Alex J A McLellan, Markus P Schlaich, Andrew J Taylor, Sandeep Prabhu, Dagmara Hering, Louise Hammond, Petra Marusic, Jacqueline Duval, Yusuke Sata, Andris Ellims, Murray Esler, Karlheinz Peter, James Shaw, Antony Walton, Jonathan M Kalman, Peter M Kistler
BACKGROUND: Hypertension is the most common modifiable risk factor associated with atrial fibrillation. OBJECTIVE: The purpose of this study was to determine the effects of blood pressure (BP) lowering after renal denervation on atrial electrophysiologic and structural remodeling in humans. METHODS: Fourteen patients (mean age 64 ± 9 years, duration of hypertension 16 ± 11 years, on 5 ± 2 antihypertensive medications) with treatment-resistant hypertension underwent baseline 24-hour ambulatory BP monitoring, echocardiography, cardiac magnetic resonance imaging, and electrophysiologic study...
May 2015: Heart Rhythm: the Official Journal of the Heart Rhythm Society