Read by QxMD icon Read


Yafeng Wang, Mingxu Wang, Xiaoqing Zhang, Qianyu Zhang, Jing Nie, Ming Zhang, Xiaohong Liu, Le Ma
Lipid metabolism may be involved in the pathogenic mechanism of age-related macular degeneration (AMD). However, conflicting results have been reported in the associations of AMD with blood lipids. We performed a meta-analysis including a total of 19 studies to evaluate associations between blood lipids and this disease. The result reported that the high level of high-density lipoprotein cholesterol (HDL-C) obtained with an increment of 1 mmol/L could result in a significantly increase in the AMD risk of approximately 18% (relative risk (RR), 1...
October 22, 2016: Nutrients
Ying Du, Juan Chen, Man-Hua Chen, Sheng-Hua Yang, Sha Li, Yuan-Lin Guo, Cheng-Gang Zhu, Rui-Xia Xu, Qian Dong, Jian-Jun Li
BACKGROUND: Diabetes mellitus (DM) is associated with coronary artery disease (CAD) progression. Although previous studies have demonstrated the association of lipid and lipoprotein ratios with CAD, no data are currently available concerning the relationship between lipid and lipoprotein ratios and the severity of new on-set CAD in diabetics. Therefore, the aim of the present study was to investigate the usefulness of lipid and lipoprotein ratios in predicting the severity of CAD in patients with type 2 DM (T2DM)...
August 2016: Journal of Geriatric Cardiology: JGC
I A Välimäki, T Vuorimaa, M Ahotupa, T Vasankari
We studied the effects of different types of exercises on the concentrations of oxidised HDL (oxHDLlipids) and LDL lipids (oxLDLlipids), serum lipids, antioxidant potential, paraoxonase and malondialdehyde in endurance runners by performing both a 40-min continuous run (velocity corresponding to 80% VO2max) and a 40-min intermittent run (2-min run, velocity corresponding to 100% VO2max, and 2-min rest) using a treadmill. Blood samples were taken before exercise, after 20 and 40 min of exercise, and 15 and 90 min after the end of exercise...
October 25, 2016: International Journal of Sports Medicine
Shun-Jin Hu, Bing Shu, Hua Jin, Xiao-Feng Li, Jia-Rong Mao, Ke-Jun Ren, Lei Gao, Li Yang, You-Wan Wu, Yong-Jun Wang
OBJECTIVE: To evaluate the renal protective effect of Tangshenkang Granule () in a rat model of diabetic nephropathy (DN). METHODS: Forty male Sprague-Dawley rats were randomly divided into control, DN, Tangshenkang and benazepril groups. DN model was established in the rats of DN, Tangshenkang and benazepril groups. Tangshenkang Granule solution and benazepril hydrochloride solution were intragastrically administered daily to the rats in the Tangshenkang and benazepril groups for 8 weeks, respectively...
October 24, 2016: Chinese Journal of Integrative Medicine
Ramin Heshmat, Gita Shafiee, Mostafa Qorbani, Fatemeh Azizi-Soleiman, Shirin Djalalinia, Mohammad Esmaeil Motlagh, Gelayol Ardalan, Zeinab Ahadi, Omid Safari, Saeid Safiri, Roya Kelishadi
Introduction: Current evidence suggests that ghrelin could contribute to the development of metabolic syndrome (MetS) in adults, but limited experience exists in adolescents. This study aims to explore the association of ghrelin levels with the MetS components among Iranian adolescents. Methods: In this case-control study, 32 adolescents with MetS and 148 healthy controls were selected randomly from the childhood and Adolescence Surveillance and Prevention of Adult Non communicable disease (CASPIAN-III) study...
2016: Journal of Cardiovascular and Thoracic Research
Ardashel Latsuzbaia, Vincent W V Jaddoe, Albert Hofman, Oscar H Franco, Janine F Felix
Lipid concentrations are heritable traits. Recently, the number of known genetic loci associated with lipid levels in adults increased from 95 to 157. The effects of these 157 loci have not been tested in children. Considering that lipid levels track from childhood to adulthood, we studied whether these variants already affect lipid concentrations in a large group of 2645 children with a median age of 6.0 years (95% range 5.7-7.3) from the population-based Generation R Study. 28 single nucleotide polymorphisms (SNPs) associated with triglycerides (TG), 39 SNPs associated with total cholesterol (TC), 28 SNPs associated with low density lipoprotein cholesterol (LDL-C), and 56 SNPs associated with high density lipoprotein cholesterol (HDL-C) were analyzed individually and combined into genetic risk scores...
October 24, 2016: Journal of Lipid Research
Kausik K Ray, Henry N Ginsberg, Michael H Davidson, Robert Pordy, Laurence Bessac, Pascal Minini, Robert H Eckel, Christopher P Cannon
BACKGROUND: -A continuous relationship between reductions in low-density lipoprotein cholesterol (LDL-C) and major adverse cardiovascular events (MACE) has been observed in statin and ezetimibe outcomes trials, down to achieved levels of 54 mg/dL. However, it is uncertain whether this relationship extends to LDL-C levels <50 mg/dL. We assessed the relationship between additional LDL-C, non-high-density lipoprotein cholesterol (non-HDL-C), and apolipoprotein B100 (apoB) reductions and MACE among patients within the ODYSSEY trials that compared alirocumab versus controls (placebo/ezetimibe), mainly as add on to maximally tolerated statin...
October 24, 2016: Circulation
Shi-Mao Zhong, Yu-Hua Qin, Zuo-Cha Li, Ye-Sheng Wei
OBJECTIVE: To investigate the relationship between atrial fibrillation (AF) and serum soluble CD163. METHODS: A total of 336 patients with heart valve disease were included in this study, including 167 with AF and 169 with sinus rhythm. The clinical data were compared between the two grops, and Logistic regression analysis was used to identify the risk factors associated with AF. RESULTS: The levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), tumor necrosis factor (TNF), interleukin-6 (IL - 6), high-sensitivity C-reactive protein (hs-CRP) and left atrial diameter (LAD) all differed significantly between the two groups (P<0...
October 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Sanna Tiainen, Riitta Luoto, Markku Ahotupa, Jani Raitanen, Tommi Vasankari
During acute exercise, the concentration of oxidized HDL lipids (ox-HDL) is reported to increase suggesting that HDL may function in decreasing the concentration of oxidized LDL lipids. However, the effect of exercise intervention on the lipid peroxide transport function of HDL is unknown. A randomized controlled trial with sedentary women (N = 161), aged 43-63, with no current use of hormone therapy, were randomized into a 6-month (mo) exercise group and a control group. During the 6-mo intervention, the concentration of ox-HDL increased in the exercise group by 5% and decreased in the control group by 2% (p = 0...
October 24, 2016: Free Radical Research
L-Z Qin, W Li, Y Huang, F Lu, S-J Li, H-Q Yang, J-W Zhang
OBJECTIVE: This study aims to investigate the expression of pentraxin3 (PTX3) in elderly patients with acute cerebral infarction (ACI) and to analyze the relationship of PTX3 with the severity and prognosis of ACI. PATIENTS AND METHODS: Between June 2014 and August 2015, 96 elderly patients with first-onset of ACI admitted to our institution were enrolled in the present study. Also, 70 healthy elderly subjects were included as controls in this study. Levels of PTX3, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, homocysteine (Hcy), fibrinogen (FIB), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were determined in all patients both pre-therapeutically and 30 days post-therapeutically...
October 2016: European Review for Medical and Pharmacological Sciences
W-J Guan, G-J Yang
OBJECTIVE: We investigated the significance of a change in retinol binding protein (RBP4) levels in the plasma of patients with coronary heart disease complicated with hyperlipidemia. PATIENTS AND METHODS: 66 cases of coronary heart disease (CHD) patients in Cardiovascular Department of our Hospital from December 2014 to December 2015 were selected. Based on the diagnostic criteria of hyperinsulinemia, patients were divided into a CHD Group with 35 cases and a CHD-Hyperinsulinemia Group (CHD-H group) with 31 cases...
October 2016: European Review for Medical and Pharmacological Sciences
W B Liu, Z-P Zou, H-P Jiang, Q Li, F-M Guo, Z Wang, Z-S Bi
OBJECTIVE: To evaluate the clinical significance dynamic changes in hs-CRP and ADAMTS13 levels in patients with no-reflow after PCI operation. PATIENTS AND METHODS: 156 patients with STEMI single-vessel were enrolled in this study. Patients were divided into the reflow and the no-reflow groups. ADAMTS13 and hs-CRP levels were compared between the two groups. RESULTS: ADAMTS13 and hs-CRP levels in the no-reflow group were significantly lower than those in the reflow group after PCI operation...
October 2016: European Review for Medical and Pharmacological Sciences
Antonis Sakellarios, Lorenz Raeber, Christos Bourantas, Themis Exarchos, Lambros Athanasiou, Gualtiero Pelosi, Oberdan Parodi, Konstantinos Koskinas, Katerina Naka, Lampros Michalis, Patrick Wjc Serruys, Hector Garcia-Garcia, Stephan Windecker, Dimitrios Fotiadis
OBJECTIVE: The aim of this study is to explore major mechanisms of atherosclerotic plaque growth, presenting a proof-of-concept numerical model. METHODS: To this aim, a human reconstructed left circumflex coronary artery is utilized for a multi-level modeling approach. More specifically, the first level consists of the modeling of blood flow and endothelial shear stress (ESS) computation. The second level includes the modeling of low and high density lipoprotein (LDL, HDL) and monocytes transport through the endothelial membrane to vessel wall...
October 19, 2016: IEEE Transactions on Bio-medical Engineering
Anna Gluba-Brzózka, Beata Franczyk, Piotr Bartnicki, Magdalena Rysz-Górzyńska, Jacek Rysz
BACKGROUND: Chronic kidney disease (CKD) poses a worldwide public health problem. CKD is an independent risk factor for cardiovascular disease (CVD). OBJECTIVE: The aim of this study was to assess the cardiovascular risk in ESRD patients and to evaluate the relationship between serum uric acid and lipoprotein subfractions. METHODS: The study group consisted of 66 patients on dialysis and control group of 25 healthy volunteers. Concentration of HDL and LDL subfractions were analysed with Lipoprint™...
October 21, 2016: Current Vascular Pharmacology
Richard A Anderson, Zhiwei Zhan, Rencai Luo, Xiuhua Guo, Qingqing Guo, Jin Zhou, Jiang Kong, Paul A Davis, Barbara J Stoecker
Cinnamon ( ròu guì) has in vitro insulin potentiating activity, and proanthocyanidins from cinnamon prevent in vitro formation of advanced glycation end products. Some human studies were equivocal, but several have shown beneficial effects of cinnamon supplementation on circulating glucose, lipids, and/or insulin. This placebo-controlled double-blind trial tested the effects of a dried water extract of cinnamon (Cinnamomum cassia) on circulating glucose, lipids, insulin, and insulin resistance. Men and women from Beijing and Dalian, China, were invited to participate if they had fasting serum glucose >6...
October 2016: Journal of Traditional and Complementary Medicine
Salgaonkar V Jaywant, A K Singh, Mundkur S Prabhu, R Ranjan
OBJECTIVE: The primary objective was to evaluate the effect of statin therapy/lipid lowering therapy (LLT) on lipid profile, in adults presenting with first acute coronary event. METHODS AND MATERIAL: A multicentre, observational, prospective cohort study of lipid profiles pre- and post-statin therapy/LLT, among adult patients with confirmed diagnosis of first acute coronary event. The primary outcome measures were low-density lipoprotein cholesterol (LDL-C) in mg/dl, high-density lipoprotein cholesterol (HDL-C) in mg/dl and triglycerides (TG) in mg/dl at baseline and end of study (EOS, 12 weeks [mean: 13...
September 2016: Indian Heart Journal
Lian Gu, Jinying Zhou, Jinjing Tan, Junwei Yang, Tingting Shen, Haiyun Jiang, Qianli Tang
Inflammatory response and lipid metabolism influence the development of ischemic stroke (IS). TLRs have an important function in inflammation and lipid metabolism. To investigate association of TLR8 rs3764880 polymorphism with susceptibility of IS and the relationship between rs3764880 with inflammation response- and lipid metabolism-related quantitative traits, we conducted a case-control study in a Han Chinese population comprising 816 cases and 816 controls being matched for age and gender. The distribution of allele of TLR8 rs3764880 had statistical significance in male group (P=0...
November 15, 2016: Journal of the Neurological Sciences
Nataša Milošević, Vladimir Jakšić, Jan Sudji, Bojan Vuković, Tijana Ičin, Nataša Milić, Milica Medić Stojanoska
Bisphenol A (BPA) is a ubiquitous environmental pollutant which is often associated with various health issues. In this study 103 healthy female volunteers in reproductive age from Serbian north province Vojvodina were enrolled and examined for the BPA exposure in the urine samples after 12 h of fasting. BPA was found in 35.92 % (37/103) of subjects. Statistically significant increment in waist circumference (p = 0.045) and waist-to-height ratio (p = 0.037) was observed among the BPA positive women in comparison with the women who had the same energetic balance and had not been exposed to BPA...
October 24, 2016: International Journal of Environmental Health Research
Jianchun Huang, Xiaojun Tang, Fangxing Ye, Junhui He, Xiaolong Kong
BACKGROUND/AIMS: Coronary heart disease is characterized by vascular stenosis or occlusion resulting in myocardial ischemia, hypoxia and necrosis. In China, the combination of aspirin and Fufang Danshen Diwan (FDD), a traditional Chinese medicine formula, has been suggested in the treatment of coronary heart disease. There have been several studies comparing the effectiveness of aspirin alone and in combination with FDD to treat coronary artery disease; however, it remains unclear whether combined aspirin therapy is superior...
October 24, 2016: Cellular Physiology and Biochemistry
Elizabete de Jesus Inês, Mônica Lopes Sampaio Silva, Joelma Nascimento de Souza, Alana Alcântara Galvão, Márcia Cristina Aquino Teixeira, Neci Matos Soares
The objective of this study was to investigate paraoxonase-1 (PON1) activity, cortisol levels, and the lipid profile in the sera of alcoholic and non-alcoholic Strongyloides stercoralis-infected and uninfected individuals in a sample of 276 individuals attended at the National Health System in Salvador, Bahia, Brazil. The activity of PON1 was measured by the Beltowski method, serum lipids, and cortisol levels using commercial kits. PON1 activity was low in both alcoholic and non-alcoholic individuals infected with S...
October 19, 2016: Acta Tropica
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"