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https://www.readbyqxmd.com/read/28135806/the-value-of-a-registrar-psychotherapy-post-to-psychiatry-training
#1
Gabriel Feiler, Denis O'Loughlin, Eugen Koh, Josephine Beatson, Ed Harari
OBJECTIVES: This paper describes the psychotherapy registrar position developed at St Vincent's Hospital Melbourne in response to the Australian Government's Specialist Training Position initiative of 2009. This impressionistic piece outlines features of the registrar's clinical work, supervision and professional development. This paper will focus on: 1) the history of the position; 2) its developmental function embedded within the clinical responsibilities of the role; 3) how this position is different from the existing Royal and Australian and New Zealand College of Psychiatry psychotherapy training requirements; and 4) infrastructure issues of the position...
January 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28132112/combining-mosced-with-molecular-simulation-free-energy-calculations-or-electronic-structure-calculations-to-develop-an-efficient-tool-for-solvent-formulation-and-selection
#2
Courtney E Cox, Jeremy R Phifer, Larissa Ferreira da Silva, Gabriel Gonçalves Nogueira, Ryan T Ley, Elizabeth J O'Loughlin, Ana Karolyne Pereira Barbosa, Brett T Rygelski, Andrew S Paluch
Solubility parameter based methods have long been a valuable tool for solvent formulation and selection. Of these methods, the MOdified Separation of Cohesive Energy Density (MOSCED) has recently been shown to correlate well the equilibrium solubility of multifunctional non-electrolyte solids. However, before it can be applied to a novel solute, a limited amount of reference solubility data is required to regress the necessary MOSCED parameters. Here we demonstrate for the solutes methylparaben, ethylparaben, propylparaben, butylparaben, lidocaine and ephedrine how conventional molecular simulation free energy calculations or electronic structure calculations in a continuum solvent, here the SMD or SM8 solvation model, can instead be used to generate the necessary reference data, resulting in a predictive flavor of MOSCED...
January 28, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28107282/early-posthepatoportoenterostomy-predictors-of-native-liver-survival-in-biliary-atresia
#3
Scott Nightingale, Michael O Stormon, Edward V O'Loughlin, Albert Shun, Gordon Thomas, Eric I Benchimol, Andrew S Day, Susan Adams, Edward Shi, Chee Y Ooi, Binita M Kamath, Annie Fecteau, Jacob C Langer, Eve A Roberts, Simon C Ling, Vicky L Ng
OBJECTIVES: Most infants with biliary atresia (BA) require liver transplantation (LT) after hepatoportoenterostomy (HPE), including those who initially clear jaundice. The aim of the present study was to identify clinical and routine laboratory factors in infants with BA post-HPE that predict native liver survival at 2 years. METHODS: A retrospective cohort study was conducted in 217 patients with BA undergoing HPE in Sydney, Australia and Toronto, Canada between January 1986 and July 2009...
February 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28100522/intraoperative-dexamethasone-does-not-increase-the-risk-of-postoperative-wound-infection-a-propensity-score-matched-post-hoc-analysis-of-the-enigma-ii-trial-endex
#4
T Corcoran, J Kasza, T G Short, E O'Loughlin, M T V Chan, K Leslie, A Forbes, M Paech, P Myles
BACKGROUND: In a post hoc analysis of the ENIGMA-II trial, we sought to determine whether intraoperative dexamethasone was associated with adverse safety outcomes. METHODS: Inverse probability weighting with estimated propensity scores was used to determine the association of dexamethasone administration with postoperative infection, quality of recovery, and adverse safety outcomes for 5499 of the 7112 non-cardiac surgery subjects enrolled in ENIGMA-II. RESULTS: Dexamethasone was administered to 2178 (40%) of the 5499 subjects included in this analysis and was not associated with wound infection [189 (8...
February 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27980033/the-brain-parenchyma-has-a-type-i-interferon-response-that-can-limit-virus-spread
#5
Eugene Drokhlyansky, Didem Göz Aytürk, Timothy K Soh, Ryan Chrenek, Elaine O'Loughlin, Charlotte Madore, Oleg Butovsky, Constance L Cepko
The brain has a tightly regulated environment that protects neurons and limits inflammation, designated "immune privilege." However, there is not an absolute lack of an immune response. We tested the ability of the brain to initiate an innate immune response to a virus, which was directly injected into the brain parenchyma, and to determine whether this response could limit viral spread. We injected vesicular stomatitis virus (VSV), a transsynaptic tracer, or naturally occurring VSV-derived defective interfering particles (DIPs), into the caudate-putamen (CP) and scored for an innate immune response and inhibition of virus spread...
January 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27979360/risk-of-post-procedural-bleeding-in-children-on-intravenous-fish-oil
#6
Prathima Nandivada, Lorenzo Anez-Bustillos, Alison A O'Loughlin, Paul D Mitchell, Meredith A Baker, Duy T Dao, Gillian L Fell, Alexis K Potemkin, Kathleen M Gura, Ellis J Neufeld, Mark Puder
BACKGROUND: Intestinal failure-associated liver disease (IFALD) can be treated with parenteral fish oil (FO) monotherapy, but practitioners have raised concerns about a potential bleeding risk. This study aims to describe the incidence of clinically significant post-procedural bleeding (CSPPB) in children receiving FO monotherapy. METHODS: A retrospective chart review was performed on patients at our institution treated with intravenous FO for IFALD. CSPPB was defined as bleeding leading to re-operation, transfer to the intensive care unit, re-admission, or death, up to one month after any invasive procedure...
December 1, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27929373/tumor-induced-mdsc-act-via-remote-control-to-inhibit-l-selectin-dependent-adaptive-immunity-in-lymph-nodes
#7
Amy W Ku, Jason B Muhitch, Colin A Powers, Michael Diehl, Minhyung Kim, Daniel T Fisher, Anand P Sharda, Virginia K Clements, Kieran O'Loughlin, Hans Minderman, Michelle N Messmer, Jing Ma, Joseph J Skitzki, Douglas A Steeber, Bruce Walcheck, Suzanne Ostrand-Rosenberg, Scott I Abrams, Sharon S Evans
Myeloid-derived suppressor cells (MDSC) contribute to an immunosuppressive network that drives cancer escape by disabling T cell adaptive immunity. The prevailing view is that MDSC-mediated immunosuppression is restricted to tissues where MDSC co-mingle with T cells. Here we show that splenic or, unexpectedly, blood-borne MDSC execute far-reaching immune suppression by reducing expression of the L-selectin lymph node (LN) homing receptor on naïve T and B cells. MDSC-induced L-selectin loss occurs through a contact-dependent, post-transcriptional mechanism that is independent of the major L-selectin sheddase, ADAM17, but results in significant elevation of circulating L-selectin in tumor-bearing mice...
December 8, 2016: ELife
https://www.readbyqxmd.com/read/27902714/evaluation-of-the-activity-of-lamivudine-and-zidovudine-against-ebola-virus
#8
Yu Cong, Julie Dyall, Brit J Hart, Lisa Evans DeWald, Joshua C Johnson, Elena Postnikova, Huanying Zhou, Robin Gross, Oscar Rojas, Isis Alexander, Nicole Josleyn, Tengfei Zhang, Julia Michelotti, Krisztina Janosko, Pamela J Glass, Mike Flint, Laura K McMullan, Christina F Spiropoulou, Tim Mierzwa, Rajarshi Guha, Paul Shinn, Sam Michael, Carleen Klumpp-Thomas, Crystal McKnight, Craig Thomas, Ann E Eakin, Kathleen G O'Loughlin, Carol E Green, Paul Catz, Jon C Mirsalis, Anna N Honko, Gene G Olinger, Richard S Bennett, Michael R Holbrook, Lisa E Hensley, Peter B Jahrling
In the fall of 2014, an international news agency reported that patients suffering from Ebola virus disease (EVD) in Liberia were treated successfully with lamivudine, an antiviral drug used to treat human immunodeficiency virus-1 and hepatitis B virus infections. According to the report, 13 out of 15 patients treated with lamivudine survived and were declared free from Ebola virus disease. In this study, the anti-Ebola virus (EBOV) activity of lamivudine and another antiretroviral, zidovudine, were evaluated in a diverse set of cell lines against two variants of wild-type EBOV...
2016: PloS One
https://www.readbyqxmd.com/read/27876012/phase-i-study-of-low-dose-metronomic-temozolomide-for-recurrent-malignant-gliomas
#9
Eric T Wong, Joshua Timmons, Amy Callahan, Lauren O'Loughlin, Bridget Giarusso, David C Alsop
BACKGROUND: The treatment goal for recurrent malignant gliomas centers on disease stabilization while minimizing therapy-related side effects. Metronomic dosing of cytotoxic chemotherapy has emerged as a promising option to achieve this objective. METHODS: This phase I study was performed using metronomic temozolomide (mTMZ) at 25 or 50 mg/m(2)/day continuously in 42-day cycles. Correlative studies were incorporated using arterial spin labeling MRI to assess tumor blood flow, analysis of matrix metalloproteinase-2 (MMP-2) and MMP-9 activities in the cerebrospinal fluid (CSF) as surrogates for tumor angiogenesis and invasion, as well as determination of CSF soluble interleukin-2 receptor alpha (sIL-2Rα) levels as a marker of immune modulation...
November 22, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27859063/habitat-augmentation-drives-secondary-invasion-an-experimental-approach-to-determine-the-mechanism-of-invasion-success
#10
Luke S O'Loughlin, Peter T Green
The entry of secondary invaders into, or their expansion within, native communities is contingent on the changes wrought by other (primary) invaders. When primary invaders have altered more than one property of the recipient community, standard descriptive and modeling approaches only provide a best guess of the mechanism permitting the secondary invasion. In rainforest on Christmas Island, we conducted a manipulative field experiment to determine the mechanism of invasion success for a community of land snails dominated by non-native species...
September 2016: Ecology
https://www.readbyqxmd.com/read/27822907/multiple-intra-hospital-transports-during-relocation-to-a-new-critical-care-unit
#11
R-A O'Leary, I Conrick-Martin, C O'Loughlin, M-R Curran, B Marsh
OBJECTIVE: Intra-hospital transport (IHT) of critically ill patients is associated with morbidity and mortality. Mass transfer of patients, as happens with unit relocation, is poorly described. We outline the process and adverse events associated with the relocation of a critical care unit. DESIGN: Extensive planning of the relocation targeted patient and equipment transfer, reduction in clinical pressure prior to the event and patient care during the relocation phase...
November 7, 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/27816041/nicotine-dependence-and-sleep-quality-in-young-adults
#12
E N Dugas, M P Sylvestre, E K O'Loughlin, J Brunet, L Kakinami, E Constantin, J O'Loughlin
INTRODUCTION: More cigarette smokers report poor sleep quality than non-smokers, but the association between nicotine dependence (ND) and sleep quality has not been well-characterized. The objective of this study was to describe the associations among frequency and intensity of cigarette smoking, ND symptoms, and sleep quality in young adults. METHODS: Data on past-year smoking frequency, number of cigarettes smoked in the past month, five ND indicators (i.e., withdrawal, craving, self-medication symptoms, mFTQ, ICD-10 criteria for tobacco dependence), and sleep quality (measured with the Pittsburgh Sleep Quality Index (PSQI)) were collected in 2011-12 in self-report questionnaires completed by 405 young adult smokers (mean age 24 (0...
February 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/27794067/social-disparities-in-children-s-exposure-to-secondhand-smoke-in-privately-owned-vehicles
#13
Annie Montreuil, Nancy Hanusaik, Michael Cantinotti, Bernard-Simon Leclerc, Yan Kestens, Michèle Tremblay, Joanna Cohen, Jennifer McGrath, Geetanjali D Datta, Jennifer L O'Loughlin
INTRODUCTION: Secondhand smoke (SHS) can quickly attain high concentrations in cars, posing health risks to passengers and especially to children. This paper assesses whether there are social disparities in children's exposure to SHS in privately owned vehicles. METHODS: On weekday mornings and afternoons from September to November 2011, trained observers were stationed at 100 selected street intersections in Montreal, Canada. For each car transporting at least one passenger aged 0-15 years travelling through the intersection, observers recorded the estimated age of the youngest child in the car, whether any occupant was smoking and the licence plate number of the car...
October 28, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27787648/cerebrofacial-arteriovenous-metameric-syndrome-cams-a-spectrum-disorder-of-craniofacial-vascular-malformations
#14
Lauren O'Loughlin, Mari L Groves, Neil R Miller, Monica S Pearl
Cerebrofacial arteriovenous metameric syndrome (CAMS) is a recent classification of vascular malformations that encompasses a spectrum of phenotypic expression involving arteriovenous malformations (AVMs) of the cerebral, orbital, and facial region. Recognizing the embryologic basis of CAMS is important for diagnosing other AVMs along the same metameric level. Visual loss is the most common presentation prompting ophthalmologic evaluation followed by neuroimaging. We present two pediatric patients with ipsilateral optic nerve and chiasmal AVMs without cutaneous manifestations, characteristic of CAMS 2...
October 27, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27714504/diabetic-charcot-neuroarthropathy-prevalence-demographics-and-outcome-in-a-regional-referral-centre
#15
A O'Loughlin, E Kellegher, C McCusker, R Canavan
BACKGROUND: Diabetic Charcot neuroarthropathy (DCN) is a devastating complication for people with diabetes mellitus. The failure to diagnose DCN and institute treatment in the acute phase leads to permanent deformity and significant morbidity. There is a paucity of data on the prevalence and characteristics of patients who have developed this complication of diabetes. AIMS: To determine the prevalence, clinical characteristics and outcomes of patients with DCN from 2006 to 2012...
February 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/27685028/the-experience-of-transitioning-from-relapsing-remitting-to-secondary-progressive-multiple-sclerosis-views-of-patients-and-health-professionals
#16
Emer O'Loughlin, Susan Hourihan, Jeremy Chataway, E Diane Playford, Afsane Riazi
PURPOSE: The majority of people with multiple sclerosis (pwMS) initially present with discreet periods of relapses followed by partial remission of symptoms (RRMS). Over time, most pwMS transition to secondary progressive MS (SPMS), characterized by a gradual accumulation of disability. This study aimed to explore the experiences, coping and needs associated with transitioning from RRMS to SPMS. METHOD: Data were collected via semi-structured interviews with nine pwMS and seven specialist MS health professionals (HPs)...
August 16, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27673709/family-impact-and-infant-emotional-outcomes-following-diagnosis-of-serious-liver-disease-or-transplantation-in-infancy
#17
Michael R Bowden, Looi C Ee, Usha Krishnan, Edward V O'Loughlin, Winita Hardikar, Diana Carmody, Cassandra Hainsworth, Vicki Jermyn, Mee-Mee Lee, Janine Sawyer, Michael Stormon, Kathe Holmes, Daniel A Lemberg, Andrew S Day, Campbell Paul, Philip Hazell
OBJECTIVES: Research is lacking into the emotional effects on families of serious chronic illness in infants. We examined the impact of the diagnosis of serious liver disease in infants upon parent psychological symptoms and family functioning. We hypothesized that parent psychological symptoms, family functioning and father engagement will predict infant emotional outcomes. METHODS: Parents of infants recently diagnosed with serious liver disease completed validated questionnaires about parent stress, family function, impact of the illness on the family, and father engagement...
September 24, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27636723/bacterial-fungal-interactions-including-quorum-sensing-between-two-opportunistic-pathogens-resulting-in-post-traumatic-sepsis-in-a-child-presenting-with-a-closed-femoral-fracture
#18
Rebecca Bradford, Alice Munro, Bhavdeep R Jani, Surendra Singham, Kate O'Loughlin, Janette Cansick
: Pseudomonas aeruginosa (P.aeruginosa) and Candida albicans (C.albicans) are opportunistic pathogens that cause systemic infections in immune-suppressed patients. They show important bacterial-fungal interactions including quorum sensing. This involves cell-signaling to communicate between the cells of their own colony as well as the cells of rival microbes or the host. It is thought that this phenomenon is vital in the potential competition and virulence of the organisms. We report a case of a previously healthy 2 year old boy, where an accidental injury had been sustained resulting in a closed fracture of femur...
September 15, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27609745/volume-and-social-context-of-physical-activity-in-association-with-mental-health-anxiety-and-depression-among-youth
#19
Isabelle Doré, Jennifer L O'Loughlin, Guy Beauchamp, Marc Martineau, Louise Fournier
There is growing interest in physical activity (PA) to prevent mental disorders in youth. However, few studies examine the association between PA and mental health. Further, how PA volume and context relate to mental health and mental disorders remains unclear, especially among youth in transition to adulthood. This study examined the cross-sectional associations among PA volume and context, mental health, and symptoms of anxiety and depression in post-secondary students. A total of 1527 post-secondary students (97...
October 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27601484/protocol-for-a-multicentre-prospective-observational-cohort-study-of-variation-in-practice-in-perioperative-analgesic-strategies-in-elective-laparoscopic-colorectal-surgery-the-lapcogesic-study
#20
Phillippa Burnell, Rachael Coates, Steven Dixon, Lucy Grant, Matthew Grey, Ben Griffiths, Mike Jones, Anantha Madhavan, Iain McCallum, Ross McClean, Karen Naru, Lydia Newton, Paul O'Loughlin, Fadlo Shaban, Anisha Sukha, Sameer Somnath, Syed Shumon, Deena Harji
INTRODUCTION: Laparoscopic surgery combined with enhanced recovery programmes has become the gold standard in the elective management of colorectal disease. However, there is no consensus with regard to the optimal perioperative analgesic regime in this cohort of patients, with a number of options available, including thoracic epidural spinal analgesia, patient-controlled analgesia, subcutaneous and/or intraperitoneal local anaesthetics, local anaesthetic wound infiltration catheters and transversus abdominis plane blocks...
September 6, 2016: BMJ Open
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