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https://www.readbyqxmd.com/read/28033587/rapid-effects-of-dorsal-hippocampal-g-protein-coupled-estrogen-receptor-on-learning-in-female-mice
#1
Jennifer Lymer, Alana Robinson, Boyer D Winters, Elena Choleris
Through rapid mechanisms of action, estrogens affect learning and memory processes. It has been shown that 17β-estradiol and an Estrogen Receptor (ER) α agonist enhances performance in social recognition, object recognition, and object placement tasks when administered systemically or infused in the dorsal hippocampus. In contrast, systemic and dorsal hippocampal ERβ activation only promote spatial learning. In addition, 17β-estradiol, the ERα and the G-protein coupled estrogen receptor (GPER) agonists increase dendritic spine density in the CA1 hippocampus...
November 24, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28027219/cancer-risk-after-fat-transfer-a-multicenter-case-cohort-study
#2
Terence M Myckatyn, I Janelle Wagner, Babak J Mehrara, Melissa A Crosby, Julie E Park, Bahjat F Qaqish, Dominic T Moore, Evan L Busch, Amanda K Silva, Surinder Kaur, David W Ollila, Clara N Lee
BACKGROUND: Fat transfer is an increasingly popular method for refining postmastectomy breast reconstructions. However, concern persists that fat transfer may promote disease recurrence. Adipocytes are derived from adipose-derived stem cells and express adipocytokines that can facilitate active breast cancer cells in laboratory models. The authors sought to evaluate the association between fat transfer to the reconstructed breast and cancer recurrence in patients diagnosed with local or regional invasive breast cancers...
January 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27983596/estrogenic-endocrine-disrupting-chemicals-influencing-nrf1-regulated-gene-networks-in-the-development-of-complex-human-brain-diseases
#3
REVIEW
Mark Preciados, Changwon Yoo, Deodutta Roy
During the development of an individual from a single cell to prenatal stages to adolescence to adulthood and through the complete life span, humans are exposed to countless environmental and stochastic factors, including estrogenic endocrine disrupting chemicals. Brain cells and neural circuits are likely to be influenced by estrogenic endocrine disruptors (EEDs) because they strongly dependent on estrogens. In this review, we discuss both environmental, epidemiological, and experimental evidence on brain health with exposure to oral contraceptives, hormonal therapy, and EEDs such as bisphenol-A (BPA), polychlorinated biphenyls (PCBs), phthalates, and metalloestrogens, such as, arsenic, cadmium, and manganese...
December 13, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27890560/the-hippocampal-transcriptomic-signature-of-stress-resilience-in-mice-with-microglial-fractalkine-receptor-cx3cr1-deficiency
#4
Neta Rimmerman, Nofar Schottlender, Ronen Reshef, Nadav Dan-Goor, Raz Yirmiya
Clinical studies suggest that key genetic factors involved in stress resilience are related to the innate immune system. In the brain, this system includes microglia cells, which play a major role in stress responsiveness. Consistently, mice with deletion of the CX3CR1 gene (CX3CR1(-/-) mice), which in the brain is expressed exclusively by microglia, exhibit resilience to chronic stress. Here, we compared the emotional, cognitive, neurogenic and microglial responses to chronic unpredictable stress (CUS) between CX3CR1(-/-) and wild type (WT) mice...
November 23, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27842943/raloxifene-increases-prefrontal-activity-during-emotional-inhibition-in-schizophrenia-based-on-estrogen-receptor-genotype
#5
Jochen Kindler, Cynthia Shannon Weickert, Peter R Schofield, Rhoshel Lenroot, Thomas W Weickert
People with schizophrenia show decreased prefrontal cortex (PFC) activity during emotional response inhibition, a cognitive process sensitive to hormonal influences. Raloxifene, a selective estrogen receptor modulator, binds estrogen receptor alpha (ESR-α), improves memory, attention and normalizes cortical and hippocampal activity during learning and emotional face recognition in schizophrenia. Here, we tested the extent to which raloxifene restores neuronal activity during emotional response inhibition in schizophrenia...
December 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27825720/ginsenoside-rd-promotes-non-amyloidogenic-pathway-of-amyloid-precursor-protein-processing-by-regulating-phosphorylation-of-estrogen-receptor-alpha
#6
Xiaodong Yan, Gengyao Hu, Weiming Yan, Tao Chen, Feng Yang, Xiao Zhang, Gang Zhao, Juanfang Liu
AIMS: Previous study demonstrated that Ginsenoside Rd. (GS-Rd) could improve cognitive and memory function in animal model of Alzheimer's disease. This study was aimed to investigate whether GS-Rd could improve non-amyloidogenic pathway by activating estrogen receptor (ER). MAIN METHODS: 10mg/kg GS-Rd in ovariectomy (OVX)+GS-Rd group and equivalent volume of saline in sham operated group and OVX group were administrated intraperitoneally for two months, respectively...
January 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/27805868/ovariectomy-alters-gene-expression-of-the-hippocampal-formation-in-middle-aged-rats
#7
Miklós Sárvári, Imre Kalló, Erik Hrabovszky, Norbert Solymosi, Zsolt Liposits
Ovarian hormones regulate the transcriptome of the hippocampus and modulate its functions. During menopause this complex signaling declines, leading to impaired learning and memory. This study was undertaken to clarify the effects of long-term, surgical ovariectomy (OVX) on the rat hippocampal transcriptome. At age of 13 months, intact control and ovariectomized groups were formed. All animals were sacrificed 5 weeks after gonadectomy, hippocampal formations were dissected and processed for transcriptome analysis...
November 2, 2016: Endocrinology
https://www.readbyqxmd.com/read/27789681/estrogen-signaling-as-a-therapeutic-target-in-neurodevelopmental-disorders
#8
Amanda Crider, Anilkumar Pillai
Estrogens, the primary female sex hormones, were originally characterized through their important role in sexual maturation and reproduction. However, recent studies have shown that estrogens play critical roles in a number of brain functions, including cognition, learning and memory, neurodevelopment, and adult neuroplasticity. A number of studies from both clinical as well as preclinical research suggest a protective role of estrogen in neurodevelopmental disorders including autism spectrum disorder (ASD) and schizophrenia...
January 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27780721/differential-effect-of-chronic-stress-on-mouse-hippocampal-memory-and-affective-behavior-role-of-major-ovarian-hormones
#9
Bhanu Chandra Karisetty, Swati Maitra, Abhipradnya Bipin Wahul, Anusha Musalamadugu, Nitin Khandelwal, Sumasri Guntupalli, Ramya Garikapati, Thatiparthi Jhansyrani, Arvind Kumar, Sumana Chakravarty
Molecular mechanisms of depression-like pathophysiology in female rodent models are less reported compared to males, despite its higher prevalence in human females. Moreover, the stress-response in brain circuitries including reward and cognition circuitries varies with age or hormonal status of the females. So, to understand the stress-induced mood and cognitive disorders in intact females (with ovaries) and ovariectomized (OVX) females, we studied changes in mouse hippocampus, a functionally heterogeneous neural structure involved in both affective and cognitive behaviors...
October 22, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27776515/protective-effects-of-hydroponic-teucrium-polium-on-hippocampal-neurodegeneration-in-ovariectomized-rats
#10
K V Simonyan, V A Chavushyan
BACKGROUND: The hippocampus is a target of ovarian hormones, and is necessary for memory. Ovarian hormone loss is associated with a progressive reduction in synaptic strength and dendritic spine. Teucrium polium has beneficial effects on learning and memory. However, it remains unknown whether Teucrium polium ameliorates hippocampal cells spike activity and morphological impairments induced by estrogen deficiency. METHODS: In the present study, we investigated the effects of hydroponic Teucrium polium on hippocampal neuronal activity and morpho-histochemistry of bilateral ovariectomized (OVX) rats...
October 24, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27736245/improvement-of-neurological-disorders-in-postmenopausal-model-rats-by-administration-of-royal-jelly
#11
A Minami, H Matsushita, D Ieno, Y Matsuda, Y Horii, A Ishii, T Takahashi, H Kanazawa, A Wakatsuki, T Suzuki
OBJECTIVE: Royal jelly (RJ) from honeybees (Apis mellifera) has estrogenic activity. Estrogen deficiency after menopause leads to a high risk of memory impairment and depression as well as metabolic syndrome and osteoporosis. We here investigated the effect of RJ on memory impairment and depression-like behaviors in ovariectomized (OVX) rats. METHODS: OVX rats were administered with RJ for 82 days. Hippocampus-dependent spatial memory and depression-like behaviors were assessed by the Morris water maze test and the forced swimming test, respectively...
October 13, 2016: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/27721710/memory-and-spatial-cognition-in-breast-cancer-patients-undergoing-adjuvant-endocrine-therapy
#12
Ute Berndt, Bernd Leplow, Robby Schoenfeld, Tilmann Lantzsch, Regina Grosse, Christoph Thomssen
INTRODUCTION: It is generally accepted that estrogens play a protective role in cognitive function. Therefore, it can be expected that subtotal estrogen deprivation following aromatase inhibition will alter cognitive performance. METHODS: In a cross-sectional study we investigated 80 postmenopausal women with breast cancer. Memory and spatial cognition were compared across 4 treatment groups: tamoxifen only (TAM, n = 22), aromatase inhibitor only (AI, n = 22), TAM followed by AI ('SWITCH group', n = 15), and patients with local therapy (LT) only (surgery and radiation, n = 21)...
August 2016: Breast Care
https://www.readbyqxmd.com/read/27685339/17%C3%AE-estradiol-augments-antidepressant-efficacy-of-escitalopram-in-ovariectomized-rats-neuroprotective-and-serotonin-reuptake-transporter-modulatory-effects
#13
Weam W Ibrahim, Marwa M Safar, Mahmoud M Khattab, Azza M Agha
The prevalence or recurrence of depression is seriously increased in women during the transition to and after menopause. The chronic hypo-estrogenic state of menopause may reduce the response to antidepressants; however the influence of estrogen therapy on their efficacy is still controversial. This study aimed at investigating the effects of combining escitalopram with 17β-estradiol on depression and cognitive impairment induced by ovariectomy, an experimental model of human menopause. Young adult female Wistar rats were subjected to either sham operation or ovariectomy...
December 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27680398/cognitive-functions-concentration-of-endogenous-estradiol-estrogen-receptor-%C3%AE-er%C3%AE-polymorphism-in-postmenopausal-women
#14
Iwona Bojar, Jarosław Pinkas, Anna Wierzbińska-Stępniak, Dorota Raczkiewicz, Alfred Owoc, Mariusz Gujski
BACKGROUND The goal of this study was to investigate the relationship between cognitive functions and the level of endogenous estradiol in postmenopausal women, according to which estrogen receptor α (ERα) polymorphism the woman carries. MATERIAL AND METHODS The study group consisted of 210 women. The inclusion criteria were: minimum 2 years after the last menstruation, FSH concentration 30 U/ml, and no dementia signs on Montreal Cognitive Assessment (MoCA). A computerized battery of Central Nervous System Vital Signs (CNS VS) test was used to diagnose cognitive functions...
September 28, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27629499/estrogen-receptor-beta-polymorphisms-and-cognitive-performance-in-women-associations-and-modifications-by-genetic-and-environmental-influences
#15
Karin Fehsel, Tamara Schikowski, Michaela Jänner, Anke Hüls, Mohammed Voussoughi, Thomas Schulte, Andrea Vierkötter, Tom Teichert, Christian Herder, Dorothea Sugiri, Ursula Krämer, Christian Luckhaus
Genetic and environmental risk factors contribute to the pathogenesis of Alzheimer's dementia. Besides known genetic risk factors like the apolipoprotein (APO) Eε4 allele, single nuclear polymorphisms (SNPs) of the estrogen receptors (ESRs) are candidate genetic risk factors, while air pollution represents an environmental risk factor for dementia. Effects of these risk factors and their interaction were investigated in the SALIA cohort of 834 non-demented elderly women. Cognitive function was assessed by the CERAD-plus test battery...
December 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27592282/17%C3%AE-estradiol-replacement-therapy-protects-myelin-sheaths-in-the-white-matter-of-middle-aged-female-ovariectomized-rats-a-stereological-study
#16
Yanmin Luo, Qian Xiao, Fenglei Chao, Qi He, Fulin Lv, Lei Zhang, Yuan Gao, Xuan Qiu, Chunxia Huang, Yongde Li, Sanrong Wang, Rong Jiang, Hengwei Gu, Yong Tang
Many studies have shown that estrogen replacement therapy (ERT) can improve cognitive function and affect the structure of the brain, including the white matter, in postmenopausal women. However, it is unclear whether ERT plays an important role in white matter remodeling in postmenopausal women. In the present study, middle-aged (9-12-month-old) female Sprague-Dawley rats were bilaterally ovariectomized (OVX) and randomly allocated to the vehicle treatment (OVX+Veh) group or the 17β-estradiol replacement (OVX+E) group...
August 8, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27580847/cell-type-and-region-specific-enhancement-of-adult-hippocampal-neurogenesis-by-daidzein-in-middle-aged-female-mice
#17
Jun Yamada, Jun Hatabe, Kaori Tankyo, Shozo Jinno
Adult hippocampal neurogenesis is associated with various brain functions, such as learning, memory, and emotion. Intriguingly, reduction in new cell production in the hippocampus in middle age may underlie some of the cognitive deficits. Among several factors that may affect adult hippocampal neurogenesis, estrogens have been suggested to be critically involved in the cognitive impairment of postmenopausal women. Phytoestrogens, such as daidzein and genistein, are expected to work as estrogen substitutes. In this study, we aimed to clarify the effects of daidzein on adult hippocampal neurogenesis using middle-aged (12-month-old) female mice...
December 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27483953/-hippocampus-synthesized-androgens-and-estrogens-enhance-memory-formation
#18
REVIEW
Suguru Kawato
No abstract text is available yet for this article.
June 2016: Seikagaku. the Journal of Japanese Biochemical Society
https://www.readbyqxmd.com/read/27476434/effects-of-developmental-exposure-to-bisphenol-a-and-ethinyl-estradiol-on-spatial-navigational-learning-and-memory-in-painted-turtles-chrysemys-picta
#19
Lindsey K Manshack, Caroline M Conard, Sarah A Johnson, Jorden M Alex, Sara J Bryan, Sharon L Deem, Dawn K Holliday, Mark R Ellersieck, Cheryl S Rosenfeld
Developmental exposure of turtles and other reptiles to endocrine disrupting chemicals (EDCs), including bisphenol A (BPA) and ethinyl estradiol (EE2, estrogen present in birth control pills), can induce partial to full gonadal sex-reversal in males. No prior studies have considered whether in ovo exposure to EDCs disrupts normal brain sexual differentiation. Yet, rodent model studies indicate early exposure to these chemicals disturbs sexually selected behavioral traits, including spatial navigational learning and memory...
September 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27470554/pelargonidin-improves-memory-deficit-in-amyloid-%C3%AE-25-35-rat-model-of-alzheimer-s-disease-by-inhibition-of-glial-activation-cholinesterase-and-oxidative-stress
#20
Hamid Sohanaki, Tourandokht Baluchnejadmojarad, Farnaz Nikbakht, Mehrdad Roghani
Alzheimer's disease (AD) is a multifactorial disorder with devastating outcomes and few mostly palliative available therapeutic strategies. Pelargonidin (Pel), an anthocyanin compound, is an estrogen receptor agonist with lower side effects versus estrogen. This study examined neuroprotective effect of Pel on intrahippocampal amyloid β25-35 (Aβ) rat model of AD. Rats were divided into groups of sham, Aβ, and Pel-pretreated Aβ (10mg/kg; p.o.). Animals underwent Morris water maze (MWM) test in addition to measurement of hippocampal oxidative stress, acetylcholinesterase (AChE) activity, glial fibrillary acidic protein (GFAP) and inducible nitric oxide synthase (iNOS)...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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