keyword
MENU ▼
Read by QxMD icon Read
search

E. o'loughlin

keyword
https://www.readbyqxmd.com/read/28967773/physical-activity-and-depressive-symptoms-after-breast-cancer-cross-sectional-and-longitudinal-relationships
#1
Jennifer Brunet, Jennifer L O'Loughlin, Katie E Gunnell, Catherine M Sabiston
OBJECTIVE: The objective of this study was to examine the cross-sectional and longitudinal relationships between moderate-to-vigorous intensity physical activity (MVPA) and depressive symptoms in women after treatment for breast cancer. METHOD: Accelerometer data on MVPA and self-report data on frequency of depressive symptoms were collected five times at ∼ 3-month intervals from women (Mage at Time 1 = 55.01 ± 10.96 years) who had completed treatment for breast cancer 3 months prior to study inception...
October 2, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28930663/the-trem2-apoe-pathway-drives-the-transcriptional-phenotype-of-dysfunctional-microglia-in-neurodegenerative-diseases
#2
Susanne Krasemann, Charlotte Madore, Ron Cialic, Caroline Baufeld, Narghes Calcagno, Rachid El Fatimy, Lien Beckers, Elaine O'Loughlin, Yang Xu, Zain Fanek, David J Greco, Scott T Smith, George Tweet, Zachary Humulock, Tobias Zrzavy, Patricia Conde-Sanroman, Mar Gacias, Zhiping Weng, Hao Chen, Emily Tjon, Fargol Mazaheri, Kristin Hartmann, Asaf Madi, Jason D Ulrich, Markus Glatzel, Anna Worthmann, Joerg Heeren, Bogdan Budnik, Cynthia Lemere, Tsuneya Ikezu, Frank L Heppner, Vladimir Litvak, David M Holtzman, Hans Lassmann, Howard L Weiner, Jordi Ochando, Christian Haass, Oleg Butovsky
Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a specific apolipoprotein E (APOE)-dependent molecular signature in microglia from models of amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Alzheimer's disease (AD) and in microglia surrounding neuritic β-amyloid (Aβ)-plaques in the brains of people with AD. The APOE pathway mediated a switch from a homeostatic to a neurodegenerative microglia phenotype after phagocytosis of apoptotic neurons...
September 19, 2017: Immunity
https://www.readbyqxmd.com/read/28746880/tgf-%C3%AE-signaling-is-necessary-and-sufficient-for-pharyngeal-arch-artery-angioblast-formation
#3
Maryline Abrial, Noëlle Paffett-Lugassy, Spencer Jeffrey, Daniel Jordan, Evan O'Loughlin, Charles J Frederick, C Geoffrey Burns, Caroline E Burns
The pharyngeal arch arteries (PAAs) are transient embryonic blood vessels that mature into critical segments of the aortic arch and its branches. Although defects in PAA development cause life-threating congenital cardiovascular defects, the molecular mechanisms that orchestrate PAA morphogenesis remain unclear. Through small-molecule screening in zebrafish, we identified TGF-β signaling as indispensable for PAA development. Specifically, chemical inhibition of the TGF-β type I receptor ALK5 impairs PAA development because nkx2...
July 25, 2017: Cell Reports
https://www.readbyqxmd.com/read/28486890/efficacy-and-safety-of-ultra-rapid-iron-polymaltose-infusion-during-general-anaesthesia
#4
R M Browning, N Alakeson, E J O'Loughlin
To assess the efficacy and safety of ultra rapid (15 minute) infusion of iron polymaltose to iron deficient patients during general anaesthesia, we performed a prospective, interventional non-randomised study on 99 adult patients with iron deficiency with or without anaemia presenting for surgery under general anaesthesia. Over 15 minutes during the maintenance phase of anaesthesia, patients were given iron polymaltose, 500 mg if not anaemic, or 1,000 mg if anaemic. Haemodynamic stability, immediate or delayed iron-related side-effects and efficacy at six weeks were assessed...
May 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28379213/energy-dense-diet-triggers-changes-in-gut-microbiota-reorganization-of-gut%C3%A2-brain-vagal-communication-and-increases-body-fat-accumulation
#5
Alexandra C Vaughn, Erin M Cooper, Patricia M DiLorenzo, Levi J O'Loughlin, Michael E Konkel, James H Peters, Andras Hajnal, Tanusree Sen, Sun Hye Lee, Claire B de La Serre, Krzysztof Czaja
Obesity is associated with consumption of energy-dense diets and development of systemic inflammation. Gut microbiota play a role in energy harvest and inflammation and can influence the change from lean to obese phenotypes. The nucleus of the solitary tract (NTS) is a brain target for gastrointestinal signals modulating satiety and alterations in gut-brain vagal pathway may promote overeating and obesity. Therefore, we tested the hypothesis that high-fat diet‑induced changes in gut microbiota alter vagal gut-brain communication associated with increased body fat accumulation...
2017: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28337769/accuracy-intra-and-inter-rater-reliability-of-three-scoring-systems-for-the-glottic-view-at-videolaryngoscopy
#6
E J O'Loughlin, A D Swann, J D English, R Ramadas
An accurate and reproducible recording of laryngoscopic view at tracheal intubation is an important aspect of anaesthetic practice. Unlike direct laryngoscopy, in which the view achieved by the line of sight directly relates to the ease of intubating the trachea, videolaryngoscopy can create a situation in which the view is good, but intubation difficult or impossible. Communicating this to a subsequent anaesthetist is important. We compared three scoring systems: Cormack and Lehane; POGO (percentage of glottic opening); and the Fremantle score, as used by 74 critical care doctors rating 30 anonymised videos of videolaryngoscopic intubations...
July 2017: Anaesthesia
https://www.readbyqxmd.com/read/28132112/combining-mosced-with-molecular-simulation-free-energy-calculations-or-electronic-structure-calculations-to-develop-an-efficient-tool-for-solvent-formulation-and-selection
#7
Courtney E Cox, Jeremy R Phifer, Larissa Ferreira da Silva, Gabriel Gonçalves Nogueira, Ryan T Ley, Elizabeth J O'Loughlin, Ana Karolyne Pereira Barbosa, Brett T Rygelski, Andrew S Paluch
Solubility parameter based methods have long been a valuable tool for solvent formulation and selection. Of these methods, the MOdified Separation of Cohesive Energy Density (MOSCED) has recently been shown to correlate well the equilibrium solubility of multifunctional non-electrolyte solids. However, before it can be applied to a novel solute, a limited amount of reference solubility data is required to regress the necessary MOSCED parameters. Here we demonstrate for the solutes methylparaben, ethylparaben, propylparaben, butylparaben, lidocaine and ephedrine how conventional molecular simulation free energy calculations or electronic structure calculations in a continuum solvent, here the SMD or SM8 solvation model, can instead be used to generate the necessary reference data, resulting in a predictive flavor of MOSCED...
February 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28100522/intraoperative-dexamethasone-does-not-increase-the-risk-of-postoperative-wound-infection-a-propensity-score-matched-post-hoc-analysis-of-the-enigma-ii-trial-endex
#8
T Corcoran, J Kasza, T G Short, E O'Loughlin, M T V Chan, K Leslie, A Forbes, M Paech, P Myles
BACKGROUND: In a post hoc analysis of the ENIGMA-II trial, we sought to determine whether intraoperative dexamethasone was associated with adverse safety outcomes. METHODS: Inverse probability weighting with estimated propensity scores was used to determine the association of dexamethasone administration with postoperative infection, quality of recovery, and adverse safety outcomes for 5499 of the 7112 non-cardiac surgery subjects enrolled in ENIGMA-II. RESULTS: Dexamethasone was administered to 2178 (40%) of the 5499 subjects included in this analysis and was not associated with wound infection [189 (8...
February 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27902714/evaluation-of-the-activity-of-lamivudine-and-zidovudine-against-ebola-virus
#9
Yu Cong, Julie Dyall, Brit J Hart, Lisa Evans DeWald, Joshua C Johnson, Elena Postnikova, Huanying Zhou, Robin Gross, Oscar Rojas, Isis Alexander, Nicole Josleyn, Tengfei Zhang, Julia Michelotti, Krisztina Janosko, Pamela J Glass, Mike Flint, Laura K McMullan, Christina F Spiropoulou, Tim Mierzwa, Rajarshi Guha, Paul Shinn, Sam Michael, Carleen Klumpp-Thomas, Crystal McKnight, Craig Thomas, Ann E Eakin, Kathleen G O'Loughlin, Carol E Green, Paul Catz, Jon C Mirsalis, Anna N Honko, Gene G Olinger, Richard S Bennett, Michael R Holbrook, Lisa E Hensley, Peter B Jahrling
In the fall of 2014, an international news agency reported that patients suffering from Ebola virus disease (EVD) in Liberia were treated successfully with lamivudine, an antiviral drug used to treat human immunodeficiency virus-1 and hepatitis B virus infections. According to the report, 13 out of 15 patients treated with lamivudine survived and were declared free from Ebola virus disease. In this study, the anti-Ebola virus (EBOV) activity of lamivudine and another antiretroviral, zidovudine, were evaluated in a diverse set of cell lines against two variants of wild-type EBOV...
2016: PloS One
https://www.readbyqxmd.com/read/27816041/nicotine-dependence-and-sleep-quality-in-young-adults
#10
E N Dugas, M P Sylvestre, E K O'Loughlin, J Brunet, L Kakinami, E Constantin, J O'Loughlin
INTRODUCTION: More cigarette smokers report poor sleep quality than non-smokers, but the association between nicotine dependence (ND) and sleep quality has not been well-characterized. The objective of this study was to describe the associations among frequency and intensity of cigarette smoking, ND symptoms, and sleep quality in young adults. METHODS: Data on past-year smoking frequency, number of cigarettes smoked in the past month, five ND indicators (i.e., withdrawal, craving, self-medication symptoms, mFTQ, ICD-10 criteria for tobacco dependence), and sleep quality (measured with the Pittsburgh Sleep Quality Index (PSQI)) were collected in 2011-12 in self-report questionnaires completed by 405 young adult smokers (mean age 24 (0...
February 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/27714504/diabetic-charcot-neuroarthropathy-prevalence-demographics-and-outcome-in-a-regional-referral-centre
#11
A O'Loughlin, E Kellegher, C McCusker, R Canavan
BACKGROUND: Diabetic Charcot neuroarthropathy (DCN) is a devastating complication for people with diabetes mellitus. The failure to diagnose DCN and institute treatment in the acute phase leads to permanent deformity and significant morbidity. There is a paucity of data on the prevalence and characteristics of patients who have developed this complication of diabetes. AIMS: To determine the prevalence, clinical characteristics and outcomes of patients with DCN from 2006 to 2012...
February 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/27685028/the-experience-of-transitioning-from-relapsing-remitting-to-secondary-progressive-multiple-sclerosis-views-of-patients-and-health-professionals
#12
Emer O'Loughlin, Susan Hourihan, Jeremy Chataway, E Diane Playford, Afsane Riazi
PURPOSE: The majority of people with multiple sclerosis (pwMS) initially present with discreet periods of relapses followed by partial remission of symptoms (RRMS). Over time, most pwMS transition to secondary progressive MS (SPMS), characterized by a gradual accumulation of disability. This study aimed to explore the experiences, coping and needs associated with transitioning from RRMS to SPMS. METHOD: Data were collected via semi-structured interviews with nine pwMS and seven specialist MS health professionals (HPs)...
August 16, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27406936/immunogenicity-and-persistence-of-immunity-of-a-quadrivalent-human-papillomavirus-hpv-vaccine-in-immunocompromised-children
#13
MULTICENTER STUDY
C Raina MacIntyre, Peter Shaw, Fiona E Mackie, Christina Boros, Helen Marshall, Michelle Barnes, Holly Seale, Sean E Kennedy, Aye Moa, Andrew Hayen, Abrar Ahmad Chughtai, Edward V O'Loughlin, Michael Stormon
AIM: The aim of this study was to determine the immunogenicity and reactogenicity of HPV vaccine in immunocompromised children. METHODS: A multi-centre clinical trial was conducted in three paediatric hospitals in Australia. Unvaccinated children 5-18years of age attending one of three paediatric hospitals with a range of specified conditions associated with immunosuppression were included. Quadrivalent HPV vaccine (Gardasil) was given to the participants and serum anti-HPV antibody levels were measured at baseline (before first dose), 7 and 24months after the first dose of vaccine...
August 5, 2016: Vaccine
https://www.readbyqxmd.com/read/27406851/tepidibacillus-decaturensis-sp-nov-a-microaerophilic-moderately-thermophilic-iron-reducing-bacterium-isolated-from-1-7-km-depth-groundwater
#14
Yiran Dong, Robert A Sanford, Maxim I Boyanov, Kenneth M Kemner, Theodore M Flynn, Edward J O'Loughlin, Randall A Locke, Joseph R Weber, Sheila M Egan, Bruce W Fouke
A Gram-stain-negative, microaerophilic rod-shaped organism designated as strain Z9T was isolated from groundwater of 1.7 km depth from the Mt. Simon Sandstone of the Illinois Basin, Illinois, USA. Cells of strain Z9T were rod shaped with dimensions of 0.3×(1-10) µm and stained Gram-negative. Strain Z9T grew within the temperature range 20-60 °C (optimum at 30-40 °C), between pH 5 and 8 (optimum 5.2-5.8) and under salt concentrations of 1-5 % (w/v) NaCl (optimum 2.5 % NaCl). In addition to growth by fermentation and nitrate reduction, this strain was able to reduce Fe(III), Mn(IV), Co(III) and Cr(VI) when H2 or organic carbon was available as the electron donor, but did not actively reduce oxidized sulfur compounds (e...
October 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27381810/controlled-moderate-hypovolaemia-in-healthy-volunteers-is-not-associated-with-the-development-of-oxidative-stress-assessed-by-plasma-f2-isoprostanes-and-isofurans
#15
Tomas B Corcoran, Emilie Mas, Anne E Barden, L Jackson Roberts, Trevor A Mori, Edmond O'Loughlin
Hypovolaemia can be associated with substantial morbidity, particularly when it occurs in the setting of trauma and in patients with comorbid diseases. Hypovolaemia and inflammation such as occur in the setting of trauma and surgery, are associated with systemic oxidative stress and free-radical injury. Free-radical injury that results from hypovolaemia-induced organ reperfusion may further augment inflammatory processes. It is unknown exactly what proportion of free-radical injury is associated with isolated hypovolaemia as opposed to the contribution from inflammation from surgery or trauma...
July 2016: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/27180028/predictors-of-the-onset-of-cigarette-smoking-a-systematic-review-of-longitudinal-population-based-studies-in-youth
#16
REVIEW
Robert J Wellman, Erika N Dugas, Hartley Dutczak, Erin K O'Loughlin, Geetanjali D Datta, Béatrice Lauzon, Jennifer O'Loughlin
CONTEXT: The onset of cigarette smoking typically occurs during childhood or early adolescence. Nicotine dependence symptoms can manifest soon after onset, contributing to sustained, long-term smoking. Previous reviews have not clarified the determinants of onset. EVIDENCE ACQUISITION: In 2015, a systematic review of the literature in PubMed and EMBASE was undertaken to identify peer-reviewed prospective longitudinal studies published between January 1984 and August 2015 that investigated predictors of cigarette smoking onset among youth aged <18 years who had never smoked...
November 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/26971510/whither-the-e-cigarette
#17
EDITORIAL
Jennifer O'Loughlin, Robert J Wellman, Louise Potvin
No abstract text is available yet for this article.
March 2016: International Journal of Public Health
https://www.readbyqxmd.com/read/26971509/e-cigarettes-addressing-gaps-in-knowledge
#18
Robert J Wellman, Jennifer O'Loughlin
No abstract text is available yet for this article.
March 2016: International Journal of Public Health
https://www.readbyqxmd.com/read/26903432/relationships-between-current-and-past-binge-drinking-and-systolic-blood-pressure-in-young-adults
#19
Robert J Wellman, John A Vaughn, Marie-Pierre Sylvestre, Erin K O'Loughlin, Erika N Dugas, Jennifer L O'Loughlin
PURPOSE: Heavy episodic (i.e., "binge") drinking (i.e., ≥five drinks/occasion) is highly prevalent among young adults; those who binge do so four times per month on average, consuming nine drinks on average on each occasion. Although it is well established that chronic heavy drinking (≥two alcoholic beverages per day) increases the risk of hypertension, the relationship between binge drinking and blood pressure is not well described. Our aim was to describe the relationship between frequency of binge drinking, both current (at age 24 years) and past (at age 20 years), and systolic blood pressure (SBP) at age 24 years...
March 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/26572739/does-the-social-context-of-early-alcohol-use-affect-risky-drinking-in-adolescents-prospective-cohort-study
#20
Louisa Degenhardt, Helena Romaniuk, Carolyn Coffey, Wayne D Hall, Wendy Swift, John B Carlin, Christina O'Loughlin, George C Patton
BACKGROUND: There are limited longitudinal data on the associations between different social contexts of alcohol use and risky adolescent drinking. METHODS: Australian prospective longitudinal cohort of 1943 adolescents with 6 assessment waves at ages 14-17 years. Drinkers were asked where and how frequently they drank. Contexts were: at home with family, at home alone, at a party with friends, in a park/car, or at a bar/nightclub. The outcomes were prevalence and incidence of risky drinking (≥5 standard drinks (10g alcohol) on a day, past week) and very risky drinking (>20 standard drinks for males and >11 for females) in early (waves 1-2) and late (waves 3-6) adolescence...
2015: BMC Public Health
keyword
keyword
120975
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"