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https://www.readbyqxmd.com/read/29138362/infant-neuromotor-development-and-childhood-problem-behavior
#1
Fadila Serdarevic, Akhgar Ghassabian, Tamara van Batenburg-Eddes, Emin Tahirovic, Tonya White, Vincent W V Jaddoe, Frank C Verhulst, Henning Tiemeier
BACKGROUND: Research of adults and school-aged children suggest a neurodevelopmental basis for psychiatric disorders. We examined whether infant neuromotor development predicted internalizing and externalizing problems in young children. METHODS: In Generation R, a population-based cohort in the Netherlands (2002-2006), trained research assistants evaluated the neuromotor development of 4006 infants aged 2 to 5 months by using an adapted version of Touwen's Neurodevelopmental Examination (tone, responses, and senses and other observations)...
November 14, 2017: Pediatrics
https://www.readbyqxmd.com/read/29135446/-cross-informant-agreement-between-parent-reported-and-adolescent-self-reported-quality-of-life-in-children-with-externalising-symptoms
#2
Dóra Szentiványi, József Halász, Lili O Horváth, Gergely Mészáros, Martina Miklós, Mónika Miklósi, Szabina Velo, Péter Vida, Judit Balázs
BACKGROUND: It is well-known phenomena both in clinical practice and research, that there is a discrepancy between the parents' and children's report about children's Quality of Life (QoL). The purpose of our research was to examine the differences in self and caregiver's proxy report of child's QoL. We also compared mothers', fathers' and other caregivers' reports of children's QoL. METHODS: Patients with externalizing symptoms in their history, aged 13-18 years were selected from the Vadaskert Child and Adolescent Psychiatry Hospital and Outpatient Clinic...
2017: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
https://www.readbyqxmd.com/read/29128740/motivational-capacities-after-prolonged-interpersonal-childhood-trauma-in-institutional-settings-in-a-sample-of-austrian-adult-survivors
#3
Dina Weindl, Matthias Knefel, Tobias M Glück, Ulrich S Tran, Brigitte Lueger-Schuster
A considerable amount of research has been conducted on the aversive impact of prolonged interpersonal childhood trauma, but data on possible associations with motivational concepts (self-efficacy, self-esteem and locus of control) in adult survivors is scarce. The purpose of this study is to investigate specific coherences between childhood abuse and adult life events with (a) motivational concepts (MC), (b) the emotion regulation strategy "goal-directed behavior" and (c) the possible mediation of emotion regulation (ER) on motivational concepts...
November 9, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29124553/intolerance-of-uncertainty-in-children-with-attention-deficit-hyperactivity-disorder
#4
Colette Gramszlo, Nicholas D Fogleman, Paul J Rosen, Janet Woodruff-Borden
Intolerance of uncertainty (IU) has often been studied in the context of internalizing disorders, but no studies to our knowledge have explored the relation between IU and externalizing disorders. Given the proposed link between IU and emotion regulation, the current study sought to examine levels of IU in an externalizing clinical population with known emotion regulation difficulties-attention-deficit/hyperactivity disorder (ADHD). IU levels in this population were compared to a clinical population known to experience elevated levels of IU...
November 9, 2017: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/29124369/exploring-the-regioselectivity-in-the-cycloaddition-of-azides-to-alkynes-catalyzed-by-dinuclear-copper-clusters-cu2aac-reaction-using-the-topologies-of-%C3%A2-2-%C3%AF-r-and-%C3%A2-%C3%A2-2-%C3%AF-r
#5
S Calvo-Losada, J J Quirante
The regioselectivity of the dinuclear-Cu(I)-catalyzed version of the Huisgen reaction, abbreviated in this paper to Cu2AAC, was analyzed using quantum topological methods in order to study how the electronic charge distribution evolved along different reaction paths. Electronic densities were computed at the LC-wPBE/6-311++G(2d,2p)//LC-wPBE/6-311++G(d,p) level. The presence of two copper ions in the catalyst was found to lead to an electrophilic site in the external alkyne carbon that, in a generalized Sharpless-type mechanism, undergoes an initial donor-acceptor interaction with the azide molecule, but with an inverted electrophile-nucleophile pattern when compared with the corresponding mononuclear process (CuAAC)...
November 9, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29122012/drug-target-ontology-to-classify-and-integrate-drug-discovery-data
#6
Yu Lin, Saurabh Mehta, Hande Küçük-McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J Yang, Cristian G Bologa, Tudor I Oprea, Stephan C Schürer
BACKGROUND: One of the most successful approaches to develop new small molecule therapeutics has been to start from a validated druggable protein target. However, only a small subset of potentially druggable targets has attracted significant research and development resources. The Illuminating the Druggable Genome (IDG) project develops resources to catalyze the development of likely targetable, yet currently understudied prospective drug targets. A central component of the IDG program is a comprehensive knowledge resource of the druggable genome...
November 9, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/29117321/the-international-glossary-on-infertility-and-fertility-care-2017
#7
Fernando Zegers-Hochschild, G David Adamson, Silke Dyer, Catherine Racowsky, Jacques de Mouzon, Rebecca Sokol, Laura Rienzi, Arne Sunde, Lone Schmidt, Ian D Cooke, Joe Leigh Simpson, Sheryl van der Poel
STUDY QUESTION: Can a consensus and evidence-driven set of terms and definitions be generated to be used globally in order to ensure consistency when reporting on infertility issues and fertility care interventions, as well as to harmonize communication among the medical and scientific communities, policy-makers, and lay public including individuals and couples experiencing fertility problems? SUMMARY ANSWER: A set of 283 consensus-based and evidence-driven terminologies used in infertility and fertility care has been generated through an inclusive consensus-based process with multiple stakeholders...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29106739/evaluation-of-tomotherapy-dose-calculations-with-intra-fractional-motion-and-motion-compensation
#8
Edward H Chao, Daniel Lucas, Eric Schnarr
PURPOSE: Anatomical motion, both cyclical and aperiodic, can impact the dose delivered during external beam radiation. In this work, we evaluate the use of a research version of the clinical TomoTherapy(®) dose calculator to calculate dose with intra-fraction rigid motion. We also evaluate the feasibility of a method of motion compensation for helical tomotherapy using the jaws and MLC. METHODS: Treatment plans were created using the TomoTherapy treatment planning system...
November 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/29106469/dfast-a-flexible-prokaryotic-genome-annotation-pipeline-for-faster-genome-publication
#9
Yasuhiro Tanizawa, Takatomo Fujisawa, Yasukazu Nakamura
Summary: We developed a prokaryotic genome annotation pipeline, DFAST, that also supports genome submission to public sequence databases. DFAST was originally started as an on-line annotation server, and to date, over 7,000 jobs have been processed since its first launch in 2016. Here, we present a newly implemented background annotation engine for DFAST, which is also available as a standalone command-line program. The new engine can annotate a typical-sized bacterial genome within 10 minutes, with rich information such as pseudogenes, translation exceptions, and orthologous gene assignment between given reference genomes...
November 2, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29103783/reprint-of-low-energy-electron-potentiometry
#10
Johannes Jobst, Jaap Kautz, Maria Mytiliniou, Rudolf M Tromp, Sense Jan van der Molen
In a lot of systems, charge transport is governed by local features rather than being a global property as suggested by extracting a single resistance value. Consequently, techniques that resolve local structure in the electronic potential are crucial for a detailed understanding of electronic transport in realistic devices. Recently, we have introduced a new potentiometry method based on low-energy electron microscopy (LEEM) that utilizes characteristic features in the reflectivity spectra of layered materials [1]...
October 25, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/29102740/clinical-outcomes-with-mri-guided-image-based-brachytherapy-in-cervical-cancer-an-institutional-experience
#11
Vijai Simha, Bhavana Rai, Firuza D Patel, Rakesh Kapoor, Suresh C Sharma, Oinam A Singh, Veenu Singla, Bhaswanth Dhanireddy, Sushmita Ghoshal
PURPOSE: To evaluate the long-term disease control and toxicity to the organs at risk after dose-escalated image-based adaptive brachytherapy (BT) in cervical cancer. METHODS AND MATERIALS: Sixty patients of cervical cancer were treated with external radiotherapy 46 Gy in 23 fractions with weekly cisplatin and MRI-guided BT 7 Gy × 4 fractions with a minimum dose of 85.7 Gy (EQD2) to the high-risk clinical target volume (HRCTV). The BT dose was initially prescribed to point A and plans were optimized to ensure coverage of both point A and HRCTV while maintaining doses to the organs at risk within the recommended constraints...
November 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29099980/parent-reported-symptoms-of-sleep-disordered-breathing-is-associated-with-increased-behavioral-problems-at-2-years-of-age-the-canadian-healthy-infant-longitudinal-development-child-birth-cohort-study
#12
Sukhpreet K Tamana, Lisa Smithson, Amanda Lau, Jennifer Mariasine, Rochelle Young, Joyce Chikuma, Diana L Lefebvre, Padmaja Subbarao, Allan B Becker, Stuart E Turvey, Malcolm R Sears, Jacqueline Pei, Piush J Mandhane
Objectives: To examine the association between the age of onset and duration of parent-reported symptoms of sleep disordered breathing (SDB) and behavioral problems at age two years. Methods: Parent-reported SDB symptoms were assessed quarterly between three months and two years among 583 Canadian Healthy Infant Longitudinal Development (CHILD) Edmonton-site participants. Parent-reported SDB symptoms were clustered into phenotypes using group-based trajectory analysis based on age of onset and duration of symptoms...
November 1, 2017: Sleep
https://www.readbyqxmd.com/read/29091131/observation-of-neonatal-behavior-cross-cultural-adaptation-of-the-newborn-behavioral-observations
#13
Marina Aguiar Pires Guimarães, Claudia Regina Lindgren Alves, Ana Amélia Cardoso, Lívia de Castro Magalhães
OBJECTIVE: To conduct the cross-cultural adaptation for Brazilian Portuguese of the Newborn Behavioral Observations (NBO), a new resource for observing neonatal behavior and sharing information with parents. METHODS: Methodological study of translation and cultural adaptation of the NBO system, which includes the Recording Form, with 18 items, the Recording Guidelines, with instructions to score each item, the Summary Form, to record suggestions based on the observation, and the Parent Questionnaire, to record the parents' experiences...
October 30, 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29074099/efficacy-and-safety-of-long-acting-pasireotide-or-everolimus-alone-or-in-combination-in-patients-with-advanced-carcinoids-of-the-lung-and-thymus-luna-an-open-label-multicentre-randomised-phase-2-trial
#14
Piero Ferolla, Maria Pia Brizzi, Tim Meyer, Wasat Mansoor, Julien Mazieres, Christine Do Cao, Hervé Léna, Alfredo Berruti, Vincenzo Damiano, Wieneke Buikhuisen, Henning Grønbæk, Catherine Lombard-Bohas, Christian Grohé, Vincenzo Minotti, Marcello Tiseo, Javier De Castro, Nicholas Reed, Gabriella Gislimberti, Neha Singh, Miona Stankovic, Kjell Öberg, Eric Baudin
BACKGROUND: There are no data from prospective studies focused exclusively on patients with advanced lung and thymic carcinoids. We aimed to assess the efficacy and safety of long-acting pasireotide and everolimus, administered alone or in combination, in patients with advanced carcinoids of the lung or thymus. METHODS: LUNA was a prospective, multicentre, randomised, open-label, phase 2 trial of adult patients (aged >18 years) with advanced (unresectable or metastatic), well differentiated carcinoid tumours of the lung or thymus, with radiological progression within 12 months before randomisation, and a WHO performance status of 0-2...
October 23, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29069479/flyatlas-2-a-new-version-of-the-drosophila-melanogaster-expression-atlas-with-rna-seq-mirna-seq-and-sex-specific-data
#15
David P Leader, Sue A Krause, Aniruddha Pandit, Shireen A Davies, Julian A T Dow
FlyAtlas 2 ( www.flyatlas2.org ) is part successor, part complement to the FlyAtlas database and web application for studying the expression of the genes of Drosophila melanogaster in different tissues of adults and larvae. Although generated in the same lab with the same fly line raised on the same diet as FlyAtlas, the FlyAtlas2 resource employs a completely new set of expression data based on RNA-Seq, rather than microarray analysis, and so it allows the user to obtain information for the expression of different transcripts of a gene...
October 24, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29068814/the-glocalization-of-medical-school-accreditation-case-studies-from-taiwan-south-korea-and-japan
#16
Ming-Jung Ho, Joan Abbas, Ducksun Ahn, Chi-Wan Lai, Nobuo Nara, Kevin Shaw
PURPOSE: In an age of globalized medical education, medical school accreditation has been hailed as an approach to external quality assurance. However, accreditation standards can vary widely across national contexts. To achieve recognition by the World Federation for Medical Education (WFME), national accrediting bodies must develop standards suitable for both local contexts and international recognition. This study framed this issue in terms of "glocalization" and aimed to shine light on this complicated multistakeholder process by exploring accreditation in Taiwan, South Korea, and Japan...
October 24, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29066611/prognostic-validation-of-a-non-laboratory-and-a-laboratory-based-cardiovascular-disease-risk-score-in-multiple-regions-of-the-world
#17
Philip Joseph, Salim Yusuf, Shun Fu Lee, Quazi Ibrahim, Koon Teo, Sumathy Rangarajan, Rajeev Gupta, Annika Rosengren, Scott A Lear, Alvaro Avezum, Patricio Lopez-Jaramillo, Sadi Gulec, Afzalhussein Yusufali, Jephat Chifamba, Fernando Lanas, Rajesh Kumar, Noushin Mohammadifard, Viswanathan Mohan, Prem Mony, Annamarie Kruger, Xu Liu, Baoxia Guo, Wenqi Zhao, Youzhu Yang, Rajamohanan Pillai, Rafael Diaz, Ambigga Krishnapillai, Romaina Iqbal, Rita Yusuf, Andrzej Szuba, Sonia S Anand
OBJECTIVE: To evaluate the performance of the non-laboratory INTERHEART risk score (NL-IHRS) to predict incident cardiovascular disease (CVD) across seven major geographic regions of the world. The secondary objective was to evaluate the performance of the fasting cholesterol-based IHRS (FC-IHRS). METHODS: Using measures of discrimination and calibration, we tested the performance of the NL-IHRS (n=100 475) and FC-IHRS (n=107 863) for predicting incident CVD in a community-based, prospective study across seven geographic regions: South Asia, China, Southeast Asia, Middle East, Europe/North America, South America and Africa...
October 24, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29062544/patient-involvement-in-guidelines-is-poor-five-years-after-institute-of-medicine-standards-review-of-guideline-methodologies
#18
Melissa J Armstrong, Joshua A Bloom
PLAIN ENGLISH SUMMARY: The 2011 standards for trustworthy development of healthcare guidelines published by the United States-based Institute of Medicine recommend that guideline developers involve patients and public representatives in the development process. The standards recommend that (1) patients and the public be actively involved as members on guideline development panels and (2) guideline developers seek patient and public input during review of the draft guideline. In this study, researchers reviewed the patient and public involvement strategies of guideline developers in the United States by looking at websites and guideline development practices...
2017: Res Involv Engagem
https://www.readbyqxmd.com/read/29057691/the-outcomes-and-risk-factors-of-fetal-bradycardia-associated-with-external-cephalic-version
#19
Fumio Suyama, Kohei Ogawa, Yukiko Tazaki, Terumi Miwa, Kosuke Taniguchi, Noriyuki Nakamura, Satomi Tanaka, Shinji Tanigaki, Haruhiko Sago
OBJECTIVE: To assess the outcomes and risk factors of fetal bradycardia after external cephalic version (ECV). METHODS: We performed a retrospective study of women who underwent ECV after 35 weeks of gestation in 2010-2016. We assessed the birth outcomes, including umbilical cord artery pH, according to the duration of fetal bradycardia and the risk factors for bradycardia. RESULTS: Among 390 cases, 189 (48.5%) cases showed fetal bradycardia during or immediately after ECV...
October 23, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29054826/viral-infections-in-common-carp-lead-to-a-disturbance-of-mucin-expression-in-mucosal-tissues
#20
Mikolaj Adamek, Dennis Hazerli, Marek Matras, Felix Teitge, Michal Reichert, Dieter Steinhagen
In response to the constant challenge by potential pathogens, external surfaces of fish, their skin, gills and intestinal tract, are coated with mucus, a gel like substance which largely prevents the entry of pathogens. This mucus gel consists mainly of water and mucins, large O-glycosylated proteins, which are responsible for forming a gel like mixture. A modulation of the mRNA expression of mucins, was described in viral diseases in mammals however there is a knowledge gap about the regulation of mucins during viral infection in fish...
October 17, 2017: Fish & Shellfish Immunology
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