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https://www.readbyqxmd.com/read/29346609/decreased-serum-levels-of-ghrelin-and-brain-derived-neurotrophic-factor-in-premenopausal-women-with-metabolic-syndrome
#1
Masoumeh Jabbari, Sorayya Kheirouri, Mohammad Alizadeh
Objective: We aimed to investigate the association between serum levels of ghrelin and brain-derived neurotrophic factor (BDNF) with MetS and its components in premenopausal women. Methods: 43 patients with MetS and 43 healthy controls participated in this study. Participants' body mass index (BMI), waist circumference (WC), systolic and diastolic blood pressure (SBP and DBP) were measured. Serum levels of total cholesterol (TC), triglyceride (TG), low and high density lipoprotein cholesterol (LDL-C and HDL-C), fasting blood sugar (FBS), insulin, BDNF and ghrelin determined...
January 12, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29345123/the-effects-of-lifestyle-changes-on-serum-lipid-levels-in-children-in-a-real-life-setting
#2
Angeline D Opina, Constance Cephus, Yunfei Wang, Samuel Younan, Douglas Moodie
OBJECTIVE: Studies have shown improvement in lipid levels after institution of lifestyle changes in children enrolled in closely monitored programs. There programs are difficult to mimic in real world clinics. We aim to determine if diet and exercise result in improvement in lipid levels in patients seen in a designated lipid clinic in a real life setting. DESIGN: Retrospective review of patients followed for dyslipidemia at the Texas Children's Hospital Lipid Clinic from May 1, 2012 to May 1, 2015...
January 18, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29344037/the-effects-of-ginger-on-fasting-blood-sugar-hemoglobin-a1c-and-lipid-profiles-in-patients-with-type-2-diabetes
#3
Motahareh Makhdoomi Arzati, Niyaz Mohammadzadeh Honarvar, Ahmad Saedisomeolia, Siyamand Anvari, Mohammad Effatpanah, Raoofe Makhdoomi Arzati, Mir Saeed Yekaninejad, Rezvan Hashemi, Mahmoud Djalali
Background: Lipid and glycemic abnormalities are prevalent in diabetes leading to long term complications. Use of safe and natural foods instead of medications is now considered by many scientists. Objectives: This study aimed at determining the effect of ginger on lipid and glucose levels of patients with type 2 diabetes mellitus. Methods: In a double-blind placebo-controlled trial, 50 patients with type 2 diabetes were randomly allocated to 2 groups of intervention (n = 25) and placebo (n = 25)...
October 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29341060/rationale-of-decreasing-low-density-lipoprotein-cholesterol-below-70-mg-dl-in-patients-with-coronary-artery-disease-a-retrospective-virtual-histology-intravascular-ultrasound-study
#4
Young Hoon Seo, Duck-Jun Seo, In Geol Song, Ki-Hong Kim, Taek-Geun Kwon, Jang-Ho Bae
BACKGROUND: The associations between statin and coronary plaque compositional changes were reported according to the use of high dose or not. An evaluation of the impact of low-density lipoprotein cholesterol (LDL-C) < 70 mg/dL by using real world dosages of statin on coronary plaque composition was undertaken. METHODS: The study subjects consisted of 61 patients (mean 59.9 years old, 45 males) who underwent percutaneous coronary intervention, baseline and follow-up (F/U; mean 8...
January 17, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29340242/a-diagnostic-model-for-minimal-change-disease-based-on-biological-parameters
#5
Hanyu Zhu, Qiuxia Han, Dong Zhang, Yong Wang, Jing Gao, Wenjia Geng, Xiaoli Yang, Xiangmei Chen
Background: Minimal change disease (MCD) is a kind of nephrotic syndrome (NS). In this study, we aimed to establish a mathematical diagnostic model based on biological parameters to classify MCD. Methods: A total of 798 NS patients were divided into MCD group and control group. The comparison of biological indicators between two groups were performed with t-tests. Logistic regression was used to establish the diagnostic model, and the diagnostic value of the model was estimated using receiver operating characteristic (ROC) analysis...
2018: PeerJ
https://www.readbyqxmd.com/read/29340036/the-association-between-elevated-fasting-plasma-glucose-levels-and-carotid-intima-media-thickness-in-non-diabetic-adults-a-population-based-cross-sectional-study
#6
Yalin Guan, Changshen Yu, Min Shi, Jingxian Ni, Yanan Wu, Hongfei Gu, Lingling Bai, Jie Liu, Jun Tu, Jinghua Wang, Xianjia Ning
We assessed the association between the mean carotid intima-media thickness (CIMT) and fasting plasma glucose (FPG) levels in a low-income population in rural China. Adults aged ≥45 years without a history of diabetes, stroke, or cardiovascular disease were recruited. All participants were categorized into four groups according to FPG level. A total of 3509 participants were analyzed in this study. In the univariate analysis, sex, age, education level, hypertension, central obesity, current smoking, alcohol consumption, and higher levels of FPG, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were associated with mean CIMT and frequency of increased CIMT...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29338972/hdl-c-apoa1-and-vldl-tg-as-biomarkers-for-the-carotid-plaque-presence-in-patients-with-metabolic-syndrome
#7
Meryem Abi-Ayad, Amine Abbou, Fatima Zahra Abi-Ayad, Omar Behadada, Mohamed Benyoucef
AIM: Hypercholesterolemia and hyper LDL-C are associated with the atherosclerosis (AS). The current study was performed to evaluate the implication of the others lipoproteins (HDL, LDL, VLDL) and apolipoproteins (ApoA1, ApoB100) with subclinical atherosclerosis (carotid plaque) in patients with metabolic syndrome (MetS) free from cardiovascular disease (CVD). METHODS: Prospective transversal study was conducted in patients with MetS free from cardiovascular disease (CVD)...
December 30, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29336935/update-on-the-laboratory-investigation-of-dyslipidemias
#8
REVIEW
I Ramasamy
The role of the clinical laboratory is evolving to provide more information to clinicians to assess cardiovascular disease (CVD) risk and target therapy more effectively. Current routine methods to measure LDL-cholesterol (LDL-C), the Friedewald calculation, ultracentrifugation, electrophoresis and homogeneous direct methods have established limitations. Studies suggest that LDL and HDL size or particle concentration are alternative methods to predict future CVD risk. At this time there is no consensus role for lipoprotein particle or subclasses in CVD risk assessment...
January 11, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29336700/effect-of-daily-exposure-to-an-isolated-soy-protein-supplement-on-body-composition-energy-and-macronutrient-intake-bone-formation-markers-and-lipid-profile-in-children-in-colombia
#9
Wilson Mejía, Diana Córdoba, Paola Durán, Yersson Chacón, Diego Rosselli
A soy protein-based supplement may optimize bone health, support physical growth, and stimulate bone formation. This study aimed to assess the effect of a daily soy protein supplement (SPS) on nutritional status, bone formation markers, lipid profile, and daily energy and macronutrient intake in children. One hundred seven participants (62 girls), ages 2 to 9, started the study and were randomly assigned to lunch fruit juice with (n = 57, intervention group) or without (n = 50, control group) addition of 45 g (230 Kcal) of a commercial SPS during 12 months; 84 children (51 girls, 33 boys) completed the study (45 and 39 intervention and control, respectively)...
January 16, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29336623/the-effect-of-phytosterol-rich-fraction-from-palm-fatty-acid-distillate-on-blood-serum-lipid-profile-of-dyslipidemia-rats
#10
Kgs Ahmadi, Huda Oktafa, Teti Estiasih
Phytosterol-rich fraction (PRF) obtained from palm fatty acid distillate (PFAD) was investigated for its effect on blood serum lipid profile of dyslipidemia rats. Dyslipidemia was induced by force feeding cholesterol to five groups of rats; one group was a control or normal group. Cholesterol force-fed groups were treated with 0, 10, 20, 30, and 40 mg PRF/kg/day for 4 weeks. All groups of rats were fed standard diet. A normal group was fed standard diet without PRF treatment and cholesterol force feeding...
January 16, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29336612/relationship-among-adiponectin-insulin-resistance-and-atherosclerosis-in-non-diabetic-hypertensive-patients-and-healthy-adults
#11
Huijuan Kou, Jie Deng, Dengfeng Gao, Anqi Song, Zhenhua Han, Jin Wei, Xin Jin, Rui Ma, Qiangsun Zheng
Adiponectin, which is secreted specifically by adipose tissue, has been shown to have anti-atherogenic and anti-inflammatory effects and to improve insulin resistance (IR). The aim of this study was to determine the correlations among adiponectin, IR and atherosclerosis in non-diabetic hypertensive patients and healthy volunteers. In this case control study, we collected complete demographic data from and measured several laboratory parameters in all enrolled subjects. The homeostasis model of assessment for insulin resistance (HOMA-IR) was calculated as an insulin sensitivity index...
January 16, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29336478/apelin-13-treatment-enhances-the-stability-of-atherosclerotic-plaques
#12
Rodrigo Araujo Fraga-Silva, Hugo Seeman, Fabrizio Montecucco, Analina Raquel da Silva, Fabienne Burger, Fabiana Pereira Costa-Fraga, Léa Anguenot, François Mach, Robson Augusto Souza Dos Santos, Nikolaos Stergiopulos, Rafaela Fernandes da Silva
BACKGROUND: Apelin is an endogenous peptidergic system which modulates cardiovascular function. Recent studies pointed out a fundamental contribution of apelin on atherosclerosis development; however, such reports revealed contradictory data, and to date, it is difficult to accurately define a beneficial or deleterious role. To better understand apelin function on atherosclerosis, we aimed to investigate apelin-13 treatment effects on atherosclerotic plaques composition. DESIGN: Apolipoprotein E gene-deleted mice were fed on Western-type diet for 11 weeks...
January 16, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29335039/replacing-carbohydrate-during-a-glucose-challenge-with-the-egg-white-portion-or-whole-eggs-protects-against-postprandial-impairments-in-vascular-endothelial-function-in-prediabetic-men-by-limiting-increases-in-glycaemia-and-lipid-peroxidation
#13
Joshua D McDonald, Chureeporn Chitchumroonchokchai, Jinhui Li, Eunice Mah, Allison N Labyk, Elizabeth J Reverri, Kevin D Ballard, Jeff S Volek, Richard S Bruno
Eggs attenuate postprandial hyperglycaemia (PPH), which transiently impairs vascular endothelial function (VEF). We hypothesised that co-ingestion of a glucose challenge with egg-based meals would protect against glucose-induced impairments in VEF by attenuating PPH and oxidative stress. A randomised, cross-over study was conducted in prediabetic men (n 20) who ingested isoenegertic meals (1674 kJ (400 kcal)) containing 100 g glucose (GLU), or 75 g glucose with 1·5 whole eggs (EGG), seven egg whites (WHITE) or two egg yolks (YOLK)...
January 16, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29334984/new-insights-into-angplt3-in-controlling-lipoprotein-metabolism-and-risk-of-cardiovascular-diseases
#14
REVIEW
Xin Su, Dao-Quan Peng
Dyslipidemia, characterized by elevation of plasma low density lipoprotein cholesterol (LDL-C), triglyceride (TG) and reduction of plasma high density lipoprotein cholesterol (HDL-C), has been verified as a causal risk factor for cardiovascular diseases (CVD), leading to a high mortality rate in general population. It is important to understand the molecular metabolism underlying dyslipidemia in order to reduce the risk and to develop effective therapeutic approaches against CVD. ANGPTL3 (human) or Angptl3 (mouse), one member of the angiopoietin-like protein (ANGPTL) family, has been identified as an important regulator of lipid metabolism by inhibiting LPL and EL activity...
January 15, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29334911/hypocholesterolemia-is-an-independent-risk-factor-for-depression-disorder-and-suicide-attempt-in-northern-mexican-population
#15
Marcela Segoviano-Mendoza, Manuel Cárdenas-de la Cruz, José Salas-Pacheco, Fernando Vázquez-Alaniz, Osmel La Llave-León, Francisco Castellanos-Juárez, Jazmín Méndez-Hernández, Marcelo Barraza-Salas, Ernesto Miranda-Morales, Oscar Arias-Carrión, Edna Méndez-Hernández
BACKGROUND: Cholesterol has been associated as a risk factor for cardiovascular disease. Recently, however, there is growing evidence about crucial requirement of neuron membrane cholesterol in the organization and function of the 5-HT1A serotonin receptor. For this, low cholesterol level has been reported to be associated with depression and suicidality. However there have been inconsistent reports about this finding and the exact relationship between these factors remains controversial...
January 15, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29334669/anti-obesity-effects-of-clausena-excavata-in-high-fat-diet-induced-obese-mice
#16
Young-Rak Cho, Jung A Lee, Yoon Yeon Kim, Jae-Shin Kang, Jae-Ho Lee, Eun-Kyung Ahn
Clausena excavata (C. excavata) has been used as a traditional medicine for the treatment of abdominal pain, enteritis, dysentery, and malaria. The present study was designed to evaluate the effect of a 50% ethanol extract of C. excavata (ECE) on weight loss, adipocyte size, and obesity-related biochemical parameters in high-fat diet (HFD)-induced obese mice. After 6 weeks of HFD + ECE administration, HFD-induced total fat, subcutaneous fat, and visceral fat were evaluated by micro-computed tomography. The serum levels of triglyceride (TG), total cholesterol (TCH), high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol were evaluated with a biochemical analyzer, and leptin and adiponectin levels in the serum were assessed via enzyme-linked immunoassay (ELISA)...
January 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29333040/pharmacological-screening-of-trachyspermum-ammi-for-antihyperlipidemic-activity-in-triton-x-100-induced-hyperlipidemia-rat-model
#17
Uzma Saleem, Saba Riaz, Bashir Ahmad, Mohammad Saleem
Background: Mortality rate is increasing due to cardiovascular problems throughout the world. These cardiac problems are directly associated with dyslipidemia. Aim: The aim of this study was to evaluate the antihyperlipidemic effect of aqueous extract and methanol extract of Trachyspermum ammi at 1 g/kg, 3 g/kg, and 5 g/kg dose levels in rats. Materials and Methods: For this purpose, 45 male albino rats were used and randomly divided into nine equal groups (n = 5)...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29332377/comparisons-of-three-different-doses-of-alirocumab-application-in-patients-with-hypercholesterolaemia-a-meta-analysis
#18
Yu-Sheng Zhang, Ye-Hua Hao, Hou-Long Luo, Bao-Cheng Xie, Jian-Ying Fu, Zhi-Kun Zhou
INTRODUCTION: Low high-density lipoprotein cholesterol (HDL-C) and high low-density lipoprotein cholesterol (LDL-C) levels are associated with incidence of cardiovascular disease (CVD). Alirocumab has been considered as an efficacious, safe and promising therapeutic modality for hypercholesterolemia. The purpose of this study is to compare the differences of the three different doses of alirocumab in patients with hypercholesterolaemia. EVIDENCE ACQUISITION: Randomized controlled trials were identified from PubMed, EMBASE, PMC and Cochrane-library databases...
January 11, 2018: Minerva Medica
https://www.readbyqxmd.com/read/29331603/metabolic-risk-factors-in-schizophrenia-and-bipolar-disorder-the-effect-of-comedication-with-selective-serotonin-reuptake-inhibitors-and-antipsychotics
#19
K K Fjukstad, A Engum, S Lydersen, I Dieset, N Eiel Steen, O A Andreassen, O Spigset
BACKGROUND: The aim of this observational study was to investigate the relationship between metabolic factors and use of selective serotonin reuptake inhibitors (SSRIs) combined with olanzapine, quetiapine or risperidone. METHODS: Data from the Norwegian Thematically Organized Psychosis study, a cross-sectional study on 1301 patients with schizophrenia (n=868) or bipolar disorder (n=433), were analyzed. As exposure variables in the linear regression model were included the dose or serum concentration of SSRIs (n=280) and of olanzapine (n=398), quetiapine (n=234) or risperidone (n=128)...
April 17, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29331538/differential-lipid-metabolism-outcomes-associated-with-adrb2-gene-polymorphisms-in-response-to-two-dietary-interventions-in-overweight-obese-subjects
#20
O Ramos-Lopez, J I Riezu-Boj, F I Milagro, L Goni, M Cuervo, J A Martinez
BACKGROUND AND AIMS: A precise nutrigenetic management of hypercholesterolemia involves the understanding of the interactions between the individual's genotype and dietary intake. The aim of this study was to analyze the response to two dietary energy-restricted interventions on cholesterol changes in carriers of two ADRB2 polymorphisms. METHODS AND RESULTS: A 4-month nutritional intervention was conducted involving two different hypo-energetic diets based on low-fat (LF) and moderately high-protein (MHP) dietary patterns...
December 5, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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