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https://www.readbyqxmd.com/read/29787819/budding-and-tumor-infiltrating-lymphocytes-combination-of-both-parameters-predicts-survival-in-colorectal-cancer-and-leads-to-new-prognostic-subgroups
#1
Corinna Lang-Schwarz, Balint Melcher, Franziska Haumaier, Klaus Lang-Schwarz, Thomas Rupprecht, Michael Vieth, William Sterlacci
Tumor budding is an independent prognostic factor in colorectal cancer (CRC) and has recently been well defined by the International Concensus Conference on Tumor Budding (ITBCC). Tumor infiltrating lymphocytes (TILs) are also an issue in different human cancers and correlate with prognosis in CRC. Here we evaluate the combination of budding and TILs in CRC with regard to prognosis. Hematoxylin and Eosin (H&E) stained slides of 501 CRC patients, diagnosed between 2005 and 2010 were reevaluated for tumor budding according to the ITBCC-criteria...
May 19, 2018: Human Pathology
https://www.readbyqxmd.com/read/29726071/a-prospective-randomised-multi-centre-study-of-the-impact-of-ga-68-psma-pet-ct-imaging-for-staging-high-risk-prostate-cancer-prior-to-curative-intent-surgery-or-radiotherapy-propsma-study-clinical-trial-protocol
#2
Michael S Hofman, Declan G Murphy, Scott G Williams, Tatenda Nzenza, Alan Herschtal, Richard De Abreu Lourenco, Dale L Bailey, Ray Budd, Rodney J Hicks, Roslyn J Francis, Nathan Lawrentschuk
INTRODUCTION: Accurate staging of patients with prostate cancer is important for therapeutic decision making. Relapse following surgery or radiotherapy of curative intent is not uncommon and, in part, represents a failure of staging with current diagnostic imaging techniques to detect disease spread. Prostate-specific-membrane-antigen (PSMA) positron emission tomography / computed tomography (PET/CT) is a new whole body scanning technique that enables visualisation of prostate cancer with high contrast...
May 3, 2018: BJU International
https://www.readbyqxmd.com/read/29724585/urothelial-carcinoma-in-children-a-case-series
#3
Federica Marinoni, Francesca Destro, Giorgio Giuseppe Orlando Selvaggio, Giovanna Riccipetitoni
OBJECTIVE: To report a series of 5 patients with urothelial bladder cancer (UBC) three of them with a history of exposure to amines and only two with gross hematuria. MATERIALS AND METHODS: After obtaining ethical and legal authorization, we performed a restrospective monocentric study. We collected information of patients with UBC over a period of 10 years. We recorded: age, sex, reason for presentation, familial history and risk factors, preoperative assessment, surgical details, histological type and grade, follow-up...
April 30, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29618617/risk-assessment-after-neoadjuvant-chemotherapy-in-luminal-breast-cancer-using-a-clinico-molecular-predictor
#4
Sibylle Loibl, Karsten Weber, Jens Huober, Kristin Krappmann, Frederik Marmé, Christian Schem, Knut Engels, Berit M Pfitzner, Sherko Kümmel, Jenny Furlanetto, Arndt Hartmann, Silvia Darb-Esfahani, Volkmar Müller, Annette Staebler, Gunter von Minckwitz, Ralf Kronenwett, Carsten Denkert
PURPOSE: This study aimed to evaluate a modified EPclin test (mEPclin), a combination of EndoPredict (EP) score, post-neoadjuvant pathological tumor size and nodal status, for predicting the risk of distance recurrence after neoadjuvant chemotherapy (NACT) in patients with residual estrogen-receptor (ER)-positive/HER2-negative breast cancer (BC). We also compared the prognostic power of the mEPclin with that of the CPS-EG score. EXPERIMENTAL DESIGN: 428 formalin-fixed, paraffin-embedded tumor samples from GeparTrio and GeparQuattro studies were evaluated for mRNA expression of eight cancer-related and three reference genes...
April 4, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29564130/prognostic-significance-of-unintentional-body-weight-loss-in-colon-cancer-patients
#5
Yi-Hung Kuo, Chung-Sheng Shi, Cheng Yi Huang, Yun-Ching Huang, Chih-Chien Chin
The aim of the present study was to investigate whether unintentional body weight loss (BWL) provides additional clinical information in terms of tumor progression and prognosis in non-metastatic colon cancer. In the present study, a total of 2,406 consecutive colon cancer patients without metastasis were retrospectively enrolled. Unintentional BWL was defined as loss of >5% of body weight within the last 6-12 months, or defined subjectively upon fulfillment of at least two of the following: Evidence of change in clothing size and corroboration of the reported weight loss by family or friend...
April 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29544528/cd19-car-t-cell-therapy-for-relapsed-refractory-acute-lymphoblastic-leukemia-factors-affecting-toxicities-and-long-term-efficacies
#6
Li-Na Zhang, Yongping Song, Delong Liu
The prognosis of adults with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL) remains dismal even at this day and age. With salvage chemotherapy, only 29% (range 18 to 44%) of the patients with R/R ALL can be induced into complete remission (CR), with a median overall survival (OS) of 4 months (range 2-6 months). Blinatumomab and inotuzumab ozogamycin (IO) are immunotherapeutic agents that increased CR to 80% and extended survival to 7.7 months in this high-risk population of patients. In the last few years, chimeric antigen receptor (CAR)--engineered T cells have led to major progress in cancer immunotherapy...
March 15, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29530632/standard-of-care-versus-metastases-directed-therapy-for-pet-detected-nodal-oligorecurrent-prostate-cancer-following-multimodality-treatment-a-multi-institutional-case-control-study
#7
T Steuber, C Jilg, P Tennstedt, A De Bruycker, D Tilki, K Decaestecker, T Zilli, B A Jereczek-Fossa, U Wetterauer, A L Grosu, W Schultze-Seemann, H Heinzer, M Graefen, A Morlacco, R J Karnes, P Ost
BACKGROUND: Most prostate cancer (PCa) patients with a biochemical failure following primary multimodality treatment (surgery and postoperative radiotherapy) relapse in the nodes. OBJECTIVE: To perform a matched-case analysis in men with lymph node recurrent PCa comparing standard of care (SOC) with metastasis-directed therapy (MDT). DESIGN, SETTING, AND PARTICIPANTS: PCa patients with a prostate-specific antigen (PSA) progression following multimodality treatment were included in this retrospective multi-institutional analysis...
March 10, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29512690/daidzein-exerts-anticancer-activity-towards-skov3-human-ovarian-cancer-cells-by-inducing-apoptosis-and-cell-cycle-arrest-and-inhibiting-the-raf-mek-erk-cascade
#8
Fu Hua, Chang-Hua Li, Xiao-Gang Chen, Xiao-Ping Liu
Ovarian cancer is the main cause of gynecological cancer‑associated mortality around the world. Despite initial responses to chemotherapy, frequent relapse occurs. Daidzein is an important flavonoid and has been shown to exhibit a diversity of pharmacological properties, including antimicrobial and anticancer activities. However, information on the anticancer activity of daidzein against ovarian cancer remains limited. Therefore, the present study evaluated the anticancer activity of daidzein against a panel of human ovarian cancer cell lines and one normal ovarian cell line (Moody)...
June 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29487696/the-evolutionary-pattern-of-mutations-in-glioblastoma-reveals-therapy-mediated-selection
#9
Andrea M Muscat, Nicholas C Wong, Katharine J Drummond, Elizabeth M Algar, Mustafa Khasraw, Roel Verhaak, Kathryn Field, Mark A Rosenthal, David M Ashley
Glioblastoma presents as a heterogeneous disease with poor prognosis despite the use of multimodal therapy. Analysis of genomic DNA changes between initial diagnosis and recurrence in response to standard treatment protocols would enhance understanding of disease progression and better inform new treatment strategies. A cohort of 21 patients with primary glioblastoma were examined between diagnosis and first recurrence. This study presented a rare opportunity to characterize molecular alterations in tumors observed in three patients who received no therapeutic intervention, other than surgery, offering a unique control...
January 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29478188/palliative-care-in-swiss-pediatric-oncology-settings-a-retrospective-analysis-of-medical-records
#10
Michael Rost, Elaine Acheson, Thomas Kühne, Marc Ansari, Nadia Pacurari, Pierluigi Brazzola, Felix Niggli, Bernice S Elger, Tenzin Wangmo
PURPOSE: This study examined the provision of palliative care and related decision-making in Swiss pediatric oncology settings. The aim was to determine if and when children who died from cancer received palliative care, whether there were differences by cancer diagnosis, and inclusion of children in decision-making regarding palliative care. METHODS: Using a standardized data extraction form, a retrospective review of medical records of deceased pediatric patients was conducted...
February 24, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29449660/gut-microbiota-injury-in-allogeneic-haematopoietic-stem-cell-transplantation
#11
REVIEW
Yusuke Shono, Marcel R M van den Brink
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is considered to be the strongest curative immunotherapy for various malignancies (primarily, but not limited to, haematologic malignancies). However, application of allo-HSCT is limited owing to its life-threatening major complications, such as graft-versus-host disease (GVHD), relapse and infections. Recent advances in large-scale DNA sequencing technology have facilitated rapid identification of the microorganisms that make up the microbiota and evaluation of their interactions with host immunity in various diseases, including cancer...
May 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29448242/the-lncrna-epel-promotes-lung-cancer-cell-proliferation-through-e2f-target-activation
#12
Seong-Min Park, Eun-Young Choi, Dong-Hyuck Bae, Hyun Ahm Sohn, Seon-Young Kim, Youn-Jae Kim
BACKGROUND/AIMS: Recent studies have revealed that many long non-coding RNAs (lncRNAs) play oncogenic or tumor-suppressive roles in various cancers. Lung cancer is the leading cause of cancer-related death worldwide, and many lung cancer patients frequently relapse after surgery, even those in the early stages. However, the oncogenic or tumor-suppressive roles and clinical implications of lncRNAs in lung cancer have not been fully elucidated. METHODS: The association between an E2F-mediated cell proliferation enhancing lncRNA (EPEL) expression and lung cancer patient survival was accessed using public microarray data with clinical information...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29439652/advantages-of-a-multi-state-approach-in-surgical-research-how-intermediate-events-and-risk-factor-profile-affect-the-prognosis-of-a-patient-with-locally-advanced-rectal-cancer
#13
G Manzini, T J Ettrich, M Kremer, M Kornmann, D Henne-Bruns, D A Eikema, P Schlattmann, L C de Wreede
BACKGROUND: Standard survival analysis fails to give insight into what happens to a patient after a first outcome event (like first relapse of a disease). Multi-state models are a useful tool for analyzing survival data when different treatments and results (intermediate events) can occur. Aim of this study was to implement a multi-state model on data of patients with rectal cancer to illustrate the advantages of multi-state analysis in comparison to standard survival analysis. METHODS: We re-analyzed data from the RCT FOGT-2 study by using a multi-state model...
February 13, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29426294/factors-associated-with-breast-cancer-recurrences-or-mortality-and-dynamic-prediction-of-death-using-history-of-cancer-recurrences-the-french-e3n-cohort
#14
Alexandre Lafourcade, Mathilde His, Laura Baglietto, Marie-Christine Boutron-Ruault, Laure Dossus, Virginie Rondeau
BACKGROUND: In addition to tumor characteristics and lifestyle factors, cancer relapses are often related to the risk of death but have not been jointly studied. We investigate the prognostic factors of recurrent events and death after a diagnosis of breast cancer and predict individual deaths including a history of recurrences. METHODS: The E3N (Etude Epidémiologique auprès de Femmes de la Mutuelle Générale de l'Education Nationale) study is a prospective cohort study that was initiated in 1990 to investigate factors associated with the most common types of cancer...
February 9, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29423096/validation-of-a-hypoxia-related-gene-signature-in-multiple-soft-tissue-sarcoma-cohorts
#15
Lingjian Yang, Laura Forker, Joely J Irlam, Nischalan Pillay, Ananya Choudhury, Catharine M L West
Purpose: There is a need for adjuvant/neo-adjuvant treatment strategies to prevent metastatic relapse in soft tissue sarcoma (STS). Tumor hypoxia is associated with a high-risk of metastasis and is potentially targetable. This study aimed to derive and validate a hypoxia mRNA signature for STS for future biomarker-driven trials of hypoxia targeted therapy. Materials and Methods: RNA sequencing was used to identify seed genes induced by hypoxia in seven STS cell lines...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29422258/expression-analysis-of-mir-29b-in-malignant-and-benign-breast-tumors-a-promising-prognostic-biomarker-for-invasive-ductal-carcinoma-with-a-possible-histotype-related-expression-status
#16
Georgia Papachristopoulou, Emmanuel I Papadopoulos, Afrodite Nonni, George Z Rassidakis, Andreas Scorilas
BACKGROUND: Aberrations in microRNA levels seem to provide valuable information regarding breast cancer prognosis and therapy. In this study, we sought to analyze miR-29b expression in breast tumors and thus explore its clinical value. MATERIALS AND METHODS: One hundred twenty-one malignant and 56 benign breast tissue specimens were collected and subjected to extraction of total RNA, which was polyadenylated and reverse transcribed to cDNA. Subsequently, a highly sensitive quantitative real-time polymerase chain reaction protocol was developed and miR-29b levels, estimated via the comparative CT method, were finally subjected to comprehensive statistical analysis...
November 21, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29402128/systematic-review-and-benchmarking-of-quality-adjusted-time-without-symptoms-or-toxicity-q-twist-in-oncology
#17
Caitlyn T Solem, Youngmin Kwon, Ruchit M Shah, Abdalla Aly, Marc F Botteman
The Quality-Adjusted Time Without Symptoms or Toxicity (Q-TWiST) has been used to evaluate the clinical benefits and risks of oncology treatments. However, limited information is available to interpret and contextualize Q-TWiST results. Areas covered: A systematic review of Q-TWiST literature was conducted to provide contextualizing benchmarks for future studies. 51 articles with 81 unique Q-TWiST comparisons were identified. The mean (95% CI) and median absolute Q-TWiST gains for treatment versus control arms were 2...
February 5, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/29401004/molecular-testing-guideline-for-the-selection-of-patients-with-lung-cancer-for-treatment-with-targeted-tyrosine-kinase-inhibitors-american-society-of-clinical-oncology-endorsement-of-the-college-of-american-pathologists-international-association-for-the-study
#18
Gregory P Kalemkerian, Navneet Narula, Erin B Kennedy, William A Biermann, Jessica Donington, Natasha B Leighl, Madelyn Lew, James Pantelas, Suresh S Ramalingam, Martin Reck, Anjali Saqi, Michael Simoff, Navneet Singh, Baskaran Sundaram
Purpose In response to advances in the field, the College of American Pathologists (CAP), the International Association for the Study of Lung Cancer (IASLC), and the Association for Molecular Pathology (AMP) recently updated their recommendations for molecular testing for the selection of patients with lung cancer for treatment with targeted tyrosine kinase inhibitors. ASCO has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations...
March 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29390367/targeted-therapy-with-apatinib-in-a-patient-with-relapsed-small-cell-lung-cancer-a-case-report-and-literature-review
#19
REVIEW
Jun Zhao, Xiaoling Zhang, Chaojie Gong, Jialei Zhang
RATIONALE: Small cell lung cancer (SCLC) is a lethal malignancy. Once relapsed, the disease is irreversible and most of the patients will die of cancer aggravation in 1 to 2 months. In the past several decades, little progress has been made in the systemic treatment of SCLC. Apatinib, as a novel small-molecule tyrosine kinase inhibitor specifically targeting the vascular endothelial growth factor receptor 2 (VEGFR2), has achieved progress in treatment of a variety of cancers. However, there has been no report of the targeted therapy with apatinib in SCLC yet...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29356463/spatial-barriers-impact-upon-appropriate-delivery-of-radiotherapy-in-breast-cancer-patients
#20
Fabrizio Stracci, Fortunato Bianconi, Chiara Lupi, Manuela Margaritelli, Alessio Gili, Cynthia Aristei
Radiotherapy (RT) is the standard treatment for breast cancer patients after conserving surgery or mastectomy when patients are at high risk of relapse. Major obstacles to appropriate RT delivery are journey times. Since studies on access to RT were carried out mostly in large countries, this study investigated factors in an Italian region and the influence of RT delivery on survival. A total of 4735 female candidates for RT were included in the study. A geographic information system calculated journey times from patients' homes and surgery hospitals to RT centers...
February 2018: Cancer Medicine
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