keyword
MENU ▼
Read by QxMD icon Read
search

Brain tumor medicine

keyword
https://www.readbyqxmd.com/read/28440967/toxicity-of-cisplatin-loaded-poly-butyl-cyanoacrylate-nanoparticles-in-a-brain-cancer-cell-line-anionic-polymerization-results
#1
Nejad Mohamadi, S Maryam Kazemi, Mahshid Mohammadian, Attabak Toofani Milani, Younes Moradi, Maryam Yasemi, Meysam Ebrahimi far, Maral Mazloumi Tabrizi, Hasan Ebrahimi Shahmabadi, Azim Akbarzadeh Khiyavi
Cancer is one of the most important issues in modern medicine and the most common cause of death after cardiovascular diseases in many countries. Brain cancer is one of the most common causes of cancer death among men and women, ranking third. Chemotherapeutic drugs that aim to prevent uncontrolled proliferation of cells in tissues of the body and induce apoptosis of tumor cells are prominent candidates for development. Since cisplatin has an apoptosisinducing role, it is widely used as an anticancer agent...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28427196/breast-cancer-subtypes-predict-the-preferential-site-of-distant-metastases-a-seer-based-study
#2
Qi Wu, Juanjuan Li, Shan Zhu, Juan Wu, Chuang Chen, Qian Liu, Wen Wei, Yimin Zhang, Shengrong Sun
BACKGROUND AND AIMS: This study aimed to access possible relationships between breast cancer subtypes and sites of distant metastasis in breast cancer. RESULTS: A total of 243,896 patients, including 226,451 cases in control groups were identified. Bone metastasis was found in 8848 cases, compared with 1,000 brain metastasis cases, 3434 liver metastasis cases and 4167 lung metastasis cases. Patients with all subtypes were most prone to bone metastases, the incidence of bone metastasis in HR+/HER2+ subtype was up to 5...
March 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28421396/-11-c-methionine-pet-ct-findings-in-benign-brain-disease
#3
REVIEW
Reiko Nakajima, Ken Kimura, Koichiro Abe, Shuji Sakai
(11)C-methionine (MET) is one of the most commonly used positron emission tomography (PET) tracers for evaluation of malignant brain tumor, with MET-PET being a sensitive technique for visualization of primary and recurrent malignant brain tumors. However, previous reports have demonstrated MET uptake in lesions associated with benign brain diseases. These diseases usually show an increase in MET uptake similar to that of malignant tumors. This pitfall in MET-PET image interpretation is important not only for nuclear medicine professionals, but also for radiologists...
April 18, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28410266/2-3-5-4-tetrahydroxystilbene-2-o-%C3%AE-d-glucoside-prevention-of-lipopolysaccharide-induced-depressive-like-behaviors-in-mice-involves-neuroinflammation-and-oxido-nitrosative-stress-inhibition
#4
Zhuo Chen, Chao Huang, Haiyan He, Wenbin Ding
Although numerous hypotheses have been raised in recent years, the exact mechanisms that promote the development of major depression are largely unknown. Recently, strategies targeting the process of neuroinflammation and oxidative stress in depression have been attracting greater attention. 2, 3, 5, 4'-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG), a compound purified from a traditional Chinese herbal medicine polygonummultiflorum, has been widely reported to inhibit neuroinflammation and oxidative stress...
April 13, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28405533/scalp-seeding-post-craniotomy-and-radiosurgery-for-solitary-brain-metastasis-a-case-report-and-systematic-review
#5
Waseem Sharieff, Liam Mulroy, Adrienne Weeks, Samina Mansoor, Rajbir Pahil, Muhammad U Islam
BACKGROUND  : Radiosurgery is being increasingly used post craniotomy for brain metastasis, instead of whole-brain radiation. We report a case of scalp metastasis following craniotomy and radiosurgery, along with a systematic review of the literature. METHODS        : Our patient was a 70-year-old male who presented with a scalp metastasis, two years after craniotomy and radiosurgery, for a solitary brain metastasis from esophageal carcinoma. Using Medline® (United States National Library of Medicine, Bethesda, MD), we performed a systematic review of the literature to identify cases of isolated scalp metastases following craniotomy for brain lesions...
March 7, 2017: Curēus
https://www.readbyqxmd.com/read/28401643/ultrafast-compartmentalized-relaxation-time-mapping-with-linear-algebraic-modeling
#6
Yi Zhang, Xiaoyang Liu, Jinyuan Zhou, Paul A Bottomley
PURPOSE: To dramatically accelerate compartmental-average longitudinal (T1 ) and transverse (T2 ) relaxation measurements using the minimal-acquisition linear algebraic modeling (SLAM) method, and to validate it in phantoms and humans. METHODS: Relaxation times were imaged at 3 Tesla in phantoms, in the abdomens of six volunteers, and in six brain tumor patients using standard inversion recovery and multi-spin-echo sequences. k-space was fully sampled to provide reference T1 and T2 measurements, and SLAM was performed using a limited set of phase encodes from central k-space...
April 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28392281/human-stem-cell-modeling-in-neurofibromatosis-type-1-nf1
#7
REVIEW
Michelle L Wegscheid, Corina Anastasaki, David H Gutmann
The future of precision medicine is heavily reliant on the use of human tissues to identify the key determinants that account for differences between individuals with the same disorder. This need is exemplified by the neurofibromatosis type 1 (NF1) neurogenetic condition. As such, individuals with NF1 are born with a germline mutation in the NF1 gene, but may develop numerous distinct neurological problems, ranging from autism and attention deficit to brain and peripheral nerve sheath tumors. Coupled with accurate preclinical mouse models, the availability of NF1 patient-derived induced pluripotent stem cells (iPSCs) provides new opportunities to define the critical factors that underlie NF1-associated nervous system disease pathogenesis and progression...
April 6, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28353033/a-novel-all-in-one-intraoperative-genotyping-system-for-idh1-mutant-glioma
#8
Fumiharu Ohka, Akane Yamamichi, Michihiro Kurimoto, Kazuya Motomura, Kuniaki Tanahashi, Hiromichi Suzuki, Kosuke Aoki, Shoichi Deguchi, Lushun Chalise, Masaki Hirano, Akira Kato, Yusuke Nishimura, Masahito Hara, Yukinari Kato, Toshihiko Wakabayashi, Atsushi Natsume
IDH1 gene mutation has been demonstrated to be an oncogenic driver in a majority of lower-grade gliomas (LGGs). In contrast to other central nervous neoplasms and normal brain tissue without IDH1 mutation, almost 80% of LGGs exhibit IDH1 mutation. Therefore, expeditious detection of IDH1 mutation is useful, not only for intraoperative diagnosis of these gliomas but also for determination of the border between the tumor and normal brain tissue. In this study, we established a rapid genotyping assay with a simple DNA extraction method, involving only incubation of the tumor specimen with Tris-EDTA buffer, which can be easily performed in an operating room...
March 28, 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28346057/the-role-of-germline-variants-in-chemotherapy-outcome-in-brain-tumors-a-systematic-review-of-pharmacogenetic-studies
#9
Marije J Klumpers, Marieke Jh Coenen, Corrie Em Gidding, D Maroeska Wm Te Loo
AIM: This systematic review provides an overview of publications concerning pharmacogenetic research in pediatric patients with medulloblastoma and low-grade glioma. MATERIALS & METHODS: Three electronic databases searches including a manual search were performed to identify studies investigating potential interactions between germline variants and chemotherapy efficacy and toxicity. RESULTS: Out of 3570 citations, 21 studies were included...
March 27, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28321903/spin-lock-imaging-of-exogenous-exchange-based-contrast-agents-to-assess-tissue-ph
#10
Zhongliang Zu, Hua Li, Xiaoyu Jiang, John C Gore
PURPOSE: Some X-ray contrast agents contain exchangeable protons that give rise to exchange-based effects on MRI, including chemical exchange saturation transfer (CEST). However, CEST has poor specificity to explicit exchange parameters. Spin-lock sequences at high field are also sensitive to chemical exchange. Here, we evaluate whether spin-locking techniques can detect the contrast agent iohexol in vivo after intravenous administration, and their potential for measuring changes in tissue pH...
March 20, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28295552/high-resolution-dynamic-oxygen-17-mr-imaging-of-mouse-brain-with-golden-ratio-based-radial-sampling-and-k-space-weighted-image-reconstruction
#11
Yuchi Liu, Yifan Zhang, Chunying Wu, Junqing Zhu, Charlie Wang, Nicholas Tomko, Mikhail D Linetsky, Robert G Salomon, Ciro Ramos-Estebanez, Yanming Wang, Xin Yu
PURPOSE: The current study aimed to develop a three-dimensional (3D) dynamic oxygen-17 ((17) O) MR imaging method with high temporal and spatial resolution to delineate the kinetics of (17) O water uptake and washout in the brains of mice with glioblastoma (GBM). METHODS: A 3D imaging method with a stack-of-stars golden-ratio-based radial sampling scheme was employed to acquire (17) O signal in vivo. A k-space-weighted image reconstruction method was used to improve the temporal resolution while preserving spatial resolution...
March 13, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28287461/alkoxy-and-enediyne-derivatives-containing-1-4-benzoquinone-subunits-synthesis-and-antitumor-activity
#12
Monika Kadela-Tomanek, Ewa Bębenek, Elwira Chrobak, Małgorzata Latocha, Stanisław Boryczka
The compounds produced by a living organism are most commonly as medicinal agents and starting materials for the preparation of new semi-synthetic derivatives. One of the largest groups of natural compounds consists of products containing a 1,4-benzoquinone subunit. This fragment occurs in three enediyne antibiotics, dynemicin A, deoxydynemicin A, and uncilamicin, which exhibit high biological activity. A series of alkoxy derivatives containing 1,4-naphthoquinone, 5,8-quinolinedione, and 2-methyl-5,8-quinolinedione moieties was synthesized...
March 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28263053/water-soluble-fullerene-derivatives-as-brain-medicine-surface-chemistry-determines-if-they-are-neuroprotective-and-antitumor
#13
Fu-Yu Hsieh, A V Zhilenkov, I I Voronov, E A Khakina, D V Mischenko, Pavel A Troshin, Shan-Hui Hsu
Delivering drugs to the central nervous system (CNS) is a major challenge in treating CNS-related diseases. Nanoparticles that can cross blood-brain barrier (BBB) are potential tools. In this study, water-soluble C60 fullerene derivatives with different types of linkages between the fullerene cage and the solubilizing addend were synthesized (compounds 1-3: C-C bonds, compounds 4-5: C-S bonds, compound 6: C-P bonds, and compounds 7-9: C-N bonds). Fullerene derivatives 1-6 were observed to induce neural stem cell (NSC) proliferation in vitro and rescue the function of injured CNS in zebrafish...
March 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28260011/ethyl-acetate-extract-from-asparagus%C3%A2-cochinchinensis-exerts-anti%C3%A2-inflammatory-effects-in-lps%C3%A2-stimulated-raw264-7-macrophage-cells-by-regulating-cox%C3%A2-2-inos-inflammatory-cytokine-expression-map-kinase-pathways-the-cell-cycle-and-anti-oxidant-activity
#14
Hyun Ah Lee, Eun Kyoung Koh, Ji Eun Sung, Ji Eun Kim, Sung Hwa Song, Dong Seob Kim, Hong Joo Son, Chung Yeoul Lee, Hee Seob Lee, Chang Joon Bae, Dae Youn Hwang
Asparagus cochinchinesis (A. cochinchinesis) is a medicine traditionally used to treat fever, cough, kidney disease, breast cancer, inflammatory disease and brain disease in northeast Asian countries. Although numerous studies of the anti‑inflammatory effects of A. cochinchinesis have been conducted, the underlying mechanisms of such effects in macrophages remain to be demonstrated. To investigate the mechanism of suppressive effects on the inflammatory response in macrophages, alterations of the nitric oxide (NO) level, the cell viability, inducible nitric oxide synthase (iNOS) and cyclooxygenase‑2 (COX‑2) expression levels, inflammatory cytokine expression, the mitogen-activated protein kinase (MAPK) signaling pathway, cell cycle arrest and reactive oxygen species (ROS) levels were measured in lipopolysaccharide (LPS)-activated RAW264...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28254368/the-impact-of-tumor-biology-on-survival-and-response-to-radiation-therapy-among-patients-with-non-small-cell-lung-cancer-brain-metastases
#15
Jacob A Miller, Rupesh Kotecha, Manmeet S Ahluwalia, Alireza M Mohammadi, John H Suh, Gene H Barnett, Erin S Murphy, Michael A Vogelbaum, Lilyana Angelov, Samuel T Chao
PURPOSE: To investigate the natural history and response to radiation therapy among ALK-rearranged, EGFR-mutated, wild-type adenocarcinoma, and squamous cell non-small cell lung cancer (NSCLC) brain metastases. METHODS AND MATERIALS: Patients with NSCLC brain metastasis diagnosed from 1989 through 2014 at a single tertiary-care institution were included. The primary outcome was overall survival, whereas secondary outcomes included local failure, distant intracranial failure, and radiation necrosis...
January 5, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28219086/first-report-of-awake-craniotomy-of-a-famous-musician-suprasellar-tumor-surgery-of-pianist-clara-haskil-in-1942
#16
Elena Romana Gasenzer, Ayhan Kanat, Edmund A M Neugebauer
Clara Haskil (January 7, 1895-December 7, 1960) was one of the most famous female pianists of the 20th century. In her life and work she set new standards in piano playing. However, her career was beset by poor health and the adversities of two world wars. In her lifetime Haskil had three major disorders: juvenile scoliosis requiring treatment in her adolescence, a tumor of the sellar region requiring surgery at age 47 years, and a traumatic brain injury causing her death at the age of 65. Her medical history illustrates the development of surgical methods and rehabilitation in medicine before and after World War II...
February 20, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/28210976/regenerative-medicine-for-parkinson-s-disease-using-differentiated-nerve-cells-derived-from-human-buccal-fat-pad-stem-cells
#17
Haruka Takahashi, Hiroshi Ishikawa, Akira Tanaka
The purpose of this study was to evaluate the utility of human adipose stem cells derived from the buccal fat pad (hBFP-ASCs) for nerve regeneration. Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive death of dopaminergic neurons. PD is a candidate disease for cell replacement therapy because it has no fundamental therapeutic methods. We examined the properties of neural-related cells induced from hBFP-ASCs as a cell source for PD treatment. hBFP-ASCs were cultured in neurogenic differentiation medium for about 2 weeks...
April 2017: Human Cell
https://www.readbyqxmd.com/read/28191774/novel-peripherally-derived-neural-like-stem-cells-as-therapeutic-carriers-for-treating-glioblastomas
#18
Alexander Birbrair, Anirudh Sattiraju, Dongqin Zhu, Gilberto Zulato, Izadora Batista, Van T Nguyen, Maria Laura Messi, Kiran Kumar Solingapuram Sai, Frank C Marini, Osvaldo Delbono, Akiva Mintz
Glioblastoma (GBM), an aggressive grade IV astrocytoma, is the most common primary malignant adult brain tumor characterized by extensive invasiveness, heterogeneity, and angiogenesis. Standard treatment options such as radiation and chemotherapy have proven to be only marginally effective in treating GBM because of its invasive nature. Therefore, extensive efforts have been put forth to develop tumor-tropic stem cells as viable therapeutic vehicles with potential to treat even the most invasive tumor cells that are harbored within areas of normal brain...
February 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28186109/astragali-radix-could-it-be-an-adjuvant-for-oxaliplatin-induced-neuropathy
#19
Lorenzo Di Cesare Mannelli, Alessandra Pacini, Laura Micheli, Angelo Pietro Femia, Mario Maresca, Matteo Zanardelli, Alfredo Vannacci, Eugenia Gallo, Anna Rita Bilia, Giovanna Caderni, Fabio Firenzuoli, Alessandro Mugelli, Carla Ghelardini
Neurotoxicity is a major side effect of platinum derivatives both during and after treatment. In the absence of effective pharmacological compounds, the opportunity to identify safe adjuvant treatments among medicinal plants seems appropriate. Astragali radix is an adaptogenic herbal product recently analyzed in platinum-treated cancer patients. With the aim of evaluating the anti-neuropathic profile of Astragali radix, a previously characterized aqueous (Aqu) and two hydroalcoholic (20%HA and 50%HA) extracts were tested in a rat model of oxaliplatin-induced neuropathy...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28169457/improving-labeling-efficiency-in-automatic-quality-control-of-mrsi-data
#20
Nuno Pedrosa de Barros, Richard McKinley, Roland Wiest, Johannes Slotboom
PURPOSE: To improve the efficiency of the labeling task in automatic quality control of MR spectroscopy imaging data. METHODS: 28'432 short and long echo time (TE) spectra (1.5 tesla; point resolved spectroscopy (PRESS); repetition time (TR)= 1,500 ms) from 18 different brain tumor patients were labeled by two experts as either accept or reject, depending on their quality. For each spectrum, 47 signal features were extracted. The data was then used to run several simulations and test an active learning approach using uncertainty sampling...
February 7, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
keyword
keyword
120938
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"