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https://www.readbyqxmd.com/read/29764522/treatment-resistant-depression-and-peripheral-c-reactive-protein
#1
Samuel R Chamberlain, Jonathan Cavanagh, Peter de Boer, Valeria Mondelli, Declan N C Jones, Wayne C Drevets, Philip J Cowen, Neil A Harrison, Linda Pointon, Carmine M Pariante, Edward T Bullmore
BACKGROUND: C-reactive protein (CRP) is a candidate biomarker for major depressive disorder (MDD), but it is unclear how peripheral CRP levels relate to the heterogeneous clinical phenotypes of the disorder.AimTo explore CRP in MDD and its phenotypic associations. METHOD: We recruited 102 treatment-resistant patients with MDD currently experiencing depression, 48 treatment-responsive patients with MDD not currently experiencing depression, 48 patients with depression who were not receiving medication and 54 healthy volunteers...
May 16, 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29761488/psychological-therapies-for-treatment-resistant-depression-in-adults
#2
REVIEW
Sharea Ijaz, Philippa Davies, Catherine J Williams, David Kessler, Glyn Lewis, Nicola Wiles
BACKGROUND: Antidepressants are a first-line treatment for adults with moderate to severe major depression. However, many people prescribed antidepressants for depression don't respond fully to such medication, and little evidence is available to inform the most appropriate 'next step' treatment for such patients, who may be referred to as having treatment-resistant depression (TRD). National Institute for Health and Care Excellence (NICE) guidance suggests that the 'next step' for those who do not respond to antidepressants may include a change in the dose or type of antidepressant medication, the addition of another medication, or the start of psychotherapy...
May 14, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29755718/categorisation-of-colour-terms-using-new-validation-tools-a-case-study-and-implications
#3
Shabnam Arbab, Jonathan A Brindle, Barbara S Matusiak, Christian A Klöckner
This article elaborates on the results of a field experiment conducted among speakers of the Chakali language, spoken in northern Ghana. In the original study, the Color-aid Corporation Chart was used to perform the focal task in which consultants were asked to point at a single colour tile on the chart. However, data from the focal task could not be analysed since the Color-aid tiles had not yet been converted into numerical values set forth by the Commission internationale de l'éclairage (CIE). In this study, the full set of 314 Color-aid tiles were measured for chromaticity and converted into the CIE values at the Daylight Laboratory of the Norwegian University of Science and Technology...
March 2018: I-Perception
https://www.readbyqxmd.com/read/29743054/australian-integrative-oncology-services-a-mixed-method-study-exploring-the-views-of-cancer-survivors
#4
Jennifer Hunter, Jane Ussher, Chloe Parton, Andrew Kellett, Caroline Smith, Geoff Delaney, Eleanor Oyston
BACKGROUND: The significant use of traditional and complementary medicine (T&CM) by cancer survivors is well documented. The aim of this study was to explore cancer survivors' views on integrating T&CM services with conventional cancer care. METHOD: A mixed-method study design with an emphasis on qualitative methodology was used to conduct and analyse four focus group interviews and an on-line survey. Purposive sampling recruited 33 cancer survivors and caregivers from Arabic, Vietnamese, Chinese and Anglo-European Australian backgrounds who participated in one of four focus group interviews, and 121 cancer survivors who responded to an on-line survey...
May 9, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29742724/a-case-report-of-immunoglobulin-g4-related-sclerosing-cholangitis-with-multiple-relapse
#5
Xiaoqin Dong, Na Huo, Zhao Wu, Guiqiang Wang, He Wang, Hong Zhao
RATIONALE: Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) is classified as a biliary tract manifestation of immunoglobulin G4-related disease (IgG4-RD). Glucocorticoid is the first-line therapy for most patients, but the optimal starting dose, adequate maintaining dose and withdrawal time remain disputable. PATIENT CONCERNS: An elderly male patient presented to our hospital with neoplasms of the bile duct and pancreas at first visit in December 2011...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29737972/a-systematic-review-of-patient-reported-outcomes-for-surgically-amenable-epiphora
#6
Christopher B Schulz, Alasdair Kennedy, Simon Rogers
PURPOSE: In evaluating epiphora and its management, the bottom line for all stakeholders is whether an intervention confers any real benefit on quality of life. A review was conducted to identify and appraise patient-reported outcome measures (PROMs) in surgically amenable epiphora. METHODS: A systematic search was conducted of studies relating to surgical intervention for epiphora. Patient-reported outcome measures were identified and assessed against standard criteria...
May 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29737219/use-of-acalabrutinib-in-patients-with-mantle-cell-lymphoma
#7
Farrukh T Awan, Wojciech Jurczak
Acalabrutinib, a selective, Bruton tyrosine kinase (BTK) inhibitor, was granted accelerated approval by the FDA on 31 October 2017 for the treatment of patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Areas covered: This narrative review provides an overview of acalabrutinib, its use in clinical practice and potential future developments. Expert commentary: BTK inhibitors have demonstrated efficacy in patients with relapsed or refractory MCL. To prepare patients for therapy, all preexisting infections should be diagnosed and treated, and infection prophylaxis undertaken...
May 8, 2018: Expert Review of Hematology
https://www.readbyqxmd.com/read/29704507/development-and-psychometric-evaluation-of-a-fatigability-index-for-full-time-wheelchair-users-with-spinal-cord-injury
#8
Alina Ionela Palimaru, William E Cunningham, Marcus Dillistone, Arturo Vargas-Bustamante, Honghu Liu, Ron D Hays
PURPOSE: To develop and evaluate psychometrically a self-reported instrument assessing physical fatigability (PF) and mental fatigability (MF) in adults with spinal cord injury (SCI). DESIGN: Cross-sectional. SETTING: Peer-support groups at rehabilitation centers, on-line support groups. PARTICIPANTS: Adults with SCI (N=464) in the US. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: The dimensional structure was assessed by confirmatory factor analysis...
April 25, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29703392/analysis-of-the-activity-of-interconsultations-conducted-by-the-departments-of-internal-medicine-reina-semi-study-registry-of-interconsultations-and-shared-care-of-the-spanish-society-of-internal-medicine
#9
R Monte-Secades, E Montero-Ruiz, J Feyjoo-Casero, M González-Anglada, M Freire-Romero, A Gil-Díaz, A Granados-Maturano, D Rubal-Bran, R Rabuñal-Rey, L Nevado Lopez-Alegria
OBJECTIVE: To analyse the activity of interconsultations conducted by internal medicine (IM) departments, their formal aspects and the profile of clinical care required and to quantify the workload they represent. MATERIAL AND METHOD: A multicentre, observational prospective study was conducted with consecutive hospitalised patients treated by IM departments using interconsultations between May 15 and June 15, 2016. We estimated the workload related to this activity (1time unit [TU]=10min)...
April 24, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29700930/an-evaluation-of-the-yaka-%C3%A5-arali-tackling-indigenous-smoking-program-in-east-arnhem-land-yol%C3%A5-u-people-and-their-connection-to-%C3%A5-arali
#10
Moana P Tane, Marita Hefler, David P Thomas
ISSUE ADDRESSED: Smoking prevalence estimated between 65% and 84% has been reported among the Yolŋu peoples of East Arnhem Land, Northern Territory. We report on findings of an evaluation of the Yaka Ŋarali' Tackling Indigenous Smoking program in East Arnhem Land. METHODS: Qualitative interviews with Yolŋu (N = 23) and non-Yolŋu (N = 7) informants were conducted in seven communities between June 2014 and September 2015, with the support of Cultural Mentors, in homeland communities throughout East Arnhem Land...
April 2018: Health Promotion Journal of Australia
https://www.readbyqxmd.com/read/29696224/barriers-to-non-small-cell-lung-cancer-trial-eligibility
#11
Jeffrey J Hardesty, Norma F Kanarek
Introduction: Cancer clinical trial (CCT) enrollment is low potentially threatening the generalizability of trial results and expedited regulatory approvals. We assessed whether type of initial patient appointment for non-small cell lung cancer (NSCLC) is associated with CCT eligibility. Methods: Using a patient-to-accrual framework, we conducted a quasi-retrospective cohort pilot study at Sidney Kimmel Comprehensive Cancer Center (SKCCC), Baltimore, Maryland. 153 NSCLC patients new to SKCCC were categorized based on type of initial appointment: patients diagnosed or treated and patients seen for a consultation...
March 2018: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29694284/publicly-funded-oral-chronic-hepatitis-b-treatment-patterns-in-ontario-over-16-years-an-ecologic-study
#12
Mina Tadrous, Mayur Brahmania, Diana Martins, Sandra Knowles, Harry L A Janssen, Muhammad M Mamdani, David N Juurlink, Tara Gomes
BACKGROUND: Reimbursement for the use of hepatitis B virus (HBV) treatments has not been previously reported for public payers. OBJECTIVE: To describe the number of users and total cost of HBV treatments over the last 16 years among residents of Ontario, Canada, who were covered by the public drug program. METHODS: We conducted a repeated cross-sectional study for HBV treatments reimbursed by the public drug program in Ontario from January 1, 2000, to December 31, 2015...
May 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29685512/causes-and-outcomes-of-finger-ischemia-in-hospitalized-patients-in-the-intensive-care-unit
#13
Gregory J Landry, Courtney J Mostul, Daniel S Ahn, Bryant J McLafferty, Timothy K Liem, Erica L Mitchell, Enjae Jung, Cherrie Z Abraham, Amir F Azarbal, Robert B McLafferty, Gregory L Moneta
OBJECTIVE: Vascular surgeons may be consulted to evaluate hospitalized patients with finger ischemia. We sought to characterize causes and outcomes of finger ischemia in intensive care unit (ICU) patients. METHODS: All ICU patients who underwent evaluation for finger ischemia from 2008 to 2015 were reviewed. All were evaluated with finger photoplethysmography. The patients' demographics, comorbidities, ICU care (ventilator status, arterial lines, use of vasoactive medications), finger amputations, and survival were also recorded...
April 20, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29676072/current-management-of-moderate-to-severe-atopic-dermatitis-a-survey-of-allergists-pediatric-allergists-and-dermatologists-in-korea
#14
Hye Yung Yum, Hyun Hee Kim, Hyun Jung Kim, Woo Kyung Kim, So Yeon Lee, Kapsok Li, Dong Hun Lee
PURPOSE: There is an unmet need for the treatment of moderate-to-severe atopic dermatitis (AD), leading to variation in management strategies. To investigate distinct features and treatment modalities according to physicians' specialties, we collected data on the current treatment approach to moderate-to-severe AD among allergists, pediatric allergists and dermatologists in Korea. METHODS: This questionnaire-based study was administered to physicians from the Korean Academy of Asthma, Allergy and Clinical Immunology (KAAACI), Korean Academy of Pediatric Allergy and Respiratory Disease (KAPARD), and Korean Atopic Dermatitis Association (KADA)...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29664945/accuracy-reliability-and-timing-of-visual-evaluations-of-decay-in-fresh-cut-lettuce
#15
Ivan Simko, Ryan J Hayes
Visual assessments are used for evaluating the quality of food products, such as fresh-cut lettuce packaged in bags with modified atmosphere. We have compared the accuracy and the reliability of visual evaluations of decay on fresh-cut lettuce performed with experienced and inexperienced raters. In addition, we have analyzed decay data from over 4.5 thousand bags to determine the optimum timing for evaluations to detect differences among accessions. Lin's concordance coefficient (ρc) that takes into consideration both the closeness of the data and the conformance to the identity line showed high repeatability (intra-rater reliability, ρc = 0...
2018: PloS One
https://www.readbyqxmd.com/read/29658306/-how-do-they-want-to-know-doctors-perspectives-on-making-and-communicating-a-diagnosis-of-dementia
#16
Cate Bailey, Jemima Dooley, Rose McCabe
Recent drives to facilitate earlier identification of dementia have led to increased memory clinic referrals and diagnoses. This study explored the perspectives of memory clinic doctors on making and delivering diagnoses. Four focus groups were conducted with 13 psychiatrists and two geriatricians in the UK. Transcripts were coded line by line using NVIVO. Thematic analysis identified 39 categories, 18 sub-themes and eight overarching themes. Inter-rater reliability on 31% of the data was 0.89. Increased public awareness of dementia was viewed positively in facilitating access to diagnosis and treatment...
January 1, 2018: Dementia
https://www.readbyqxmd.com/read/29656745/severe-adverse-events-impact-overall-survival-and-costs-in-elderly-patients-with-advanced-non-small-cell-lung-cancer-on-second-line-therapy
#17
Hossein Borghaei, Yeun Mi Yim, Annie Guerin, Irina Pivneva, Sherry Shi, Mayank Gandhi, Raluca Ionescu-Ittu
OBJECTIVES: Elderly patients with advanced non-small lung cancer (aNSCLC) represent a high-risk patient population due to disease burden, comorbidities, and performance status, particularly after progressing on first-line therapy. Among elderly patients who receive second-line therapy, treatment related toxicities can have substantial impact on both clinical and economic outcomes. This study assessed the impact of severe adverse events (AEs) during second-line therapy on overall survival (OS) and all-cause heathcare costs in elderly with aNSCLC...
May 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29650198/analysis-on-the-implementation-of-a-health-improvement-project-garbage-clinical-insurance-in-indonesia-a-literature-review
#18
Efa Apriyanti
OBJECTIVE: Indonesia Medika has established "Garbage Clinical Insurance" (GCI), which enables the population below the poverty line (BPL) to obtain health insurance by donating their garbage to pay the premium. The objective of this paper was to critically examine the implementation of GCI in Indonesia by reviewing the background, effects, and sustainability of this program. METHOD: A literature search of studies related to GCI, other types of micro health insurance, and their applications in developing countries was conducted...
February 2018: Enfermería Clínica
https://www.readbyqxmd.com/read/29626833/enablers-to-seeking-professional-help-for-psychological-distress-a-study-on-chinese-primary-care-attenders
#19
Kai Sing Sun, Tai Pong Lam, Kwok Fai Lam, Tak Lam Lo, David Vai Kiong Chao, Edmund Wing Wo Lam
This study investigated enablers to seeking professional help for psychological distress among Chinese primary care attenders in Hong Kong. Nine focus groups and six individual interviews were conducted among adult patients with/without known distress, significant others of the distressed, and the general public. The identified potential enablers were further investigated in a questionnaire survey with data from 1626 patients. Survey respondents who had sought professional help for distress (n = 231) and those without this experience (n = 1395) showed similar attitudes to the enabler items...
March 24, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29626702/risk-factors-associated-with-dehydration-in-older-people-living-in-nursing-homes-scoping-review
#20
REVIEW
Olga Masot, Ana Lavedán, Carmen Nuin, Miguel A Escobar-Bravo, Jèssica Miranda, Teresa Botigué
BACKGROUND: Dehydration in the older people is a prevalent problem that is often associated with physiological changes, physical limitations and environmental conditions. OBJECTIVES: The scoping review was carried out to identify risk factors associated with dehydration in older people living in nursing homes. DESIGN: The revised scoping methodology framework of Arksey and O'Malley (2005) was applied. Study selection was carried out in accordance with Davis et al...
March 27, 2018: International Journal of Nursing Studies
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