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https://www.readbyqxmd.com/read/29467281/the-myo6-interactome-reveals-adaptor-complexes-coordinating-early-endosome-and-cytoskeletal-dynamics
#1
Thomas O'Loughlin, Thomas A Masters, Folma Buss
The intracellular functions of myosin motors requires a number of adaptor molecules, which control cargo attachment, but also fine-tune motor activity in time and space. These motor-adaptor-cargo interactions are often weak, transient or highly regulated. To overcome these problems, we use a proximity labelling-based proteomics strategy to map the interactome of the unique minus end-directed actin motor MYO6. Detailed biochemical and functional analysis identified several distinct MYO6-adaptor modules including two complexes containing RhoGEFs: the LIFT (LARG-Induced F-actin for Tethering) complex that controls endosome positioning and motility through RHO-driven actin polymerisation; and the DISP (DOCK7-Induced Septin disPlacement) complex, a novel regulator of the septin cytoskeleton...
February 21, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29419406/microglial-phenotypes-and-functions-in-multiple-sclerosis
#2
REVIEW
Elaine O'Loughlin, Charlotte Madore, Hans Lassmann, Oleg Butovsky
Microglia are the resident immune cells that constantly survey the central nervous system. They can adapt to their environment and respond to injury or insult by altering their morphology, phenotype, and functions. It has long been debated whether microglial activation is detrimental or beneficial in multiple sclerosis (MS). Recently, the two opposing yet connected roles of microglial activation have been described with the aid of novel microglial markers, RNA profiling, and in vivo models. In this review, microglial phenotypes and functions in the context of MS will be discussed with evidence from both human pathological studies, in vitro and in vivo models...
February 1, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29355345/attachment-avoidance-alexithymia-and-gender-examining-their-associations-with-distress-disclosure-tendencies-and-event-specific-disclosure
#3
Julia I O'Loughlin, Daniel W Cox, Jeffrey H Kahn, Amery D Wu
Distress disclosure has been linked with reduced psychological distress, increased wellbeing, and successful psychotherapeutic outcome. Because of the importance of distress disclosure, researchers have worked to develop and improve theoretical models of disclosure to facilitate counseling practices that reduce impediments to disclosure. Presently, we conducted a 2-part study to investigate distress disclosure's associations with attachment avoidance, gender, and alexithymia-3 constructs frequently linked with disclosure...
January 2018: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/29277114/developing-a-falls-prevention-program-for-community-dwelling-stroke-survivors-in-singapore-client-and-caregiver-perspectives
#4
Tianma Xu, Kate O'Loughlin, Lindy Clemson, Natasha A Lannin, Catherine Dean, Gerald Koh
PURPOSE: Drawing on the perspectives of stroke survivors, family members and domestic helpers, this study explores participants' experiences of self-perceived fall risk factors after stroke, common fall prevention strategies used, and challenges to community participation after a fall. METHODS: Semi-structured interviews were conducted in Singapore with community-dwelling stroke survivors with a previous fall (n = 9), family caregivers (n = 4), and domestic helpers (n = 4) who have cared for a stroke survivor with a previous fall...
December 25, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29242444/the-current-status-of-neocnus-arredondo-1961-mammalia-edentata-pilosa-megalonichidae-and-a-replacement-name-for-its-junior-homonym-in-the-sea-cucumber-family-cucumariidae-echinodermata-holothuroidea-dendrochirotida-cucumariidae
#5
Ahmed S Thandar, Lazaro W V Vinola
This short communication addresses the problem associated with the current taxonomic status of the prehistoric edentate genus Neocnus Arredondo, 1961 (with type species Micronocnus gliriformis Matthew, 1931) which has long been considered a senior homonym of the dendrochirotid sea cucumber genus Neocnus Cherbonnier, 1972 (type species Neocnus incubans Cherbonnier, 1972) and replaces the latter (junior homonym) with Incubocnus n.g. The diagnosis of the new genus is the same as the cucumariid Neocnus as amended by O'Loughlin & O'Hara (1992)...
October 17, 2017: Zootaxa
https://www.readbyqxmd.com/read/29220820/application-of-an-in-situ-soil-sampler-for-assessing-subsurface-biogeochemical-dynamics-in-a-diesel-contaminated-coastal-site-during-soil-flushing-operations
#6
Man Jae Kwon, Edward J O'Loughlin, Baknoon Ham, Yunho Hwang, Moojoon Shim, Soonjae Lee
Subsurface biogeochemistry and contaminant dynamics during the remediation of diesel-contamination by in-situ soil flushing were investigated at a site located in a coastal region. An in-situ sampler containing diesel-contaminated soils separated into two size fractions (<0.063- and <2-mm) was utilized in two monitoring wells: DH1 (located close to the injection and extraction wells for in-situ soil flushing) and DH2 (located beyond sheet piles placed to block the transport of leaked diesel). Total petroleum hydrocarbon (TPH) concentrations and biogeochemical properties were monitored both in soil and groundwater for six months...
December 5, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29211018/parameter-search-algorithms-for-microwave-radar-based-breast-imaging-focal-quality-metrics-as-fitness-functions
#7
Declan O'Loughlin, Bárbara L Oliveira, Muhammad Adnan Elahi, Martin Glavin, Edward Jones, Milica Popović, Martin O'Halloran
Inaccurate estimation of average dielectric properties can have a tangible impact on microwave radar-based breast images. Despite this, recent patient imaging studies have used a fixed estimate although this is known to vary from patient to patient. Parameter search algorithms are a promising technique for estimating the average dielectric properties from the reconstructed microwave images themselves without additional hardware. In this work, qualities of accurately reconstructed images are identified from point spread functions...
December 6, 2017: Sensors
https://www.readbyqxmd.com/read/29156153/hyperbaric-oxygen-therapy-is-not-associated-with-oxidative-stress-assessed-using-plasma-f2-isoprostanes-and-isofurans
#8
Tomas Corcoran, Sonya Ting, Emilie Mas, Michael Phillips, Edmond O'Loughlin, Anne Barden, Trevor A Mori
BACKGROUND AND AIMS: Hyperbaric oxygen (HBO) therapy is increasingly used in medical practice as a means of enhancing the formation of collagen matrix and angiogenesis, thus promoting healing in wounds and necrotic tissue. However, there are concerns that oxygen can also associate with increased production of oxygen free radicals and oxidative stress. F2-Isoprostanes (F2-IsoPs) formed by non-enzymatic oxidation of arachidonic acid (AA) are reliable measures for assessing oxidative stress in vivo...
December 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29143910/the-effect-of-sms-text-message-reminders-on-attendance-at-a-community-adult-mental-health-service-clinic-do-sms-reminders-really-increase-attendance
#9
Lucy Moran, Kieran O'Loughlin, Brendan D Kelly
BACKGROUND: Non-attendance at outpatient clinics is common and costly. AIMS: This study aimed to determine if sending SMS ('short message service' or text message) reminders to patients before appointments reduced non-attendance. METHODS: We collected outpatient data at Ballyfermot and Lucan Community Adult Mental Health Service, Dublin, Ireland during 6-month periods (a) immediately prior to the introduction of SMS reminders for outpatient appointments; (b) immediately following the introduction of SMS reminders; and (c) two and a half years later...
November 16, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29133575/childhood-sports-participation-and-adolescent-sport-profile
#10
François Gallant, Jennifer L O'Loughlin, Jennifer Brunet, Catherine M Sabiston, Mathieu Bélanger
OBJECTIVES: We aimed to increase understanding of the link between sport specialization during childhood and adolescent physical activity (PA). The objectives were as follows: (1) describe the natural course of sport participation over 5 years among children who are early sport samplers or early sport specializers and (2) determine if a sport participation profile in childhood predicts the sport profile in adolescence. METHODS: Participants (n = 756, ages 10-11 years at study inception) reported their participation in organized and unorganized PA during in-class questionnaires administered every 4 months over 5 years...
November 13, 2017: Pediatrics
https://www.readbyqxmd.com/read/29133569/efficacy-of-tilorone-dihydrochloride-against-ebola-virus-infection
#11
Sean Ekins, Mary A Lingerfelt, Jason E Comer, Alexander N Freiberg, Jon C Mirsalis, Kathleen O'Loughlin, Anush Harutyunyan, Claire McFarlane, Carol E Green, Peter B Madrid
Tilorone dihydrochloride (tilorone) is a small-molecule, orally bioavailable drug that is used clinically as an antiviral outside of the US. A machine learning model trained on anti-Ebola virus (EBOV) screening data previously identified tilorone as a potent in vitro EBOV inhibitor, making it a candidate for the treatment of Ebola virus disease (EVD). In the present study, a series of in vitro ADMET (absorption, distribution, metabolism, excretion, toxicity) assays demonstrated the drug has excellent solubility, high Caco-2 permeability, was not a P-glycoprotein substrate and had no inhibitory activity against five human CYP450 enzymes (3A4, 2D6, 2C19, 2C9 and 1A2)...
November 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29116338/socioeconomic-status-is-associated-with-the-prevalence-and-co-occurrence-of-risk-factors-for-cigarette-smoking-initiation-during-adolescence
#12
Robert J Wellman, Marie-Pierre Sylvestre, Erin K O'Loughlin, Hartley Dutczak, Annie Montreuil, Geetanjali D Datta, Jennifer O'Loughlin
OBJECTIVES: To investigate whether the prevalence or co-occurrence of risk factors for cigarette smoking initiation differ by socioeconomic status (SES) and whether SES interacts with risk factors to increase initiation. METHODS: In 2005, 1451 5th grade never smokers (mean age 10.7 years) in Montréal, Canada, provided baseline data, with follow-up in 6th and/or 7th grade (2005-2007). Poisson regression analyses estimated the association between 13 risk factors and initiation...
November 7, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/29105889/obstructive-sleep-apnoea-in-a-paediatric-patient-with-laryngeal-crohn-s-disease
#13
Tasnuba Pervez, Cheng Hiang Lee, Chris Seton, Marco Raftopulos, Catherine Birman, Edward O'loughlin
No abstract text is available yet for this article.
November 6, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29096641/acute-in-utero-exposure-to-lipopolysaccharide-induces-inflammation-in-the-pre-and-postnatal-brain-and-alters-the-glial-cytoarchitecture-in-the-developing-amygdala
#14
Elaine O'Loughlin, Janelle M P Pakan, Deniz Yilmazer-Hanke, Kieran W McDermott
BACKGROUND: Maternal immune activation (MIA) is a risk factor for neurodevelopmental disorders such as autism and schizophrenia, as well as seizure development. The amygdala is a brain region involved in the regulation of emotions, and amygdalar maldevelopment due to infection-induced MIA may lead to amygdala-related disorders. MIA priming of glial cells during development has been linked to abnormalities seen in later life; however, little is known about its effects on amygdalar biochemical and cytoarchitecture integrity...
November 2, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29095039/women-with-hypoactive-sexual-desire-disorder-versus-sexual-interest-arousal-disorder-an-empirical-test-of-raising-the-bar
#15
Julia I O'Loughlin, Rosemary Basson, Lori A Brotto
In 2013, the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) was published with a major revision to the sexual dysfunction categories, and the diagnosis of female hypoactive sexual desire disorder (HSDD) was replaced with female sexual interest/arousal disorder (SIAD). Since being introduced, concern has been expressed that SIAD inappropriately "raises the bar" for diagnosis. To address these concerns, we sought to evaluate the number of women with a diagnosis of HSDD who also met criteria for SIAD...
November 2, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29073392/screen-and-nonscreen-sedentary-behavior-and-sleep-in-adolescents
#16
Vanessa C Brunetti, Erin K O'Loughlin, Jennifer O'Loughlin, Evelyn Constantin, Étienne Pigeon
OBJECTIVE: This study examined the associations between screen (computer, videogame, TV) and nonscreen (talking on the phone, doing homework, reading) sedentary time, and sleep in adolescents. PARTICIPANTS: Data were drawn from AdoQuest, a prospective investigation of 1843 grade 5 students aged 10-12 years at inception in the greater Montreal (Canada) area. METHODS: Data for this cross-sectional analysis on screen and nonscreen sedentary time, sleep duration, and daytime sleepiness were collected in 2008-2009 from 1233 participants (67% of 1843) aged 14-16 years...
December 2016: Sleep Health
https://www.readbyqxmd.com/read/29063348/differential-contribution-of-microglia-and-monocytes-in-neurodegenerative-diseases
#17
REVIEW
Caroline Baufeld, Elaine O'Loughlin, Narghes Calcagno, Charlotte Madore, Oleg Butovsky
Neuroinflammation is a hallmark of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). Microglia, the innate immune cells of the CNS, are the first to react to pathological insults. However, multiple studies have also demonstrated an involvement of peripheral monocytes in several neurodegenerative diseases. Due to the different origins of these two cell types, it is important to distinguish their role and function in the development and progression of these diseases...
October 23, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29043020/secondary-invasion-when-invasion-success-is-contingent-on-other-invaders-altering-the-properties-of-recipient-ecosystems
#18
REVIEW
Luke S O'Loughlin, Peter T Green
Positive interactions between exotic species may increase ecosystem-level impacts and potentially facilitate the entry and spread of other exotic species. Invader-facilitated invasion success-"secondary invasion"-is a key conceptual aspect of the well-known invasional meltdown hypothesis, but remains poorly defined and empirically underexplored. Drawing from heuristic models and published empirical studies, we explore this form of "secondary invasion" and discuss the phenomenon within the recognized conceptual framework of the determinants of invasion success...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28989200/man-thou-art-dust-rites-of-passage-in-austere-times
#19
Deirdre M O'Loughlin, Isabelle Szmigin, Morven G McEachern, Belem Barbosa, Kalipso Karantinou, María Eugenia Fernández-Moya
In response to recent calls for further cross-disciplinary research on austerity and a deeper sociological understanding of the impact and aftermath of the economic crisis on individuals and societies, this article builds on extant austerity literature through an exploration of its effects on European men. Informed by theories of liminality and rites of passage, this qualitative investigation examines the experience of austerity from the perspective of 11 men through the three liminal stages of separation, transition and reaggregation and investigates its impact on their identity, responsibilities and expectations...
October 2017: Sociology
https://www.readbyqxmd.com/read/28967773/physical-activity-and-depressive-symptoms-after-breast-cancer-cross-sectional-and-longitudinal-relationships
#20
Jennifer Brunet, Jennifer L O'Loughlin, Katie E Gunnell, Catherine M Sabiston
OBJECTIVE: The objective of this study was to examine the cross-sectional and longitudinal relationships between moderate-to-vigorous intensity physical activity (MVPA) and depressive symptoms in women after treatment for breast cancer. METHOD: Accelerometer data on MVPA and self-report data on frequency of depressive symptoms were collected five times at ∼ 3-month intervals from women (Mage at Time 1 = 55.01 ± 10.96 years) who had completed treatment for breast cancer 3 months prior to study inception...
October 2, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
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