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Joachim Alexandre, Xavier Humbert, Marion Sassier, Paul Milliez, Antoine Coquerel, Sophie Fedrizzi
Cluster headache (CH) is a primary headache disorder with relatively effective treatments. Although few sufficiently controlled trials are available, verapamil is recommended as the first-line prophylactic drug for CH by the French Headache Society (with a low level of evidence, level B) and by the EFNS (European Federation of Neurological Societies, level A). Daily doses of more than 480 mg (and up to 1200 mg daily) are frequently used off-label, while 360 mg daily is the only dosage to have demonstrated its effectiveness in a double-blind trial against placebo, and the usual label posology used by cardiologists is 240 mg daily in hypertension...
December 2015: Drug Saf Case Rep
Steven Black
SCOTLAND'S first three consultantnurses are to be in public health, midwifery and services for olderpeople. Two will be based in the Greater Glasgow Health Boardarea, the third in Forth Valley.
February 16, 2000: Nursing Standard
A Vahl, B Elsman, A van Enst
- Revision of the 2005 guideline 'Diagnostics and treatment of lower extremity peripheral arterial disease' and the development of an audit have instigated a degree of efficiency and transparency for the treatment of patients with peripheral arterial disease (PAD). - The key recommendations are that first-line treatment of patients, who - preferably by means of a consultation in a vascular laboratory - are diagnosed with intermittent claudication, is supervised exercise therapy and secondary prevention. Referral for second-line treatment only needs to occur when invasive therapy is considered, for example when there is insufficient improvement in symptoms or in patients who have or are developing critical ischemia...
2016: Nederlands Tijdschrift Voor Geneeskunde
Lene Hammer-Helmich, Allan Linneberg, Simon Francis Thomsen, Line Tang, Charlotte Glümer
BACKGROUND: Atopic diseases, for example, eczema, asthma, and hay fever, are among the most common chronic diseases of childhood. Knowledge on health service use among children with atopic disease is limited. This study aimed to investigate the total use and costs of health services for children with and without eczema, asthma, and hay fever in a Danish general population. METHODS: We conducted a health survey with four complete birth cohorts from the City of Copenhagen...
2016: Clinical Epidemiology
(no author information available yet)
The Green Paper announced in the House of Commons last week includes ambitious targets to reduce the number of deaths from preventable diseases and promote good health, bringing England into line with the World Health Organization's target of 'Health for All by the year 2000'. It is open for consultation until October, when a White Paper will be drawn up.
June 12, 1991: Nursing Standard
Carol S Wood, Christopher P Weis, Carla M Caro, Amy Roe
In 2015, the American Board of Toxicology (ABT), with collaboration from the Society of Toxicology (SOT), in consultation with Professional Examination Service, performed a practice analysis study of the knowledge required for general toxicology. The purpose of this study is to help assure that the examination and requirements for attainment of Diplomate status are relevant to modern toxicology and based upon an empirical foundation of knowledge. A profile of the domains and tasks used in toxicology practice was developed by subject-matter experts representing a broad range of experiences and perspectives...
September 16, 2016: Regulatory Toxicology and Pharmacology: RTP
Alexandra Gauthier-Vasserot, Christel Thauvin-Robinet, Ange-Line Bruel, Yannis Duffourd, Judith St-Onge, Thibaud Jouan, Jean-Baptiste Rivière, Delphine Heron, Jean Donadieu, Christine Bellanné-Chantelot, Claire Briandet, Frédéric Huet, Paul Kuentz, Daphné Lehalle, Laurence Duplomb-Jego, Elodie Gautier, Isabelle Maystadt, Lucile Pinson, Daniel Amram, Salima El Chehadeh, Judith Melki, Sophia Julia, Laurence Faivre, Julien Thevenon
Neutropenia can be qualified as congenital when of neonatal onset or when associated with extra-hematopoietic manifestations. Overall, 30% of patients with congenital neutropenia (CN) remain without a molecular diagnosis after a multidisciplinary consultation and tedious diagnostic strategy. In the rare situations when neutropenia is identified and associated with intellectual disability (ID), there are few diagnostic hypotheses to test. This retrospective multicenter study reports on a clinically heterogeneous cohort of 10 unrelated patients with CN associated with ID and no molecular diagnosis prior to whole-exome sequencing (WES)...
September 12, 2016: American Journal of Medical Genetics. Part A
Peter M Mota, Jonathan H Norris
We assess current practice using topical phenylephrine by British Oculoplastic Surgery Society (BOPSS) consultants in the surgical management of ptosis. All UK consultant BOPSS members were invited to participate in a web-based survey, consisting of 8 questions relating to the surgical management of adult primary involutional ptosis with normal levator function and the use of phenylephrine in the management of ptosis. 53 BOPSS consultants (43%) completed the survey, of which 76% perform anterior approach levator advancement as first-line surgery...
September 6, 2016: Orbit
Aurélie Henry, Marie-Julie Nokin, Natacha Leroi, François Lallemand, Jérémy Lambert, Nicolas Goffart, Patrick Roncarati, Elettra Bianchi, Paul Peixoto, Arnaud Blomme, Andrei Turtoi, Olivier Peulen, Yvette Habraken, Félix Scholtes, Philippe Martinive, Philippe Delvenne, Bernard Rogister, Vincent Castronovo, Akeila Bellahcène
Glioblastoma (GBM) represents the most aggressive and common solid human brain tumor. We have recently demonstrated the importance of osteopontin (OPN) in the acquisition/maintenance of stemness characters and tumorigenicity of glioma initiating cells. Consultation of publicly available TCGA database indicated that high OPN expression correlated with poor survival in GBM patients. In this study, we explored the role of OPN in GBM radioresistance using an OPN-depletion strategy in U87-MG, U87-MG vIII and U251-MG human GBM cell lines...
August 22, 2016: Oncotarget
Aleena M Wojcieszek, Hanna E Reinebrant, Susannah Hopkins Leisher, Emma Allanson, Michael Coory, Jan Jaap Erwich, J Frederik Frøen, Jason Gardosi, Sanne Gordijn, Metin Gulmezoglu, Alexander E P Heazell, Fleurisca J Korteweg, Elizabeth McClure, Robert Pattinson, Robert M Silver, Gordon Smith, Zheyi Teoh, Özge Tunçalp, Vicki Flenady
BACKGROUND: Despite the global burden of perinatal deaths, there is currently no single, globally-acceptable classification system for perinatal deaths. Instead, multiple, disparate systems are in use world-wide. This inconsistency hinders accurate estimates of causes of death and impedes effective prevention strategies. The World Health Organisation (WHO) is developing a globally-acceptable classification approach for perinatal deaths. To inform this work, we sought to establish a consensus on the important characteristics of such a system...
2016: BMC Pregnancy and Childbirth
Maria Xiridou, Anna Lugnér, Henry J C de Vries, Jan E A M van Bergen, Hannelore M Götz, Birgit H B van Benthem, Jacco Wallinga, Marianne A B van der Sande
BACKGROUND: In response to the rising threat of resistance to first-line antibiotics for gonorrhea, international guidelines recommend dual antimicrobial therapy. However, some countries continue to recommend monotherapy. We assess the cost-effectiveness of dual therapy with ceftriaxone and azithromycin compared with monotherapy with ceftriaxone, for control of gonorrhea among men who have sex with men in the Netherlands. METHODS: We developed a transmission model and calculated the numbers of new gonorrhea infections, consultations at health care specialists, tests, and antibiotic doses...
September 2016: Sexually Transmitted Diseases
Brenda Mori, Kathleen E Norman, Dina Brooks, Jodi Herold, Dorcas E Beaton
PURPOSE: To investigate face and content validity of a draft measure to be used across Canada to assess physiotherapy students' performance in clinical education, through broad consultation with physiotherapy clinical instructors (CIs) across Canada. METHODS: An online survey was used to collect input on the draft measure. In addition to demographics, the questionnaire included questions on the preferred rating scale, the items within the measure that should have their own rating scale, and general impressions...
2016: Physiotherapy Canada. Physiothérapie Canada
Rosemary Wyber, Ben J Boyd, Samantha Colquhoun, Bart J Currie, Mark Engel, Joseph Kado, Ganesan Karthikeyan, Mark Sullivan, Anita Saxena, Meru Sheel, Andrew Steer, Joseph Mucumbitsi, Liesl Zühlke, Jonathan Carapetis
Rheumatic fever is caused by an abnormal immune reaction to group A streptococcal infection. Secondary prophylaxis with antibiotics is recommended for people after their initial episode of rheumatic fever to prevent recurrent group A streptococcal infections, recurrences of rheumatic fever and progression to rheumatic heart disease. This secondary prophylaxis must be maintained for at least a decade after the last episode of rheumatic fever. Benzathine penicillin G is the first line antibiotic for secondary prophylaxis, delivered intramuscularly every 2 to 4 weeks...
October 2016: Drug Delivery and Translational Research
Masayuki Takahashi, Masaru Arima, Yohei Iwata, Kayoko Suzuki, Yoshikazu Mizoguchi, Makoto Kuroda, Kayoko Matsunaga
A 72-year-old male visited a nearby hospital with a large tumor in his occipital region, which had existed since 20 years. Since malignant tumor was suspected, he was referred to our department. At the initial consultation, an elastic-hard, yellow-brown, sessile tumor, measuring 8 × 7 × 5 cm and with a flat surface, was observed in the occipital region. The tumor was resected and covered with artificial dermis. Histopathologically, the lesion was composed of basal-cell-like cells with nest formation in the dermis...
May 2016: Case Reports in Dermatology
Iracema Mp Calderon
OBJECTIVE: This review aims to develop a critical and current analysis of the basic structure of a Postgraduate program for proposing improvement actions and new evaluation criteria. METHOD: To examine the items that are areas of concentration (AC), research lines (LP), research projects (PP), curricular structure and fundraising were consulted the Area Document, the 2013 Evaluation Report and the Assessment Sheets of Medicine III programs, evaluated in the 2010-2012 period...
2015: Revista do Colégio Brasileiro de Cirurgiões
Mark W Ball, Ashok K Hemal, Mohamad E Allaf
OBJECTIVE: To provide an evidence-based systematic review of the use of laparoscopic and robotic adrenalectomy in the treatment of adrenal disease as part of the International Consultation on Urologic Diseases and European Association of Urology consultation on Minimally Invasive Surgery in Urology. METHODS: A systematic literature search (January 204-January 2014) was conducted to identify comparative studies assessing the safety and efficacy of minimally invasive adrenal surgery...
July 19, 2016: BJU International
Nadine Kacenelenbogen, Michèle Dramaix-Wilmet, M Schetgen, M Roland, Isabelle Godin
BACKGROUND: In Western countries, about a quarter of children are affected by parental separation and a number of authors have previously investigated how familial structure impacts children's health. The purpose of the work: to analyze the psychomotor development of children aged 28 to 32 months based on family structure (parents together or separated), independently of the influence of socio-economic environment that is well documented. To analyse the psychomotor development of children younger than 3 years based on family structure (parents together or separated) independently of the influence of socio-economic environment that is well documented...
2016: BMC Pediatrics
Julie A Kreyenbuhl, Deborah R Medoff, Joseph P McEvoy, Thomas E Smith, Ann L Hackman, Ilana R Nossel, Lisa B Dixon, Susan M Essock, Robert W Buchanan
OBJECTIVE: This study examined the adherence of psychiatrists to the Schedule of Recommended First and Second Line Antipsychotic Medications ("Antipsychotic Schedule"), which was implemented in two Recovery After an Initial Schizophrenia Episode (RAISE) Connection Program Implementation and Evaluation Study clinics. METHODS: Sixty-five individuals with a first episode of psychosis were enrolled in the RAISE Connection Program clinics. Two psychiatrists received training and ongoing consultation on use of a shared decision-making approach to prescribing antipsychotic medications according to the Antipsychotic Schedule...
July 1, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
Patricia A Parker, Smita C Banerjee, Matthew J Matasar, Carma L Bylund, Kara Franco, Yuelin Li, Tomer T Levin, Paul B Jacobsen, Alan B Astrow, Howard Leventhal, Steven Horwitz, David W Kissane
INTRODUCTION: Survivors of cancer often describe a sense of abandonment post-treatment, with heightened worry, uncertainty, fear of recurrence and limited understanding of what lies ahead. This study examines the efficacy of a communication skills training (CST) intervention to help physicians address survivorship issues and introduce a new consultation focused on the use of a survivorship care plan for patients with Hodgkin's lymphoma and diffuse large B-cell lymphoma. METHODS AND ANALYSIS: Specifically, this randomised, 4-site trial will test the efficacy of a survivorship planning consultation (physicians receive CST and apply these skills in a new survivorship-focused office visit using a survivorship plan) with patients who have achieved complete remission after completion of first-line therapy versus a control arm in which physicians are trained to subsequently provide a time-controlled, manualised wellness rehabilitation consultation focused only on discussion of healthy nutrition and exercise as rehabilitation postchemotherapy...
2016: BMJ Open
W Szczesny, I Vistad, J Kaern, J Nakling, C Tropé, T Paulsen
The purpose of this study was to investigate the impact of hospital type determined at primary treatment and find possible predictors of survival in a cohort of patients with advanced epithelial ovarian cancer (EOC) who recurred twice and received three lines of treatment during eight-year follow-up. Using the Norwegian Cancer Registry, the authors identified 174 women with FIGO Stage IIIC EOC diagnosed in 2002. First-line treatment consisted of up-front debulking surgery and chemotherapy, received in either a teaching hospital (TH, n = 84) or a non-teaching hospital (NTH, n = 90)...
2016: European Journal of Gynaecological Oncology
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