keyword
MENU ▼
Read by QxMD icon Read
search

Precision 2.0

keyword
https://www.readbyqxmd.com/read/28453861/functional-lung-avoidance-and-response-adaptive-escalation-flare-rt-multimodality-plan-dosimetry-of-a-precision-radiation-oncology-strategy
#1
Eunsin Lee, Jing Zeng, Robert S Miyaoka, Jatinder Saini, Paul E Kinahan, George A Sandison, Tony Wong, Hubert J Vesselle, Ramesh Rengan, Stephen R Bowen
PURPOSE: Non-small cell lung cancer (NSCLC) patient radiation therapy (RT) is planned without consideration of spatial heterogeneity in lung function or tumor response. We assessed the dosimetric and clinical feasibility of functional lung avoidance and response-adaptive escalation (FLARE) RT to reduce dose to [(99m) Tc]MAA-SPECT/CT perfused lung while redistributing an escalated boost dose within [(18) F]FDG-PET/CT-defined biological target volumes (BTV). METHODS: Eight stage IIB-IIIB NSCLC patients underwent FDG-PET/CT and MAA-SPECT/CT treatment planning scans...
April 28, 2017: Medical Physics
https://www.readbyqxmd.com/read/28448765/digital-assays-part-i-partitioning-statistics-and-digital-pcr
#2
Amar S Basu
A digital assay is one in which the sample is partitioned into many small containers such that each partition contains a discrete number of biological entities (0, 1, 2, 3, …). A powerful technique in the biologist's toolkit, digital assays bring a new level of precision in quantifying nucleic acids, measuring proteins and their enzymatic activity, and probing single-cell genotypes and phenotypes. Part I of this review begins with the benefits and Poisson statistics of partitioning, including sources of error...
April 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/28448305/possible-risk-factors-of-pulmonary-metastases-in-patients-with-international-federation-of-gynecology-and-obstetrics-stage-i-endometrioid-type-endometrial-cancer
#3
Wei Jiang, Jun Chen, Xiang Tao, Feifei Huang, Menghan Zhu, Chao Wang, Weiwei Feng
OBJECTIVE: Limited data have been obtained in regard to pulmonary metastasis (PM) in patients with stage I endometrial cancer. The aims of the study were (1) to present the clinical and pathological characteristics of patients with PM in the setting of stage I endometrioid-type endometrial cancer (EEC) and (2) to define possible factors that may be used to predict PM. METHODS: Six hundred thirty patients with stage I EEC, including 12 with PM, 19 with extra-PM (EPM), and 599 with no recurrence, were observed...
April 26, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28447447/nuclear-targeting-gold-nanorods-for-extremely-low-nir-activated-photothermal-therapy
#4
Limin Pan, Jianan Liu, Jianlin Shi
Photo-related nanomedicine is of particular interest as an emerging paradigm toward precise cancer therapy, as demonstrated by the recent developments of photothermal therapy (PTT), an emerging technique employing light converting agents to burn cancerous cells by over-dosed optical energy-converted heat. However, most of the laser irradiations needed for effective PTT significantly exceed the maximal permissible power density in human skin, which is likely to damage surrounding normal tissues. Herein, we report a strategy of intranuclear PTT of cancer enabled by nuclear-targeted delivery of gold nanorods of ~ 10...
April 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28446525/effectiveness-of-befriending-interventions-a-systematic-review-and-meta-analysis
#5
Joyce Siette, Megan Cassidy, Stefan Priebe
OBJECTIVE: Befriending is an emotional supportive relationship in which one-to-one companionship is provided on a regular basis by a volunteer. It is commonly and increasingly offered by the voluntary sector for individuals with distressing physical and mental conditions. However, the effectiveness of this intervention on health outcomes is largely unknown. We aim to conduct a systematic review of the benefits of befriending. DESIGN: Systematic review. METHODS: A systematic search of electronic databases was conducted to identify randomised controlled trials and quasi-experimental trials of befriending for a range of physical and mental health indications including depression, anxiety, mental illness, cancer, physical illness and dementia...
April 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/28446332/dna-polymerase-inhibition-by-high-kinetic-stability-of-t-hg-ii-t-base-pairs
#6
Olivia P Schmidt
A fluorescent surrogate of thymidine called DMAT was used for the first fluorescence-based study of HgII binding to discrete T-T sites in duplex DNA. The fluorescent properties of DMAT-A base pairs were highly sensitive to wild-type T-HgII-T base pair formation at an adjacent site, allowing for a determination of the precise thermodynamic and kinetic parameters of these metal binding reactions. T-HgII-T complexes exhibited equilibrium dissociation constants of Kd ≈ 8-50 nM. These high-affinity binding interactions are characterized by very slow association and dissociation kinetics (kon ≈ 104- 105 M-1s-1, koff ≈ 10-4 - 10-3s-1), revealing exceptionally high kinetic stabilities of T-HgII-T base pairs (half-lives = 0...
April 26, 2017: Chimia
https://www.readbyqxmd.com/read/28445849/a-reference-measurement-procedure-for-amino-acids-in-blood-using-isotope-dilution-ultra-performance-liquid-chromatography-tandem-mass-spectrometry
#7
Juok Kim, Tran Thi Thanh Huong, Seon-Pyo Hong, Ji-Seon Jeong
We described a reference measurement procedure for amino acid (AA) quantification in blood samples based on deproteinization with 5-sulfosalicylic acid (SSA) and an isotope dilution-ultra performance liquid chromatography-tandem mass spectrometry (LC-MS) method. The serum was deproteinized with 15% v/v SSA and the supernatant was injected directly into the LC-MS system without further processing. Compared with the use of other precipitants and water as a control, five model AAs-valine, isoleucine, leucine, tyrosine, and phenylalanine-in the SSA-treated samples showed ionization enhancement as well as stable background signals without significant ion suppression effects...
April 17, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28445815/lc-ms-ms-determination-of-tranexamic-acid-in-human-plasma-after-phospholipid-clean-up
#8
Nicolas Fabresse, Fanta Fall, Isabelle Etting, Philippe Devillier, Jean-Claude Alvarez, Stanislas Grassin-Delyle
Tranexamic acid is a widely used antifibrinolytic drug but its pharmacology and pharmacokinetics remains poorly understood. Owing to the recent knowledge on phospholipid-induced matrix effects during human plasma analysis, our aim was to develop a liquid chromatography-mass spectrometry method for the quantitation of tranexamic acid after efficient sample clean-up. Sample preparation consisted in phospholipid removal and protein precipitation. Hydrophilic interaction liquid chromatography was used and the detection was achieved with multiple reaction monitoring...
April 19, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28445409/quantification-of-a-novel-photosensitizer-of-chlorin-e6-c15-monomethyl-ester-in-beagle-dog-plasma-using-hplc-application-to-pharmacokinetic-studies
#9
Xiuxiu Li, Jun Wen, Jingjing Jiang, Xin Zhao, Tingting Zhou, Guorong Fan
Chlorin e6-C15-monomethyl ester (CMME) is a novel photosensitizer, which is synthetized from the degradation products of silkworm excrement. Preclinical studies on the promising photosensitizer CMME are necessary to determine its therapeutic efficacy and druglikeness. A high-performance liquid chromatography with UV detection (HPLC-UV) method was established for the determination of CMME in beagle dog plasma. The sample preparation involved a protein-precipitation method with acetonitrile after the addition of tanshinone IIA as an internal standard (IS)...
April 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28444375/evaluation-of-the-alpha-amylase-activity-as-an-indicator-of-pasteurization-efficiency-and-microbiological-quality-of-liquid-whole-eggs
#10
Guilherme Resende da Silva, Liliane Denize Miranda Menezes, Isabela Pereira Lanza, Daniela Duarte de Oliveira, Carla Aparecida Silva, Roger Wilker Tavares Klein, Débora Cristina Sampaio de Assis, Silvana de Vasconcelos Cançado
In order to evaluate the efficiency of the pasteurization process in liquid whole eggs, an UV/visible spectrophotometric method was developed and validated for the assessment of alpha-amylase activity. Samples were collected from 30 lots of raw eggs (n = 30) and divided into three groups: one was reserved for analysis of the raw eggs, the second group was pasteurized at 61.1°C for 3.5 minutes (n = 30), and the third group was pasteurized at 64.4°C for 2.5 minutes (n = 30). In addition to assessing alpha-amylase activity, the microbiological quality of the samples was also evaluated by counting total and thermotolerant coliforms, mesophilic aerobic microorganisms, Staphylococcus spp...
April 24, 2017: Poultry Science
https://www.readbyqxmd.com/read/28444179/a-novel-method-for-superimposition-and-measurements-on-maxillary-digital-3d-models-studies-on-validity-and-reliability
#11
Niels Ganzer, Ingalill Feldmann, Per Liv, Lars Bondemark
Background: Serial 3D models can be used to analyze changes, but correct superimposition is crucial before measurements can be assessed. Earlier studies show that every palatal structure changes due to growth or treatment. Here, we describe a new method that uses an algorithm-based analysis to perform superimpositions and measurements in maxillary 3D models. This method can be used to identify deformations. In a second step, only unchanged areas are used for superimposition. Objectives: This study investigates the validity and reliability of this novel method...
April 22, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28443889/the-passivating-effect-of-cadmium-in-pbs-cds-colloidal-quantum-dots-probed-by-nm-scale-depth-profiling
#12
Pip C J Clark, Hanna Radtke, Atip Pengpad, Andrew I Williamson, Ben F Spencer, Samantha J O Hardman, Marina A Leontiadou, Darren C J Neo, Simon M Fairclough, Andrew A R Watt, Igor Pis, Silvia Nappini, Federica Bondino, Elena Magnano, Karsten Handrup, Karina Schulte, Mathieu G Silly, Fausto Sirotti, Wendy R Flavell
Achieving control of the surface chemistry of colloidal quantum dots (CQDs) is essential to fully exploit their properties in solar cells, but direct measurement of the chemistry and electronic structure in the outermost atomic layers is challenging. Here we probe the surface oxidation and passivation of cation-exchanged PbS/CdS core/shell CQDs with sub nm-scale precision using synchrotron-radiation-excited depth-profiling photoemission. We investigate the surface composition of the topmost 1-2.5 nm of the CQDs as a function of depth, for CQDs of varying CdS shell thickness, and examine how the surface changes after prolonged air exposure...
April 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/28443538/iohexol-clearance-for-determination-of-glomerular-filtration-rate-in-cynomolgus-monkeys-macaca-fascicularis
#13
Changqing Zhang, Shanshan Ding, Yupeng Fang, Li Zhang, Weimin Hu, Jinlian Lu, Tao Jing, Yi Tao, Xin Zhang
The purpose of this study was to validate a method for determine the glomerular filtration rate (GFR) in healthy cynomolgus monkeys by using iohexol. Eighteen healthy cynomolgus macaque monkeys (age, 4 to 6 y [mean, 5 y]; weight, 2 to 6 kg [mean, 4 kg]) were randomly entered into 3 different doses groups (3 male and 3 female macaques per group) of 30, 60, 90 mg I/kg to receive an intravenous bolus injection of iohexol. Serum iohexol concentrations were determined by using liquid chromatography-tandem mass spectrometry, and clearance rate were determined by using WinNonlin software...
April 25, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28442787/the-upper-limit-of-the-in-plane-spin-splitting-of-gaussian-beam-reflected-from-a-glass-air-interface
#14
Wenguo Zhu, Jianhui Yu, Heyuan Guan, Huihui Lu, Jieyuan Tang, Jun Zhang, Yunhan Luo, Zhe Chen
Optical spin splitting has a promising prospect in quantum information and precision metrology. Since it is typically small, many efforts have been devoted to its enhancement. However, the upper limit of optical spin splitting remains uninvestigated. Here, we investigate systematically the in-plane spin splitting of a Gaussian beam reflected from a glass-air interface and find that the spin splitting can be enhanced in three different incident angular ranges: around the Brewster angle, slightly smaller than and larger than the critical angle for total reflection...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28442071/observational-practice-of-incentive-spirometry-in-stroke-patients
#15
Íllia N D F Lima, Guilherme A F Fregonezi, Rêncio B Florêncio, Tânia F Campos, Gardênia H Ferreira
BACKGROUND: Stroke may lead to several health problems, but positive effects can be promoted by learning to perform physical therapy techniques correctly. OBJECTIVE: To compare two different types of observational practice (video instructions and demonstration by a physical therapist) during the use of incentive spirometry (IS). METHOD: A total of 20 patients with diagnosis of stroke and 20 healthy individuals (56±9.7 years) were allocated into two groups: one with observational practice with video instructions for the use of IS and the other with observational practice with demonstration by a physical therapist...
January 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28441929/endothelial-progenitor-cells-and-plaque-burden-in-stented-coronary-artery-segments-an-optical-coherence-tomography-study-six-months-after-elective-pci
#16
Sylvia Otto, Kristina Nitsche, Christian Jung, Aleh Kryvanos, Andrey Zhylka, Kerstin Heitkamp, Juan-Luis Gutiérrez-Chico, Björn Goebel, P Christian Schulze, Hans R Figulla, Tudor C Poerner
BACKGROUND: Endothelial progenitor cells (EPC) are involved in neovascularization and endothelial integrity. They might be protective in atherosclerosis. Optical coherence tomography (OCT) is a precise intracoronary imaging modality that allows assessment of subintimal plaque development. We evaluated the influence of EPC on coronary plaque burden in stable disease and implemented a novel computational plaque analysis algorithm using OCT. METHODS: Forty-three patients (69...
April 26, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28441537/determination-of-dihydralazine-based-on-chemiluminescence-resonance-energy-transfer-of-hollow-carbon-nanodots
#17
Suqin Han, Zheyan Fan, Xiaoxia Chen, Yunfang Wu, Jianbo Wang
The famous weak chemiluminescence (CL) system of potassium permanganate and sodium bisulfite (KMnO4-HSO3(-)) was enhanced by the hollow fluorescent carbon nanodots (HCNs). The investigation of mechanism revealed that the enhanced CL was induced by the excited-state HCNs (HCNs(⁎)), which could be produced from the electron-transfer annihilation of positively charged HCNs (HCNs(+)) and negatively charged HCNs (HCNs(-)) as well as by CL resonance energy transfer (CRET) from excited SO2 (SO2(⁎))/(1)O2 to HCNs...
April 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28441352/high-throughput-determination-of-sodium-danshensu-in-beagle-dogs-by-the-lcms-ms-method-employing-liquid-liquid-extraction-based-on-96-well-format-plates
#18
Jingjing Jiang, Xin Zhao, Xiuxiu Li, Shengyuan Wu, Shidan Yu, Yuefen Lou, Guorong Fan
Sodium Danshensu (sodium d-(+)-β-(3,4-dihydroxyphenyl) lactate), one of the water-soluble ingredients in Salvia miltiorrhiza, exhibits potent relaxation of the coronary artery and anticoagulation effection. A high-throughput, rapid, and sensitive method combining liquid chromatography with electrospray ionization tandem mass spectrometry to determine the sodium danshensu in beagle dog plasma was developed and validated, using gallic acid as an internal standard (IS). Acidified plasma samples were extracted using 96-well liquid-liquid extraction, and were eluted on a CNW Athena C18 column (3 μm, 2...
April 25, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28440630/a-hydrolytically-stable-luminescent-cationic-metal-organic-framework-for-highly-sensitive-and-selective-sensing-of-chromate-anion-in-natural-water-systems
#19
Wei Liu, Yanlong Wang, Zhuanling Bai, Yuxiang Li, Yaxing Wang, Lanhua Chen, Lin Xu, Juan Diwu, Zhifang Chai, Shuao Wang
The effective detection of chromate anion in aqueous solution is highly desirable due to its high solubility, environmental mobility, carcinogenicity, and bioaccumulation effect. New strategy for precise detection of chromate anion in the presence of large excess of other anions such as Cl-, NO3-, HCO3- in drinking water and natural water systems remains a challenge. Herein, a hydrolytically stable cationic luminescent europium(III) based metal organic framework (MOF) 1 is successfully synthesized and investigated as a luminescent sensor which exhibits instant and selective luminescence quenching property toward CrO42- in aqueous solutions...
April 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28440621/gas-phase-sensing-of-alcohols-by-metal-organic-framework-polymer-composite-materials
#20
Sumit Sachdeva, Sander J H Koper, Anahid Sabetghadam, Dimitri Soccol, Dirk J Gravesteijn, Freek Kapteijn, Ernst J R Sudhölter, Jorge Gascon, Louis C P M de Smet
Affinity layers play a crucial role in chemical sensors for the selective and sensitive detection of analytes. Here, we report the use of composite affinity layers containing Metal Organic Frameworks (MOFs) in a polymeric matrix for sensing purposes. Nanoparticles of NH2-MIL-53(Al) were dispersed in a Matrimid polymer matrix with different weight ratios (0-100 wt %) and drop-casted on planar capacitive transducer devices. These coated devices were electrically analyzed using impedance spectroscopy and investigated for their sensing properties toward the detection of a series of alcohols and water in the gas phase...
April 25, 2017: ACS Applied Materials & Interfaces
keyword
keyword
120931
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"