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Sang Min Yoon, Baek-Yeol Ryoo, So Jung Lee, Jong Hoon Kim, Ji Hoon Shin, Ji Hyun An, Han Chu Lee, Young-Suk Lim
Importance: Patients with hepatocellular carcinoma showing macroscopic vascular invasion have a poor prognosis. Sorafenib is the sole treatment option for these patients, with unsatisfactory response and survival benefit. Combined treatment with transarterial chemoembolization (TACE) plus external beam radiotherapy (RT) has shown promising results for these patients in observational studies. Objective: To evaluate the efficacy and safety of TACE plus RT compared with sorafenib for patients with hepatocellular carcinoma and macroscopic vascular invasion...
March 15, 2018: JAMA Oncology
Verónica Schiariti, Eileen Fowler, Joline E Brandenburg, Eric Levey, Sarah Mcintyre, Theresa Sukal-Moulton, Sharon L Ramey, Jessica Rose, Susan Sienko, Elaine Stashinko, Laura Vogtle, Robin S Feldman, James I Koenig
To increase the efficiency and effectiveness of clinical research studies, cerebral palsy (CP) specific Common Data Elements (CDEs) were developed through a partnership between the National Institute of Neurological Disorders and Stroke (NINDS) and the American Academy of Cerebral Palsy and Developmental Medicine (AACPDM). International experts reviewed existing NINDS CDEs and tools used in studies of children and young people with CP. CDEs were compiled, subjected to internal review, and posted online for external public comment in September 2016...
March 15, 2018: Developmental Medicine and Child Neurology
Alessandra Busonera, Stefania Cataudella, Jessica Lampis, Marco Tommasi, Giulio Cesare Zavattini
BACKGROUND: The Prenatal Attachment Inventory (PAI) is a widely used questionnaire to measure prenatal attachment. However, its internal structure is controversial. None of the previous studies have investigated the dimensions of the Italian version of the scale using both an exploratory and a confirmatory approach. There is also a need to explore extensively the external validity of the Italian PAI. OBJECTIVE: We designed a study aimed at shedding further light on the dimensionality of the questionnaire and expanding the evidence of its reliability and validity...
November 2017: Journal of Reproductive and Infant Psychology
A S Malalagama, S Tennakoon, D R R Abeyasinghe
PURPOSE: Youth suicide rates are rising worldwide, including Sri Lanka, where 46.5/100,000 among 15-19yrs was reported in 1986. Identifying high risk adolescents is vital. Dearth of trained professionals, demands an instrument utilizable by non-psychiatrists. Such was not available in Sinhalese. Adolescent Suicide Assessment Protocol (ASAP-20) and its' manual was translated and validated to Sri Lankan adolescents. METHOD: A validation study. Forward/back translations followed by cultural adaptation...
February 24, 2018: Asian Journal of Psychiatry
Laura Lara, Javier López-Cepero
The Dating Violence Questionnaire (DVQ) is a 42-item questionnaire that measures victimization in romantic relationships between young people, through eight interrelated scales assessing detachment, humiliation, coercion, emotional punishment, gender-based, sexual, physical, and instrumental violence. It has been validated in a myriad of countries and languages and is commonly used in Spanish-speaking countries; however, two scales (emotional punishment and instrumental violence) have shown reliability issues...
March 1, 2018: Journal of Interpersonal Violence
Stephen J Kaplan, Heather M Seabott, Erika B Cunningham, James D Helman, Alvin Calderon, Richard C Thirlby, Kimberly D Schenarts
OBJECTIVE: The purpose of this study is to develop and generate validity evidence for an instrument to measure social capital in residents. DESIGN: Mixed-methods, phased approach utilizing a modified Delphi technique, focus groups, and cognitive interviews. SETTING: Four residency training institutions in Washington state between February 2016 and March 2017. PARTICIPANTS: General surgery, anesthesia, and internal medicine residents ranging from PGY-1 to PGY-6...
February 27, 2018: Journal of Surgical Education
Yun Hee Lee, Jeong Won Lee, Hong Seok Jang
BMC CANCER (2017) 17:541 DOI: 10.1186/S12885-017-3508-X: In the original version of this article [1], published on 12 August 2017, the affiliations and author contributor details were not correct. In this Correction the incorrect affiliations and author contributor details and correct affiliations and author contributor details are shown.
February 27, 2018: BMC Cancer
Charles T Lee, Yanqun Dong, Tianyu Li, Samuel Freedman, Jordan Anaokar, Thomas J Galloway, Mark A Hallman, Stephanie E Weiss, Shelly B Hayes, Robert A Price, C M Charlie Ma, Joshua E Meyer
PURPOSE: To evaluate the efficacy and toxicity of external beam reirradiation using a pulsed low-dose-rate (PLDR) technique. METHODS AND MATERIALS: We evaluated patients treated with PLDR reirradiation from 2009 to 2016 at a single institution. Toxicity was graded using the Common Terminology Criteria for Adverse Events, version 4.0, and local control was assessed using the Response Evaluation Criteria In Solid Tumors, version 1.1. On univariate analysis (UVA), the χ2 and Fisher exact tests were used to assess the toxicity outcomes...
March 15, 2018: International Journal of Radiation Oncology, Biology, Physics
Miklós Antal Werner, Eugene Demler, Alain Aspect, Gergely Zaránd
We propose to apply a modified version of the excitation scheme introduced by Volchkov et al. on bosons experiencing hyperfine state dependent disorder to address the critical state at the mobility edge of the Anderson localization transition, and to observe its intriguing multifractal structure. An optimally designed, spatially focused external radio frequency pulse can be applied to generate transitions to eigenstates in a narrow energy window close to the mobility edge, where critical scaling and multifractality emerge...
February 26, 2018: Scientific Reports
Michael W Lawlor, Susan T Iannaccone, Katherine Mathews, Francesco Muntoni, Sherita Alai-Hansen, Joanne C Odenkirchen, Robin S Feldman
BACKGROUND: A Congenital Muscular Dystrophy (CMD) Working Group (WG) consisting of international experts reviewed common data elements (CDEs) previously developed for other neuromuscular diseases (NMDs) and made recommendations for all types of studies on CMD. OBJECTIVES: To develop a comprehensive set of CDEs, data definitions, case report forms and guidelines for use in CMD clinical research to facilitate interoperability of data collection, as part of the CDE project at the National Institute of Neurological Disorders and Stroke (NINDS)...
2018: Journal of Neuromuscular Diseases
Stephen Nowicki, Steven Gregory, Genette L Ellis, Yasmin Iles-Caven, Jean Golding
The purpose of the present study was to examine whether parents' locus of control (LOC) obtained before the birth of their child predicts the child's behavior at school in School Years 3 (ages 7-8) and 6 (ages 10-11). A modified version of the adult Nowicki-Strickland internal-external locus of control scale was completed by mothers and fathers in their own home during pregnancy. Externality was defined as a score greater than the median and internality as equal to, or less than, the median. Outcomes were the five individual subscales and the total difficulties of Goodman's strengths and difficulties' questionnaire completed by the children's class teachers at the end of School Years 3 and 6...
2018: Frontiers in Psychology
John Marsden, Camille Goetz, Tim Meynen, Luke Mitcheson, Garry Stillwell, Brian Eastwood, John Strang, Nick Grey
BACKGROUND: Cocaine use disorder (CUD) is a debilitating condition with no NICE-recommended medication or specific psychosocial interventions. In the United Kingdom (UK), general counselling (treatment-as-usual; TAU) is widely delivered, but has limited effectiveness. We tested the feasibility, safety and preliminary efficacy of a novel, adjunctive psychosocial intervention for CUD, called 'memory-focused cognitive therapy' (MFCT). METHODS: We did a two-arm, external pilot randomised controlled trial at a specialist community National Health Service addictions clinic in London, UK...
February 2, 2018: EBioMedicine
Joshua L Golubovsky, Haariss Ilyas, Jinxiao Chen, Joseph E Tanenbaum, Thomas E Mroz, Michael P Steinmetz
BACKGROUND CONTEXT: Postoperative Urinary Retention (POUR) is a very common post-operative complication of all surgeries (5 - 70%) that may lead to complications such as urinary tract infection (UTI), bladder over-distention, autonomic dysregulation, and increased postoperative length of stay (LOS). Within the field of spine surgery, the reported incidence of POUR is highly variable (5.6 - 38%). Lack of clear stratification of surgical level, spinal pathology, and inadequate sample size is a major limitation of available studies concerning POUR following spine surgery that may lead to inconsistency in the incidence of POUR and the ability to model its occurrence and consequences...
February 12, 2018: Spine Journal: Official Journal of the North American Spine Society
Jen Tarr, Flora Cornish, Elena Gonzalez-Polledo
Pain is difficult to communicate and translate into language, yet most social research on pain experience uses questionnaires and semi-structured interviews that rely on words. In addition to the mind/body dualism prevalent in pain medicine in these studies pain communication is characterised by further value-laden binaries such as real/unreal, visible/invisible, and psychological/physical. Starting from the position that research methods play a role in constituting their object, this article examines the potential of participatory arts workshops for developing different versions of pain communication...
February 13, 2018: Sociology of Health & Illness
Hortense Ravoux, Bruno Pereira, Georges Brousse, Samuel Dewavrin, Thomas Cornet, Martial Mermillod, Laurie Mondillon, Guillaume Vallet, Farès Moustafa, Frédéric Dutheil
BACKGROUND: Work addiction is a significant public health problem with a growing prevalence. The Work Addiction Risk Test (WART) is the gold standard questionnaire to detect workaholism. OBJECTIVE: The main objective of this study was to validate the French version of the WART. METHODS: Questionnaires were proposed to voluntary French workers using the WittyFit software. There were no exclusion criteria. The questionnaire was administered anonymously for initial validity testing and readministered one week later for test-retest reliability...
February 13, 2018: JMIR Mental Health
E Morris, C Hippman, G Murray, E E Michalak, J E Boyd, J Livingston, A Inglis, P Carrion, J Austin
BACKGROUND: Serious mental illness (SMI) is profoundly stigmatised, such that there is even an impact on relatives of people with SMI. Aims To develop and validate a scale to comprehensively measure self-stigma among first-degree relatives of individuals with SMI. METHOD: We conducted group interviews focusing on self-stigma with first-degree relatives (n = 20) of people with SMI, from which 74 representative quotations were reframed as Likert-type items. Cognitive interviews with relatives (n = 11) identified 30 items for the Self-Stigma in Relatives of people with Mental Illness (SSRMI) scale...
February 5, 2018: British Journal of Psychiatry: the Journal of Mental Science
Arkan S Sayed-Noor, Raymond Pollock, Bassem T Elhassan, Bakir Kadum
BACKGROUND: The influence of preoperative rotator cuff fatty infiltration (FI) and muscle atrophy (MA) on the postoperative outcome of total shoulder arthroplasty (TSA) has only rarely been investigated and reported in the literature. We hypothesized that more FI and MA would be associated with a worse postoperative functional outcome. METHODS: This prospective cohort study included 63 patients (31 female and 32 male patients; mean age, 71 years [range, 53-89 years; standard deviation, 7 years]) with primary osteoarthritis of the shoulder operated on with anatomic stemless TSA...
February 9, 2018: Journal of Shoulder and Elbow Surgery
Qian Zhang, Yan Ge, Weina Qu, Kan Zhang, Xianghong Sun
Traffic safety climate is defined as road users' attitudes and perceptions of traffic in a specific context at a given point in time. The current study aimed to validate the Chinese version of the Traffic Climate Scale (TCS) and to explore its relation to drivers' personality and dangerous driving behavior. A sample of 413 drivers completed the Big Five Inventory (BFI), the Chinese version of the TCS, the Dula Dangerous Driving Index (DDDI) and a demographic questionnaire. Exploratory factor analysis and confirmatory factor analysis were performed to confirm a three-factor (external affective demands, internal requirements and functionality) solution of the TCS...
February 8, 2018: Accident; Analysis and Prevention
Hiroko Kashiwagi, Akiko Kikuchi, Mayuko Koyama, Daisuke Saito, Naotsugu Hirabayashi
Background: The Structured Assessment of PROtective Factors for violence risk (SAPROF) was recently developed as a strength-based addition to the risk assessment of future violent behavior. We examined the interrater reliability and predictive accuracy of the SAPROF for violence in forensic mental health inpatient units in Japan. Methods: This retrospective record study provides an initial validation of the SAPROF in a Japanese sample of 95 forensic psychiatric inpatients from a complete 2008-2013 cohort...
2018: Annals of General Psychiatry
K A Lee, M Dunne, C Small, P J Kelly, O McArdle, J O'Sullivan, D Hacking, M Pomeroy, J Armstrong, M Moriarty, A Clayton-Lea, I Parker, C D Collins, P Thirion
BACKGROUND: The optimal primary external beam radiation therapy (EBRT) radiation schedule for malignant epidural spinal cord compression (MSCC) remains to be determined. The ICORG 05-03 trial assessed if a 10 Gy single fraction radiation schedule was not inferior to one with 20 Gray (Gy) in five daily fractions, in terms of functional motor outcome, for the treatment of MSCC in patients not proceeding with surgical decompression. This article reports on two of the secondary endpoints, Quality of life (QoL), assessed according to the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30) version 3...
February 8, 2018: Acta Oncologica
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