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https://www.readbyqxmd.com/read/27896660/ayahuasca-exposure-descriptive-analysis-of-calls-to-us-poison-control-centers-from-2005-to-2015
#1
C William Heise, Daniel E Brooks
BACKGROUND: Ayahuasca is a hallucinogenic plant preparation which usually contains the vine Banisteriopsis caapi and the shrub Psychotria viridis. This tea originates from the Amazon Basin where it is used in religious ceremonies. Because interest in these religious groups spreading as well as awareness of use of ayahuasca for therapeutic and recreational purposes, its use is increasing. Banisteriopsis caapi is rich in β-carbolines, especially harmine, tetrahydroharmine and harmaline, which have monoamine oxidase inhibiting (MAOI) activity...
November 28, 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27856296/tyramine-and-histamine-risk-assessment-related-to-consumption-of-dry-fermented-sausages-by-the-spanish-population
#2
M L Latorre-Moratalla, O Comas-Basté, S Bover-Cid, M C Vidal-Carou
Tyramine and histamine are the main dietary bioactive amines related to acute adverse health effects. Dry fermented sausages can easily accumulate high levels of these hazards and are frequently consumed in Spain. The present work aims to assess the exposure to tyramine and histamine from the consumption of dry fermented sausages by the Spanish population and to assess the risk to suffer acute health effects from this exposure. A probabilistic estimation of the exposure to these hazards was derived combining probability distributions of these amines in dry fermented sausages (n = 474) and their consumption by the Spanish population...
November 14, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27783998/hepatocellular-carcinoma-and-antidepressants-a-nationwide-population-based-study
#3
Vincent Chin-Hung Chen, Chiao-Fan Lin, Yi-Hsuan Hsieh, Hsin-Yi Liang, Kuo-You Huang, Wei-Che Chiu, Yena Lee, Roger S McIntyre, Hsiang-Lin Chan
Hepatocellular carcinoma (HCC) is highly prevalent in Asia. Antidepressants have been associated with increase in hepatocellular carcinoma. This is the first Asian population-based study to evaluate the association between antidepressant use and risk of HCC. Based on Taiwan's National Health Insurance Research Database, we conducted a nationwide population-based study. A total of 49,998 cases with HCC were identified and paired with 244,236 randomly selected controls. The data was analyzed via the conditional logistic regression model adjusting for several confounding factors...
October 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27715253/an-overview-of-analytical-methods-for-the-determinationof-monoamine-oxidase-inhibitors-in-pharmaceutical-formulations-and-biological-fluids
#4
Cafer Saka
Monoamine oxidase inhibitors (MAOIs) were the first type of antidepressant developed. MAOIs elevate the levels of norepinephrine, serotonin, and dopamine by inhibiting an enzyme called monoamine oxidase. They are also used in the treatment of Parkinson's disease, tuberculosis, and several other disorders. Therefore, it is very important to develop efficient analytical methods for monitoring and management. There are two isoforms of monoamine oxidase, MAO-A and MAO-B. In this article, analyses of MAOIs in pharmaceutical formulations and biological fluids were reviewed from 2000 to the present, including all types of chromatographic, spectrophotometric, electrophoretic, and voltammetric techniques, focusing on isoniazid, tranylcypromine, moclobemide, rasagiline, and selegiline...
October 7, 2016: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/27709018/development-of-a-mechanism-based-pharmacokinetic-pharmacodynamic-model-to-characterize-the-thermoregulatory-effects-of-serotonergic-drugs-in-mice
#5
Xi-Ling Jiang, Hong-Wu Shen, Donald E Mager, Stephan Schmidt, Ai-Ming Yu
We have shown recently that concurrent harmaline, a monoamine oxidase-A inhibitor (MAOI), potentiates serotonin (5-HT) receptor agonist 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT)-induced hyperthermia. The objective of this study was to develop an integrated pharmacokinetic/pharmacodynamic (PK/PD) model to characterize and predict the thermoregulatory effects of such serotonergic drugs in mice. Physiological thermoregulation was described by a mechanism-based indirect-response model with adaptive feedback control...
September 2016: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/27618521/antidepressants-and-benzodiazepines-for-panic-disorder-in-adults
#6
Irene Bighelli, Carlotta Trespidi, Mariasole Castellazzi, Andrea Cipriani, Toshi A Furukawa, Francesca Girlanda, Giuseppe Guaiana, Markus Koesters, Corrado Barbui
BACKGROUND: A panic attack is a discrete period of fear or anxiety that has a rapid onset, reaches a peak within 10 minutes and in which at least four of 13 characteristic symptoms are experienced, including racing heart, chest pain, sweating, shaking, dizziness, flushing, stomach churning, faintness and breathlessness. Panic disorder is common in the general population with a lifetime prevalence of 1% to 4%. The treatment of panic disorder includes psychological and pharmacological interventions...
September 12, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27444984/drug-interactions-between-hormonal-contraceptives-and-psychotropic-drugs-a-systematic-review
#7
Erin N Berry-Bibee, Myong-Jin Kim, Katharine B Simmons, Naomi K Tepper, Halley E M Riley, H Pamela Pagano, Kathryn M Curtis
OBJECTIVE: To examine whether the co-administration of hormonal contraceptives (HC) and psychotropic drugs commonly used to treat anxiety and/or depression results in safety or efficacy concerns for either drug. METHODS: We searched PubMed and Cochrane libraries for clinical or pharmacokinetic (PK) studies that examined co-administration of any HC with psychotropic drugs [selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), oral benzodiazepines, bupropion, mirtazapine, trazadone, buspirone, hydroxyzine, monoamine oxidase inhibitors (MAOIs), or atypical antipsychotics] in reproductive aged women...
July 18, 2016: Contraception
https://www.readbyqxmd.com/read/27423475/-antidepressant-and-tolerance-determinants-and-management-of-major-side-effects
#8
D J David, D Gourion
Antidepressant therapy aims to reach remission of depressive symptoms while reducing the complications and risks of relapse. Even though they have proven their efficacy, it takes several weeks for antidepressants to demonstrate full effectiveness, and adverse effects occur more quickly or (quicker) which can be a source of poor compliance. This latest aspect often leads to dose reduction and/or change of molecule that have the effect of delaying remission. This review attempts to present, from the pharmacological properties of the major classes of antidepressants (monoamine oxidase inhibitor [MAOI], tricyclic antidepressants [TCA], selective serotonin reuptake inhibitor [SSRI] and serotonin and noradrenaline reuptake inhibitor [SNRI]), to the pharmacological mechanisms involved in adverse effects by focusing on sexual dysfunction, nausea/vomiting, and weight changes and sleep disruption...
July 14, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27421270/new-pharmacological-agents-to-aid-smoking-cessation-and-tobacco-harm-reduction-what-has-been-investigated-and-what-is-in-the-pipeline
#9
REVIEW
Emma Beard, Lion Shahab, Damian M Cummings, Susan Michie, Robert West
A wide range of support is available to help smokers to quit and to aid attempts at harm reduction, including three first-line smoking cessation medications: nicotine replacement therapy, varenicline and bupropion. Despite the efficacy of these, there is a continual need to diversify the range of medications so that the needs of tobacco users are met. This paper compares the first-line smoking cessation medications with (1) two variants of these existing products: new galenic formulations of varenicline and novel nicotine delivery devices; and (2) 24 alternative products: cytisine (novel outside Central and Eastern Europe), nortriptyline, other tricyclic antidepressants, electronic cigarettes, clonidine (an anxiolytic), other anxiolytics (e...
October 2016: CNS Drugs
https://www.readbyqxmd.com/read/27377797/a-rapid-and-simple-method-for-the-determination-of-psychoactive-alkaloids-by-ce-uv-application-to-peganum-harmala-seed-infusions
#10
Marcos Tascón, Fernando Benavente, Nora M Vizioli, Leonardo G Gagliardi
The β-carboline alkaloids of the harmala (HAlks) group are compounds widely spread in many natural sources, but found at relatively high levels in some specific plants like Peganum harmala (Syrian rue) or Banisteriopsis caapi. HAlks are a reversible Mono Amino Oxidase type A Inhibitor (MAOI) and, as a consequence, these plants or their extracts can be used to produce psychotropic effects when are combined with psychotropic drugs based on amino groups. Since the occurrence and the levels of the HAlks in natural sources are subject to significant variability, more widespread use is not clinical but recreational or ritual, for example B...
July 5, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27213169/major-depressive-disorder-and-kappa-opioid-receptor-antagonists
#11
Wei Li, Huijiao Sun, Hao Chen, Xicheng Yang, Li Xiao, Renyu Liu, Liming Shao, Zhuibai Qiu
Major depressive disorder (MDD) is a common psychiatric disease worldwide. The clinical use of tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs) and selective serotonin reuptake inhibitors (SSRIs)/serotonin-norepinephrine reuptake inhibitor (SNRIs) for this condition have been widely accepted, but they were challenged by unacceptable side-effects, potential drug-drug interactions (DDIs) or slow onset/lack of efficacy. The endogenous opioid system is involved in stress and emotion regulatory processes and its role in MDD has been implicated...
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/27187783/comparative-safety-of-pharmacologic-treatments-for-persistent-depressive-disorder-a-systematic-review-and-network-meta-analysis
#12
Ramona Meister, Alessa von Wolff, Hannes Mohr, Martin Härter, Yvonne Nestoriuc, Lars Hölzel, Levente Kriston
We aimed to compare the safety of antidepressants for the treatment of persistent depressive disorder (PDD) with each other and with placebo. We conducted a systematic electronic search and included randomized controlled trials that investigated antidepressants for the treatment of PDD in adults. Outcomes were the incidence of experiencing any adverse event, specific adverse events and related treatment discontinuations. We analyzed the data using traditional and network meta-analyses. Thirty-four studies that comprised 4,769 patients and examined 20 individual agents in nine substance classes were included...
2016: PloS One
https://www.readbyqxmd.com/read/27127395/-ping-pong-gaze-secondary-to-monoamine-oxidase-inhibitor-overdose
#13
Amy Attaway, Laila Sroujieh, Tracey L Mersfelder, Christopher Butler, Daniel Ouellette
An infrequent manifestation of monoamine oxidase inhibitor (MAOI) toxicity is "ping-pong gaze" (PPG). We describe the case of a 26-year-old female who was found unresponsive after taking 40 tablets of phenelzine. On presentation to the hospital, her eyes were moving in characteristic "ping pong" fashion. After 6 hours her gaze terminated. The following day her neurologic exam was benign and she had no long-term sequelae. While the etiology of PPG is unknown, it is most often seen with irreversible structural brain damage...
January 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27118978/evaluation-of-the-isoflavone-genistein-as-reversible-human-monoamine-oxidase-a-and-b-inhibitor
#14
Najla O Zarmouh, Samia S Messeha, Faisel M Elshami, Karam F A Soliman
Monoamine oxidases inhibitors (MAOIs) are effective therapeutic drugs for managing Parkinson's disease (PD) and depression. However, their irreversibility may lead to rare but serious side effects. As finding safer and reversible MAOIs is our target, we characterized the recombinant human (h) MAO-A and MAO-B inhibition potentials of two common natural isoflavones, genistein (GST) and daidzein (DZ) using luminescence assay. The results obtained showed that DZ exhibits partial to no inhibition of the isozymes examined while GST inhibited hMAO-B (IC50 of 6...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/26995510/-other-therapeutic-strategies
#15
REVIEW
Ghassen Saba, Isabel Nieto, Rémy Bation, Najib Allaïli, Djamila Bennabi, Fanny Moliere, Raphaëlle Richieri, Jérôme Holtzmann, Maxime Bubrovszky, Vincent Camus, Thomas Charpeaud, Philippe Courtet, Pierre Courvoisier, Frédéric Haesebaert, Olivier Doumy, Wissam El-Hage, Marion Garnier, Thierry d'Amato, Thierry Bougerol, Christophe Lançon, Emmanuel Haffen, Pierre-Michel Llorca, Guillaume Vaiva, Frank Bellivier, Marion Leboyer, Bruno Aouizerate
Non-selective and irreversible MAOI have become as third or fourth-line strategy for the management of treatment-resistant depression. Non-selective and irreversible MAOI requires careful monitoring of drug interactions and dietary restrictions. Nutritional supplements such as omega-3 have been found to produce beneficial effects in the management of treatment-resistant depression when administered in combination with the ongoing antidepressant treatment. The glutamate antagonist ketamine has been found to produce beneficial effects in the management of treatment-resistant depression while administered alone...
March 2016: La Presse Médicale
https://www.readbyqxmd.com/read/26977821/modification-of-5-methoxy-n-n-dimethyltryptamine-induced-hyperactivity-by-monoamine-oxidase-a-inhibitor-harmaline-in-mice-and-the-underlying-serotonergic-mechanisms
#16
Xi-Ling Jiang, Hong-Wu Shen, Ai-Ming Yu
BACKGROUND: 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and harmaline are indolealkylamine (IAA) drugs often abused together. Our recent studies have revealed the significant effects of co-administered harmaline, a monoamine oxidase inhibitor (MAOI), on 5-MeO-DMT pharmacokinetics and thermoregulation. This study was to delineate the impact of harmaline and 5-MeO-DMT on home-cage activity in mouse models, as well as the contribution of serotonin (5-HT) receptors. METHODS: Home-cage activities of individual animals were monitored automatically in the home cages following implantation of telemetry transmitters and administration of various doses of IAA drugs and 5-HT receptor antagonists...
June 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/26917855/maois-does-the-evidence-warrant-their-resurrection
#17
David Menkes, Peter Bosanac, David Castle
OBJECTIVE: The place of monoamine oxidase inhibitors (MAOIs) in psychiatry is reviewed, and the question posed as to whether they are now justifiably disregarded by prescribers. METHOD: Multiple databases (PubMed, Medline, Embase, Cochrane) were interrogated to provide an overview regarding the use, efficacy and toxicity of MAOIs. Data regarding funded use of these agents in New Zealand were obtained from PHARMAC. RESULTS: Evidence supports the use of MAOIs in major depressive disorder, certain anxiety disorders and, to lesser extent, bipolar depression...
August 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/26845268/antidepressant-treatment-and-risk-of-dementia-a-population-based-retrospective-case-control-study
#18
Cynthia Wei-Sheng Lee, Cheng-Li Lin, Fung-Chang Sung, Ji-An Liang, Chia-Hung Kao
OBJECTIVE: We investigated the relationship between antidepressant use and the risk of subsequent dementia development. METHOD: A population-based retrospective case-control analysis was conducted using the Taiwan National Health Insurance Research Database. From patients enrolled in the National Health Insurance program between 2005 and 2011, we identified 2 subsets: 5,394 cases, who had major depression in 1997-2004 and subsequently were diagnosed with dementia (ICD-9-CM code 290) in 2005-2011, and 5,232 controls, who had major depression in 2005-2011 but no dementia history...
January 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/26837935/critical-appraisal-of-selegiline-transdermal-system-for-major-depressive-disorder
#19
REVIEW
Mario A Cristancho, Michael E Thase
INTRODUCTION: Although safer and easier to use antidepressants (ie.,SSRIs/SNRIs) have largely displaced MAOIs, these medications still have a role in difficult to treat conditions. Efforts to improve MAOIs benefit-risk profile resulted on the reversible MAOI and in the first antidepressant patch (selegiline transdermal delivery system-STS). The later had been available in the US since 2006. Thus a review on its safety profile and comparative efficacy is timely. AREAS COVERED: This review provides an overview of STS's clinical pharmacology and summarizes what has been learned across nearly a decade of experience...
2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/26805422/binge-ethanol-exposure-increases-the-kr%C3%A3-ppel-like-factor-11-monoamine-oxidase-mao-pathway-in-rats-examining-the-use-of%C3%A2-mao-inhibitors-to-prevent-ethanol-induced-brain-injury
#20
Jeremy W Duncan, Xiao Zhang, Niping Wang, Shakevia Johnson, Sharonda Harris, Chinelo Udemgba, Xiao-Ming Ou, Moussa B Youdim, Craig A Stockmeier, Jun Ming Wang
Binge drinking induces several neurotoxic consequences including oxidative stress and neurodegeneration. Because of these effects, drugs which prevent ethanol-induced damage to the brain may be clinically beneficial. In this study, we investigated the ethanol-mediated KLF11-MAO cell death cascade in the frontal cortex of Sprague-Dawley rats exposed to a modified Majchowicz 4-day binge ethanol model and control rats. Moreover, MAO inhibitors (MAOIs) were investigated for neuroprotective activity against binge ethanol...
June 2016: Neuropharmacology
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