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Thrombolysis urokinase

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https://www.readbyqxmd.com/read/28184959/endovascular-treatment-strategy-using-catheter-directed-thrombolysis-percutaneous-aspiration-thromboembolectomy-and-angioplasty-for-acute-upper-limb-ischemia
#1
Tatsuo Ueda, Satoru Murata, Izumi Miki, Daisuke Yasui, Fumie Sugihara, Hiroyuki Tajima, Tetsuro Morota, Shin-Ichiro Kumita
PURPOSE: To evaluate the usefulness and safety of endovascular treatments for acute upper limb ischemia (AULI) by using multiple techniques, and to compare catheter-directed thrombolysis (CDT) and percutaneous aspiration thromboembolectomy (PAT) as initial procedures. MATERIALS AND METHODS: The study included 18 patients (4 men and 14 women) with AULI, who underwent a total of 20 sessions of endovascular treatment using various endovascular techniques between January 2005 and April 2016...
February 9, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28182117/fibrin-sheaths-in-central-venous-port-catheters-treatment-with-low-dose-single-injection-of-urokinase-on-an-outpatient-basis
#2
De-Hua Chang, Kamal Mammadov, Tilman Hickethier, Jan Borggrefe, Martin Hellmich, David Maintz, Christoph Kabbasch
PURPOSE: Evaluation of the efficacy of single-shot, low-dose urokinase administration for the treatment of port catheter-associated fibrin sheaths. METHODS: Forty-six patients were retrospectively evaluated for 54 episodes of port catheter dysfunction. The presence of a fibrin sheath was detected by angiographic contrast examinations. On an outpatient basis, patients subsequently received thrombolysis consisting of a single injection of urokinase (15.000 IU in 1...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28133174/-a-case-of-pulmonary-embolism-developed-during-combination-chemotherapy-with-s-1-and-cisplatin-in-a-young-female-patient-with-type-4gastric-cancer
#3
Noboru Kobayashi, Kazuyoshi Yamamoto, Kiyotaka Hagihara, Kazuhiro Nishikawa, Motohiro Hirao, Sakae Maeda, Mamoru Uemura, Masakazu Miyake, Naoki Hama, Atsushi Miyamoto, Michihiko Miyazaki, Masataka Ikeda, Shoji Nakamori, Mitsugu Sekimoto
We report a case of a 23-year-old womanwho developed pulmonary embolism(PE)during chemotherapy for advanced gastric cancer following total gastrectomy(R1). She presented with type 4 gastric cancer with peritoneal dissemination and positive washing cytology. Palliative total gastrectomy was performed(R1)and first-line chemotherapy with S-1(80mg/m2, days 1 to 21) plus CDDP(60mg/m2, day 8)(SP; every 35 days)was administered. PE occurred on day 15 of the 3rd courses of SP. Computed tomography(CT)revealed massive PE in both the pulmonary arteries, and ultrasonography indicated an increase in right-sided pressure...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28064304/evaluation-of-ophthalmic-artery-branch-retrograde-intervention-in-the-treatment-of-central-retinal-artery-occlusion-crao
#4
Runsheng Wang, Lu Qian, Yi Wang, Yi Zheng, Shanshuang Du, Tao Lei, Peilin Lv, Tan Long, Wenjun Wang
BACKGROUND Central retinal artery occlusion (CRAO) is the occlusion of the central retinal artery resulting in retinal infarction and acute vision loss. Digital subtraction angiography (DSA)-guided superselective ophthalmic artery or selective carotid thrombolysis remains the preferred treatment method for CRAO. This study aimed to evaluate the safety and clinical efficacy of the novel ophthalmic artery branch retrograde thrombolytic intervention for CRAO. MATERIAL AND METHODS Fifty patients with monocular CRAO were enrolled, including 28 males and 22 females (mean age: 55...
January 8, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27930543/left-branch-of-portal-vein-thrombosis-in-a-liver-transplant-recipient-with-donation-after-cardiac-death-donor-a-case-report
#5
Maogen Chen, Weiqiang Ju, Xiaohong Lin, Qiang Zhao, Dongping Wang, Xiaoshun He
INTRODUCTION: Portal vein thrombosis (PVT) is one of the most severe complications after liver transplantation, which usually causes graft loss and recipient mortality. The founding of the embolic branch of portal system and its result are not well described in the literature. CLINICAL FINDINGS AND DIAGNOSES: We report here an unusual case of complete right branch thrombosis of portal vein after orthotopic liver transplantation from a donation after cardiac death donor, without obvious malaise...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27810050/therapeutic-fibrinolysis-how-efficacy-and-safety-can-be-improved
#6
REVIEW
Victor Gurewich
Therapeutic fibrinolysis has been dominated by the experience with tissue-type plasminogen activator (t-PA), which proved little better than streptokinase in acute myocardial infarction. In contrast, endogenous fibrinolysis, using one-thousandth of the t-PA concentration, is regularly lysing fibrin and induced Thrombolysis In Myocardial Infarction flow grade 3 patency in 15% of patients with acute myocardial infarction. This efficacy is due to the effects of t-PA and urokinase plasminogen activator (uPA). They are complementary in fibrinolysis so that in combination, their effect is synergistic...
November 8, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27689864/thrombolysis-based-on-magnetically-controlled-surface-functionalized-fe3o4-nanoparticle
#7
Ming Chang, Yu-Hao Lin, Jacque Lynn Gabayno, Qian Li, Xiaojun Liu
In this study, the control of magnetic fields to manipulate surface-functionalized Fe3O4 nanoparticles by urokinase coating is investigated for thrombolysis in a microfluidic channel. The urokinase-coated Fe3O4 nanoparticles are characterized using particle size distribution, zeta potential measurement and spectroscopic data. Thrombolytic ratio tests reveal that the efficiency for thrombus cleaning is significantly improved when using magnetically-controlled urokinase-coated Fe3O4 nanoparticles than pure urokinase solution...
January 2, 2017: Bioengineered
https://www.readbyqxmd.com/read/27489692/acute-embolic-occlusion-of-the-right-common-iliac-artery-after-revision-total-hip-arthroplasty-treated-with-catheter-directed-thrombolysis-and-balloon-angioplasty-a-case-report
#8
Hongqi Yang, Qing Lei, Song Chen, Li Chen, Yuefeng Li, Yasheng Chai, Ping Wei, Shunchi Xu, Tangyou Liu, Feng Liu, Zhuo Zhang
METHODS: A 63-year-old woman with atrial fibrillation presented clinical symptoms and signs of acute ischemia in the right lower extremity on the 17th postoperative day after revision total hip arthroplasty of the left hip for aseptic loosening of femoral component. Aspirin was discontinued 7 days before surgery. Both computed tomography angiography and digital subtraction angiography demonstrated complete occlusion of the right common iliac artery. An emergency catheter-directed thrombolysis with urokinase combined with balloon angioplasty was performed to obtain complete patency of the right common iliac artery...
2015: SAGE open medical case reports
https://www.readbyqxmd.com/read/27465303/pulmonary-embolism-with-floating-right-atrial-thrombus-successfully-treated-with-streptokinase-a-case-report
#9
Sahela Nasrin, Fathima Aaysha Cader, Md Salahuddin, Tahera Nazrin, Masuma Jannat Shafi
BACKGROUND: Massive pulmonary embolism (PE) is associated with significant mortality, especially if compounded by haemodynamic instability, right ventricular (RV) dysfunction and right atrial (RA) thrombus. Thrombolysis can be lifesaving in patients with major embolism and cardiogenic shock, and accelerates the resolution of thrombus. Only three fibrinolytic agents-namely streptokinase, urokinase, and recombinant tissue plasminogen activator (alteplase) have been approved in the treatment of PE, with studies demonstrating similar safety profiles...
July 28, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27444259/stenting-as-a-rescue-treatment-after-failure-of-mechanical-thrombectomy-for-anterior-circulation-large-artery-occlusion
#10
Jang-Hyun Baek, Byung Moon Kim, Dong Joon Kim, Ji Hoe Heo, Hyo Suk Nam, Joonsang Yoo
BACKGROUND AND PURPOSE: We hypothesized that permanent stenting may be a rescue treatment for stentriever-failed anterior circulation large artery occlusion. We compared the outcomes among patients with permanent stenting and those without stenting after stentriever failure. METHODS: We retrospectively evaluated 208 patients who underwent stentriever thrombectomy for anterior circulation large artery occlusion between September 2010 and September 2015. Modified thrombolysis in cerebral ischemia 2b-3 recanalization was achieved with stentriever alone or in combination with Penumbra device in 155 patients (74...
September 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27386456/delayed-presentation-of-endovenous-heat-induced-thrombosis-treated-by-thrombolysis-and-subsequent-open-thrombectomy
#11
Jung Hak Kwak, Sang Il Min, Song-Yi Kim, Ahram Han, Chanjoong Choi, Sanghyun Ahn, Jongwon Ha, Seung-Kee Min
Although endovenous heat-induced thrombosis (EHIT) is frequently reported after endovenous laser ablation (EVLA), the incidence and timing of occurrence of EHIT are not fully understood. We present a case of EHIT successfully treated with a combination of surgical and endovascular treatments. A 57-year-old woman, two months post bilateral EVLA, presented with a swollen leg. Deep vein thrombosis was diagnosed by Doppler ultrasonography and computerized tomographic venography. We treated the patient with catheter-directed thrombolysis with urokinase after insertion of an inferior vena cava filter...
June 2016: Vascular Specialist International
https://www.readbyqxmd.com/read/27122863/percutaneous-transluminal-angioplasty-and-stenting-for-hepatic-vessel-stenosis-after-orthotopic-liver-transplantation
#12
Ming-Yuan Luo, Yi-Ju Wu, Tung-Chao Lin, Thau-Yun Shen, Ho-Pang Yang, Chien-Cheng Chen, Fu-Chung Chen
BACKGROUND: This study aimed to evaluate the efficacy of vascular intervention in percutaneous transluminal angioplasty (PTA) for the treatment of hepatic artery and hepatic vein stenosis after liver transplantation (LT), including thrombotic total occluded lesions. METHODS: Percutaneous transluminal angioplasty after orthotopic liver transplantation was performed to re-open hepatic vessel lesions. We daily used routine Doppler ultrasound during admission for early detection of graft hepatic vessel lesions, including hepatic artery and vein lesions...
March 2015: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27089231/catheter-directed-therapy-for-acute-renal-vein-thrombosis-in-systemic-lupus-erythematosus-a-case-report
#13
Chien-Boon Jong, Wei-Yung Lo, Mu-Yang Hsieh
We report our experience using catheter-directed thrombectomy/thrombolysis (CDT) to treat a patient with acute renal vein thrombosis (RVT) associated with systemic lupus erythematosus (SLE). A 34-year-old woman presented with persistent left flank pain, and a renal ultrasonography examination revealed an enlarged left kidney. Contrast-enhanced computed tomography confirmed the presence of acute left RVT. Because medical treatment failed to relieve her pain and the renal function was deteriorating, we attempted to salvage the occluded left renal vein using an endovascular approach...
April 18, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27081228/outcomes-of-catheter-directed-treatment-of-lower-extremity-deep-vein-thrombosis-of-patients-presenting-to-a-tertiary-care-hospital
#14
Gaurav Sundar, Shyamkumar N Keshava, Vinu Moses, George K Chiramel, Munawwar Ahmed, Suraj Mammen, Sunil Aggarwal, Edwin Stephen
BACKGROUND: Lower extremity deep vein thrombosis (DVT) is a common illness with an annual incidence of 1 per 1000 adults. The major long-term complication of DVT is post-thrombotic syndrome (PTS) which occurs in up to 60% of patients within 2 years of an episode of DVT. AIMS: We aim to evaluate the outcomes of catheter-directed treatment (CDT) for symptomatic acute or subacute lower extremity DVT. MATERIALS AND METHODS: A retrospective 12-year study was conducted on the outcomes of CDT on 54 consecutive patients who presented with acute or subacute lower extremity DVT to our hospital...
January 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/27022419/thrombus-targeted-theranostic-microbubbles-a-new-technology-towards-concurrent-rapid-ultrasound-diagnosis-and-bleeding-free-fibrinolytic-treatment-of-thrombosis
#15
Xiaowei Wang, Yannik Gkanatsas, Jathushan Palasubramaniam, Jan David Hohmann, Yung Chih Chen, Bock Lim, Christoph E Hagemeyer, Karlheinz Peter
RATIONALE: Myocardial infarction and stroke are leading causes of morbidity/mortality. The typical underlying pathology is the formation of thrombi/emboli and subsequent vessel occlusion. Systemically administered fibrinolytic drugs are the most effective pharmacological therapy. However, bleeding complications are relatively common and this risk as such limits their broader use. Furthermore, a rapid non-invasive imaging technology is not available. Thereby, many thrombotic events are missed or only diagnosed when ischemic damage has already occurred...
2016: Theranostics
https://www.readbyqxmd.com/read/27022012/mid-term-outcome-of-endovascular-treatment-for-acute-lower-extremity-deep-venous-thrombosis
#16
Kun Jiang, Xiao-Qiang Li, Hong-Fei Sang, Ai-Min Qian, Jian-Jie Rong, Cheng-Long Li
PURPOSES OF THE STUDY: To evaluate the benefit of stenting the iliac vein in patients with residual iliac vein stenosis treated with catheter-directed thrombolysis for acute iliofemoral deep venous thrombosis. PROCEDURES: In this randomized prospective study, patients with a first-time acute lower extremity deep venous thrombosis that had persisted <14 days were treated with catheter-directed thrombolysis. After catheter-directed thrombolysis, patients with >50% residual iliac vein stenosis were randomly divided into two groups: catheter-directed thrombolysis + Stent Group and catheter-directed thrombolysis Alone Group...
March 27, 2016: Phlebology
https://www.readbyqxmd.com/read/26998029/tirofiban-combined-with-urokinase-selective-intra-arterial-thrombolysis-for-the-treatment-of-middle-cerebral-artery-occlusion
#17
Lei Feng, Jun Liu, Yunzhen Liu, Jian Chen, Chunhai Su, Chuanfeng Lv, Yuzhen Wei
The aims of the present study were to establish a model of embolic stroke in rabbits and to evaluate the efficacy and safety of intra-arterially administered tirofiban combined with urokinase thrombolysis. The middle cerebral artery occlusion model (MCAO) of embolic stroke was established in New Zealand rabbits via an autologous clot. The model rabbits were allocated at random into four groups: Tirofiban group (T group), urokinase group (UK group), tirofiban and urokinase group (T + UK group) and the control group (C group)...
March 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26957269/low-level-of-low-density-lipoprotein-cholesterol-is-related-with-increased-hemorrhagic-transformation-after-acute-ischemic-cerebral-infarction
#18
N Yang, M Lin, B-G Wang, W-Y Zeng, Y-F He, H-Y Peng, J Zeng, Z-Y Wu, Y Zhong
OBJECTIVE: The prevalence of hemorrhagic transformation (HT) after acute ischemic infarction varies greatly. Risk factors of HT include ageing, severity of stroke, baseline hypertension, high NIH Stroke Scale (NIHSS) scores, hyperglycemia and cardioembolic infarction and low levels of low-density lipoprotein (LDL). We investigated the relationship between LDL, lipid profile and HT after acute ischemic infarction and suggested precautions for HT management. PATIENTS AND METHODS: Three hundred and forty-eight patients with acute infarction were included in the study...
2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26951903/optimization-of-dialysis-catheter-function
#19
REVIEW
Maurizio Gallieni, Antonino Giordano, Umberto Rossi, Maurizio Cariati
Central venous catheters (CVCs) are essential in the management of hemodialysis patients, but they also carry unintended negative consequences and in particular thrombosis and infection, adversely affecting patient morbidity and mortality. This review will focus on the etiology, prevention, and management of CVC-related dysfunction, which is mainly associated with inadequate blood flow. CVC dysfunction is a major cause of inadequate depuration. Thrombus, intraluminal and extrinsic, as well as fibrous connective tissue sheath (traditionally indicated as fibrin sheath) formation play a central role in establishing CVC dysfunction...
March 2016: Journal of Vascular Access
https://www.readbyqxmd.com/read/26935163/massive-pulmonary-embolism-mimicking-acute-myocardial-infarction-successful-use-of-extracorporeal-membrane-oxygenation-support-as-bridge-to-diagnosis
#20
Yung-Kun Hsieh, Fu-Yuan Siao, Chun-Chieh Chiu, Hsu-Heng Yen, Yao-Li Chen
Prolonged cardiac arrest with pulseless electrical activity (PEA) results in death if its aetiology cannot be corrected immediately. We describe the case of a 75-year-old man with chest pain and his electrocardiogram (ECG) revealing ST-segment elevation in leads II, III, and aVf. Inferior wall myocardial infarction was subsequently diagnosed. Before performing emergency coronary angiography, however, a sudden cardiac arrest with PEA developed and the patient was placed on advanced cardiac life support. Oxygenation support for the extracorporeal membrane was initiated approximately 65min after prolonged cardiopulmonary resuscitation...
July 2016: Heart, Lung & Circulation
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