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https://www.readbyqxmd.com/read/29328959/impact-of-individual-and-neighborhood-factors-on-disparities-in-prostate-cancer-survival
#1
Mindy C DeRouen, Clayton W Schupp, Jocelyn Koo, Juan Yang, Andrew Hertz, Salma Shariff-Marco, Myles Cockburn, David O Nelson, Sue A Ingles, Esther M John, Scarlett L Gomez
BACKGROUND: We addressed the hypothesis that individual-level factors act jointly with social and built environment factors to influence overall survival for men with prostate cancer and contribute to racial/ethnic and socioeconomic (SES) survival disparities. METHODS: We analyzed multi-level data, combining (1) individual-level data from the California Collaborative Prostate Cancer Study, a population-based study of non-Hispanic White (NHW), Hispanic, and African American prostate cancer cases (N = 1800) diagnosed from 1997 to 2003, with (2) data on neighborhood SES (nSES) and social and built environment factors from the California Neighborhoods Data System, and (3) data on tumor characteristics, treatment and follow-up through 2009 from the California Cancer Registry...
January 9, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29320763/a-de-novo-50-bp-gnas-intragenic-duplication-in-a-patient-with-pseudohypoparathyroidism-type-1a
#2
Erina Suzuki, Ryosuke Bo, Kaori Sue, Hiroyuki Awano, Tsutomu Ogata, Satoshi Narumi, Masayo Kagami, Shinichiro Sano, Maki Fukami
Germline intragenic mutations in the GNAS locus result in pseudohypoparathyroidism type 1a (PHP1a) and related conditions. Nearly half of the previously reported GNAS intragenic mutations were structural variants, including 3 tandem duplications of 12-25 bp. However, the precise mutation spectrum and the genomic basis of GNAS structural variants remain to be clarified. Here, we report a de novo 50-bp tandem duplication in GNAS (c.723_772dup50, p.Glu259Leufs*29) identified in a patient with typical clinical features of PHP1a...
January 11, 2018: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/29318985/a-randomised-controlled-trial-and-economic-evaluation-of-intraoperative-cell-salvage-during-caesarean-section-in-women-at-risk-of-haemorrhage-the-salvo-cell-salvage-in-obstetrics-trial
#3
Khalid S Khan, Philip Moore, Matthew Wilson, Richard Hooper, Shubha Allard, Ian Wrench, Tracy Roberts, Carol McLoughlin, Lee Beresford, James Geoghegan, Jane Daniels, Sue Catling, Vicki A Clark, Paul Ayuk, Stephen Robson, Fang Gao-Smith, Matthew Hogg, Louise Jackson, Doris Lanz, Julie Dodds
BACKGROUND: Caesarean section is associated with blood loss and maternal morbidity. Excessive blood loss requires transfusion of donor (allogeneic) blood, which is a finite resource. Cell salvage returns blood lost during surgery to the mother. It may avoid the need for donor blood transfusion, but reliable evidence of its effects is lacking. OBJECTIVES: To determine if routine use of cell salvage during caesarean section in mothers at risk of haemorrhage reduces the rates of blood transfusion and postpartum maternal morbidity, and is cost-effective, in comparison with standard practice without routine salvage use...
January 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29315370/optimal-healthcare-delivery-to-care-homes-in-the-uk-a-realist-evaluation-of-what-supports-effective-working-to-improve-healthcare-outcomes
#4
Adam L Gordon, Claire Goodman, Sue L Davies, Tom Dening, Heather Gage, Julienne Meyer, Justine Schneider, Brian Bell, Jake Jordan, Finbarr C Martin, Steve Iliffe, Clive Bowman, John R F Gladman, Christina Victor, Andrea Mayrhofer, Melanie Handley, Maria Zubair
Introduction: care home residents have high healthcare needs not fully met by prevailing healthcare models. This study explored how healthcare configuration influences resource use. Methods: a realist evaluation using qualitative and quantitative data from case studies of three UK health and social care economies selected for differing patterns of healthcare delivery to care homes. Four homes per area (12 in total) were recruited. A total of 239 residents were followed for 12 months to record resource-use...
January 5, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29313265/a-systematic-review-of-discrete-choice-experiments-and-conjoint-analysis-studies-in-people-with-multiple-sclerosis
#5
REVIEW
Edward J D Webb, David Meads, Ieva Eskyte, Natalie King, Naila Dracup, Jeremy Chataway, Helen L Ford, Joachim Marti, Sue H Pavitt, Klaus Schmierer, Ana Manzano
BACKGROUND: Multiple sclerosis (MS) is a chronic disabling, inflammatory, and degenerative disease of the central nervous system that, in most cases, requires long-term disease-modifying treatment (DMT). The drugs used vary in efficacy and adverse effect profiles. Several studies have used attribute-based stated-preference methods, primarily to investigate patient preferences for initiating or escalating DMT. OBJECTIVES: To conduct a systematic review of attribute-based stated-preference studies in people with MS to identify common methods employed and to assess study quality, with reference to the specific challenges of this disease area...
January 8, 2018: Patient
https://www.readbyqxmd.com/read/29302712/exposure-assessment-of-process-related-contaminants-in-food-by-biomarker-monitoring
#6
REVIEW
Ivonne M C M Rietjens, P Dussort, Helmut Günther, Paul Hanlon, Hiroshi Honda, Angela Mally, Sue O'Hagan, Gabriele Scholz, Albrecht Seidel, James Swenberg, Justin Teeguarden, Gerhard Eisenbrand
Exposure assessment is a fundamental part of the risk assessment paradigm, but can often present a number of challenges and uncertainties. This is especially the case for process contaminants formed during the processing, e.g. heating of food, since they are in part highly reactive and/or volatile, thus making exposure assessment by analysing contents in food unreliable. New approaches are therefore required to accurately assess consumer exposure and thus better inform the risk assessment. Such novel approaches may include the use of biomarkers, physiologically based kinetic (PBK) modelling-facilitated reverse dosimetry, and/or duplicate diet studies...
January 4, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29300123/developing-successful-social-support-an-interpretative-phenomenological-analysis-of-mechanisms-and-processes-in-a-chronic-pain-support-group
#7
Katherine A Finlay, Sue Peacock, James Elander
OBJECTIVE: The experience of long-term membership of a successful chronic pain support group (CPSG) was explored to identify; (i) factors associated with social support, and; (ii) ways that health care professionals (HCPs) could help CPSGs become more effective and supportive. DESIGN: Interpretative Phenomenological Analysis enabled exploration of participants' experiences of membership and rationales for continued attendance. MAIN OUTCOME MEASURES: Twelve participants (four males, eight females), recruited from a regional CPSG, completed semi-structured interviews lasting from 45 to 120 minutes...
January 4, 2018: Psychology & Health
https://www.readbyqxmd.com/read/29261655/cell-salvage-and-donor-blood-transfusion-during-cesarean-section-a-pragmatic-multicentre-randomised-controlled-trial-salvo
#8
Khalid S Khan, Philip A S Moore, Matthew J Wilson, Richard Hooper, Shubha Allard, Ian Wrench, Lee Beresford, Tracy E Roberts, Carol McLoughlin, James Geoghegan, Jane P Daniels, Sue Catling, Vicki A Clark, Paul Ayuk, Stephen Robson, Fang Gao-Smith, Matthew Hogg, Doris Lanz, Julie Dodds
BACKGROUND: Excessive haemorrhage at cesarean section requires donor (allogeneic) blood transfusion. Cell salvage may reduce this requirement. METHODS AND FINDINGS: We conducted a pragmatic randomised controlled trial (at 26 obstetric units; participants recruited from 4 June 2013 to 17 April 2016) of routine cell salvage use (intervention) versus current standard of care without routine salvage use (control) in cesarean section among women at risk of haemorrhage...
December 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29248195/is-chemotherapy-always-necessary-for-patients-with-nonmetastatic-gestational-trophoblastic-neoplasia-with-histopathological-diagnosis-of-choriocarcinoma
#9
Antonio Braga, Vanessa Campos, Jorge Rezende Filho, Lawrence H Lin, Sue Yazaki Sun, Christiani Bisinoto de Souza, Rita de Cássia Alves Ferreira da Silva, Elaine Azevedo Soares Leal, Eduardo Silveira, Izildinha Maestá, José Mauro Madi, Elza H Uberti, Maurício Viggiano, Kevin M Elias, Neil Horowitz, Ross S Berkowitz
OBJECTIVE: To evaluate expectant management versus immediate chemotherapy following pathological diagnosis of gestational choriocarcinoma (GCC) in patients with nonmetastatic disease. METHODS: Multicenter retrospective cohort that included patients with histological diagnosis of GCC with nonmetastatic disease followed at one of thirteen Brazilian referral centers for gestational trophoblastic disease from January 2000 to December 2016. RESULTS: Among 3191 patients with gestational trophoblastic neoplasia, 199 patients with nonmetastatic GCC were identified...
December 13, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29244005/ghost-global-hepatitis-outbreak-and-surveillance-technology
#10
Atkinson G Longmire, Seth Sims, Inna Rytsareva, David S Campo, Pavel Skums, Zoya Dimitrova, Sumathi Ramachandran, Magdalena Medrzycki, Hong Thai, Lilia Ganova-Raeva, Yulin Lin, Lili T Punkova, Amanda Sue, Massimo Mirabito, Silver Wang, Robin Tracy, Victor Bolet, Thom Sukalac, Chris Lynberg, Yury Khudyakov
BACKGROUND: Hepatitis C is a major public health problem in the United States and worldwide. Outbreaks of hepatitis C virus (HCV) infections associated with unsafe injection practices, drug diversion, and other exposures to blood are difficult to detect and investigate. Effective HCV outbreak investigation requires comprehensive surveillance and robust case investigation. We previously developed and validated a methodology for the rapid and cost-effective identification of HCV transmission clusters...
December 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29229573/merkel-cell-carcinoma-an-update-and-review-part-ii-current-and-future-therapy
#11
REVIEW
Tiffany L Tello, Kathleen Coggshall, Sue S Yom, Siegrid S Yu
Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin associated with a high risk of local recurrence and distant metastases. It most commonly occurs on sun-exposed areas of Caucasian patients over the age of 65.1,2 The Merkel cell polyomavirus (MCV) is thought to be responsible for malignant transformation in approximately 80% of cases in the northern hemisphere,3 while ultraviolet radiation induced DNA damage is implicated in MCV-negative tumors.4 The overall incidence of MCC is low, with approximately 1600 cases diagnosed annually in the United States...
December 8, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29228835/the-self-management-balancing-act-of-spousal-care-partners-in-the-case-of-parkinson-s-disease
#12
Sue Berger, Tiffany Chen, Jenna Eldridge, Cathi A Thomas, Barbara Habermann, Linda Tickle-Degnen
BACKGROUND: Living with and caring for someone with chronic illness can lead to limitations in activity and social participation for the care partner. Past research emphasizes the importance of care partners taking care of themselves physically and emotionally so they can stay healthy to support the care recipient. There is little information regarding how the care partner takes care of their own social lives. The purpose of this study was to explore the concept of social self-management from the perspective of spousal care partners of people with Parkinson's disease...
December 12, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29225949/improving-postpartum-care-delivery-and-uptake-by-implementing-context-specific-interventions-in-four-countries-in-africa-a-realist-evaluation-of-the-missed-opportunities-in-maternal-and-infant-health-momi-project
#13
Nehla Djellouli, Sue Mann, Bejoy Nambiar, Paula Meireles, Diana Miranda, Henrique Barros, Fadima Y Bocoum, W Maurice E Yaméogo, Clarisse Yaméogo, Sylvie Belemkoabga, Halima Tougri, Abou Coulibaly, Seni Kouanda, Vernon Mochache, Omar K Mwakusema, Eunice Irungu, Peter Gichangi, Zione Dembo, Angela Kadzakumanja, Charles Vidonji Makwenda, Judite Timóteo, Misete G Cossa, Malica de Melo, Sally Griffin, Nafissa B Osman, Severiano Foia, Emilomo Ogbe, Els Duysburgh, Tim Colbourn
Postpartum care (PPC) has remained relatively neglected in many interventions designed to improve maternal and neonatal health in sub-Saharan Africa. The Missed Opportunities in Maternal and Infant Health project developed and implemented a context-specific package of health system strengthening and demand generation in four African countries, aiming to improve access and quality of PPC. A realist evaluation was conducted to enable nuanced understanding of the influence of different contextual factors on both the implementation and impacts of the interventions...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29203628/predicting-out-of-office-blood-pressure-in-the-clinic-for-the-diagnosis-of-hypertension-in-primary-care-an-economic-evaluation
#14
Mark Monahan, Sue Jowett, Kate Lovibond, Paramjit Gill, Marshall Godwin, Sheila Greenfield, Janet Hanley, F D Richard Hobbs, Una Martin, Jonathan Mant, Brian McKinstry, Bryan Williams, James P Sheppard, Richard J McManus
Clinical guidelines in the United States and United Kingdom recommend that individuals with suspected hypertension should have ambulatory blood pressure (BP) monitoring to confirm the diagnosis. This approach reduces misdiagnosis because of white coat hypertension but will not identify people with masked hypertension who may benefit from treatment. The Predicting Out-of-Office Blood Pressure (PROOF-BP) algorithm predicts masked and white coat hypertension based on patient characteristics and clinic BP, improving the accuracy of diagnosis while limiting subsequent ambulatory BP monitoring...
December 4, 2017: Hypertension
https://www.readbyqxmd.com/read/29195320/symmetry-hopf-bifurcation-and-the-emergence-of-cluster-solutions-in-time-delayed-neural-networks
#15
Zhen Wang, Sue Ann Campbell
We consider the networks of N identical oscillators with time delayed, global circulant coupling, modeled by a system of delay differential equations with ZN symmetry. We first study the existence of Hopf bifurcations induced by the coupling time delay and then use symmetric Hopf bifurcation theory to determine how these bifurcations lead to different patterns of symmetric cluster oscillations. We apply our results to a case study: a network of FitzHugh-Nagumo neurons with diffusive coupling. For this model, we derive the asymptotic stability, global asymptotic stability, absolute instability, and stability switches of the equilibrium point in the plane of coupling time delay (τ) and excitability parameter (a)...
November 2017: Chaos
https://www.readbyqxmd.com/read/29190430/evaluating-uk-national-guidance-for-screening-of-children-for-tb-a-prospective-multi-centre-study
#16
Beate Kampmann, James A Seddon, James Paton, Zohreh Nademi, Denis Keane, Bhanu Williams, Amanda Williams, Sue Liebeschutz, Anna Riddell, Jolanta Bernatoniene, Sanjay Patel, Nuria Martinez, Paddy McMaster, Robindra Basu-Roy, Steven B Welch
Rationale and Objective In order to identify infected contacts of tuberculosis (TB) cases, the UK National Institute for Health and Care Excellence (NICE) recommended the addition of interferon-gamma release assays (IGRA) to the tuberculin skin test (TST) in its 2006 TB guidelines. Treatment for TB infection was no longer recommended for children screened TST-positive but IGRA-negative. We carried out a cohort study to evaluate the risk of TB disease in this group. Methods Children exposed to an infectious case of TB in their household were recruited from 11 paediatric TB clinics...
November 30, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29181459/gallium-67-scintigraphy-in-differential-diagnosis-of-malignant-tumours-from-non-tumorous-lesions-of-the-maxilla
#17
Ichiro Ogura, Takaaki Oda, Mikiko Sue, Yoshihiko Sasaki, Kazuhide Hayama
OBJECTIVE: To assess the gallium-67 (67Ga) scintigraphy in differential diagnosis of malignant tumours from non-tumorous lesions of the maxilla. METHODS: Nineteen patients with malignant tumours (six cases of squamous cell carcinoma and one case of malignant melanoma) and non-tumorous lesions (seven cases of maxillary sinusitis and five cases of postoperative maxillary changes) in the maxilla underwent 67Ga and bone scintigraphy with CT and MRI. The statistical analysis with respect to comparison between imaging features of 67Ga and bone scintigraphy and maxillary lesions was performed with the Pearson's chi-squared test...
2017: Chinese Journal of Dental Research
https://www.readbyqxmd.com/read/29177366/glycaemic-blood-pressure-and-low-density-lipoprotein-cholesterol-control-in-adult-patients-with-diabetes-in-singapore-a-review-of-singapore-literature-over-two-decades
#18
Zhongxian Poh, Kavita Venkataraman, Sue-Anne Es Toh, Lian Leng Low
INTRODUCTION: Diabetes mellitus is a burgeoning global health epidemic, with an estimated 422 million people living with diabetes in 2014. The number of adult diabetic patients in Singapore is expected to rise to 1 million in 2050. Despite advances made in the management of diabetes and improvements in healthcare accessibility and delivery, the rate and complications of diabetes (myocardial infarction, stroke, kidney failure and lower limb amputation) in Singapore have not decreased. Gaps between guidelines and practice have been reported in several parts of the world...
October 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29175115/comparison-of-four-pd-l1-immunohistochemical-assays-in-lung-cancer
#19
Shona Hendry, David J Byrne, Gavin M Wright, Richard J Young, Sue Sturrock, Wendy A Cooper, Stephen B Fox
INTRODUCTION: Four different PD-L1 immunohistochemical assays are approved or in development as companion or complementary diagnostics to different immunotherapeutic agents in lung carcinoma. We sought to determine whether these assays are technically equivalent and whether one antibody can be used on an alternate staining platform. METHODS: Serial sections of tissue microarrays constructed from 368 cases of resected lung cancer were stained for 22C3 and 28-8 on the Dako Link 48 platform, and for SP142 and SP263 on the Ventana Benchmark Ultra platform, strictly as per product insert...
November 23, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29167754/a-mass-that-has-no-ebus-echo
#20
Matthew K Rosenblum, Sue X Wang, Eric J Seeley
We report findings for a patient that underwent endobronchial ultrasound (EBUS) guided transbronchial needle aspiration (TBNA) for diagnostic purposes after an abnormal chest CT. The patient initially presented with cough and shortness of breath. Chest CT revealed a 6 cm soft tissue mass with mildly enlarged right hilar lymph nodes (LNs) and a small right sided pleural effusion. Based on these radiologic findings, the patient underwent an EBUS guided FNA of the mass. To our surprise, the mass was hypoechoic by EBUS and on aspiration, the syringe filled with yellow fluid...
2018: Respiratory Medicine Case Reports
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