keyword
MENU ▼
Read by QxMD icon Read
search

Systemic urokinase

keyword
https://www.readbyqxmd.com/read/29455018/acute-massive-pulmonary-thromboembolism-treated-by-selective-catheter-directed-thrombolysis
#1
Feng Hai, Chen Xueming, Zhang Zhiwen, Li Chenyu, Fang Jie, Zhang Zhe, Lian Lishan, Zhu Renming, Yu Hongzhi, Liu Bin
OBJECTIVE: To evaluate the safety and efficacy of selective catheter-directed thrombolysis in treating acute massive pulmonary thromboembolism (AMPTE). MATERIALS AND METHODS: Twenty-six AMPTE patients were enrolled between March 2010 and March 2013. A Uni*Fuse infusion system was inserted into the main pulmonary artery thrombus. The thrombolytic regimen included an intraoperative bolus injection of 250,000 IU urokinase, followed by continuous thrombolytic infusion of 5,000IU/kg...
February 15, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29445239/the-urokinase-receptor-induces-a-mesenchymal-gene-expression-signature-in-glioblastoma-cells-and-promotes-tumor-cell-survival-in-neurospheres
#2
Andrew S Gilder, Letizia Natali, Danielle M Van Dyk, Cristina Zalfa, Michael A Banki, Donald P Pizzo, Huawei Wang, Richard L Klemke, Elisabetta Mantuano, Steven L Gonias
PLAUR encodes the urokinase receptor (uPAR), which promotes cell survival, migration, and resistance to targeted cancer therapeutics in glioblastoma cells in culture and in mouse model systems. Herein, we show that patient survival correlates inversely with PLAUR mRNA expression in gliomas of all grades, in glioblastomas, and in the subset of glioblastomas that demonstrate the mesenchymal gene expression signature. PLAUR clusters with genes that define the more aggressive mesenchymal subtype in transcriptome profiles of glioblastoma tissue and glioblastoma cells in neurospheres, which are enriched for multipotent cells with stem cell-like qualities...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29415937/-portal-vein-thrombosis-associated-with-idiopathic-hypereosinophilic-syndrome
#3
Satoshi Kaito, Sakiko Harada, Masao Tsukada, Akira Kojima, Kanichi Iwama, Kazunari Yamada, Kouichi Kajiwara, Kentaro Morikawa, Keiki Shimizu, Yasuji Kozai, Hideki Koudo
A 35-year-old man who previously underwent splenectomy for hereditary spherocytosis at age 29 visited our hospital complaining of fatigue that had started 7 days ago and right upper abdominal pain. Laboratory data showed increased white blood cell and eosinophil count accompanied by severe transaminitis and clotting abnormalities. Computed tomography scan showed multiple embolisms in the portal vein, superior mesenteric vein, right pulmonary artery, and inferior vena cava. Severe liver damage presumably caused by portal vein thrombosis was also observed...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29412186/cyclic-rgd-functionalized-liposomes-encapsulating-urokinase-for-thrombolysis
#4
Nengpan Zhang, Chunlin Li, Dayong Zhou, Chen Ding, Yaqing Jin, Qingmei Tian, Xiangzhou Meng, Kefeng Pu, Yimin Zhu
Thrombosis, a critical event in blood vessels, not only is associated with myocardial infarction and stroke, but also accounts for considerable morbidity and mortality. Thrombolytic drugs are usually applied to the treatment of acute myocardial infarction, acute cerebral infarction and pulmonary embolism. However, thrombolytic drugs show limited efficacy in clinical practice because of the short half-life in plasma and systemic side effects. In this study, the cyclic RGD (cRGD) functionalized liposomes were prepared to encapsulate urokinase, a cheap and widely used thrombolytic drug in clinic and better thrombolysis efficacy was achieved...
February 2, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29407621/endothelial-cell-functions-impaired-by-interferon-in-vitro-insights-into-the-molecular-mechanism-of-thrombotic-microangiopathy-associated-with-interferon-therapy
#5
Haiyan Jia, Craig Thelwell, Paula Dilger, Chris Bird, Sarah Daniels, Meenu Wadhwa
INTRODUCTION: Interferon (IFN)-α and IFN-β approved for treatment of chronic hepatitis C viral infection and multiple sclerosis respectively have been linked to thrombotic microangiopathy (TMA) affecting renal function. Since the molecular mechanisms underlying this severe complication remain largely unclear, we aimed to investigate whether IFN affects directly in vitro endothelial cell functions associated with angiogenesis and blood haemostasis, as well as endothelial cell-derived vasodilators of nitric oxide (NO) and prostacyclin...
January 30, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29387432/supar-predicts-postoperative-complications-and-mortality-in-patients-with-asymptomatic-aortic-stenosis
#6
Gethin W Hodges, Casper N Bang, Jesper Eugen-Olsen, Michael H Olsen, Kurt Boman, Simon Ray, Antero Y Kesäniemi, Jørgen L Jeppesen, Kristian Wachtell
Background: We evaluated whether early measurement of soluble urokinase plasminogen activator receptor (suPAR) could predict future risk of postoperative complications in initially asymptomatic patients with mild-moderate aortic stenosis (AS) undergoing aortic valve replacement (AVR) surgery. Methods: Baseline plasma suPAR levels were available in 411 patients who underwent AVR surgery during follow-up in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study...
2018: Open Heart
https://www.readbyqxmd.com/read/29387404/prognostic-value-of-urokinase-plasminogen-activator-system-in-non-small-cell-lung-cancer-a-systematic-review-and-meta-analysis
#7
Jia-Ju Lu, Hong Guo, Bo Gao, Yun Zhang, Qing-Ling Lin, Jiang Shi, Jing-Jing Liu, Jian Liu
Current relevant research suggests there are significant differences between the expression of the urokinase plasminogen activator (uPA) system in cancer tissues and in normal tissues. However, the potential effectiveness of the uPA system as a prognostic biomarker of non-small cell lung cancer (NSCLC) remains unclear. In the present study, a systematic review and meta-analysis were performed to evaluate the relevance of the uPA system in the prognosis of patients with NSCLC. Using the PubMed, EMBASE, Web of Science and Cochrane Library databases, data from relevant academic journal articles were extracted and subjected to analysis...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29354803/current-advances-in-circulating-inflammatory-biomarkers-in-atherosclerosis-and-related-cardio-cerebrovascular-diseases
#8
Jun-Xuan Lv, Qi Kong, Xin Ma
Atherosclerosis (AS) is a systemic chronic disease affecting both the coronary and cerebral arteries. Inflammation plays a key role in the initiation and progression of AS, and numerous inflammatory factors have been proposed as potential biomarkers. This article reviews recent research in studies on major circulating inflammatory biomarkers to identify surrogates that may reflect processes associated with AS development and the risk of AS-related vascular events, such as Von Willebrand factor, lectin-like oxidized low-density-lipoprotein receptor-1, soluble urokinase plasminogen activator receptor, regulated upon activation, normal T-cell expressed and secreted, and microparticles, which may provide new perspectives for clinical AS evaluation and risk stratification...
December 2017: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29344165/overexpression-of-forkhead-box-m1-and-urokinase-type-plasminogen-activator-in-gastric-cancer-is-associated-with-cancer-progression-and-poor-prognosis
#9
Jie Ma, Guangwei Qi, Ji Xu, Haibing Ni, Wulin Xu, Guoqing Ru, Zhongsheng Zhao, Wenjuan Xu, Xujun He
Forkhead box M1 (FOXM1) and urokinase-type plasminogen activator (uPA) are overexpressed and associated with the pathogenesis of multiple types of human malignancy. The aims of the present study were to investigate FOXM1 and uPA expression levels in human gastric cancer using tissue microarray techniques; determining their association with clinicopathological characteristics as well as their prognostic value. Tissue microarray blocks, comprising 436 gastric cancer cases and 92 non-cancerous adjacent normal gastric tissues, were analyzed for FOXM1 and uPA protein expression levels using immunohistochemistry...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29342922/can-egcg-alleviate-symptoms-of-down-syndrome-by-altering-proteolytic-activity
#10
REVIEW
Marzena Wyganowska-Świątkowska, Maja Matthews-Kozanecka, Teresa Matthews-Brzozowska, Ewa Skrzypczak-Jankun, Jerzy Jankun
Down syndrome (DS), also known as "trisomy 21", is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. Silencing these extra genes is beyond existing technology and seems to be impractical. A number of pharmacologic options have been proposed to change the quality of life and lifespan of individuals with DS. It was reported that treatment with epigallocatechin gallate (EGCG) improves cognitive performance in animal models and in humans, suggesting that EGCG may alleviate symptoms of DS...
January 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29340706/prognostic-implications-of-the-co-detection-of-the-urokinase-plasminogen-activator-system-and-osteopontin-in-patients-with-non-small-cell-lung-cancer-undergoing-radiotherapy-and-correlation-with-gross-tumor-volume
#11
C Ostheimer, C Evers, M Bache, T Reese, D Vordermark
BACKGROUND: The urokinase plasminogen activator system (uPA, uPAR, PAI‑1) is upregulated in cancer and high plasma levels are associated with poor prognosis. Their interaction with hypoxia-related osteopontin (OPN) which is also overexpressed in malignant tumors suggests potential clinical relevance. However, the prognostic role of the uPA system in the radiotherapy (RT) of non-small-cell lung cancer (NSCLC), particularly in combination with OPN, has not been investigated so far. METHODS: uPA, uPAR, PAI‑1 and OPN plasma levels of 81 patients with locally advanced or metastasized NSCLC were prospectively analyzed by ELISA before RT and were correlated to clinical patient/tumor data and prognosis after RT...
January 16, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29328476/effect-of-a-synthetic-inhibitor-of-urokinase-plasminogen-activator-on-the-migration-and-invasion-of-human-cervical-cancer-cells-in-vitro
#12
Xuechun Wang, Zhongqing Jiang, Jian An, Xiaodan Mao, Fen Lin, Pengming Sun
As a notable feature of malignant tumors, invasion and metastasis are important events in the process of tumor progression. Amiloride, a synthetic inhibitor of urokinase plasminogen activator (uPA), is involved in these events. To evaluate the therapeutic value of amiloride in cervical cancer, HeLa cells were used as in vitro cellular models. The migration and invasion abilities of HeLa cells, in addition to the mRNA expression of matriptase, uPA, uPA receptor and 72 kDa type IV collagenase (MMP‑2), were detected using scratch assays, Transwell chamber assays and reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR)...
January 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29318541/biotin-chasing-assay-to-evaluate-upar-stability-and-cleavage-on-the%C3%A2-surface-of-cells
#13
Vladimir Leksa, Herbert B Schiller, Hannes Stockinger
The plasminogen activation system, i.e., the fibrinolytic system, is one of the major plasma proteolytic pathways. The proteolytic conversion of the zymogen plasminogen to the active serine protease plasmin is on the cell surface catalyzed by the serine protease urokinase-type plasminogen activator (urokinase, uPA). Upon binding to the urokinase receptor (uPAR, CD87), single-chain pro-uPA is processed to double-chain uPA which in turn specifically converts cell-bound plasminogen to plasmin. Plasmin is harnessed in many physiological processes, e...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29296974/urokinase-plasminogen-activator-and-receptor-promote-collagen-induced-arthritis-through-expression-in-hematopoietic-cells
#14
Sherry Thornton, Harini Raghu, Carolina Cruz, Malinda D Frederick, Joseph S Palumbo, Eric S Mullins, Kasper Almholt, Pernille A Usher, Matthew J Flick
The plasminogen activation (PA) system has been implicated in driving inflammatory arthritis, but the precise contribution of PA system components to arthritis pathogenesis remains poorly defined. Here, the role of urokinase plasminogen activator (uPA) and its cognate receptor (uPAR) in the development and severity of inflammatory joint disease was determined using uPA- and uPAR-deficient mice inbred to the strain DBA/1J, a genetic background highly susceptible to collagen-induced arthritis (CIA). Mice deficient in uPA displayed a near-complete amelioration of macroscopic and histological inflammatory joint disease following CIA challenge...
March 28, 2017: Blood Advances
https://www.readbyqxmd.com/read/29179674/value-of-soluble-urokinase-plasminogen-activator-receptor-over-age-as-a-biomarker-of-impaired-myocardial-relaxation
#15
Angela S Koh, Bhaarathy Velmurugan, Fei Gao, Ru San Tan, Jia-Ing Wong, Louis L Y Teo, Bryan M H Keng, Serene J M Chua, Jian-Min Yuan, Woon-Puay Koh, Christine Cheung
BACKGROUND: SuPAR is a biomarker that reflects the level of immune activation. As inflammation plays an important role in the ageing process of the cardiovascular system, we hypothesized that suPAR might be a useful predictive biomarker of the ageing heart. METHODS: We performed conventional and tissue Doppler echocardiography and measured plasma suPAR levels. RESULTS: We studied community adults (n=120, 37.5% female) (mean age: 70.3±9.3 years) without known cardiovascular disease (CVD)...
November 28, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29157906/novel-decellularized-liver-matrix-alginate-hybrid-gel-beads-for-the-3d-culture-of-hepatocellular-carcinoma-cells
#16
Dongsheng Sun, Yang Liu, Huihui Wang, Fei Deng, Ying Zhang, Shan Zhao, Xiaojun Ma, Huijian Wu, Guangwei Sun
Developing reliable three-dimensional (3D) cell culture systems that can mimic native tumor microenvironments is necessary for investigating the mechanism of hepatocellular carcinoma (HCC) metastasis and screen therapeutic drugs. In the present study, we developed decellularized liver matrix-alginate (DLM-ALG) hybrid gel beads. DLM powder was prepared by optimized decellularization methods and liquid nitrogen grinding. DLM-ALG beads were generated by dropping alginate solution containing DLM powder into a gelling bath...
November 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29113154/synergistic-inhibitory-effects-of-an-engineered-antibody-like-molecule-atf-fc-and-trastuzumab-on-tumor-growth-and-invasion-in-a-human-breast-cancer-xenograft-mouse-model
#17
Hongwei Zhou, Hongwei Wang, Guangyuan Yu, Zhihong Wang, Xi Zheng, Haifeng Duan, Junzhong Sun
The overexpression of the oncogene human epidermal growth factor receptor 2 (HER-2) has been associated with decreased disease-free survival and is a marker of poor prognosis of invasive breast cancer. Although the high efficacy of trastuzumab, a drug that targets the HER-2 oncogene, has been widely recognized, the efficiency of the treatment remains at ~30%. Therefore, novel effective treatments are required for patients with recurrent metastatic breast cancer. The present study aimed to investigate the effects of an engineered antibody-like molecule administered alone or in combination with trastuzumab on the tumor growth and metastasis of HER-2-positive breast cancer...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29107218/dual-targeting-wnt-and-upa-receptors-using-peptide-conjugated-ultra-small-nanoparticle-drug-carriers-inhibited-cancer-stem-cell-phenotype-in-chemo-resistant-breast-cancer
#18
Jasmine Miller-Kleinhenz, Xiangxue Guo, Weiping Qian, Hongyu Zhou, Erica N Bozeman, Lei Zhu, Xin Ji, Y Andrew Wang, Toncred Styblo, Ruth O'Regan, Hui Mao, Lily Yang
Heterogeneous tumor cells, high incidence of tumor recurrence, and decrease in overall survival are the major challenges for the treatment of chemo-resistant breast cancer. Results of our study showed differential chemotherapeutic responses among breast cancer patient derived xenograft (PDX) tumors established from the same patients. All doxorubicin(Dox)-resistant tumors expressed higher level of cancer stem-like cell biomarkers, including CD44, Wnt and its receptor LRP5/6, relative to Dox-sensitive tumors...
October 21, 2017: Biomaterials
https://www.readbyqxmd.com/read/29097819/mechanisms-of-plasminogen-activator-inhibitor-1-action-in-stromal-remodeling-and-related-diseases
#19
Jelena Milenkovic, Maja Milojkovic, Tatjana Jevtovic Stoimenov, Boris Djindjic, Edita Miljkovic
Plasminogen activator inhibitor type 1 (PAI-1) is the main physiologic inhibitor of fibrinolysis. However, it is also involved in many physiological processes such as extracellular matrix (ECM) proteolysis and remodeling, cell adhesion, motility, and apoptosis, angiogenesis, etc. The aim of the study was to summarize current knowledge and gain insights into the mechanisms of PAI-1 action in the processes of stromal remodeling and diseases with considerable matrix pathologies (atherosclerosis, tissue fibrosis, cancer metastasis, pregnancy related complications, etc)...
November 2, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29061810/anticancer-effects-of-colchicine-on-hypopharyngeal-cancer
#20
Jung Hae Cho, Young Hoon Joo, Eun Young Shin, Eun Ji Park, Min Sik Kim
Colchicine is an alkaloid widely used for the treatment of inflammatory diseases, such as gout. It suppresses cell division by inhibiting mitosis. We investigated the anticancer effects of colchicine on human hypopharyngeal cancer cells and the mechanisms underlying its anticancer effects. XTT cell proliferation assay showed that colchicine inhibited the growth and proliferation of human hypopharyngeal cancer cells (FaDu and SNU1041) in a dose- and time-dependent manner. Colchicine also inhibited the migration, invasion, and adhesion of hypopharyngeal cancer cells in a dose-dependent manner...
November 2017: Anticancer Research
keyword
keyword
120947
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"