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https://www.readbyqxmd.com/read/29673035/climate-change-and-the-health-of-older-people-in-australia-a-scoping-review-on-the-role-of-mobile-applications-apps-in-ameliorating-impact
#1
REVIEW
Deborah A Black, Kate O'Loughlin, Leigh A Wilson
OBJECTIVES: Due to the impact of climate change, mobile applications (apps) providing information about the external environment have the potential to improve the health of older people. The purpose of this research was to undertake a scoping review of the evidence on the usability, feasibility and effectiveness of mobile apps to encourage access to activities outside the home in older people. METHODS: A search of databases was undertaken with relevant keywords...
April 19, 2018: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/29622653/no-one-is-an-island
#2
Luke O'Loughlin
No abstract text is available yet for this article.
April 6, 2018: Science
https://www.readbyqxmd.com/read/29589413/physiological-demands-of-daily-riding-gaits-in-jockeys
#3
Michael A Kiely, Giles D Warrington, Adrian McGOLDRICK, Gillian O'Loughlin, Sarahjane Cullen
BACKGROUND: Jockeys should maintain a high level of physical fitness to meet the physical demands of horse racing. The aim of this study was to determine the physiological requirements of the riding gaits used regularly in training. METHODS: Eleven trainee jockeys performed a maximal incremental Wattbike cycle ergometer test. Mean absolute and relative oxygen uptake (VO2) and heart rate (HR) were recorded for the steady-state period during a walk, trot and canter...
March 27, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29569418/monitoring-of-ph-and-temperature-of-neuropathic-diabetic-and-non-diabetic-foot-ulcers-for-12-weeks-an-observational-study
#4
G Gethin, G M O'Connor, J Abedin, J Newell, L Flynn, D Watterson, A O'Loughlin
Wound bed assessment is largely reliant on subjective interpretation without recourse to objective tools or biomarkers. The identification of a point of care, reliable biomarker would enhance assessment and ultimately clinical decision-making. Two potentially emerging wound biomarkers exist: surface pH and surface temperature. To date, knowledge of their use has been predominantly in wound prevention, in vitro studies and single time measurements. Our objective was to determine surface pH, size and surface temperature in non-infected, neuropathic foot ulcers at baseline and at 12 weeks...
March 22, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29533532/another-nail-in-the-coffin-for-learning-styles-disparities-among-undergraduate-anatomy-students-study-strategies-class-performance-and-reported-vark-learning-styles
#5
Polly R Husmann, Valerie Dean O'Loughlin
The concept and existence of learning styles has been fraught with controversy, and recent studies have thrown their existence into doubt. Yet, many students still hold to the conventional wisdom that learning styles are legitimate, and may adapt their outside of class study strategies to match these learning styles. Thus, this study aims to assess if undergraduate anatomy students are more likely to utilize study strategies that align with their hypothetical learning styles (using the VARK analysis from Fleming and Mills, , Improve Acad...
March 13, 2018: Anatomical Sciences Education
https://www.readbyqxmd.com/read/29533264/implication-of-major-adverse-postoperative-events-and-myocardial-injury-on-disability-and-survival-a-planned-subanalysis-of-the-enigma-ii-trial
#6
W Scott Beattie, Duminda N Wijeysundera, Matthew T V Chan, Philip J Peyton, Kate Leslie, Michael J Paech, Daniel I Sessler, Sophie Wallace, Paul S Myles, W Galagher, C Farrington, A Ditoro, S Baulch, S Sidiropoulos, R Bulach, D Bryant, E O'Loughlin, V Mitteregger, S Bolsin, C Osborne, R McRae, M Backstrom, R Cotter, S March, B Silbert, S Said, R Halliwell, J Cope, D Fahlbusch, D Crump, G Thompson, A Jefferies, M Reeves, N Buckley, T Tidy, T Schricker, R Lattermann, D Iannuzzi, J Carroll, M Jacka, C Bryden, N Badner, M W Y Tsang, B C P Cheng, A C M Fong, L C Y Chu, E G Y Koo, N Mohd, L E Ming, D Campbell, D McAllister, S Walker, S Olliff, R Kennedy, A Eldawlatly, T Alzahrani, N Chua, R Sneyd, H McMillan, I Parkinson, A Brennan, P Balaji, J Nightingale, G Kunst, M Dickinson, B Subramaniam, V Banner-Godspeed, J Liu, A Kurz, B Hesler, A Y Fu, C Egan, A N Fiffick, M T Hutcherson, A Turan, A Naylor, D Obal, E Cooke
BACKGROUND: Globally, >300 million patients have surgery annually, and ≤20% experience adverse postoperative events. We studied the impact of both cardiac and noncardiac adverse events on 1-year disability-free survival after noncardiac surgery. METHODS: We used the study cohort from the Evaluation of Nitrous oxide in Gas Mixture of Anesthesia (ENIGMA-II) trial, an international randomized trial of 6992 noncardiac surgical patients. All were ≥45 years of age and had moderate to high cardiac risk...
March 12, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29522067/sex-differences-in-attaining-cigarette-smoking-and-nicotine-dependence-milestones-in-novice-smokers
#7
Marie-Pierre Sylvestre, Miguel Chagnon, Robert J Wellman, Erika N Dugas, Jennifer O'Loughlin
No abstract text is available yet for this article.
March 7, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29505154/characterization-of-fatty-acid-profiles-in-infants-with-intestinal-failure-associated-liver-disease
#8
Meredith A Baker, Paul D Mitchell, Alison A O'Loughlin, Alexis K Potemkin, Lorenzo Anez-Bustillos, Duy T Dao, Gillian L Fell, Kathleen M Gura, Mark Puder
BACKGROUND: The purpose of this study was to characterize fatty acid profiles (FAPs) in parenteral nutrition (PN)-dependent infants with intestinal failure-associated liver disease (IFALD) receiving soybean oil-based lipid emulsion (SO) doses of ∼3 and ∼1 g/kg/d. METHODS: Prospectively collected data were retrospectively reviewed. Serum FAPs of patients <1 year old who experienced development of IFALD while receiving standard PN with SO were examined before transitioning to a fish oil-based lipid emulsion for IFALD treatment...
January 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29467281/the-myo6-interactome-reveals-adaptor-complexes-coordinating-early-endosome-and-cytoskeletal-dynamics
#9
Thomas O'Loughlin, Thomas A Masters, Folma Buss
The intracellular functions of myosin motors requires a number of adaptor molecules, which control cargo attachment, but also fine-tune motor activity in time and space. These motor-adaptor-cargo interactions are often weak, transient or highly regulated. To overcome these problems, we use a proximity labelling-based proteomics strategy to map the interactome of the unique minus end-directed actin motor MYO6. Detailed biochemical and functional analysis identified several distinct MYO6-adaptor modules including two complexes containing RhoGEFs: the LIFT (LARG-Induced F-actin for Tethering) complex that controls endosome positioning and motility through RHO-driven actin polymerisation; and the DISP (DOCK7-Induced Septin disPlacement) complex, a novel regulator of the septin cytoskeleton...
February 21, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29419406/microglial-phenotypes-and-functions-in-multiple-sclerosis
#10
REVIEW
Elaine O'Loughlin, Charlotte Madore, Hans Lassmann, Oleg Butovsky
Microglia are the resident immune cells that constantly survey the central nervous system. They can adapt to their environment and respond to injury or insult by altering their morphology, phenotype, and functions. It has long been debated whether microglial activation is detrimental or beneficial in multiple sclerosis (MS). Recently, the two opposing yet connected roles of microglial activation have been described with the aid of novel microglial markers, RNA profiling, and in vivo models. In this review, microglial phenotypes and functions in the context of MS will be discussed with evidence from both human pathological studies, in vitro and in vivo models...
February 1, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29355345/attachment-avoidance-alexithymia-and-gender-examining-their-associations-with-distress-disclosure-tendencies-and-event-specific-disclosure
#11
Julia I O'Loughlin, Daniel W Cox, Jeffrey H Kahn, Amery D Wu
Distress disclosure has been linked with reduced psychological distress, increased wellbeing, and successful psychotherapeutic outcome. Because of the importance of distress disclosure, researchers have worked to develop and improve theoretical models of disclosure to facilitate counseling practices that reduce impediments to disclosure. Presently, we conducted a 2-part study to investigate distress disclosure's associations with attachment avoidance, gender, and alexithymia-3 constructs frequently linked with disclosure...
January 2018: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/29277114/developing-a-falls-prevention-program-for-community-dwelling-stroke-survivors-in-singapore-client-and-caregiver-perspectives
#12
Tianma Xu, Kate O'Loughlin, Lindy Clemson, Natasha A Lannin, Catherine Dean, Gerald Koh
PURPOSE: Drawing on the perspectives of stroke survivors, family members and domestic helpers, this study explores participants' experiences of self-perceived fall risk factors after stroke, common fall prevention strategies used, and challenges to community participation after a fall. METHODS: Semi-structured interviews were conducted in Singapore with community-dwelling stroke survivors with a previous fall (n = 9), family caregivers (n = 4), and domestic helpers (n = 4) who have cared for a stroke survivor with a previous fall...
December 25, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29242444/the-current-status-of-neocnus-arredondo-1961-mammalia-edentata-pilosa-megalonichidae-and-a-replacement-name-for-its-junior-homonym-in-the-sea-cucumber-family-cucumariidae-echinodermata-holothuroidea-dendrochirotida-cucumariidae
#13
Ahmed S Thandar, Lazaro W V Vinola
This short communication addresses the problem associated with the current taxonomic status of the prehistoric edentate genus Neocnus Arredondo, 1961 (with type species Micronocnus gliriformis Matthew, 1931) which has long been considered a senior homonym of the dendrochirotid sea cucumber genus Neocnus Cherbonnier, 1972 (type species Neocnus incubans Cherbonnier, 1972) and replaces the latter (junior homonym) with Incubocnus n.g. The diagnosis of the new genus is the same as the cucumariid Neocnus as amended by O'Loughlin & O'Hara (1992)...
October 17, 2017: Zootaxa
https://www.readbyqxmd.com/read/29220820/application-of-an-in-situ-soil-sampler-for-assessing-subsurface-biogeochemical-dynamics-in-a-diesel-contaminated-coastal-site-during-soil-flushing-operations
#14
Man Jae Kwon, Edward J O'Loughlin, Baknoon Ham, Yunho Hwang, Moojoon Shim, Soonjae Lee
Subsurface biogeochemistry and contaminant dynamics during the remediation of diesel-contamination by in-situ soil flushing were investigated at a site located in a coastal region. An in-situ sampler containing diesel-contaminated soils separated into two size fractions (<0.063- and <2-mm) was utilized in two monitoring wells: DH1 (located close to the injection and extraction wells for in-situ soil flushing) and DH2 (located beyond sheet piles placed to block the transport of leaked diesel). Total petroleum hydrocarbon (TPH) concentrations and biogeochemical properties were monitored both in soil and groundwater for six months...
January 15, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29211018/parameter-search-algorithms-for-microwave-radar-based-breast-imaging-focal-quality-metrics-as-fitness-functions
#15
Declan O'Loughlin, Bárbara L Oliveira, Muhammad Adnan Elahi, Martin Glavin, Edward Jones, Milica Popović, Martin O'Halloran
Inaccurate estimation of average dielectric properties can have a tangible impact on microwave radar-based breast images. Despite this, recent patient imaging studies have used a fixed estimate although this is known to vary from patient to patient. Parameter search algorithms are a promising technique for estimating the average dielectric properties from the reconstructed microwave images themselves without additional hardware. In this work, qualities of accurately reconstructed images are identified from point spread functions...
December 6, 2017: Sensors
https://www.readbyqxmd.com/read/29156153/hyperbaric-oxygen-therapy-is-not-associated-with-oxidative-stress-assessed-using-plasma-f2-isoprostanes-and-isofurans
#16
Tomas Corcoran, Sonya Ting, Emilie Mas, Michael Phillips, Edmond O'Loughlin, Anne Barden, Trevor A Mori
BACKGROUND AND AIMS: Hyperbaric oxygen (HBO) therapy is increasingly used in medical practice as a means of enhancing the formation of collagen matrix and angiogenesis, thus promoting healing in wounds and necrotic tissue. However, there are concerns that oxygen can also associate with increased production of oxygen free radicals and oxidative stress. F2-Isoprostanes (F2-IsoPs) formed by non-enzymatic oxidation of arachidonic acid (AA) are reliable measures for assessing oxidative stress in vivo...
December 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29143910/the-effect-of-sms-text-message-reminders-on-attendance-at-a-community-adult-mental-health-service-clinic-do-sms-reminders-really-increase-attendance
#17
Lucy Moran, Kieran O'Loughlin, Brendan D Kelly
BACKGROUND: Non-attendance at outpatient clinics is common and costly. AIMS: This study aimed to determine if sending SMS ('short message service' or text message) reminders to patients before appointments reduced non-attendance. METHODS: We collected outpatient data at Ballyfermot and Lucan Community Adult Mental Health Service, Dublin, Ireland during 6-month periods (a) immediately prior to the introduction of SMS reminders for outpatient appointments; (b) immediately following the introduction of SMS reminders; and (c) two and a half years later...
November 16, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29133575/childhood-sports-participation-and-adolescent-sport-profile
#18
François Gallant, Jennifer L O'Loughlin, Jennifer Brunet, Catherine M Sabiston, Mathieu Bélanger
OBJECTIVES: We aimed to increase understanding of the link between sport specialization during childhood and adolescent physical activity (PA). The objectives were as follows: (1) describe the natural course of sport participation over 5 years among children who are early sport samplers or early sport specializers and (2) determine if a sport participation profile in childhood predicts the sport profile in adolescence. METHODS: Participants ( n = 756, ages 10-11 years at study inception) reported their participation in organized and unorganized PA during in-class questionnaires administered every 4 months over 5 years...
December 2017: Pediatrics
https://www.readbyqxmd.com/read/29133569/efficacy-of-tilorone-dihydrochloride-against-ebola-virus-infection
#19
Sean Ekins, Mary A Lingerfelt, Jason E Comer, Alexander N Freiberg, Jon C Mirsalis, Kathleen O'Loughlin, Anush Harutyunyan, Claire McFarlane, Carol E Green, Peter B Madrid
Tilorone dihydrochloride (tilorone) is a small-molecule, orally bioavailable drug that is used clinically as an antiviral outside of the US. A machine learning model trained on anti-Ebola virus (EBOV) screening data previously identified tilorone as a potent in vitro EBOV inhibitor, making it a candidate for the treatment of Ebola virus disease (EVD). In the present study, a series of in vitro ADMET (absorption, distribution, metabolism, excretion, toxicity) assays demonstrated the drug has excellent solubility, high Caco-2 permeability, was not a P-glycoprotein substrate and had no inhibitory activity against five human CYP450 enzymes (3A4, 2D6, 2C19, 2C9 and 1A2)...
November 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29116338/socioeconomic-status-is-associated-with-the-prevalence-and-co-occurrence-of-risk-factors-for-cigarette-smoking-initiation-during-adolescence
#20
Robert J Wellman, Marie-Pierre Sylvestre, Erin K O'Loughlin, Hartley Dutczak, Annie Montreuil, Geetanjali D Datta, Jennifer O'Loughlin
OBJECTIVES: To investigate whether the prevalence or co-occurrence of risk factors for cigarette smoking initiation differ by socioeconomic status (SES) and whether SES interacts with risk factors to increase initiation. METHODS: In 2005, 1451 5th grade never smokers (mean age 10.7 years) in Montréal, Canada, provided baseline data, with follow-up in 6th and/or 7th grade (2005-2007). Poisson regression analyses estimated the association between 13 risk factors and initiation...
January 2018: International Journal of Public Health
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