Scott C Tadler, Keith G Jones, Carter Lybbert, Jason C Huang, Rana Jawish, Daniela Solzbacher, E Jeremy Kendrick, Matthew D Pierson, Kamile Weischedel, Noreen Rana, Rebecca Jacobs, Lily C Vonesh, Daniel A Feldman, Claire Larson, Nathan Hoffman, Jacob E Jessop, Adam L Larson, Norman E Taylor, David H Odell, Kai Kuck, Brian J Mickey
BACKGROUND: Anesthetic agents including ketamine and nitrous oxide have shown antidepressant properties when appropriately dosed. Our recent open-label trial of propofol, an intravenous anesthetic known to elicit transient positive mood effects, suggested that it may also produce robust and durable antidepressant effects when administered at a high dose that elicits an electroencephalographic (EEG) burst-suppression state. Here we report findings from a randomized controlled trial ( NCT03684447 ) that compared two doses of propofol...
September 15, 2023: medRxiv