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https://www.readbyqxmd.com/read/29742397/anca-anharmonic-conformational-analysis-of-biomolecular-simulations
#1
Akash Parvatikar, Gabriel S Vacaliuc, Arvind Ramanathan, S Chakra Chennubhotla
Anharmonicity in time-dependent conformational fluctuations is noted to be a key feature of functional dynamics of biomolecules. Although anharmonic events are rare, long-timescale (μs-ms and beyond) simulations facilitate probing of such events. We have previously developed quasi-anharmonic analysis to resolve higher-order spatial correlations and characterize anharmonicity in biomolecular simulations. In this article, we have extended this toolbox to resolve higher-order temporal correlations and built a scalable Python package called anharmonic conformational analysis (ANCA)...
May 8, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29713137/does-parent-training-format-affect-treatment-engagement-a-randomized-study-of-families-at-social-risk
#2
Deborah Gross, Harolyn M E Belcher, Chakra Budhathoki, Mirian E Ofonedu, Melissa K Uveges
We examined whether parent engagement in parent training (PT) differed based on PT format (parent group-based with video versus mastery-based individual coaching with child) in an economically disadvantaged sample of families seeking behavioral treatment for their preschool children in an urban mental health clinic. Parents (N=159; 76.1% mothers, 69.8% African American, 73% low-income) were randomized to one of two interventions, Chicago Parent Program (parent group + video; CPP) or Parent Child Interaction Therapy (individualized mastery-based coaching; PCIT)...
May 2018: Journal of Child and Family Studies
https://www.readbyqxmd.com/read/29683872/social-support-moderates-the-relationship-between-perceived-stress-and-quality-of-life-in-patients-with-a-left-ventricular-assist-device
#3
Martha Abshire, Stuart D Russell, Patricia M Davidson, Chakra Budhathoki, Hae-Ra Han, Kathleen L Grady, Shashank Desai, Cheryl Dennison Himmelfarb
BACKGROUND: Living with a left ventricular assist device has significant psychosocial sequelae that affect health-related quality of life (HRQOL). OBJECTIVE: The purpose of this study was to (1) describe psychosocial indicators of stress including perceived stress, depression, fatigue, and coping; (2) examine relationships among stress indicators by level of perceived stress; (3) examine relationships among indicators of stress and clinical outcomes; and (4) test the moderation of social support on the relationship between stress and clinical outcomes...
April 20, 2018: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29478822/conservation-of-dynamics-associated-with-biological-function-in-an-enzyme-superfamily
#4
Chitra Narayanan, David N Bernard, Khushboo Bafna, Donald Gagné, Chakra S Chennubhotla, Nicolas Doucet, Pratul K Agarwal
Enzyme superfamily members that share common chemical and/or biological functions also share common features. While the role of structure is well characterized, the link between enzyme function and dynamics is not well understood. We present a systematic characterization of intrinsic dynamics of over 20 members of the pancreatic-type RNase superfamily, which share a common structural fold. This study is motivated by the fact that the range of chemical activity as well as molecular motions of RNase homologs spans over 105 folds...
March 6, 2018: Structure
https://www.readbyqxmd.com/read/29457520/caregiver-reactions-to-aggressive-behaviors-in-persons-with-dementia-in-a-diverse-community-dwelling-sample
#5
Bryan R Hansen, Nancy A Hodgson, Chakra Budhathoki, Laura N Gitlin
PURPOSE: To describe caregiver challenges with and confidence managing three aggressive behavior types in persons with dementia: verbal aggression, destroying property, and threatening to hurt others. DESIGN AND METHOD: Secondary analysis of baseline data from the 2001-2004 Resources for Enhancing Alzheimer's Caregiver Health II (REACH II) initiative. RESULTS: One or more aggressive behaviors within 1 week were reported by more than a third of caregivers, with most expressing upset but fewer expressing confidence managing the behaviors...
February 1, 2018: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29294944/unwanted-sexual-acts-among-university-students-correlates-of-victimization-and-perpetration
#6
Jacquelyn C Campbell, Bushra Sabri, Chakra Budhathoki, Michelle R Kaufman, Jeanne Alhusen, Michele R Decker
Unwanted sexual experiences are common among university students in the United States and pose a substantial public health concern. Campus policies and programs to prevent unwanted sexual incidents in university settings require research on prevalence and risk correlates of both victimization and perpetration. This study determined the prevalence of unwanted sexual victimization and perpetration experiences among students, both before and after joining the university, and examined risk correlates for both unwanted sexual victimization and perpetration experiences...
October 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29224986/the-effectiveness-of-a-modified-metaizeau-technique-in-fixation-of-adult-radial-neck-fractures-a-prospective-study-with-a-modification-of-the-broberg-morrey-classification
#7
Nagmani Singh, Chakra Raj Pandey, Rakesh John, Rajesh Singh, Bhupal Tamang, Sandeep Bhandari
BACKGROUND: The incidence of adult radial neck fractures is lower compared with its pediatric counterpart. The literature on adult radial neck fracture management is limited; also, there is a lack of a detailed fracture classification system. In our study, we are evaluating the modified Metaizeau technique for the treatment of adult radial neck fractures. We also describe a modification to the existing fracture classification proposed by Broberg and Morrey to make it more inclusive of different fracture patterns...
March 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29217853/comprehensive-cardiopulmonary-life-support-ccls-for-cardiopulmonary-resuscitation-by-trained-paramedics-and-medics-inside-the-hospital
#8
Rakesh Garg, Syed Moied Ahmed, Mukul Chandra Kapoor, Ssc Chakra Rao, Bibhuti Bhusan Mishra, M Venkatagiri Kalandoor, Baljit Singh, Jigeeshu Vasishtha Divatia
The cardiopulmonary resuscitation (CPR) guideline of comprehensive cardiopulmonary life support (CCLS) for management of the patient with cardiopulmonary arrest in adults provides an algorithmic step-wise approach for optimal outcome of the patient inside the hospital by trained medics and paramedics. This guideline has been developed considering the infrastructure of healthcare delivery system in India. This is based on evidence in the international and national literature. In the absence of data from the Indian population, the extrapolation has been made from international data, discussed with Indian experts and modified accordingly to ensure their applicability in India...
November 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29217852/basic-cardiopulmonary-life-support-bcls-for-cardiopulmonary-resuscitation-by-trained-paramedics-and-medics-outside-the-hospital
#9
Rakesh Garg, Syed Moied Ahmed, Mukul Chandra Kapoor, Bibhuti Bhusan Mishra, Ssc Chakra Rao, M Venkatagiri Kalandoor, Jigeeshu Vasishtha Divatia, Baljit Singh
The cardiopulmonary resuscitation guideline of Basic Cardiopulmonary Life Support (BCLS) for management of adult victims with cardiopulmonary arrest outside the hospital provides an algorithmic stepwise approach for optimal outcome of the victims by trained medics and paramedics. This guideline has been developed considering the need to have a universally acceptable practice guideline for India and keeping in mind the infrastructural limitations of some areas of the country. This guideline is based on evidence elicited in the international and national literature...
November 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29217851/compression-only-life-support-cols-for-cardiopulmonary-resuscitation-by-layperson-outside-the-hospital
#10
Syed Moied Ahmed, Rakesh Garg, Jigeeshu Vasishtha Divatia, Ssc Chakra Rao, Bibhuti Bhusan Mishra, M Venkatagiri Kalandoor, Mukul Chandra Kapoor, Baljit Singh
The cardiopulmonary resuscitation (CPR) guidelines of compression-only life support (COLS) for management of the victim with cardiopulmonary arrest in adults provide a stepwise algorithmic approach for optimal outcome of the victim outside the hospital by untrained laypersons. These guidelines have been developed to recommend practical, uniform and acceptable resuscitation algorithms across India. As resuscitation data of the Indian population are inadequate, these guidelines have been based on international literature...
November 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29217850/indian-society-of-anaesthesiologists-cardiopulmonary-resuscitation-guidelines-ushering-in-a-new-initiative
#11
EDITORIAL
Mukul Chandra Kapoor, Ssc Chakra Rao, Bibhuti Bhushan Mishra
No abstract text is available yet for this article.
November 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29092944/platform-for-quantitative-evaluation-of-spatial-intratumoral-heterogeneity-in-multiplexed-fluorescence-images
#12
Daniel M Spagnolo, Yousef Al-Kofahi, Peihong Zhu, Timothy R Lezon, Albert Gough, Andrew M Stern, Adrian V Lee, Fiona Ginty, Brion Sarachan, D Lansing Taylor, S Chakra Chennubhotla
We introduce THRIVE (Tumor Heterogeneity Research Interactive Visualization Environment), an open-source tool developed to assist cancer researchers in interactive hypothesis testing. The focus of this tool is to quantify spatial intratumoral heterogeneity (ITH), and the interactions between different cell phenotypes and noncellular constituents. Specifically, we foresee applications in phenotyping cells within tumor microenvironments, recognizing tumor boundaries, identifying degrees of immune infiltration and epithelial/stromal separation, and identification of heterotypic signaling networks underlying microdomains...
November 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/29017250/reply-to-dobler
#13
Christina Greenaway, Ian Shrier, Claire Nour Abou Chakra, Sonya Cnossen, Matthew P Cheng, Cedric P Yansouni, Dick Menzies
No abstract text is available yet for this article.
October 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29016418/improving-posthospital-discharge-telephone-reach-rates-through-prehospital-discharge-face-to-face-meetings
#14
Franz H Vergara, Daniel J Sheridan, Nancy J Sullivan, Chakra Budhathoki
PURPOSE OF THE STUDY: The purpose of this study was to determine whether a face-to-face meeting with patients by a telephonic case manager prehospital discharge would result in increased telephone follow-up (TFU) reach rates posthospital discharge. PRIMARY PRACTICE SETTING: Acute care adult medicine inpatient units. METHODOLOGY AND SAMPLE: A quasiexperimental design was utilized. Two adult inpatient medicine units were selected as the intervention and comparison groups...
November 2017: Professional Case Management
https://www.readbyqxmd.com/read/28994344/phase-i-randomized-trial-of-doxorubicin-hydrochloride-liposome-injection-versus-caelyx-%C3%A2-in-multiple-myeloma
#15
Shravanti Bhowmik, Subhas Bhowmick, Kuntal Maiti, Amaresh Chakra, Pradeep Shahi, Thennati Rajamannar
No abstract text is available yet for this article.
October 10, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28857618/the-home-heart-walk-study-a-self-administered-walk-test-on-perceived-physical-functioning-and-self-care-behaviour-in-people-with-stable-chronic-heart-failure-a-randomized-controlled-trial
#16
Huiyun Du, Phillip J Newton, Chakra Budhathoki, Bronwyn Everett, Yenna Salamonson, Peter S Macdonald, Patricia M Davidson
BACKGROUND: Adherence to self-care recommendations is associated with improved patient outcomes and improved quality of life for people living with heart failure. The Home-Heart-Walk (HHW) is an intervention to promote physical activity adapting the elements of a six minute walk test, a reliable and valid measure. This adaptation was designed to support self-monitoring of physical functioning and promote the self-care of people with heart failure. The primary outcome of the Home-Heart-Walk was perceived physical functioning and the secondary outcomes were six-minute walk test distance, health related quality of life, self-care behaviour, self-efficacy and physical activity level...
March 2018: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28841089/intimate-partner-violence-small-for-gestational-age-birth-and-cigarette-smoking-in-the-pregnancy-risk-assessment-monitoring-system
#17
Jeanne L Alhusen, Ruth Geller, Jerry Jellig, Chakra Budhathoki, Michele Decker
BACKGROUND: Exposure to intimate partner violence (IPV) in the perinatal period is associated with obstetric complications, poor maternal mental health, neonatal complications, and increased risk of infant mortality and morbidity. Less is known about how IPV may influence small for gestational age (SGA) birth. MATERIALS AND METHODS: Data were obtained for 231,081 United States mothers who delivered neonates from 2004 to 2011 and completed the Pregnancy Risk Assessment Monitoring System survey 2-9 months after delivery...
August 25, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28806915/evaluating-the-maintenance-of-disease-associated-variation-at-the-blood-group-related-gene-b4galnt2-in-house-mice
#18
Marie Vallier, Maria Abou Chakra, Laura Hindersin, Miriam Linnenbrink, Arne Traulsen, John F Baines
BACKGROUND: B4galnt2 is a blood group-related glycosyltransferase that displays cis-regulatory variation for its tissue-specific expression patterns in house mice. The wild type allele, found e.g. in the C57BL/6 J strain, directs intestinal expression of B4galnt2, which is the pattern observed among vertebrates, including humans. An alternative allele class found in the RIIIS/J strain and other mice instead drives expression in blood vessels, which leads to a phenotype similar to type 1 von Willebrand disease (VWD), a common human bleeding disorder...
August 14, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28783758/evaluation-of-a-nurse-practitioner-physician-task-sharing-model-for-multidrug-resistant-tuberculosis-in-south-africa
#19
Jason E Farley, Norbert Ndjeka, Ana M Kelly, Erin Whitehouse, Simmi Lachman, Chakra Budhathoki, Kelly Lowensen, Ellie Bergren, Hloniphile Mabuza, Ntombasekhaya Mlandu, Martie van der Walt
BACKGROUND: Treatment success rates for multidrug-resistant tuberculosis (MDR-TB) in South Africa remain close to 50%. Lack of access to timely, decentralized care is a contributing factor. We evaluated MDR-TB treatment outcomes from a clinical cohort with task-sharing between a clinical nurse practitioner (CNP) and a medical officer (MO). METHODS: We completed a retrospective evaluation of outcomes from a prospective, programmatically-based MDR-TB cohort who were enrolled and received care between 2012 and 2015 at a peri-urban hospital in KwaZulu-Natal, South Africa...
2017: PloS One
https://www.readbyqxmd.com/read/28592150/atrial-fibrillation-in-patients-hospitalized-with-heart-failure-patient-characteristics-and-outcomes-from-the-hearts-registry
#20
M Ajlan, L Almazroa, Khalid F AlHabib, Abdelfatah A Elasfar, Hussam Alfaleh, Hanan Albackr, Tarek Kashour, Ahmad Hersi, Gamal A Hussein, Layth Mimish, Ali Almasood, Waleed AlHabeeb, Saleh AlGhamdi, Mubrouk Alsharari, Esmail Chakra, Asif Malik, Raza Soomro, Abdullah Ghabashi, Mushabab Al-Murayeh, Ahmed Abuosa
Effect of atrial fibrillation (AF) on short- and long-term outcomes in heart failure (HF) is controversial. Accordingly, we examined this relationship in a national multicenter project using data from the Hearts Function Assessment Registry Trial in Saudi Arabia that studied the clinical features and outcomes of patients admitted with de novo and acute on chronic HF. Out of 2593 patients with HF, 449 (17.8%) had AF at presentation. Patients with AF were more likely to be males and older (mean age 65.2 ± 15...
February 2018: Angiology
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