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https://www.readbyqxmd.com/read/28516309/assessing-the-process-of-retirement-a-cross-cultural-review-of-available-measures
#1
Julia C Rafalski, Jack H Noone, Kate O'Loughlin, Alexsandro L de Andrade
Retirement research is now expanding beyond the post-World War II baby boomers' retirement attitudes and plans to include the nature of their workforce exit and how successfully they adjust to their new life. These elements are collectively known as the process of retirement. However, there is insufficient research in developing countries to inform the management of their ageing populations regarding this process. This review aims to facilitate national and cross-cultural research in developing and non-English speaking countries by reviewing the existing measures of the retirement process published in English and Portuguese...
May 18, 2017: Journal of Cross-cultural Gerontology
https://www.readbyqxmd.com/read/28486890/efficacy-and-safety-of-ultra-rapid-iron-polymaltose-infusion-during-general-anaesthesia
#2
R M Browning, N Alakeson, E J O'Loughlin
To assess the efficacy and safety of ultra rapid (15 minute) infusion of iron polymaltose to iron deficient patients during general anaesthesia, we performed a prospective, interventional non-randomised study on 99 adult patients with iron deficiency with or without anaemia presenting for surgery under general anaesthesia. Over 15 minutes during the maintenance phase of anaesthesia, patients were given iron polymaltose, 500 mg if not anaemic, or 1,000 mg if anaemic. Haemodynamic stability, immediate or delayed iron-related side-effects and efficacy at six weeks were assessed...
May 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28453315/the-implementation-of-the-vessel-health-and-preservation-framework
#3
Valya Weston, Adele Nightingale, Chris O'Loughlin, Roy Ventura
Vascular access is an important component of health care but is not without associated risks, some of which can be life-threatening. The Vessel Health and Preservation (VHP) framework was developed with the intention of providing frontline staff with a resource to assist in assessing and selecting the best vascular access device to meet individual patient needs and to preserve veins for future use. This article examines the impact of the introduction of the framework into a haematology ward in an acute hospital in the North West of England during a 3-month pilot study...
April 27, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28408711/a-randomized-controlled-trial-to-determine-the-appropriate-time-to-initiate-peritoneal-dialysis-after-insertion-of-catheter-timely-pd-study
#4
Dwarakanathan Ranganathan, George John, Edward Yeoh, Nicola Williams, Barry O'Loughlin, Thin Han, Lakshman Jeyaseelan, Ramanathan Kavitha, Helen Healy
♦Background: The optimal time for the commencement of peritoneal dialysis (PD) after PD catheter insertion is unclear. If dialysis is started too soon after insertion, dialysate leaks and infection could occur. However, by starting PD earlier, morbidity and costs can be reduced through lesser hemodialysis requirements. This is the first randomized controlled trial to determine the safest and shortest interval to commence PD after catheter insertion. ♦ Methods: All consecutive patients undergoing PD catheter insertion at the Royal Brisbane and Women's Hospital and Rockhampton Hospital from 1 March 2008 to 31 May 2013 who met the inclusion and exclusion criteria were invited to participate in the trial...
April 13, 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28399489/gender-differences-in-risk-factors-for-cigarette-smoking-initiation-in-childhood
#5
Marie-Pierre Sylvestre, Robert J Wellman, Erin K O'Loughlin, Erika N Dugas, Jennifer O'Loughlin
INTRODUCTION: We investigated whether established risk factors for initiating cigarette smoking during adolescence (parents, siblings, friends smoke; home smoking rules, smokers at home, exposure to smoking in cars, academic performance, susceptibility to smoking, depressive symptoms, self-esteem, school connectedness, use of other tobacco products) are associated with initiation in preadolescents, and whether the effects of these factors differ by gender. METHODS: In spring 2005, baseline data were collected in self-report questionnaires from 1801 5th grade students including 1553 never-smokers (mean age=10...
April 4, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28392161/functional-delivery-of-lipid-conjugated-sirna-by-extracellular-vesicles
#6
Aisling J O'Loughlin, Imre Mäger, Olivier G de Jong, Miguel A Varela, Raymond M Schiffelers, Samir El Andaloussi, Matthew J A Wood, Pieter Vader
Extracellular vesicles (EVs) are cell-derived, membranous nanoparticles that mediate intercellular communication by transferring biomolecules, including proteins and RNA, between cells. As a result of their suggested natural capability to functionally deliver RNA, EVs may be harnessed as therapeutic RNA carriers. One major limitation for their translation to therapeutic use is the lack of an efficient, robust, and scalable method to load EVs with RNA molecules of interest. Here, we evaluated and optimized methods to load EVs with cholesterol-conjugated small interfering RNAs (cc-siRNAs) by systematic evaluation of the influence of key parameters, including incubation time, volume, temperature, and EV:cc-siRNA ratio...
April 6, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28383961/the-effect-of-episodic-retrieval-on-inhibition-in-task-switching
#7
James A Grange, Agnieszka W Kowalczyk, Rory O'Loughlin
Inhibition in task switching is inferred from n-2 repetition costs: the observation that ABA task switching sequences are responded to slower than CBA sequences. This is thought to reflect the persisting inhibition of Task A, which slows reactivation attempts. Mayr (2002) reported an experiment testing a critical noninhibitory account of this effect, namely episodic retrieval: If the trial parameters for Task A match across an ABA sequence, responses should be facilitated because of priming from episodic retrieval; a cost would occur if trial parameters mismatch...
April 6, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28379213/energy-dense-diet-triggers-changes-in-gut-microbiota-reorganization-of-gut%C3%A2-brain-vagal-communication-and-increases-body-fat-accumulation
#8
Alexandra C Vaughn, Erin M Cooper, Patricia M DiLorenzo, Levi J O'Loughlin, Michael E Konkel, James H Peters, Andras Hajnal, Tanusree Sen, Sun Hye Lee, Claire B de La Serre, Krzysztof Czaja
Obesity is associated with consumption of energy-dense diets and development of systemic inflammation. Gut microbiota play a role in energy harvest and inflammation and can influence the change from lean to obese phenotypes. The nucleus of the solitary tract (NTS) is a brain target for gastrointestinal signals modulating satiety and alterations in gut-brain vagal pathway may promote overeating and obesity. Therefore, we tested the hypothesis that high-fat diet‑induced changes in gut microbiota alter vagal gut-brain communication associated with increased body fat accumulation...
2017: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28363262/psychometric-evaluation-of-the-mental-health-continuum-short-form-in-french-canadian-young-adults
#9
Isabelle Doré, Jennifer L O'Loughlin, Catherine M Sabiston, Louise Fournier
OBJECTIVE: To examine the factor structure, internal consistency, reliability, sex invariance, and discriminant validity of the French Canadian version of the Mental Health Continuum-Short Form (MHC-SF). METHOD: A total of 1485 French-speaking postsecondary students in Quebec, Canada (58% female; mean age = 18.4, SD = 2.4), completed the MHC-SF. Confirmatory factor analysis (CFA) was used to assess the factorial structure of the MHC-SF. Internal consistency was assessed with Cronbach's alpha, and reliability was assessed with the rho reliability coefficient...
April 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28346152/associations-between-physical-activity-and-sedentary-behavior-with-sleep-quality-and-quantity-in-young-adults
#10
Lisa Kakinami, Erin K O'Loughlin, Jennifer Brunet, Erika N Dugas, Evelyn Constantin, Catherine M Sabiston, Jennifer O'Loughlin
OBJECTIVES: Intensity and duration of physical activity (PA) and sedentary behavior are individually associated with sleep, but their independent associations are poorly characterized. The objectives of this study were to determine if PA and/or sedentary behavior are/is associated with sleep quality and/or quantity in a young adult sample. DESIGN: Cross-sectional. SETTING: Montreal, Canada. PARTICIPANTS: Participants (n=658) from the Nicotine Dependence in Teens Study...
February 2017: Sleep Health
https://www.readbyqxmd.com/read/28337769/accuracy-intra-and-inter-rater-reliability-of-three-scoring-systems-for-the-glottic-view-at-videolaryngoscopy
#11
E J O'Loughlin, A D Swann, J D English, R Ramadas
An accurate and reproducible recording of laryngoscopic view at tracheal intubation is an important aspect of anaesthetic practice. Unlike direct laryngoscopy, in which the view achieved by the line of sight directly relates to the ease of intubating the trachea, videolaryngoscopy can create a situation in which the view is good, but intubation difficult or impossible. Communicating this to a subsequent anaesthetist is important. We compared three scoring systems: Cormack and Lehane; POGO (percentage of glottic opening); and the Fremantle score, as used by 74 critical care doctors rating 30 anonymised videos of videolaryngoscopic intubations...
March 24, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28332273/reducing-the-incidence-of-hepatic-artery-thrombosis-in-pediatric-liver-transplantation-effect-of-microvascular-techniques-and-a-customized-anticoagulation-protocol
#12
William A Ziaziaris, Alexandre Darani, Andrew J A Holland, Angus Alexander, Jonathan Karpelowsky, Pasquale Barbaro, Michael Stormon, Edward O'Loughlin, Albert Shun, Gordon Thomas
We aimed to assess the incidence of HAT over three eras following implementation of microvascular techniques and a customized anticoagulation protocol in a predominantly cadaveric split liver transplant program. We retrospectively reviewed pediatric liver transplants performed between April 1986 and 2016 and analyzed the incidence HAT over three eras. In E1, 1986-2008, each patient received a standard dose of 5 U/kg/h of heparin and coagulation profiles normalized passively. In E2, 2008-2012, microvascular techniques were introduced...
June 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28318910/predictors-of-cigarette-smoking-initiation-in-early-middle-and-late-adolescence
#13
Jennifer O'Loughlin, Erin K O'Loughlin, Robert J Wellman, Marie-Pierre Sylvestre, Erika N Dugas, Miguel Chagnon, Hartley Dutczak, Johanne Laguë, Jennifer J McGrath
PURPOSE: Little is known about age-related differences in risk factors for cigarette smoking initiation. We identified predictors of initiation in early, middle, and late adolescence from among sociodemographic factors, indicators of smoking in the social environment, psychological characteristics, lifestyle indicators, and perceived need for cigarettes. METHODS: Data were drawn from a longitudinal study of 1,801 children recruited at age 10-11 years from 29 elementary schools in Montreal, Canada...
March 15, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28283919/preventing-returns-to-the-emergency-department-followingbariatric-surgery
#14
Jennwood Chen, Justin Mackenzie, Yan Zhai, James O'Loughlin, Rebecca Kholer, Ellen Morrow, Robert Glasgow, Eric Volckmann, Anna Ibele
BACKGROUND: Unnecessary emergency department (ED) visits following bariatric surgery represent a significant source of inefficient resource utilization. This study aimed to identify potential strategies aimed at preventing unnecessary returns to the ED following bariatric surgery. The study was conducted in University Hospital, USA. METHODS: The electronic medical records of all patients who underwent bariatric surgery at our institution between January 2011 and October 2015 were retrospectively reviewed...
March 10, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28273067/aboriginal-mitogenomes-reveal-50-000-years-of-regionalism-in-australia
#15
Ray Tobler, Adam Rohrlach, Julien Soubrier, Pere Bover, Bastien Llamas, Jonathan Tuke, Nigel Bean, Ali Abdullah-Highfold, Shane Agius, Amy O'Donoghue, Isabel O'Loughlin, Peter Sutton, Fran Zilio, Keryn Walshe, Alan N Williams, Chris S M Turney, Matthew Williams, Stephen M Richards, Robert J Mitchell, Emma Kowal, John R Stephen, Lesley Williams, Wolfgang Haak, Alan Cooper
Aboriginal Australians represent one of the longest continuous cultural complexes known. Archaeological evidence indicates that Australia and New Guinea were initially settled approximately 50 thousand years ago (ka); however, little is known about the processes underlying the enormous linguistic and phenotypic diversity within Australia. Here we report 111 mitochondrial genomes (mitogenomes) from historical Aboriginal Australian hair samples, whose origins enable us to reconstruct Australian phylogeographic history before European settlement...
April 13, 2017: Nature
https://www.readbyqxmd.com/read/28135806/the-value-of-a-registrar-psychotherapy-post-to-psychiatry-training
#16
Gabriel Feiler, Denis O'Loughlin, Eugen Koh, Josephine Beatson, Ed Harari
OBJECTIVES: This paper describes the psychotherapy registrar position developed at St Vincent's Hospital Melbourne in response to the Australian Government's Specialist Training Position initiative of 2009. This impressionistic piece outlines features of the registrar's clinical work, supervision and professional development. This paper will focus on: 1) the history of the position; 2) its developmental function embedded within the clinical responsibilities of the role; 3) how this position is different from the existing Royal and Australian and New Zealand College of Psychiatry psychotherapy training requirements; and 4) infrastructure issues of the position...
January 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28132112/combining-mosced-with-molecular-simulation-free-energy-calculations-or-electronic-structure-calculations-to-develop-an-efficient-tool-for-solvent-formulation-and-selection
#17
Courtney E Cox, Jeremy R Phifer, Larissa Ferreira da Silva, Gabriel Gonçalves Nogueira, Ryan T Ley, Elizabeth J O'Loughlin, Ana Karolyne Pereira Barbosa, Brett T Rygelski, Andrew S Paluch
Solubility parameter based methods have long been a valuable tool for solvent formulation and selection. Of these methods, the MOdified Separation of Cohesive Energy Density (MOSCED) has recently been shown to correlate well the equilibrium solubility of multifunctional non-electrolyte solids. However, before it can be applied to a novel solute, a limited amount of reference solubility data is required to regress the necessary MOSCED parameters. Here we demonstrate for the solutes methylparaben, ethylparaben, propylparaben, butylparaben, lidocaine and ephedrine how conventional molecular simulation free energy calculations or electronic structure calculations in a continuum solvent, here the SMD or SM8 solvation model, can instead be used to generate the necessary reference data, resulting in a predictive flavor of MOSCED...
January 28, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28107282/early-posthepatoportoenterostomy-predictors-of-native-liver-survival-in-biliary-atresia
#18
Scott Nightingale, Michael O Stormon, Edward V O'Loughlin, Albert Shun, Gordon Thomas, Eric I Benchimol, Andrew S Day, Susan Adams, Edward Shi, Chee Y Ooi, Binita M Kamath, Annie Fecteau, Jacob C Langer, Eve A Roberts, Simon C Ling, Vicky L Ng
OBJECTIVES: Most infants with biliary atresia (BA) require liver transplantation (LT) after hepatoportoenterostomy (HPE), including those who initially clear jaundice. The aim of the present study was to identify clinical and routine laboratory factors in infants with BA post-HPE that predict native liver survival at 2 years. METHODS: A retrospective cohort study was conducted in 217 patients with BA undergoing HPE in Sydney, Australia and Toronto, Canada between January 1986 and July 2009...
February 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28100522/intraoperative-dexamethasone-does-not-increase-the-risk-of-postoperative-wound-infection-a-propensity-score-matched-post-hoc-analysis-of-the-enigma-ii-trial-endex
#19
T Corcoran, J Kasza, T G Short, E O'Loughlin, M T V Chan, K Leslie, A Forbes, M Paech, P Myles
BACKGROUND: In a post hoc analysis of the ENIGMA-II trial, we sought to determine whether intraoperative dexamethasone was associated with adverse safety outcomes. METHODS: Inverse probability weighting with estimated propensity scores was used to determine the association of dexamethasone administration with postoperative infection, quality of recovery, and adverse safety outcomes for 5499 of the 7112 non-cardiac surgery subjects enrolled in ENIGMA-II. RESULTS: Dexamethasone was administered to 2178 (40%) of the 5499 subjects included in this analysis and was not associated with wound infection [189 (8...
February 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27980033/the-brain-parenchyma-has-a-type-i-interferon-response-that-can-limit-virus-spread
#20
Eugene Drokhlyansky, Didem Göz Aytürk, Timothy K Soh, Ryan Chrenek, Elaine O'Loughlin, Charlotte Madore, Oleg Butovsky, Constance L Cepko
The brain has a tightly regulated environment that protects neurons and limits inflammation, designated "immune privilege." However, there is not an absolute lack of an immune response. We tested the ability of the brain to initiate an innate immune response to a virus, which was directly injected into the brain parenchyma, and to determine whether this response could limit viral spread. We injected vesicular stomatitis virus (VSV), a transsynaptic tracer, or naturally occurring VSV-derived defective interfering particles (DIPs), into the caudate-putamen (CP) and scored for an innate immune response and inhibition of virus spread...
January 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
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