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renal perfusion

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https://www.readbyqxmd.com/read/29456983/the-role-of-mas-receptor-on-renal-hemodynamic-responses-to-angiotensin-1-7-in-both-irreversible-and-reversible-unilateral-ureteral-obstruction-rats
#1
Jalal Hassanshahi, Mehdi Nematbakhsh
Background: Unilateral ureteral obstruction (UUO) alters the expression of renin-angiotensin system (RAS) components and angiotensin 1-7 (Ang 1-7) as a main arm of RAS is affected by UUO. The role of Mas receptor antagonist (A779) was examined in renal hemodynamic responses to Ang 1-7 in 3-day UUO and UUO removal (RUUO) in rats. Materials and Methods: Forty-five male Wistar rats were randomly divided into three groups of sham operated, UUO, and RUUO, while each group was divided into two subgroups treated with vehicle or A779...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29456225/perfused-nonfunctioning-renal-allograft-case-report-and-review-of-the-literature
#2
Mohamed Zahran, Ahmed Othman, Abd-Elaty Saker, Mohamed Wagih, Mohamed Soliman, Mona Badr
We report a case of very early postoperative iatrogenic dissection of common iliac artery (CIA), external iliac artery (EIA) causing acute ischemia of the right lower limb, and impairing the perfusion of a renal allograft. This was managed successfully by graft nephrectomy and interposition polytetrafluoroethylene grafting of the CIA and EIA with re-implantation of the kidney allograft and restoration of its perfusion and function, together with restoration of the lower limb circulation.
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29451075/short-term-outcomes-of-preoperative-intra-aortic-balloon-pump-use-in-patients-undergoing-adjunctive-coronary-endarterectomy-a-retrospective-observational-study
#3
Liangshan Wang, Xing Hao, Xiaomeng Wang, Chengxiong Gu, Hong Wang, Xiaotong Hou
BACKGROUND: Coronary artery bypass grafting (CABG) combined with coronary endarterectomy (CE) can be associated with high operative mortality and morbidity. An intra-aortic balloon pump (IABP) has been the most widely used mechanical circulatory support device during perfusion treatment. However, the benefits of preoperative IABP in CABG combined with CE remain unknown. We conducted a retrospective observational study to evaluate the efficacy of preoperative IABP therapy in patients undergoing adjunctive right coronary artery (RCA) endarterectomy...
February 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29446551/targeting-murine-mesenchymal-stem-cells-to-kidney-injury-molecule-1-improves-their-therapeutic-efficacy-in-chronic-ischemic-kidney-injury
#4
Xiangyu Zou, Kai Jiang, Amrutesh S Puranik, Kyra L Jordan, Hui Tang, Xiangyang Zhu, Lilach O Lerman
Mesenchymal stem cells (MSC) have been experimentally used for kidney repair, but modest retention limits their efficacy. Cell-surface coating allows modulating MSC homing and interaction with target cells. We coated mouse adipose tissue-derived MSC with antibodies directed against kidney injury molecule-1 (ab-KIM1), which is upregulated in injured kidneys, and tested the hypothesis that this would enhance their therapeutic effects in ischemic kidney injury. Untreated MSC, ab-KIM1-coated MSC (KIM-MSC), or vehicle, were injected systemically into the carotid artery of 2-kidneys, 1-clip mice 2 weeks after surgery...
February 15, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29445015/influence-of-ageing-on-quantitative-contrast-enhanced-ultrasound-of-the-kidneys-in-healthy-cats
#5
Emmelie Stock, Dominique Paepe, Sylvie Daminet, Luc Duchateau, Jimmy H Saunders, Katrien Vanderperren
The degenerative effects of ageing on the kidneys have been extensively studied in humans. However, only recently interest has been focused on renal ageing in veterinary medicine. Contrast-enhanced ultrasound allows non-invasive evaluation of renal perfusion in conscious cats. Renal perfusion parameters were obtained in 43 healthy cats aged 1-16 years old, and the cats were divided in four age categories: 1-3 years, 3-6 years, 6-10 years and over 10 years. Routine renal parameters as serum creatinine, serum urea, urine-specific gravity, urinary protein:creatinine ratio and systolic blood pressure were also measured...
February 14, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29432378/low-perfusion-pressure-is-associated-with-renal-tubular-injury-in-infants-undergoing-cardiac-surgery-with-cardiopulmonary-bypass-a-secondary-analysis-of-an-observational-study
#6
Mirela Bojan, Maria C Basto Duarte, Vanessa Lopez, Laurent Tourneur, Stephanie Vicca, Marc Froissart
BACKGROUND: Earlier work on adults undergoing surgery with cardiopulmonary bypass suggests that there is a close relationship between the lower limit of the cerebral and renal autoregulation pressures. Although cerebral autoregulation during bypass in infants has been extensively investigated, the impact of bypass on kidney function is not well known. It is, nevertheless, acknowledged that the main pathophysiological process involved in cardiac surgery-related kidney damage is tubular injury, and that urine neutrophil gelatinase-associated lipocaline (uNGAL) is a reliable biomarker of injury...
February 9, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29429749/total-renal-artery-occlusion-recovery-of-function-after-revascularization
#7
Sandhya Manohar, Abdurrahman Hamadah, Sandra M Herrmann, Stephen C Textor
Current trends in managing atherosclerotic renal artery stenosis favor medical therapy, on account of negative results from prospective trials of revascularization, such as CORAL and ASTRAL. One result of this trend has been encountering occasional patients with progressive disease, sometimes leading to total arterial occlusion. We illustrate a case of accelerated hypertension with complete renal artery occlusion in which the patient recovered function after surgical bypass and we review the clinical approach used and the advanced imaging modalities available to us...
February 8, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29429244/-assessment-of-renal-function-with-intravoxel-incoherent-motion-and-diffusion-tensor-imaging-in-type-2-diabetic-patients
#8
S N Chen, Y C Wang, Y L Feng, Y T Gao, S S Ju
Objective: To evaluate the application value of intravoxel incoherent motion (IVIM) and diffusion tensor imaging (DTI) in detecting early-stage diabetic nephropathy and to assess the damage of ralated renal function. Methods: A total of 52 patients with type 2 diabetes diagnosed in Zhongda Hospital were collected from April 2016 to May 2017 and were assigned to DM group (diabetes without nephropathy, n=32) and DN group (diabetes with nephropathy, n=20) according to detection of microalbuminuria, a cohort of healthy recipients were included as control group (n=27) in the meantime...
January 30, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29423383/biodistribution-of-99mtc-maa-on-spect-ct-performed-for-90y-radioembolization-therapy-planning-a-pictorial-review
#9
J J Bailey, Y Dewaraja, D Hubers, R Srinivasa, K A Frey
Purpose: To evaluate the frequency of 99mTc-MAA uptake in extrahepatic organs during 90Y radioembolization therapy planning. Methods: This retrospective case series of 70 subjects who underwent 99mTc-MAA hepatic artery perfusion studies between January 2014 and July 2016 for 90Y radioembolization therapy planning at our institution involved direct image review for all subjects, with endpoints recorded: lung shunt fraction, extrahepatic radiotracer uptake, time from MAA injection to imaging...
October 2017: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29421424/renal-fenestration-closure-technique-in-fenestrated-endovascular-repair-for-para-renal-aortic-aneurysm
#10
E Gallitto, M Gargiulo, G Faggioli, A Sonetto, C Mascoli, R Pini, M Abualhin, A Stella
PURPOSE: To describe an endovascular technique to close a renal artery fenestration during fenestrated endograft implant for a para-renal aneurysm (p-AAA) without interfering with other visceral vessels REPORT: A 76-year-old-male with p-AAA underwent repair by a four fenestrations custom-made endograft. At the intra-procedural angiography, the right renal artery was occluded. In order to avoid a high-flow endoleak from fenestration, we performed the following technique: a 9F-steerable sheath was used to advance a 7F-sheath through the fenestration into aneurism...
February 5, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29412702/%C3%AE-ketoglutarate-stimulates-pendrin-dependent-cl-absorption-in-the-mouse-ccd-through-protein-kinase-c
#11
Yoskaly Lazo-Fernandez, Paul A Welling, Susan M Wall
Alpha-ketoglutarate (αKG) is a citric acid cycle intermediate and a glutamine catabolism product. It is also the natural ligand of OXGR1, a Gq-protein coupled receptor expressed on the apical membrane of intercalated cells. In the CCD, Cl-/HCO3- exchange increases upon αKG binding to the OXGR1. To determine the signaling pathway(s) by which αKG stimulates Cl- absorption, we examined αKG-stimulated Cl- absorption in isolated perfused mouse CCDs. αKG increased electroneutral Cl- absorption in CCDs from wild type mice, but had no effect on Cl- absorption in pendrin KO mice...
February 7, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29412691/lack-of-contribution-of-nitric-oxide-synthase-to-cholinergic-vasodilation-in-murine-renal-afferent-arterioles
#12
Sungmi Park, Benjamin J Bivona, Lisa M Harrison-Bernard
We have previously reported significant increases in neuronal nitric oxide synthase (NOS) immunostaining in renal arterioles of angiotensin type 1A receptor (AT1A) knockout mice, and in arterioles and macula densa cells of AT1A/AT1B knockout mice. The contribution of nitric oxide derived from endothelial and macula densa cells in the maintenance of afferent arteriolar tone and acetylcholine-induced vasodilation were functionally determined in kidneys of wild-type, AT1A, and AT1A/AT1B knockout mice. Acetylcholine-induced changes in arteriolar diameters of in vitro blood perfused juxtamedullary nephrons were measured during control conditions, in the presence of the nonspecific NOS inhibitor, Nw-nitro-L-arginine methyl ester (NLA), or the highly selective neuronal NOS inhibitor, N5-(1-imino-3-butenyl)-L-ornithine (VNIO)...
February 7, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29407336/perfusion-parameters-of-donation-after-cardiac-death-kidneys-predict-early-transplant-outcomes-based-on-expanded-criteria-donor-designation
#13
Q Tai, W Xue, X Ding, P Tian, H Xiang, X Feng, H Yan, J Hou
BACKGROUND: Donation after cardiac death is the only source of the deceased donor in China at present. Hypothermic machine perfusion has been used increasingly over the years. We determined the hypothermic machine perfusion parameters associated with early transplant outcomes based on the expanded criteria donor (ECD) designation. METHODS: There were 446 consecutive kidneys donated after cardiac death and preserved by hypothermic machine perfusion (LifePort) in our center that were included in this study...
January 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29407316/functional-results-of-renal-preservation-in-hypothermic-pulsatile-machine-perfusion-versus-cold-preservation-systematic-review-and-meta-analysis-of-clinical-trials
#14
L Martínez Arcos, J J Fabuel Alcañiz, V Gómez Dos Santos, F J Burgos Revilla
BACKGROUND: Hypothermic pulsatile machine perfusion (HPMP) decreases the rate of delayed graft function (DGF) in kidney grafts, compared with cold storage. However, it is not clear its use in the different subgroups of grafts. The objective was to review systematically all studies with better methodologic quality that compare HPMP versus cold storage. METHODS: A systematic review was performed. The sources were Pubmed, Pubmed Central, Cochrane Library, Clinical Key, and Ovid...
January 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29407090/long-term-prognostic-significance-of-urinary-sodium-concentration-in-patients-with-acute-heart-failure
#15
Satoshi Honda, Toshiyuki Nagai, Kunihiro Nishimura, Michikazu Nakai, Yasuyuki Honda, Hiroki Nakano, Naotsugu Iwakami, Yasuo Sugano, Yasuhide Asaumi, Takeshi Aiba, Teruo Noguchi, Kengo Kusano, Hiroyuki Yokoyama, Hisao Ogawa, Satoshi Yasuda, Toshihisa Anzai
BACKGROUND: Lower urinary sodium concentration (UNa) may reflect impaired renal perfusion, higher neurohormonal activity and diuretic resistance. However, the prognostic impact of UNa in patients with acute heart failure (AHF) has not been fully elucidated. METHODS: We investigate the association between UNa and clinical outcomes in 669 patients admitted with AHF in our prospective registry. Patients were stratified into tertiles based on UNa in a spot urine sample on admission...
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29400088/effects-of-continuous-and-pulsatile-flows-generated-by-ventricular-assist-devices-on-renal-function-and-pathology
#16
Takuma Miyamoto, Jamshid H Karimov, Kiyotaka Fukamachi
Continuous-flow (CF) left ventricular assist devices (LVADs) are widely used to treat end-stage heart failure. Despite substantial improvement in clinical results, numerous complications remain associated with this technology. Worsening renal function is one, associated with morbidity and mortality in patients supported by CF LVADs. The effects of CF LVAD support on renal function have been investigated since the mid-1990s by many research groups. Area covered: We review the current status of LVAD therapy, experimental results regarding the effects of types of flow generated by LVADs on renal function and pathology, changes in renal function after LVAD implant, the influence of renal function on outcomes, and risk factors for renal dysfunction post implant...
February 5, 2018: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29399104/protective-effect-of-vascular-endothelial-growth-factor-against-cardiopulmonary-bypass-associated-acute-kidney-injury-in-beagles
#17
Yiping Bai, Yabing Zhang, Shuting Yang, Mengjun Wu, Yibin Fang, Jianguo Feng, Bin Liu
The present study aimed to examine the hypothesis that vascular endothelial growth factor (VEGF) has a protective effect against cardiopulmonary bypass (CPB)-associated acute kidney injury (AKI). Eighteen male beagles were randomly allocated to three groups (n=6 per group): Sham group, animals received sternotomy without going through CPB; CPB group, animals received CPB only; VEGF group, animals received CPB and VEGF. VEGF infusion was completed 1 h prior to the initiation of CPB. Renal microcirculation perfusion, serum creatinine (SCr) and blood urea nitrogen (BUN), histopathological injury score and apoptotic index were determined...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29383520/the-prognostic-and-predictive-value-of-vascular-response-parameters-measured-by-dynamic-contrast-enhanced-ct-mri-and-us-in-patients-with-metastatic-renal-cell-carcinoma-receiving-sunitinib
#18
John M Hudson, Colleen Bailey, Mostafa Atri, Greg Stanisz, Laurent Milot, Ross Williams, Alex Kiss, Peter N Burns, Georg A Bjarnason
OBJECTIVES: To identify dynamic contrast-enhanced (DCE) imaging parameters from MRI, CT and US that are prognostic and predictive in patients with metastatic renal cell cancer (mRCC) receiving sunitinib. METHODS: Thirty-four patients were monitored by DCE imaging on day 0 and 14 of the first course of sunitinib treatment. Additional scans were performed with DCE-US only (day 7 or 28 and 2 weeks after the treatment break). Perfusion parameters that demonstrated a significant correlation (Spearman p < 0...
January 30, 2018: European Radiology
https://www.readbyqxmd.com/read/29381939/utilizing-flat-panel-detector-parenchymal-blood-volume-imaging-fd-pbv-for-quantitative-kidney-perfusion-analysis-during-the-process-of-percutaneous-transluminal-renal-angioplasty-ptra-a-case-report
#19
Chenyang Qiu, Jiang Shao, Xiu Liu, Bao Liu
RATIONALE: Traditional digital subtraction angiography (DSA) provides lumen morphology of renal artery as indicators for vascular patency in patients with renal artery stenosis (RAS). It, however, lacks hemodynamic information toward target kidney. To solve this shortcoming, a novel technique, flat-panel detector parenchymal blood volume imaging (FD-PBV), is introduced, which is able to evaluate hemodynamic changes of target kidney intraoperatively. PATIENTS CONCERNS: A 77-year-old female presented with hypertension, intermittent dizziness, nausea, and fatigue...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29380818/renin-cells-in-homeostasis-regeneration-and-immune-defence-mechanisms
#20
REVIEW
R Ariel Gomez, Maria Luisa S Sequeira-Lopez
An accumulating body of evidence suggests that renin-expressing cells have developed throughout evolution as a mechanism to preserve blood pressure and fluid volume homeostasis as well as to counteract a number of homeostatic and immunological threats. In the developing embryo, renin precursor cells emerge in multiple tissues, where they differentiate into a variety of cell types. The function of those precursors and their progeny is beginning to be unravelled. In the developing kidney, renin-expressing cells control the morphogenesis and branching of the renal arterial tree...
January 30, 2018: Nature Reviews. Nephrology
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