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https://www.readbyqxmd.com/read/28248747/intention-to-use-mhealth-in-older-adults-with-heart-failure
#1
Maan Isabella Cajita, Nancy A Hodgson, Chakra Budhathoki, Hae-Ra Han
BACKGROUND: mHealth, or the use of mobile technology in healthcare, is becoming increasingly common. In heart failure (HF), mHealth has been associated with improved self-management and quality of life. However, it is known that older adults continue to lag behind their younger counterparts when it comes to mobile technology adoption. OBJECTIVE: The primary aim of this study was to examine factors that influence intention to use mHealth among older adults with HF...
February 28, 2017: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28231035/biologically-relevant-heterogeneity-metrics-and-practical-insights
#2
Albert Gough, Andrew M Stern, John Maier, Timothy Lezon, Tong-Ying Shun, Chakra Chennubhotla, Mark E Schurdak, Steven A Haney, D Lansing Taylor
Heterogeneity is a fundamental property of biological systems at all scales that must be addressed in a wide range of biomedical applications, including basic biomedical research, drug discovery, diagnostics, and the implementation of precision medicine. There are a number of published approaches to characterizing heterogeneity in cells in vitro and in tissue sections. However, there are no generally accepted approaches for the detection and quantitation of heterogeneity that can be applied in a relatively high-throughput workflow...
March 2017: SLAS Discov
https://www.readbyqxmd.com/read/28218233/multi-institutional-study-of-nuclear-kifc1-as-a-biomarker-of-poor-prognosis-in-african-american-women-with-triple-negative-breast-cancer
#3
Angela Ogden, Chakravarthy Garlapati, Xiaoxian Bill Li, Ravi Chakra Turaga, Gabriela Oprea-Ilies, Nikita Wright, Shristi Bhattarai, Karuna Mittal, Ceyda Sönmez Wetherilt, Uma Krishnamurti, Michelle D Reid, Mildred Jones, Meenakshi Gupta, Remus Osan, Sonal Pattni, Ansa Riaz, Sergey Klimov, Arundhati Rao, Guilherme Cantuaria, Padmashree C G Rida, Ritu Aneja
Nuclear KIFC1 (nKIFC1) predicts worse outcomes in breast cancer, but its prognostic value within racially distinct triple-negative breast cancer (TNBC) patients is unknown. Thus, nKIFC1 expression was assessed by immunohistochemistry in 163 African American (AA) and 144 White TNBC tissue microarrays (TMAs) pooled from four hospitals. nKIFC1 correlated significantly with Ki67 in White TNBCs but not in AA TNBCs, suggesting that nKIFC1 is not merely a surrogate for proliferation in AA TNBCs. High nKIFC1 weighted index (WI) was associated with significantly worse overall survival (OS), progression-free survival (PFS), and distant metastasis-free survival (DMFS) (Hazard Ratios [HRs] = 3...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28207994/use-of-virtual-simulation-to-impact-nursing-students-cognitive-and-affective-knowledge-of-evidence-based-practice
#4
Cynthia L Foronda, Krysia Warren Hudson, Chakra Budhathoki
No abstract text is available yet for this article.
February 16, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28193199/a-population-based-study-of-chronic-hepatitis-c-in-immigrants-and-non-immigrants-in-quebec-canada
#5
Christina Greenaway, Laurent Azoulay, Robert Allard, Joseph Cox, Viet Anh Tran, Claire Nour Abou Chakra, Russ Steele, Marina Klein
BACKGROUND: Immigrants originating from intermediate and high HCV prevalence countries may be at increased risk of exposure to hepatitis C infection (HCV) in their countries of origin, however they are not routinely screened after arrival in most low HCV prevalence host countries. We aimed to describe the epidemiology of HCV in immigrants compared to the Canadian born population. METHODS: Using the reportable infectious disease database linked to the landed immigration database and several provincial administrative databases, we assembled a cohort of all reported cases of HCV in Quebec, Canada (1998-2008)...
February 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28184421/risk-of-active-tuberculosis-in-patients-with-cancer-a-systematic-review-and-metaanalysis
#6
Matthew P Cheng, Claire Nour Abou Chakra, Cedric P Yansouni, Sonya Cnossen, Ian Shrier, Dick Menzies, Christina Greenaway
No abstract text is available yet for this article.
December 13, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28167510/preclinical-development-of-a-non-toxic-oral-formulation-of-monoethanolamine-a-lipid-precursor-for-prostate-cancer-treatment
#7
Roopali Saxena, Chunhua Yang, Mukkavilli Rao, Ravi Chakra C Turaga, Chakravarthy Garlapati, Sushma Reddy Gundala, Kimberly Myers, Ahmed Ghareeb, Shristi Bhattarai, Golnaz Kamilinia, Sangina Bristi, Dan Su, Giovanni Gadda, Padmashree Cg Rida, Guilherme Cantuaria, Ritu Aneja
PURPOSE: Most currently-available chemotherapeutic agents target rampant cell division in cancer cells, thereby affecting rapidly-dividing normal cells resulting in toxic side-effects. This non-specificity necessitates identification of novel cellular pathways that are reprogrammed selectively in cancer cells and can be exploited to develop pharmacologically superior and less-toxic therapeutics. Despite growing awareness on dysregulation of lipid metabolism in cancer cells, targeting lipid biosynthesis is still largely uncharted territory...
February 6, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27994939/pointwise-mutual-information-quantifies-intratumor-heterogeneity-in-tissue-sections-labeled-with-multiple-fluorescent-biomarkers
#8
Daniel M Spagnolo, Rekha Gyanchandani, Yousef Al-Kofahi, Andrew M Stern, Timothy R Lezon, Albert Gough, Dan E Meyer, Fiona Ginty, Brion Sarachan, Jeffrey Fine, Adrian V Lee, D Lansing Taylor, S Chakra Chennubhotla
BACKGROUND: Measures of spatial intratumor heterogeneity are potentially important diagnostic biomarkers for cancer progression, proliferation, and response to therapy. Spatial relationships among cells including cancer and stromal cells in the tumor microenvironment (TME) are key contributors to heterogeneity. METHODS: We demonstrate how to quantify spatial heterogeneity from immunofluorescence pathology samples, using a set of 3 basic breast cancer biomarkers as a test case...
2016: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/27986665/risk-of-active-tuberculosis-in-patients-with-cancer-a-systematic-review-and-meta-analysis
#9
Matthew P Cheng, Claire Nour Abou Chakra, Cedric P Yansouni, Sonya Cnossen, Ian Shrier, Dick Menzies, Christina Greenaway
BACKGROUND: Cancer is a known risk factor for developing active tuberculosis (TB). We determined the incidence and relative risk of active TB in cancer patients compared to the general population. METHODS: Electronic databases were searched up to December 2015: Medline, Medline InProcess, EMBASE, PubMed, the Cochrane Database of Systematic Reviews, Cancerlit, and Web of Science. Studies of pathologically confirmed cancer patients were included if active TB was identified concurrently or after the diagnosis...
December 16, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27942064/the-isolation-of-morphine-by-serturner
#10
Chandrasekhar Krishnamurti, Ssc Chakra Rao
No abstract text is available yet for this article.
November 2016: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/27914870/co-occurrence-and-predictors-of-three-commonly-occurring-behavioral-symptoms-in-dementia-agitation-aggression-and-rejection-of-care
#11
Scott Seung W Choi, Chakra Budhathoki, Laura N Gitlin
OBJECTIVE: To investigate co-occurrences of agitation, aggression, and rejection of care in community-dwelling families living with dementia. METHODS: Cross-sectional, secondary analysis from a randomized controlled trial testing a nonpharmacological intervention to reduce behavioral symptoms. We examined frequency of occurrence of presenting behaviors at baseline and their combination. Omnibus tests compared those exhibiting combinations of behaviors on contributory factors...
November 3, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27768332/nonergodic-phases-in-strongly-disordered-random-regular-graphs
#12
B L Altshuler, E Cuevas, L B Ioffe, V E Kravtsov
We combine numerical diagonalization with semianalytical calculations to prove the existence of the intermediate nonergodic but delocalized phase in the Anderson model on disordered hierarchical lattices. We suggest a new generalized population dynamics that is able to detect the violation of ergodicity of the delocalized states within the Abou-Chakra, Anderson, and Thouless recursive scheme. This result is supplemented by statistics of random wave functions extracted from exact diagonalization of the Anderson model on ensemble of disordered random regular graphs (RRG) of N sites with the connectivity K=2...
October 7, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27752679/folding-propensity-of-intrinsically-disordered-proteins-by-osmotic-stress
#13
Amanda L Mansouri, Laura N Grese, Erica L Rowe, James C Pino, S Chakra Chennubhotla, Arvind Ramanathan, Hugh M O'Neill, Valerie Berthelier, Christopher B Stanley
Proteins imparted with intrinsic disorder conduct a range of essential cellular functions. To better understand the folding and hydration properties of intrinsically disordered proteins (IDPs), we used osmotic stress to induce conformational changes in nuclear co-activator binding domain (NCBD) and activator for thyroid hormone and retinoid receptor (ACTR) separate from their mutual binding. Osmotic stress was applied by the addition of small and polymeric osmolytes, where we discovered that water contributions to NCBD folding always exceeded those for ACTR...
November 15, 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/27733038/-ag67-sphme2-32-pph3-8-3-synthesis-total-structure-and-optical-properties-of-a-large-box-shaped-silver-nanocluster
#14
Mohammad J Alhilaly, Megalamane S Bootharaju, Chakra P Joshi, Tabot M Besong, Abdul-Hamid Emwas, Rosalba Juarez-Mosqueda, Sami Kaappa, Sami Malola, Karim Adil, Aleksander Shkurenko, Hannu Häkkinen, Mohamed Eddaoudi, Osman M Bakr
Engineering the surface ligands of metal nanoparticles is critical in designing unique arrangements of metal atoms. Here, we report the synthesis and total structure determination of a large box-shaped Ag67 nanocluster (NC) protected by a mixed shell of thiolate (2,4-dimethylbenzenethiolate, SPhMe2) and phosphine (triphenylphosphine, PPh3) ligands. Single crystal X-ray diffraction (SCXRD) and electrospray ionization mass spectrometry (ESI-MS) revealed the cluster formula to be [Ag67(SPhMe2)32(PPh3)8](3+). The crystal structure shows an Ag23 metal core covered by a layer of Ag44S32P8 arranged in the shape of a box...
November 9, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27482245/predictive-validity-of-some-common-animal-models-of-bipolar-disorder-using-lithium-and-lamotrigine-therapy-an-attempt-towards-a-battery-based-approach-for-the-evaluation-of-mood-stabilizers
#15
Manu Kumar, Chakra Dhar Tripathi, Veena Verma, Biswa Mohan Padhy, Girish Gulab Meshram, B Abhilash
OBJECTIVE: To determine the predictive validity of some of the commonly employed models of mania and depression using standard drugs i.e. lithium (70 mg/kg) and lamotrigine (5 mg/kg) in male Wistar rats. METHODS: The depression facet of bipolar disorder was evaluated using forced swim test, tail suspension test, and chronic mild stress test. The models used to evaluate the mania facet of bipolar disorder were isolation-induced aggression test, saccharine preference test, and morphine-sensitized hyperlocomotion test...
July 2016: Psychiatry Investigation
https://www.readbyqxmd.com/read/27362744/synthesis-and-characterization-of-mixed-ligand-chiral-nanoclusters
#16
Zekiye P Guven, Burcin Ustbas, Kellen M Harkness, Hikmet Coskun, Chakra P Joshi, Tabot M D Besong, Francesco Stellacci, Osman M Bakr, Ozge Akbulut
Chiral mixed ligand silver nanoclusters were synthesized in the presence of a chiral and an achiral ligand. While the chiral ligand led mostly to the formation of nanoparticles, the presence of the achiral ligand drastically increased the yield of nanoclusters with enhanced chiral properties.
July 28, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27331307/drug-combinations-in-diabetic-neuropathic-pain-an-experimental-validation
#17
Chakra Dhar Tripathi, Ashish K Mehta, Amol M Yadav
BACKGROUND: Diabetic neuropathy is the most common complication of diabetes mellitus, and the different drug combinations available do not provide effective pain relief. The present study was performed to observe the effect of amitripyline, duloxetine, sitagliptin, and pregabalin, and their combinations on streptozotocin (STZ)-induced diabetic neuropathy. METHODS: Diabetic neuropathy was induced by STZ, and the tail-flick test was used to assess thermal hyperalgesia before and after (at 30, 60, and 120 min) drug administration...
November 1, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27293783/coevolutionary-interactions-between-farmers-and-mafia-induce-host-acceptance-of-avian-brood-parasites
#18
Maria Abou Chakra, Christian Hilbe, Arne Traulsen
Brood parasites exploit their host in order to increase their own fitness. Typically, this results in an arms race between parasite trickery and host defence. Thus, it is puzzling to observe hosts that accept parasitism without any resistance. The 'mafia' hypothesis suggests that these hosts accept parasitism to avoid retaliation. Retaliation has been shown to evolve when the hosts condition their response to mafia parasites, who use depredation as a targeted response to rejection. However, it is unclear if acceptance would also emerge when 'farming' parasites are present in the population...
May 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27241473/rational-design-of-a-protein-that-binds-integrin-%C3%AE-v%C3%AE-3-outside-the-ligand-binding-site
#19
Ravi Chakra Turaga, Lu Yin, Jenny J Yang, Hsiauwei Lee, Ivaylo Ivanov, Chunli Yan, Hua Yang, Hans E Grossniklaus, Siming Wang, Cheng Ma, Li Sun, Zhi-Ren Liu
Integrin αvβ3 expression is altered in various diseases and has been proposed as a drug target. Here we use a rational design approach to develop a therapeutic protein, which we call ProAgio, that binds to integrin αvβ3 outside the classical ligand-binding site. We show ProAgio induces apoptosis of integrin αvβ3-expressing cells by recruiting and activating caspase 8 to the cytoplasmic domain of integrin αvβ3. ProAgio also has anti-angiogenic activity and strongly inhibits growth of tumour xenografts, but does not affect the established vasculature...
2016: Nature Communications
https://www.readbyqxmd.com/read/27186202/investigating-the-effect-of-therapeutic-touch-on-the-intensity-of-acute-chemotherapy-induced-vomiting-in-breast-cancer-women-under-chemotherapy
#20
Pegah Matourypour, Zohreh Vanaki, Zahra Zare, Valiolah Mehrzad, Mojtaba Dehghan, Mehdi Ranjbaran
BACKGROUND: Nausea and vomiting are the worst and the most prevalent complications experienced by 70-80% of patients. Complementary treatments including therapeutic touch are cost-effective and low-risk, independent nursing interventions. Present research aims at investigating the effect of therapeutic touch on the intensity of acute chemotherapy-induced vomiting in these patients. MATERIALS AND METHODS: As a single-blind, randomized clinical trial, the present research was carried out on women with breast cancer undergoing chemotherapy in Isfahan, Iran...
May 2016: Iranian Journal of Nursing and Midwifery Research
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