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colorectal anastomotic leakage

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https://www.readbyqxmd.com/read/28717916/colon-perfusion-patterns-during-colorectal-resection-using-visible-light-spectroscopy
#1
Henry Hoffmann, Tarik Delko, Philipp Kirchhoff, Rachel Rosenthal, Juliane Schäfer, Marko Kraljević, Christoph Kettelhack
BACKGROUND: The impact of blood supply to the anastomosis on development of anastomotic leakage is still a matter of debate. Considering that bowel perfusion may be affected by manipulation during surgery, perfusion assessment of the anastomosis alone may be of limited value. We propose perfusion assessment at different time points during surgery to explore the dynamics of bowel perfusion during colorectal resection and its impact on outcome. METHODS: In this prospective cohort study, patients undergoing elective colorectal resection were eligible...
July 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28687432/nonsteroidal-anti-inflammatory-drugs-and-the-risk-of-anastomotic-leakage-after-anterior-resection-for-rectal-cancer
#2
D Kverneng Hultberg, E Angenete, M-L Lydrup, J Rutegård, P Matthiessen, M Rutegård
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used in colorectal surgery due to their opioid-sparing effect. However, several studies have indicated an increased risk of anastomotic leakage following NSAID treatment, although conflicting results exist. The primary goal of this study was to further examine whether postoperative NSAIDs are independently associated with anastomotic leakage after anterior resection for rectal cancer. METHODS: Patients who underwent anterior resection for rectal cancer during 2007-2013 in 15 different hospitals in three healthcare regions in Sweden were included in the study...
June 28, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28682968/prognostic-impact-of-intra-abdominal-pelvic-inflammation-after-radical-surgery-for-locally-recurrent-rectal-cancer
#3
Masahiro Tanaka, Yukihide Kanemitsu, Dai Shida, Hiroki Ochiai, Shunsuke Tsukamoto, Masato Nagino, Yoshihiro Moriya
BACKGROUND: The influence of postoperative infectious complications, such as anastomotic leakage, on survival has been reported for various cancers, including colorectal cancer. However, it remains unclear whether intra-abdominal/pelvic inflammation after radical surgery for locally recurrent rectal cancer is relevant to its prognosis. OBJECTIVE: The purpose of this study was to evaluate factors associated with survival after radical surgery for locally recurrent rectal cancer...
August 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28682966/management-of-low-colorectal-anastomotic-leakage-in-the-laparoscopic-era-more-than-a-decade-of-experience
#4
Stephen Alexander Boyce, Craig Harris, Andrew Stevenson, John Lumley, David Clark
BACKGROUND: Anastomotic leak after colorectal surgery increases postoperative mortality, cancer recurrence, permanent stoma formation, and poor bowel function. Anastomosis between the colon and rectum is a particularly high risk. Traditional management mandates laparotomy, disassembly of the anastomosis, and formation of an often-permanent stoma. After laparoscopic colorectal surgery it may be possible to manage anastomotic failure with laparoscopy, thus avoiding laparotomy. OBJECTIVE: The purpose of this study was to determine the feasibility of the laparoscopic management of failed low colorectal anastomoses...
August 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28664443/vacuum-assisted-early-transanal-closure-of-leaking-low-colorectal-anastomoses-the-clean-study
#5
W A A Borstlap, G D Musters, L P S Stassen, H L van Westreenen, D Hess, S van Dieren, S Festen, E J van der Zaag, P J Tanis, W A Bemelman
INTRODUCTION: Non-healing of anastomotic leakage can be observed in up to 50% after total mesorectal excision for rectal cancer. This study investigates the efficacy of early transanal closure of anastomotic leakage after pre-treatment with the Endosponge(®) therapy. METHODS: In this prospective, multicentre, feasibility study, transanal suturing of the anastomotic defect was performed after vacuum-assisted cleaning of the presacral cavity. Primary outcome was the proportion of patients with a healed anastomosis at 6 months after transanal closure...
June 29, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28634627/influence-of-multiple-stapler-firings-used-for-rectal-division-on-colorectal-anastomotic-leak-rate
#6
Tamara Braunschmid, Nikolaus Hartig, Lukas Baumann, Bernhard Dauser, Friedrich Herbst
BACKGROUND: Anastomotic leakage following colorectal resection remains one of the most significant complications with relevant morbidity and mortality. There is evidence that a higher number of stapler firings for rectal division can affect the leak rate in double stapling anastomosis. However, there are no data concerning compression anastomosis. We present our institutional experience addressing this issue. DESIGN: This is a retrospective review of a prospective institutional database of patients undergoing colonic and rectal resection for benign and malignant indications between January 2008 and December 2014 at the surgical department of the St...
June 20, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28628777/effects-of-adipose-stem-cell-sheets-on-colon-anastomotic-leakage-in-an-experimental-model-proof-of-principle
#7
Panithi Sukho, Geesien S A Boersema, Abigael Cohen, Nicole Kops, Johan F Lange, Jolle Kirpensteijn, Jan Willem Hesselink, Yvonne M Bastiaansen-Jenniskens, Femke Verseijden
The most dreaded complication of colorectal surgery is anastomotic leakage. Adipose tissue-derived stem cell sheets (ASC sheets) prepared from temperature-responsive culture surfaces can be easily transplanted onto tissues. These sheets are proposed to improve cell transplant efficiency and enhance wound healing. The aim of this study was to investigate whether application of ASC sheets could prevent leakage of sutured colorectal anastomoses. Insufficient suturing of colorectal anastomoses was performed in Wistar rats to create a colorectal anastomotic leakage model...
June 9, 2017: Biomaterials
https://www.readbyqxmd.com/read/28628353/effect-of-early-vs-late-start-of-oral-intake-on-anastomotic-leakage-following-elective-lower-intestinal-surgery-a-systematic-review
#8
Boudewijn J J Smeets, Emmeline G Peters, Eelco C J Horsten, Teus J Weijs, Harm J T Rutten, Willem A Buurman, Wouter J de Jonge, Misha D P Luyer
BACKGROUND: Experimental and clinical studies have demonstrated a beneficial effect of early enteral nutrition (EN) on anastomotic leakage following colorectal surgery. Early oral intake is a common form of early EN with various clinical benefits, but the effect on anastomotic leakage is unclear. This systematic review investigates the effect of early vs late start of oral intake on anastomotic leakage following lower intestinal surgery. METHODS: A systematic literature search was performed using the PubMed, Embase, Medline, and Cochrane databases...
June 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28614172/the-relationship-between-the-number-of-intersections-of-staple-lines-and-anastomotic-leakage-after-the-use-of-a-double-stapling-technique-in-laparoscopic-colorectal-surgery
#9
SeungHun Lee, ByungKwon Ahn, SeungHyun Lee
PURPOSE: Laparoscopic intracorporeal colorectal anastomosis with double stapling technique is difficult because of unsuitable cutting angle in narrow pelvic cavity. For reasons of tilted and long linear staple line of rectal stump, circular anastomotic plane can make multiple intersections. The present study was designed to assess whether multiple intersections after double stapling technique is the risk factor of anastomotic complication in laparoscopic colorectal surgery. MATERIALS AND METHODS: In total, 128 consecutive left colon and rectal cancer patients who underwent laparoscopic rectal resection with double stapling technique were enrolled in this study...
June 13, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28612478/high-stoma-prevalence-and-stoma-reversal-complications-following-anterior-resection-for-rectal-cancer-a-population-based-multi-centre-study
#10
Klas Holmgren, Daniel Kverneng Hultberg, Markku M Haapamäki, Peter Matthiessen, Jörgen Rutegård, Martin Rutegård
AIM: Fashioning a defunctioning stoma is common when performing an anterior resection for rectal cancer in order to avoid and mitigate consequences of an anastomotic leakage. We investigated the permanent stoma prevalence, factors influencing stoma outcome and complication rates following stoma reversal surgery. METHODS: Patients who had undergone an anterior resection for rectal cancer between 2007 and 2013 in the Northern healthcare region were identified using the Swedish Colorectal Cancer Registry and were followed until the end of 2014 regarding stoma outcome...
June 14, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28608118/oncologic-impact-of-anastomotic-leakage-following-colorectal-cancer-surgery-a-systematic-review-and-meta-analysis
#11
Gi Won Ha, Jong Hun Kim, Min Ro Lee
BACKGROUND: Anastomotic leakage (AL) is a major complication of surgery for colorectal cancer (CRC), and is associated with increased morbidity and mortality; However, there are conflicting results on the impact of AL on long-term oncologic outcomes. OBJECTIVE: The aim of this meta-analysis was to assess the oncologic outcomes of AL following restorative surgery for CRC. METHODS: Multiple comprehensive databases, including PubMed, EMBASE, and The Cochrane Library, were searched for studies that assessed the oncologic effects of AL following surgery for CRC...
June 12, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28595813/reinforcement-of-the-colon-anastomosis-with-cyanoacrylate-glue-a-porcine-model
#12
Geesien S A Boersema, Sandra Vennix, Zhouqiao Wu, Maaike Te Lintel Hekkert, Dirk-Jan G M Duncker, King H Lam, Anand G Menon, Gert-Jan Kleinrensink, Johan F Lange
BACKGROUND: Previous experimental studies on cyanoacrylate (CA) glue for the prevention of colorectal anastomotic leakage (AL) have shown promising results. The aim of this study was to investigate the effect of CA in prevention of leakage in a porcine model of ischemic colorectal AL. METHODS: Twenty-four animals were divided into four groups of six: (1)ischemic anastomosis with sufficient suture (ISCH), (2)ischemic anastomosis with sufficient suture and CA reinforcement (CA-ISCH), (3)ischemic anastomosis with insufficient suture (ISCH-AI), and (4)ischemic anastomosis with insufficient suture and CA reinforcement (CA-ISCH-AI)...
May 10, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28594720/clinical-relevance-of-a-grading-system-for-anastomotic-leakage-after-low-anterior-resection-analysis-from-a-national-cohort-database
#13
Martine A Frouws, Heleen S Snijders, Steve H Malm, Gerrit-Jan Liefers, Cornelis J H Van de Velde, Peter A Neijenhuis, Hidde M Kroon
BACKGROUND: Anastomotic leakage is a severe complication after low anterior resection for rectal cancer. With a global increase in registration initiatives, adapting uniform definitions and grading systems is highly relevant. OBJECTIVE: This study aimed to provide clinical parameters to categorize anastomotic leakage into subcategories according to the International Study Group of Rectal Cancer. DESIGN: All of the patients who underwent a low anterior resection in the Netherlands with primary anastomosis were included using the population-based Dutch Surgical Colorectal Audit...
July 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28593782/the-impact-of-screening-on-short-term-outcome-after-surgery-for-colorectal-cancer
#14
Enric Sebastian, Ricard Courtier, Francesc Macià, Luís Grande, Miguel Pera
AIM: To investigate the influence of a screening program on the short-term outcome of patients undergoing surgery for colorectal cancer. METHODS: Between April 2010 and December 2012 patients diagnosed with colorectal cancer via the screening program (n = 80) were compared with patients diagnosed elsewhere (n = 106). Only patients of ≥ 50 and ≤ 69 years of age diagnosed outside the program were selected as controls. The clinical variables included age, sex, American Society of Anesthesiologists (ASA) status, Charlson index, preoperative hemoglobin and serum albumin levels, surgical approach, tumor location and stage, perioperative transfusion and postoperative morbidity...
June 8, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28557608/substantial-underreporting-of-anastomotic-leakage-after-anterior-resection-for-rectal-cancer-in-the-swedish-colorectal-cancer-registry
#15
Martin Rutegård, Daniel Kverneng Hultberg, Eva Angenete, Marie-Louise Lydrup
BACKGROUND: The causes and effects of anastomotic leakage after anterior resection are difficult to study in small samples and have thus been evaluated using large population-based national registries. To assess the accuracy of such research, registries should be validated continuously. MATERIAL AND METHODS: Patients who underwent anterior resection for rectal cancer during 2007-2013 in 15 different hospitals in three healthcare regions in Sweden were included in the study...
May 30, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28536898/impact-of-tissue-adhesives-on-the-prevention-of-anastomotic-leakage-of-colonic-anastomoses-an-in-vivo-study
#16
Konstantinos A Vakalopoulos, Joanna W A M Bosmans, Kevin W Y van Barneveld, Ruben R M Vogels, Geesien S A Boersema, Zhouqiao Wu, Marion J J Gijbels, Johannes Jeekel, Gert-Jan Kleinrensink, Nicole D Bouvy, Johan F Lange
BACKGROUND: Tissue adhesives (TA) may be useful to strengthen colorectal anastomoses, thereby preventing anastomotic leakage (AL). Previous studies have identified cyanoacrylate (CA) TAs as the most promising colonic anastomotic sealants. This study investigates the protective effects of sealing colonic anastomoses with various CAs. MATERIALS AND METHODS: Fifty-five Wistar rats underwent laparotomy and transection of the proximal colon. An anastomosis was created with 4 interrupted sutures followed by either application of Histoacryl Flexible, Omnex, Glubran 2, or no TA seal...
July 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28514887/transanal-inspection-and-management-of-low-colorectal-anastomosis-performed-with-a-new-technique-the-ticrant-study
#17
Francesco Crafa, Sebastian Smolarek, Giulia Missori, Mostafa Shalaby, Silvia Quareisma, Adele Noviello, Diletta Cassini, Pasquale Ascenzi, Luana Franceschilli, Paolo Delrio, Giannandrea Baldazzi, Ucchino Giampiero, Jacques Megevand, Giovanni Maria Romano, Pierpaolo Sileri
BACKGROUND: Anastomotic leakage is one of the most serious complications after rectal cancer surgery. METHOD: A prospective multicenter interventional study to assess a newly described technique of creating the colorectal and coloanal anastomosis. The primary outcome was to access the safety and efficacy of this technique in the reduction of anastomotic leak. RESULT: Fifty-three patients with rectal cancer who underwent low or ultra-low anterior resection were included in the study...
May 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28488729/randomized-clinical-trial-of-biodegradeable-intraluminal-sheath-to-prevent-anastomotic-leak-after-stapled-colorectal-anastomosis
#18
I S Bakker, A N Morks, H O Ten Cate Hoedemaker, J G M Burgerhof, H G Leuvenink, J B van Praagh, R J Ploeg, K Havenga
BACKGROUND: Anastomotic leakage is a potential major complication after colorectal surgery. The C-seal was developed to help reduce the clinical leakage rate. It is an intraluminal sheath that is stapled proximal to a colorectal anastomosis, covering it intraluminally and thus preventing intestinal leakage in case of anastomotic dehiscence. The C-seal trial was initiated to evaluate the efficacy of the C-seal in reducing anastomotic leakage in stapled colorectal anastomoses. METHODS: This RCT was performed in 41 hospitals in the Netherlands, Germany, France, Hungary and Spain...
May 10, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28483663/e-r-a-s-pathway-in-colorectal-surgery-in-elderly-our-experience-a%C3%A2-retrospective-cohort-study
#19
Basilio Pirrera, Andrea Lucchi, Carlo Gabbianelli, Vincenzo Alagna, Giacomo Martorelli, Pierluigi Berti, Ilaria Panzini, Elisabetta Fabbri, Gianluca Garulli
AIM: Numerous geriatric patients develop colorectal disease. Elderly patients are often considered high-risk surgical candidates. Enhanced recovery after surgery (E.R.A.S.) has been proven to be beneficial for patients. The aim of the study was to evaluate the results of an ERAS protocol in older patients that underwent colorectal surgery compared to younger patients. METHOD: In the period between January 2010 to December 2015 a total of 589 patients underwent elective colorectal surgical interventions treated within the E...
May 5, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28472929/ethnic-differences-in-colon-cancer-care-in-the-netherlands-a-nationwide-registry-based-study
#20
M Lamkaddem, M A G Elferink, M C Seeleman, E Dekker, C J A Punt, O Visser, M L Essink-Bot
BACKGROUND: Ethnic differences in colon cancer (CC) care were shown in the United States, but results are not directly applicable to European countries due to fundamental healthcare system differences. This is the first study addressing ethnic differences in treatment and survival for CC in the Netherlands. METHODS: Data of 101,882 patients diagnosed with CC in 1996-2011 were selected from the Netherlands Cancer Registry and linked to databases from Statistics Netherlands...
May 4, 2017: BMC Cancer
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