin, Chioma Oringanje, Mohammad A Oshaghi, Nazzy Pakpour, Philippos A Papathanos, Ashley N Peery, Michael Povelones, Anil Prakash, David P Price, Ashok Rajaraman, Lisa J Reimer, David C Rinker, Antonis Rokas, Tanya L Russell, N'Fale Sagnon, Maria V Sharakhova, Terrance Shea, Felipe A Simão, Frederic Simard, Michel A Slotman, Pradya Somboon, Vladimir Stegniy, Claudio J Struchiner, Gregg W C Thomas, Marta Tojo, Pantelis Topalis, José M C Tubio, Maria F Unger, John Vontas, Catherine Walton, Craig S Wilding, Judith H Willis, Yi-Chieh Wu, Guiyun Yan, Evgeny M Zdobnov, Xiaofan Zhou, Flaminia Catteruccia, George K Christophides, Frank H Collins, Robert S Cornman, Andrea Crisanti, Martin J Donnelly, Scott J Emrich, Michael C Fontaine, William Gelbart, Matthew W Hahn, Immo A Hansen, Paul I Howell, Fotis C Kafatos, Manolis Kellis, Daniel Lawson, Christos Louis, Shirley Luckhart, Marc A T Muskavitch, José M Ribeiro, Michael A Riehle, Igor V Sharakhov, Zhijian Tu, Laurence J Zwiebel, Nora J Besansky
Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila...
January 2, 2015: Science
Collynn F Woeller, Charles W O'Loughlin, Elisa Roztocil, Steven E Feldon, Richard P Phipps
Although scarring is a component of wound healing, excessive scar formation is a debilitating condition that results in pain, loss of tissue function, and even death. Many tissues, including the lungs, heart, skin, and eyes, can develop excessive scar tissue as a result of tissue injury, chronic inflammation, or autoimmune disease. Unfortunately, there are few, if any, effective treatments to prevent excess scarring, and new treatment strategies are needed. Using HEK293FT cells stably transfected with a TGFβ-dependent luciferase reporter, we performed a small molecule screen to identify novel compounds with antiscarring activity...
February 6, 2015: Journal of Biological Chemistry
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