Laia Puig-Blasco, Krzysztof B Piotrowski, Signe R Michaelsen, Nicolai S Bager, Aušrinė Areškevičiūtiė, Marie-Louise Thorseth, Xiao-Feng Sun, Ulrich Auf dem Keller, Bjarne W Kristensen, Daniel H Madsen, Sebastian P Gnosa, Marie Kveiborg
Tumor progression and response to treatment are highly affected by interactions between cancer cells and the tumor microenvironment (TME). Many of the soluble factors and signaling receptors involved in this crosstalk are shed by a disintegrin and metalloproteinases (ADAMs). Upregulation of ADAM15 has been linked to worse survival in cancer patients and a tumor-promoting function both in vitro and in murine cancer models. Although ADAM15 has been involved in cell-cell and cell-extracellular matrix interactions, its role in the crosstalk between cancer cells and the TME in vivo remains unexplored...
August 21, 2023: International Journal of Cancer. Journal International du Cancer