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Precision 2.0

Sidney C Silva, Walace D Monteiro, Felipe A Cunha, Paulo Farinatti
Silva, SC, Monteiro, WD, Cunha, FA, and Farinatti, P. Influence of different treadmill inclinations on V[Combining Dot Above]O2max and ventilatory thresholds during maximal ramp protocols. J Strength Cond Res XX(X): 000-000, 2018-Ramp protocols for cardiopulmonary exercise testing (CPET) lack precise recommendations, including optimal treadmill inclination. This study investigated the impact of treadmill grades applied in ramp CPETs on maximal oxygen uptake (V[Combining Dot Above]O2max), ventilatory thresholds (VT1/VT2), and V[Combining Dot Above]O2 vs...
June 21, 2018: Journal of Strength and Conditioning Research
Stephani L Stancil, Leon van Haandel, Susan Abdel-Rahman, Robin E Pearce
An ultra-performance liquid-chromatography mass-spectrometry (UPLC-MS/MS) method for simultaneous quantitation of metronidazole and 2-hydroxymetronidazole in human plasma was developed and validated. Metronidazole and 2-hydroxymetronidazole were extracted from a small volume of human plasma (10 μL) by hydrophilic lipophilic balanced solid phase extraction on 96-well μ-elution plates. Chromatographic separation of analytes was achieved on an Acquity UPLC BEH C18 column (1.7 μm, 2.1 × 100 mm) using gradient elution with a blend of 0...
June 14, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Noha N Atia, Marwa F B Ali
A rapid, highly sensitive and roubst spectrofluorimetric method was developed for trace analysis of silymarin (SLM) in active pharmaceutical ingredient (API), pharmaceutical preparations and human plasma. The proposed method is based on reaction of SLM with a novel reagent; 3-amino-5-pyridin-3-yl-1,2,4-triazole (3-APT); in the presence of 0.04 M sodium hydroxide. The formed fluorescent product was formed within 5 min and was measured at 504 nm after excitation at 390 nm. All reaction parameters were optimized and the proposed method was validated according to ICH guidelines...
June 12, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Adrien Lons, Florian Boureau, Elodie Drumez, Gilles Pasquier, Sophie Putman
INTRODUCTION: Arthroscopic meniscectomy and medial meniscal repair are frequent procedures, liable to be complicated by iatrogenic cartilage lesions, especially in tight knee. Medial collateral ligament pie-crusting was developed to counter this, but, although the technique is employed, its impact on medial laxity has not been precisely determined. We therefore conducted a prospective observational study to compare radiographic laxity preoperatively versus 6 weeks following pie-crusting...
June 19, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Kohsuke Mori, Taiki Sano, Hisayoshi Kobayashi, Hiromi Yamashita
The hydrogenation of carbon dioxide (CO2 ) to formic acid (FA; HCOOH), a renewable hydrogen storage material, is a promising means of realizing an economical CO2 -mediated hydrogen energy cycle. The development of reliable heter-ogeneous catalysts is an urgent yet challenging task associated with such systems, although precise catalytic site design protocols are still lacking. In the present study, we demonstrate that PdAg alloy nanoparticles (NPs) supported on TiO2 promote the efficient selective hydrogenation of CO2 to give FA even under mild reaction conditions (2...
June 22, 2018: Journal of the American Chemical Society
Melissa J Palmer, Sharmani Barnard, Pablo Perel, Caroline Free
BACKGROUND: Cardiovascular disease (CVD) is a major cause of disability and mortality globally. Premature fatal and non-fatal CVD is considered to be largely preventable through the control of risk factors via lifestyle modifications and preventive medication. Lipid-lowering and antihypertensive drug therapies for primary prevention are cost-effective in reducing CVD morbidity and mortality among high-risk people and are recommended by international guidelines. However, adherence to medication prescribed for the prevention of CVD can be poor...
June 22, 2018: Cochrane Database of Systematic Reviews
Yi Zhou, Rui Zhang, Shixin Wang, Futao Wang
With the advent of high spatial resolution remote sensing imagery, numerous image features can be utilized. Applying a reasonable feature selection approach is critical to effectively reduce feature redundancy and improve the efficiency and accuracy of classification. This paper proposes a novel feature selection approach, in which ReliefF, genetic algorithm, and support vector machine (RFGASVM) are integrated to extract buildings. We adopt the ReliefF algorithm to preliminary filter high-dimensional features in the feature database...
June 22, 2018: Sensors
Eu Gene Chin, Erin M Buchanan, Chad Ebesutani, John Young
The 21-item Depression, Anxiety, and Stress Scales (DASS-21) is a self-report measure that is easy to administer, quick to score, and is freely available. Widely used in diverse settings and populations, confirmatory factor analytic evidence has accumulated for a bifactor model underlying this multidimensional measure. Studies employing an exploratory bifactor approach to more closely examine its underlying structure and inter-relations of factors, however, have been scarce. This is unfortunate because confirmatory techniques often employ indirect ways of handling model misspecification, whereas exploratory methods enable more direct approaches...
January 1, 2018: Psychological Reports
Emma A Amissah, Julie Brown, Jane E Harding
BACKGROUND: Preterm infants require high protein intake to achieve adequate growth and development. Although breast milk feeding has many benefits for this population, the protein content is highly variable, and inadequate to support rapid infant growth. This is a 2018 update of a Cochrane Review first published in 1999. OBJECTIVES: To determine whether protein-supplemented human milk compared with unsupplemented human milk, fed to preterm infants, improves growth, body composition, cardio-metabolic, and neurodevelopmental outcomes, without significant adverse effects...
June 22, 2018: Cochrane Database of Systematic Reviews
Jack Hanson, Kuldip Paliwal, Thomas Litfin, Yuedong Yang, Yaoqi Zhou
Motivation: Accurate prediction of a protein contact map depends greatly on capturing as much contextual information as possible from surrounding residues for a target residue pair. Recently, ultra-deep residual convolutional networks were found to be state-of-the-art in the latest Critical Assessment of Structure Prediction techniques (CASP12, (Schaarschmidt et al., 2018)) for protein contact map prediction by attempting to provide a protein-wide context at each residue pair. Recurrent neural networks have seen great success in recent protein residue classification problems due to their ability to propagate information through long protein sequences, especially Long Short-Term Memory (LSTM) cells...
June 19, 2018: Bioinformatics
Vinod K Ahirrao, Vipul P Rane, Kiran R Patil, Vijay J Patil, Ravindra D Yeole, Mahesh V Patel
A highly stereo-specific liquid chromatographic method was developed and validated for the quantification of enantiomeric impurity (R-enantiomer) in novel oxazolidinone antibacterial agent (WCK 4086), a drug substance. The separation was achieved on Chiralpak AD-H (amylose-based chiral stationary phase) using a mobile phase consisting of n-hexane:2-propanol:methanol:trifluoroacetic acid (80:10:10:0.4, v/v/v/v) at a flow rate of 1.0 mL min-1. Chromatographic resolution between two enantiomers was found to be more than 2...
May 30, 2018: Journal of Chromatographic Science
Matthias Falmbigl, Igor A Karateev, Iryna S Golovina, Aleksandr V Plokhikh, Thomas C Parker, Alexander L Vasiliev, Jonathan E Spanier
Thin films of ≈50 nm thickness with Ba/Ti-ratios ranging from 0.8 to 1.06 were prepared by depositing alternating layers of Ba(OH)2 and TiO2. Annealing at 750 °C promoted the solid-solid transformation into polycrystalline BaTiO3 films containing a mixture of the perovskite and the hexagonal polymorphs with average crystallite sizes smaller than 14 nm and without impurity phases. This, together with an increase of the cubic lattice parameters for Ba-rich films, suggests an extended metastable solubility range for the perovskite-phase in these nanocrystalline thin films on both sides of the stoichiometric composition...
June 22, 2018: Nanoscale
Somayeh Taymouri, Jaleh Varshosaz, Shaghayegh Haghjooy Javanmard, Farshid Hassanzadeh
Background: A simple and sensitive reversed-phase high-performance liquid chromatography (HPLC) method based on liquid-liquid extraction was established and validated for determination of docetaxel (DTX) in plasma of rat. Materials and Methods: Samples were spiked with paclitaxel as the internal standard and the chromatographic separation was carried out using C18 HPLC column. The mobile phase consisted of a mixture of acetonitrile/water with the ratio of 60/40 v/v...
2018: Advanced Biomedical Research
Trine Munk-Olsen, Xiaoqin Liu, Alexander Viktorin, Hilary K Brown, Arianna Di Florio, Brian M D'Onofrio, Tara Gomes, Louise M Howard, Hind Khalifeh, Holly Krohn, Henrik Larsson, Paul Lichtenstein, Clare L Taylor, Inge Van Kamp, Richard Wesseloo, Samantha Meltzer-Brody, Simone N Vigod, Veerle Bergink
BACKGROUND: Concerns about teratogenicity and maternal and offspring complications restrict the use of lithium during pregnancy for the treatment of mood disorders. We aimed to investigate the association between in-utero lithium exposure and risk of pregnancy complications, delivery outcomes, neonatal morbidity, and congenital malformations. METHODS: In this meta-analysis, primary data from pregnant women and their children from six international cohorts based in the community (Denmark, Sweden, and Ontario, Canada) and in clinics (the Netherlands, UK, and USA) were analysed...
June 18, 2018: Lancet Psychiatry
Chien-Chun Liu, Chih-Chuan Lin, Yung-Chin Hsiao, Po-Jung Wang, Jau-Song Yu
Deinagkistrodon acutus, Trimeresurus stejnegeri, Protobothrops mucrosquamatus, Daboia russelii siamensis, Bungarus multicinctus and Naja atra are the six medically important venomous snake species in Taiwan. In this study, we characterized and compared their venom protein profiles using proteomic approaches. The major snake venom proteins were identified by GeLC-MS/MS and the total venom proteome was characterized by in-solution digestion coupled with LC-MS/MS. A total of 27-52 proteins, categorized into 23 protein families, were identified in each snake's venom...
June 18, 2018: Journal of Proteomics
Ai-Min Wu, Kai Zhang, Xun-Lin Li, Xiao-Fei Cheng, Tang-Jun Zhou, Lin Du, Chen Chen, Hai-Jun Tian, Xiao-Jiang Sun, Chang-Qing Zhao, Yan Michael Li, Jie Zhao
Background: The L5 nerve root could be compressed at both L4-5 and L5-S1 regions. If L5 nerve root has confirmed compression at L4-5 level and questionable compression at L5-S1 foramina, performing both surgeries at L4-5 and L5-S1 levels may induce unnecessary extra surgery on L5-S1; however, ignoring foraminal stenosis of L5/S1 may require re-exploration. Methods: Two hundred seventeen patients with L5 nerve root compressed at L4-5 lateral access were performed with L4-5 decompression and interbody fusion...
May 2018: Quantitative Imaging in Medicine and Surgery
Kathleen M Sturgeon, Wayne Y Foo, Mariane L Heroux, Kathryn Schmitz
Breast cancer survivors who carry a genetic mutation for one of the BRCA genes often undergo surgically-induced menopause a decade or more before the usual age of natural menopause. These women are at elevated risk for multiple negative health outcomes, including metabolic diseases, heart disease, and cancer recurrence. Effects of a 12-month commercially available web-based lifestyle program (Precision Nutrition) were tested on body composition and markers of inflammation in a randomized controlled trial. Participants (N=35) were BRCA1/2+, breast cancer survivors, and had completed surgically-induced menopause at age <45 years...
June 20, 2018: Cancer Prevention Research
Koichiro Fujisue, Suguru Nagamatsu, Hideki Shimomura, Takuro Yamashita, Koichi Nakao, Sunao Nakamura, Masaharu Ishihara, Kunihiko Matsui, Nobuyasu Yamamoto, Shunichi Koide, Toshiyuki Matsumura, Kazuteru Fujimoto, Ryusuke Tsunoda, Yasuhiro Morikami, Koshi Matsuyama, Shuichi Oshima, Kenji Sakamoto, Yasuhiro Izumiya, Koichi Kaikita, Seiji Hokimoto, Hisao Ogawa, Kenichi Tsujita
BACKGROUND: Chronic kidney disease (CKD) deteriorates the prognosis of patients undergoing percutaneous coronary intervention (PCI). Because coronary artery disease (CAD) is the major cause of death in CKD patients, cardiovascular risk reduction has been clinically important in CKD. We hypothesized intensive lipid-lowering with statin/ezetimibe attenuated coronary atherosclerotic development even in patients with CKD. METHODS: In the prospective, randomized, controlled, multicenter PRECISE-IVUS trial, 246 patients undergoing intravascular ultrasound (IVUS)-guided PCI were randomly assigned to receive atorvastatin/ezetimibe combination or atorvastatin alone (the dosage of atorvastatin was up-titrated to achieve the level of low-density lipoprotein cholesterol < 70 mg/dL)...
June 18, 2018: International Journal of Cardiology
Rachel F Eyler, Sara Cordes, Benjamin R Szymanski, Liana Fraenkel
BACKGROUND: As patients become more engaged in decisions regarding their medical care, they must weigh the potential benefits and harms of different treatments. Patients who are low in numeracy may be at a disadvantage when making these decisions, as low numeracy is correlated with less precise representations of numerical magnitude. The current study looks at the feasibility of improving number representations. The aim of this study was to evaluate whether providing a small amount of feedback to adult subjects could improve performance on a number line placement task and to determine characteristics of those individuals who respond best to this feedback...
June 20, 2018: BMC Medical Informatics and Decision Making
Emma A Amissah, Julie Brown, Jane E Harding
BACKGROUND: As preterm infants do not experience the nutrient accretion and rapid growth phase of the third trimester of pregnancy, they are vulnerable to postnatal nutritional deficits, including of fat. Consequently, they require higher fat intakes compared to their full term counterparts to achieve adequate growth and development. Human milk fat provides the major energy needs of the preterm infant and also contributes to several metabolic and physiological functions. Although human milk has many benefits for this population, its fat content is highly variable and may be inadequate for their optimum growth and development...
June 19, 2018: Cochrane Database of Systematic Reviews
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