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Saud Alanazi, Maryam Alnoman, Saeed Banawas, Ryoichi Saito, Mahfuzur R Sarker
C. perfringens type A is the causative agent of C. perfringens type A food poisoning (FP) and non-food-borne (NFB) human gastrointestinal diseases. Due to its ability to form highly heat-resistant spores, it is of great interest to develop strategies alternative to thermal processing to inactivate C. perfrinegens. Thus, in this study we evaluated the inhibitory effects of essential oil constituents (EOCs) (cinnamaldehyde, eugenol, allyl isothiocyanate (AITC), and carvacrol) against germination, outgrowth and vegetative growth of spores of C...
August 2018: Food Microbiology
A Dang, S Miller, D Horvat, T Klassen-Ross, M Graveline, R Collins, R Olson
Background: Across our province, post-radiotherapy (rt) handover notes are sent to family physicians (fps) after rt. Based on previous fp feedback, we created a revised post-radiotherapy handover note with more information requested by fps. The purpose of this study was to determine whether the revised handover note improved the note as a communication aid. Methods: Potential common and rare treatment side effects, oncologist contact information, and treatment intent were added to the revised handover note...
February 2018: Current Oncology
Inki Lee, Jin Su Kim, Joon Yeun Park, Byung Hyun Byun, Su Yeon Park, Joon Ho Choi, Hansol Moon, Jung Young Kim, Kyo Chul Lee, Dae Yoon Chi, Kyeong Min Kim, Ilhan Lim, Joo Hyun Kang, Soon Hyuk Ahn, Byung Il Kim, Jeong Ho Ha, Sang Moo Lim
123 I-FP-CIT and18 F-FP-CIT are radiotracers which are widely used to diagnose Parkinson's disease (PD). However, to our knowledge, no studies to date have made head-to-head comparisons between123 I-FP-CIT and18 F-FP-CIT. Therefore, in this study,123 I-FP-CIT SPECT/CT was compared with18 F-FP-CIT PET/CT in the same cohort of subjects. Patients with PD and essential tremor (ET) underwent123 I-FP-CIT SPECT/CT and18 F-FP-CIT PET/CT. Visual and semi-quantitative analyses were conducted. The specific binding ratio (SBR) and putamen to caudate ratio (PCR) were compared between subjects who underwent123 I-FP-CIT SPECT/CT and18 F-FP-CIT PET/CT...
February 27, 2018: Synapse
Kathleen Melan, Frederic Amant, Jacqueline Veronique-Baudin, Clarisse Joachim, Eustase Janky
BACKGROUND: Fertility preservation (FP) is a major determinant of quality of life after cancer remission for women who may not have achieved their ideal family size. This article describes the FP services and strategy currently available, highlighting issues of oncofertility worldwide. For these patients in complex situations, health networks are essential to improve coordination of care, and the strengthening of this coordination is a major challenge to improve the performance of the health system...
February 17, 2018: BMC Cancer
Mads Olsen, Logan Douglas Schneider, Joseph Cheung, Paul E Peppard, Poul J Jennum, Emmanuel Mignot, Helge Bjarup Dissing Sorensen
Study objectives: The current definition of sleep arousals neglects to address the diversity of arousals and their systemic cohesion. Autonomic arousals (AA) are autonomic activations often associated with cortical arousals (CA), but they may also occur in isolation in relation to a respiratory event, a leg movement event or spontaneously, without any other physiological associations. AA should be acknowledged as essential events to understand and explore the systemic implications of arousals...
January 10, 2018: Sleep
S Cascianelli, C Tranfaglia, M L Fravolini, F Bianconi, M Minestrini, S Nuvoli, N Tambasco, M E Dottorini, B Palumbo
OBJECTIVE: The differential diagnosis of Parkinson's disease (PD) and other conditions, such as essential tremor and drug-induced parkinsonian syndrome or normal aging brain, represents a diagnostic challenge. 123I-FP-CIT brain SPET is able to contribute to the differential diagnosis. Semiquantitative analysis of radiopharmaceutical uptake in basal ganglia (caudate nuclei and putamina) is very useful to support the diagnostic process. An artificial neural network classifier using 123I-FP-CIT brain SPET data, a classification tree (CIT), was applied...
September 2017: Hellenic Journal of Nuclear Medicine
Eliud Wekesa, Ian Askew, Timothy Abuya
CONTEXT: Ambivalence in pregnancy intentions is well-documented in sub-Saharan African (SSA) settings and has been associated with inconsistent use of contraception, thereby exposing women using contraception to the possibility of unintended pregnancies. A better understanding of the potential role for client counseling interventions in enabling women to achieve their pregnancy intentions is essential for aiding program efforts to reduce unintended pregnancies. OBJECTIVE: To measure ambivalence in pregnancy intentions longitudinally and determine its association with the quality of care received, controlling for demographic, socio-economic and contextual factors among a cohort of family planning (FP) clients in Kenya...
2018: PloS One
Malte Renz, Christian Wunder
Photoactivatable fluorescent proteins (PA-FPs) have been widely used to assess the dynamics of cell biological processes. In addition, PA-FPs enabled single-molecule based super-resolution imaging (photoactivated localization microscopy) and thereby provided unprecedented structural insight. For the lack of tools, however, the fraction of PA-FPs that is, actually being switched on to fluoresce, that is, the photoactivation efficiency, has been difficult to assess. Uncertainty about photoactivation efficiency has hampered an understanding of the absolute amount of PA-FPs, that is, being examined...
December 29, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
Michael T Banco, Vidhi Mishra, Samantha C Greeley, Donald R Ronning
S-adenosylmethionine (AdoMet) dependent methyltransferases (MTases) are an essential superfamily of enzymes that catalyze the transfer of a methyl group to several biomolecules. Alterations in the methylation of cellular components crucially impact vital biological processes, making MTases attractive drug targets for treating infectious diseases and diseases caused by overactive human-encoded MTases. Several methods have been developed for monitoring the activity of MTases, but most MTase assays have inherent limitations or are not amenable for high-throughput screening...
December 25, 2017: Analytical Chemistry
Amicia D Elliott, Noah Bedard, Alessandro Ustione, Michelle A Baird, Michael W Davidson, Tomasz Tkaczyk, David W Piston
Fluorescent protein (FP) biosensors based on Förster resonance energy transfer (FRET) are commonly used to study molecular processes in living cells. There are FP-FRET biosensors for many cellular molecules, but it remains difficult to perform simultaneous measurements of multiple biosensors. The overlapping emission spectra of the commonly used FPs, including CFP/YFP and GFP/RFP make dual FRET measurements challenging. In addition, a snapshot imaging modality is required for simultaneous imaging. The Image Mapping Spectrometer (IMS) is a snapshot hyperspectral imaging system that collects high resolution spectral data and can be used to overcome these challenges...
2017: PloS One
Jenna A Perry, Amy N Sinclair-Davis, Michael R McAllaster, Christopher L de Graffenried
Trypanosoma brucei uses multiple mechanisms to evade detection by its insect and mammalian hosts. The flagellar pocket (FP) is the exclusive site of uptake from the environment in trypanosomes and shields receptors from exposure to the host. The FP neck is tightly associated with the flagellum via a series of cytoskeletal structures that include the hook complex (HC) and the centrin arm. These structures are implicated in facilitating macromolecule entry into the FP and nucleating the flagellum attachment zone (FAZ), which adheres the flagellum to the cell surface...
February 2018: Molecular Microbiology
Chris van Weel, Faisal Alnasir, Taghreed Farahat, Jinan Usta, Mona Osman, Mariam Abdulmalik, Nagwa Nashat, Wadeia Mohamed Alsharief, Salwa Sanousi, Hassan Saleh, Mohammed Tarawneh, Felicity Goodyear-Smith, Amanda Howe, Ryuki Kassai
BACKGROUND: Primary healthcare (PHC) is essential for equitable access and cost-effective healthcare. This makes PHC a key factor in the global strategy for universal health coverage (UHC). Implementing PHC requires an understanding of the health system under prevailing circumstances, but for most countries, no data are available. OBJECTIVES: This paper describes and analyses the health systems of Bahrain, Egypt, Lebanon, Qatar, Sudan and the United Arab Emirates, in relation to PHC...
November 23, 2017: European Journal of General Practice
Qihan Yao, Zhou Shi, Qingqing Liu, Zhengyang Gu, Ruihuan Ning
This research focused on the influence of different separator compartments on the performance of capacitive deionization (CDI) cells in terms of brackish water treatment. For comparison, different separators including filter paper(FP), carbon nanotube (CNT), and stainless steel fiber (SSF) on deionization and desorption rate of salt were examined. The best performance was obtained when the CNT separator was packed, followed by SSF and FP. Reducing the cell voltage from 1.2 to 0.4 V decreased the salt removal and electrode regeneration rate of SSF-CDI...
November 17, 2017: Environmental Science and Pollution Research International
S Mojahedi Jahromi, M Montazerozohori, A Masoudiasl, E Houshyar, S Joohari, J M White
The nitrate complexes of group 12 elements with a tridentate Schiff base ligand (L = (E)-N1-((E)-3- phenylallylidene)-N2-(2-((E)-((E)-3-phenylallylidene) amino)ethyl) ethane-1,2-diamine) were synthesized via sonochemical process and characterized by various physical and chemical methods. The structural analysis of the zinc nitrate complex by single crystal X-ray diffraction analysis shows that the central atom is seven-coordinated by three nitrogen atoms from the Schiff base ligand as well as four oxygen atoms from two different nitrate anions...
March 2018: Ultrasonics Sonochemistry
Hirokazu Hashimoto, Wen Jiang, Takeshi Yoshimura, Kyeong-Hye Moon, Jinwoong Bok, Kazuhiro Ikenaka
In the mouse neural tube, sonic hedgehog (Shh) secreted from the floor plate (FP) and the notochord (NC) regulates ventral patterning of the neural tube, and later is essential for the generation of oligodendrocyte precursor cells (OPCs). During early development, the NC is adjacent to the neural tube and induces ventral domains in it, including the FP. In the later stage of development, during gliogenesis in the spinal cord, the pMN domain receives strong Shh signaling input. While this is considered to be essential for the generation of OPCs, the actual role of this strong input in OPC generation remains unclear...
November 6, 2017: Neurochemistry International
Wenhua Chen, Zhenghui Huang, Wanyan Wang, Fei Mao, Longfei Guan, Yun Tang, Hualiang Jiang, Jian Li, Jin Huang, Lubin Jiang, Jin Zhu
Malaria parasites are a leading cause of worldwide mortality from infectious disease. Cysteine protease falcipain-2 (FP-2) and Plasmodium falciparum dihydrofolate reductase (PfDHFR) play vital roles, which are absolutely essential, in the parasite life cycle. In this study, based on the structures of uniform fragments of reported PfDHFR inhibitors and the first-generation dual inhibitors against FP-2 and PfDHFR, we identified a novel series of dual inhibitors through fragments assembly. Lead optimization led to the discovery of 24, which showed high potency against FP-2 (IC50  = 10...
December 15, 2017: Bioorganic & Medicinal Chemistry
Yawei Ni, Jianhua Guo, Debra Turner, Ian Tizard
A highly effective antigen construct for presenting conserved antigen domains is essential to the development of a universal influenza vaccine. We have developed a novel dual-domain nanoparticle fusion protein (DDNFP) which allows independent presentation of two conserved domains. The conserved domains used were from two separate viral surface proteins, M2e of M2 and fusion peptide (FP) or long alpha helix (CD) of HA2. The carrier is a novel nanoparticle protein - the dodecameric DNA binding protein from starved cells (Dps) of bacteria or archaea...
December 15, 2017: Vaccine
Isabel Cristina Martins Emmerick, Monica Rodrigues Campos, Vera Lucia Luiza, Luisa Arueira Chaves, Andrea Dâmaso Bertoldi, Dennis Ross-Degnan
OBJECTIVES: 'Farmácia Popular' (FP) programme was launched in 2004, expanded in 2006 and changed the cost sharing for oral hypoglycaemic (OH) and antihypertensive (AH) medicines in 2009 and in 2011. This paper describes patterns of usage and continuity of coverage for OH and AH medicines following changes in patient cost sharing in the FP. STUDY DESIGN: Interrupted time series study using retrospective administrative data. METHODS: Monthly programme participation (PP) and proportion of days covered (PDC) were the two outcome measures...
November 3, 2017: BMJ Open
Anna Albisetti, Célia Florimond, Nicolas Landrein, Keni Vidilaseris, Marie Eggenspieler, Johannes Lesigang, Gang Dong, Derrick Roy Robinson, Mélanie Bonhivers
Trypanosoma brucei belongs to a group of unicellular, flagellated parasites that are responsible for human African trypanosomiasis. An essential aspect of parasite pathogenicity is cytoskeleton remodelling, which occurs during the life cycle of the parasite and is accompanied by major changes in morphology and organelle positioning. The flagellum originates from the basal bodies and exits the cell body through the flagellar pocket (FP) but remains attached to the cell body via the flagellum attachment zone (FAZ)...
November 2017: PLoS Pathogens
Maria Cristina Burla, Benedetta Carrozzini, Giovanni Luca Cascarano, Carmelo Giacovazzo, Giampiero Polidori
Difference electron densities do not play a central role in modern phase refinement approaches, essentially because of the explosive success of the EDM (electron-density modification) techniques, mainly based on observed electron-density syntheses. Difference densities however have been recently rediscovered in connection with the VLD (Vive la Difference) approach, because they are a strong support for strengthening EDM approaches and for ab initio crystal structure solution. In this paper the properties of the most documented difference electron densities, here denoted as F - Fp, mF - Fp and mF - DFp syntheses, are studied...
November 1, 2017: Acta Crystallographica. Section A, Foundations and Advances
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