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renal perfusion

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https://www.readbyqxmd.com/read/29049782/rotational-speed-modulation-used-with-continuous-flow-left-ventricular-assist-device-provides-good-pulsatility
#1
Noritsugu Naito, Takashi Nishimura, Kei Iizuka, Yoshiaki Takewa, Akihide Umeki, Masahiko Ando, Minoru Ono, Eisuke Tatsumi
OBJECTIVES: Continuous-flow left ventricular assist devices (CF-LVADs) are widely used to treat patients with end-stage heart failure. Although continuous flow is different from physiological flow, patients show improved outcomes after CF-LVAD implantation. A novel rotational speed (RS) modulation system used with CF-LVAD (EVAHEART) has been developed, which can change RS in synchronization with the native cardiac cycle. We conducted the present study to investigate the influence of the system on pulsatility in peripheral perfusion...
August 10, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29046642/cooperative-oxygen-sensing-by-the-kidney-and-carotid-body-in-blood-pressure-control
#2
Daniela Patinha, Wioletta Pijacka, Julian F R Paton, Maarten P Koeners
Oxygen sensing mechanisms are vital for homeostasis and survival. When oxygen levels are too low (hypoxia), blood flow has to be increased, metabolism reduced, or a combination of both, to counteract tissue damage. These adjustments are regulated by local, humoral, or neural reflex mechanisms. The kidney and the carotid body are both directly sensitive to falls in the partial pressure of oxygen and trigger reflex adjustments and thus act as oxygen sensors. We hypothesize a cooperative oxygen sensing function by both the kidney and carotid body to ensure maintenance of whole body blood flow and tissue oxygen homeostasis...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29041878/-influence-of-sympathetic-denervation-of-the-renal-artery-on-the-level-of-arterial-blood-pressure-cerebral-blood-flow-and-cognitive-function-in-patients-with-resistant-arterial-hypertension
#3
Y N Efimova, A V Lichikaki, B Y Lishmanov
PURPOSE: To study the effect of radiofrequency ablation of renal arteries on regional cerebral blood flow and cognitive function in patients with resistant arterial hypertension (AH). MATERIAL AND METHODS: Transcatheter renal denervation (TRD) was performed in 17 patients with resistant AH. Examination before and after TRD included SPECT with mTc-HMPAO, 24-hours blood pressure (BP) monitoring, and comprehensive neuropsychological testing. Fifteen patients without angiographic signs of carotid atherosclerosis, coronary artery disease and AH, neurological and psychiatric disorders were investigated as control group...
July 2017: Kardiologiia
https://www.readbyqxmd.com/read/29040214/untreated-relative-hypotension-measured-as-perfusion-pressure-deficit-during-management-of-shock-and-new-onset-acute-kidney-injury-a-literature-review
#4
Rakshit Panwar
Maintaining an optimal blood pressure (BP) during shock is a fundamental tenet of critical care. Optimal BP targets maybe different for different patients. In current practice, too often, uniform BP targets are pursued which may result in inadvertently accepting a degree of untreated relative hypotension i.e., the deficit between patients' usual pre-morbid basal BP and the achieved BP, during vasopressor support. Relative hypotension is a common but an under-recognized and an under-treated sign among patients with potential shock state...
October 16, 2017: Shock
https://www.readbyqxmd.com/read/29039888/which-is-best-method-for-instillation-of-topical-therapy-to-the-upper-urinary-tract-an-in-vivo-porcine-study-to-evaluate-three-delivery-methods
#5
Zhenbang Liu, Junxiang Ng, Arianto Yuwono, Yadong Lu, Yung Khan Tan
PURPOSE: To compare the staining intensity of the upper urinary tract (UUT) urothelium among three UUT delivery methods in an in vivo porcine model. MATERIALS AND METHODS: A fluorescent dye solution (indigo carmine) was delivered to the UUT via three different methods: antegrade perfusion, vesico-ureteral reflux via indwelling ureteric stent and retrograde perfusion via a 5F open-ended ureteral catheter. Twelve renal units were tested with 4 in each method. After a 2-hour delivery time, the renal-ureter units were harvested en bloc...
October 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29034514/measurement-of-murine-single-kidney-glomerular-filtration-rate-using-dynamic-contrast-enhanced-mri
#6
Kai Jiang, Hui Tang, Prasanna K Mishra, Slobodan I Macura, Lilach O Lerman
PURPOSE: To develop and validate a method for measuring murine single-kidney glomerular filtration rate (GFR) using dynamic contrast-enhanced MRI (DCE-MRI). METHODS: This prospective study was approved by the Institutional Animal Care and Use Committee. A fast longitudinal relaxation time (T1 ) measurement method was implemented to capture gadolinium dynamics (1 s/scan), and a modified two-compartment model was developed to quantify GFR as well as renal perfusion using 16...
October 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29031027/evaluation-of-renal-perfusion-in-hyperthyroid-cats-before-and-after-radioiodine-treatment
#7
E Stock, S Daminet, D Paepe, E Buresova, E Vandermeulen, P Smets, L Duchateau, J H Saunders, K Vanderperren
BACKGROUND: Hyperthyroidism and chronic kidney disease (CKD) are common in elderly cats. Consequently, both diseases often occur concurrently. Furthermore, renal function is affected by thyroid status. Because changes in renal perfusion play an important role in functional renal changes in hyperthyroid cats, investigation of renal perfusion may provide novel insights. OBJECTIVES: To evaluate renal perfusion in hyperthyroid cats with contrast-enhanced ultrasound (CEUS)...
October 14, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29030579/effect-of-iodinated-contrast-media-on-renal-perfusion-a-randomized-comparison-study-in-pigs-using-quantitative-contrast-enhanced-ultrasound-ceus
#8
Philipp Lamby, Friedrich Jung, Stefanie Graf, Lotte Schellenberg, Johannes Falter, Natascha Platz-da-Silva, Stephan Schreml, Lukas Prantl, Ralf P Franke, Ernst M Jung
The administration of iodinated contrast media (CM) can cause microcirculatory disorder leading to acute renal dysfunction. In a prospective, randomized investigation two CM (Iodixanol vs Iopromide) were compared in 16 pigs. Each animal received 10 intra-aortal injections (5 ml Iodixanol or 4.32 ml Iopromide). Microcirculation was assessed using contrast-enhanced ultrasound (CEUS) directly on the kidney surface using time-to-peak (TTP) and blood-volume-analysis. Macroscopic observations were documented...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29027577/assessment-of-renal-perfusion-impairment-in-a-rat-model-of-acute-renal-congestion-using-contrast-enhanced-ultrasonography
#9
Kaoru Komuro, Yoshihiro Seo, Masayoshi Yamamoto, Seika Sai, Tomoko Ishizu, Kyo Shimazu, Yumi Takahashi, Shogo Imagawa, Teisuke Anzai, Kazuya Yonezawa, Kazutaka Aonuma
Renal congestion is caused by elevated central venous pressure (CVP), and decreases glomerular filtration in patients with congestive heart failure. Since real-time contrast-enhanced ultrasonography (CEUS) using microbubble-based contrast agents can visualize the perfused microvascular bed, we sought to evaluate the impairment of renal perfusion during acute renal congestion with CEUS. In Wister rats, CEUS of kidney was performed with the direct monitoring of CVP and intra-renal pressure (IRP). When CVP was elevated to 10 and 15 mmHg after the bolus injection of normal saline via the femoral vein, peak intensity (PI, dB) and time to PI (TTP) in the renal cortex and medulla were compared with control rats...
October 13, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29025386/preoperative-cardiac-risk-assessment-in-renal-transplant-recipients-a-single-center-experience
#10
Kerem Can Yilmaz, Arzu Neslihan Akgün, Orcun Ciftci, Haldun Muderrisoglu, Siren Sezer, Gokhan Moray, Mehmet Haberal
OBJECTIVES: Cardiovascular disease is the major cause of morbidity and mortality in patients on renal replacement therapy and in kidney transplant recipients. There are no specific recommendations for preoperative cardiac risk assessment before renal transplant. The aim of our study was to analyze preoperative cardiac test frequencies, test results, patient characteristics, and relations between cardiac stress test results and severe coronary artery disease. MATERIALS AND METHODS: We retrospectively examined patients who underwent renal transplant between December 2011 and December 2016 in our hospital (Ankara, Turkey)...
October 12, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29022080/urinary-potassium-to-urinary-potassium-plus-sodium-ratio-can-accurately-identify-hypovolemia-in-nephrotic-syndrome-a-provisional-study
#11
Werner Keenswijk, Mohamad Ikram Ilias, Ann Raes, Raymond Donckerwolcke, Johan Vande Walle
There is evidence pointing to a decrease of the glomerular filtration rate (GFR) in a subgroup of nephrotic children, likely secondary to hypovolemia. The aim of this study is to validate the use of urinary potassium to the sum of potassium plus sodium ratio (UK/UK+UNa) as an indicator of hypovolemia in nephrotic syndrome, enabling detection of those patients who will benefit from albumin infusion. We prospectively studied 44 nephrotic children and compared different parameters to a control group (36 children)...
October 11, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28992906/renal-amyloidosis-associated-with-kartagener-syndrome-in-a-dog
#12
Bartolo Celona, Chiara Crinò, Carmelo Bruno, Simona Di Pietro, Elisabetta Giudice
A 4-year-old cocker spaniel, male, of 12kg body weight was presented because of the onset of polyuria or polydipsia. From the first months of its life, the dog had exhibited constant serous to mucopurulent nasal discharge, productive cough, sneezing, reverse sneezing, otitis, and recurrent episodes of fever. The respiratory signs had been treated several times with antibiotics, without ever achieving a complete resolution. Clinical examination revealed normal rectal temperature (38.3°C), increased respiratory rate (40breaths/min), a copious mucous nasal discharge and right deviation of the heart apex beat (ictus cordis)...
June 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/28985850/the-administration-of-argon-during-ex-vivo-normothermic-perfusion-in-an-experimental-model-of-kidney-ischemia-reperfusion-injury
#13
Stephanie F Smith, Thomas Adams, Sarah A Hosgood, Michael L Nicholson
BACKGROUND: Argon has shown potential as an organoprotective agent in numerous models of ischemia-reperfusion injury (IRI). The aim of this study was to evaluate the effects of argon gas during ex vivo normothermic perfusion (EVNP) in an experimental porcine model of kidney IRI. MATERIALS AND METHODS: After a warm ischemia time of 15 min and 17 h of static cold storage, porcine kidneys underwent 1 h of EVNP using leukocyte-depleted blood. During EVNP, kidneys were perfused with a gas composition either of 70% argon (n = 6), 70% nitrogen control (n = 6), or standard 95% oxygen (n = 6) balanced with 5% carbon dioxide...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28984775/clinicopathological-features-of-progressive-renal-involvement-in-tafro-syndrome-a-case-report-and-literature-review
#14
REVIEW
Mari Tanaka, Hiraku Tsujimoto, Kojiro Yamamoto, Saeko Shimoda, Kazumasa Oka, Hiroya Takeoka
RATIONALE: TAFRO syndrome is a systemic inflammatory disease characterized by a constellation of symptoms: Thrombocytopenia, Anasarca, MyeloFibrosis, Renal dysfunction, and Organomegaly. Progressive renal insufficiency is a predominant symptom; however, the mechanism of acute kidney injury (AKI) remains unclear, probably because severe thrombocytopenia prevents kidney biopsy. We report a rare case of TAFRO syndrome with histologically confirmed renal involvement. PATIENTS CONCERNS: A 70-year-old man developed fever, anasarca, AKI, thrombocytopenia, and hepatosplenomegaly...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28982104/repair-of-an-autologous-saphenous-vein-graft-aneurysm-ten-years-after-renal-artery-reconstruction-during-live-donor-renal-transplantation
#15
Markus Oelschlaeger, Ioannis Sokolakis, Charis Kalogirou, Lea Frey, Hubertus Riedmiller, Hubert Kübler, Richard Kellersmann, Daniel Vergho
Saphenous vein graft (SVG) aneurysms (SVGA) after renal transplantation represents a rare vascular complication with subsequent challenging multidisciplinary treatment. We present a case of a 30-year-old female who received a live donor kidney transplantation for end-stage renal disease that was caused due to the hemolytic uremic syndrome. Postoperatively, an insufficient graft perfusion due to an arterial kinking was noted and repaired using an autologous SVG interposition. Ten years later, a 3-cm aneurysm of the SVG at the anastomotic site with the common iliac artery was discovered...
October 6, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28980283/low-diastolic-blood-pressure-is-associated-with-a-high-atherosclerotic-burden-in-patients-with-obstructive-coronary-artery-disease
#16
Vichai Senthong, Upa Kukongviriyapan, Nongnuch Settasatian, Chatri Settasatian, Nantarat Komanasin
BACKGROUND: The optimal blood pressure (BP) treatment target is still being debated, specifically diastolic BP in patients with obstructive coronary artery disease (CAD); a diastolic BP which is too low could compromise myocardial perfusion and is associated with adverse outcomes. METHODS: This study examined the relationship between diastolic BP (DBP) levels and the severity and atherosclerotic burden of CAD in 231 consecutive stable patients with evidence of obstructive CAD as detected by elective coronary angiography...
October 5, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28977099/fluid-overload-in-children-undergoing-mechanical-ventilation
#17
Clarice Laroque Sinott Lopes, Jefferson Pedro Piva
Patients admitted to an intensive care unit are prone to cumulated fluid overload and receive intravenous volumes through the aggressive resuscitation recommended for septic shock treatment, as well as other fluid sources related to medications and nutritional support. The liberal liquid supply strategy has been associated with higher morbidity and mortality. Although there are few prospective pediatric studies, new strategies are being proposed. This non-systematic review discusses the pathophysiology of fluid overload, its consequences, and the available therapeutic strategies...
September 28, 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/28972665/impact-of-machine-perfusion-after-long-static-cold-storage-on-delayed-graft-function-incidence-and-duration-and-time-to-hospital-discharge
#18
Ana Cristina Carvalho Matos, Lúcio Roberto Requiao Moura, Milton Borrelli, Mario Nogueira, Gabriela Clarizia, Paula Ongaro, Marcelino Souza Durao, Alvaro Pacheco-Silva
Delayed graft function (DGF) is very high in our center (70-80%), we usually receive a kidney for transplant after more than 22 hours of static cold ischemia time (CIT). Also, there is an inadequate care of the donors contributing to a high rate of delayed graft function (DGF). We decided to test whether machine perfusion (MP) after a cold ischemic time (CIT) improved the outcome of our transplant patients. We analyzed the incidence of DGF, its duration and the length of hospital stay (LOS) in patients who received a kidney preserved with MP after a CIT (Hybrid Perfusion - HP)...
October 3, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28964618/long-term-fate-of-renal-function-after-open-surgery-for-juxtarenal-and-pararenal-aortic-aneurysm
#19
Masayuki Sugimoto, Noriko Takahashi, Kiyoaki Niimi, Akio Kodama, Hiroshi Banno, Kimihiro Komori
BACKGROUND: Although the indications for endovascular aneurysm repair for abdominal aortic aneurysm have been expanding, our primary strategy for pararenal and juxtarenal abdominal aortic aneurysm (P/JRAA) is open surgery (OS). One consequence of OS for P/JRAA is transient renal ischemia owing to renal artery clamping, which can be followed by acute kidney injury (AKI). Prior studies referred to the impact of renal ischemia on AKI, but they have rarely evaluated longer-term renal function...
September 27, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28959212/multiparametric-renal-magnetic-resonance-imaging-validation-interventions-and-alterations-in-chronic-kidney-disease
#20
Eleanor F Cox, Charlotte E Buchanan, Christopher R Bradley, Benjamin Prestwich, Huda Mahmoud, Maarten Taal, Nicholas M Selby, Susan T Francis
Background: This paper outlines a multiparametric renal MRI acquisition and analysis protocol to allow non-invasive assessment of hemodynamics (renal artery blood flow and perfusion), oxygenation (BOLD T2(*)), and microstructure (diffusion, T1 mapping). Methods: We use our multiparametric renal MRI protocol to provide (1) a comprehensive set of MRI parameters [renal artery and vein blood flow, perfusion, T1, T2(*), diffusion (ADC, D, D(*), fp), and total kidney volume] in a large cohort of healthy participants (127 participants with mean age of 41 ± 19 years) and show the MR field strength (1...
2017: Frontiers in Physiology
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