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https://www.readbyqxmd.com/read/29245132/transcriptome-analysis-reveals-novel-insights-into-the-response-to-pb-exposure-in-phanerochaete-chrysosporium
#1
Chao Huang, Rongzhong Wang, Guangming Zeng, Danlian Huang, Cui Lai, Jiachao Zhang, Zhihua Xiao, Jia Wan, Piao Xu, Xiaomin Gong, Wenjing Xue, Xiaoya Ren
Metals released into the environment continue to be of concern for human health. Using white-rot fungi as biosorbents for heavy metals removal is an attractive alternative owing to its good performance and low cost. However, the molecular mechanism underlying heavy metal tolerance in white-rot fungi has not yet been fully elucidated. This study identified and analyzed the lead (Pb)-induced transcriptional changes in Phanerochaete chrysosporium, a well-known heavy metal hyperaccumulating white-rot fungus. The results confirmed its outstanding ability in Pb tolerance and effective defense system...
December 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/29245056/subcutaneous-trastuzumab-herceptin-versus-intravenous-trastuzumab-for-the-treatment-of-patients-with-her2-positive-breast-cancer-a-time-motion-and-cost-assessment-study-in-a-lean-operating-day-care-oncology-unit
#2
Wiebren A A Tjalma, Tom Van den Mooter, Tim Mertens, Valerie Bastiaens, Manon T Huizing, Konstantinos Papadimitriou
OBJECTIVE: The subcutaneous (SC) formulation of trastuzumab represents an alternative to the intravenous (IV) infusion in the treatment of patients with HER2-positive metastatic and early breast cancer. We compared the two formulations in terms of time and cost differential. STUDY DESING: We conducted a time, motion and cost assessment study in a lean operating day care oncology unit to determine and compare the time and costs of trastuzumab SC versus IV administration in patients with HER2-positive breast cancer...
December 7, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29244862/application-of-system-dynamics-and-participatory-spatial-group-model-building-in-animal-health-a-case-study-of-east-coast-fever-interventions-in-lundazi-and-monze-districts-of-zambia
#3
Chisoni Mumba, Eystein Skjerve, Magda Rich, Karl M Rich
East Coast Fever (ECF) is the most economically important production disease among traditional beef cattle farmers in Zambia. Despite the disease control efforts by the government, donors, and farmers, ECF cases are increasing. Why does ECF oscillate over time? Can alternative approaches such as systems thinking contribute solutions to the complex ECF problem, avoid unintended consequences, and achieve sustainable results? To answer these research questions and inform the design and implementation of ECF interventions, we qualitatively investigated the influence of dynamic socio-economic, cultural, and ecological factors...
2017: PloS One
https://www.readbyqxmd.com/read/29243998/adjacent-segment-disease-after-thoracic-pedicle-screw-fixation
#4
Nitin Agarwal, Robert F Heary, Prateek Agarwal
OBJECTIVE Pedicle screw fixation is a technique widely used to treat conditions ranging from spine deformity to fracture stabilization. Pedicle screws have been used traditionally in the lumbar spine; however, they are now being used with increasing frequency in the thoracic spine as a more favorable alternative to hooks, wires, or cables. Although safety concerns, such as the incidence of adjacent-segment disease (ASD) after cervical and lumbar fusions, have been reported, such issues in the thoracic spine have yet to be addressed thoroughly...
December 15, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29243813/antiepileptic-drug-monotherapy-for-epilepsy-a-network-meta-analysis-of-individual-participant-data
#5
REVIEW
Sarah J Nevitt, Maria Sudell, Jennifer Weston, Catrin Tudur Smith, Anthony G Marson
BACKGROUND: Epilepsy is a common neurological condition with a worldwide prevalence of around 1%. Approximately 60% to 70% of people with epilepsy will achieve a longer-term remission from seizures, and most achieve that remission shortly after starting antiepileptic drug treatment. Most people with epilepsy are treated with a single antiepileptic drug (monotherapy) and current guidelines from the National Institute for Health and Care Excellence (NICE) in the United Kingdom for adults and children recommend carbamazepine or lamotrigine as first-line treatment for partial onset seizures and sodium valproate for generalised onset seizures; however a range of other antiepileptic drug (AED) treatments are available, and evidence is needed regarding their comparative effectiveness in order to inform treatment choices...
December 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29243481/occurrence-and-partitioning-of-bisphenol-analogues-in-adults-blood-from-china
#6
Hangbiao Jin, Jing Zhu, Zhongjian Chen, Yanjun Hong, Zongwei Cai
The widespread human exposure and associated adverse health effects led to regulations on the usage of bisphenol A (BPA). Several bisphenol analogues (BPs) have been introduced as BPA alternatives in various applications. However, these BPs have been shown to exhibit similar or even stronger endocrine-disrupting activities compared with BPA. Currently, information on the human exposure to BPA alternatives remains limited. In this study, nine BPs were quantified in 81 pairs of plasma and red blood cell (RBC) samples from Chinese participants...
December 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29243369/burden-of-influenza-respiratory-syncytial-virus-and-other-respiratory-viruses-and-the-completeness-of-respiratory-viral-identification-among-respiratory-inpatients-canada-2003-2014
#7
Dena L Schanzer, Myriam Saboui, Liza Lee, Andrea Nwosu, Christina Bancej
BACKGROUND: A regression-based study design has commonly been used to estimate the influenza burden; however, these estimates are not timely and many countries lack sufficient virological data. Alternative approaches that would permit a timelier assessment of the burden, including a sentinel surveillance approach recommended by the World Health Organization (WHO), have been proposed. We aimed to estimate the hospitalization burden attributable to influenza, respiratory syncytial virus (RSV), and other respiratory viruses (ORV) and to assess both the completeness of viral identification among respiratory inpatients in Canada and the implications of adopting other approaches...
December 15, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29243364/perceived-needs-of-carers-of-people-with-psychosis-an-australian-longitudinal-population-based-study-of-caregivers-of-people-with-psychotic-disorders
#8
Abner Weng Cheong Poon, Lynette Joubert, Carol Harvey
Studies have documented the perceived needs of carers of people with psychosis but most recruitment has utilised convenience sampling resulting in limited understanding of carers' needs. This longitudinal study was conducted within the second Australian prevalence study of psychosis, aiming to obtain generalisable findings regarding perceived needs of carers of people with psychosis. Semi-structured interviews were conducted with 98 carers of people with psychosis recruited in the Australian prevalence study of psychosis...
December 15, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/29243351/is-it-cost-effective-to-provide-internet-based-interventions-to-complement-the-current-provision-of-smoking-cessation-services-in-the-netherlands-an-analysis-based-on-the-equiptmod
#9
Kei-Long Cheung, Ben F M Wijnen, Mickaël Hiligsmann, Kathryn Coyle, Doug Coyle, Subhash Pokhrel, Hein de Vries, Maximilian Präger, Silvia M A A Evers
BACKGROUND AND AIM: The cost-effectiveness of internet-based smoking cessation interventions is difficult to determine when they are provided as a complement to current smoking cessation services. The aim of this study was to evaluate the cost-effectiveness of such an alternate package compared with existing smoking cessation services alone (current package). METHODS: A literature search was conducted to identify internet-based smoking cessation interventions in the Netherlands...
December 15, 2017: Addiction
https://www.readbyqxmd.com/read/29243338/a-partially-linear-additive-model-for-clustered-proportion-data
#10
Weihua Zhao, Heng Lian, Dipankar Bandyopadhyay
Proportion data with support lying in the interval [0,1] are a commonplace in various domains of medicine and public health. When these data are available as clusters, it is important to correctly incorporate the within-cluster correlation to improve the estimation efficiency while conducting regression-based risk evaluation. Furthermore, covariates may exhibit a nonlinear relationship with the (proportion) responses while quantifying disease status. As an alternative to various existing classical methods for modeling proportion data (such as augmented Beta regression) that uses maximum likelihood, or generalized estimating equations, we develop a partially linear additive model based on the quadratic inference function...
December 15, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29243043/quality-of-life-in-a-broader-perspective-does-ascot-reflect-the-capability-approach
#11
M S van Loon, K M van Leeuwen, R W J G Ostelo, J E Bosmans, G A M Widdershoven
PURPOSE: Economic evaluation of services and interventions in care services tends to focus on quality of life(QoL) based on health-related measures such as EQ5D, with a major focus on health and functioning. The Capability Approach (CA) provides an alternative framework for measuring QoL and challenges some of the conventional issues in the current practice of measurement of QoL. The Adult Social Care Outcomes Toolkit (ASCOT) aims to measure social care-related QoL in a broad sense. This article investigates whether and, if so, how the ASCOT addresses issues put on the agenda by the CA...
December 14, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29243017/diabetes-self-care-behaviors-among-marshallese-adults-living-in-the-united-states
#12
Holly Felix, Brett Rowland, Christopher R Long, Marie-Rachelle Narcisse, Michelle Piel, Peter A Goulden, Pearl A McElfish
Marshallese experience high rates of type 2 diabetes. Proper management of diabetes requires multiple self-care behaviors, yet little is known about Marshallese's diabetes-related self-care behaviors. Survey data from 111 Marshallese adults with diabetes were used to examine relationships between self-care behaviors and socio-demographic characteristics. The most common self-care behavior was attending annual doctor visits, while the least common was maintaining a normal weight. Age group, education level, and having a regular doctor were significantly associated with engaging in self-care behaviors...
December 14, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29242175/developing-mhealth-messages-to-promote-postmenstrual-regulation-contraceptive-use-in-bangladesh-participatory-interview-study
#13
Elisabeth Eckersberger, Erin Pearson, Kathryn Andersen, Altaf Hossain, Katharine Footman, Kamal Kanti Biswas, Sadid Nuremowla, Kate Reiss
BACKGROUND: Abortions are restricted in Bangladesh, but menstrual regulation is an approved alternative, defined as a procedure of regulating the menstrual cycle when menstruation is absent for a short duration. Use of contraception after menstrual regulation can reduce subsequent unintended pregnancy, but in Bangladesh, the contraceptive method mix is dominated by short-term methods, which have higher discontinuation and failure rates. Mobile phones are a channel via which menstrual regulation clients could be offered contraceptive support after leaving the clinic...
December 14, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29242147/shared-and-divergent-neural-reactivity-to-non-drug-operant-response-outcomes-in-current-smokers-and-ex-smokers
#14
Liam J Nestor, Ella McCabe, Jennifer Jones, Luke Clancy, Hugh Garavan
Addiction to cigarettes presents with considerable health risks and induces high costs on healthcare resources. While the majority of cigarette smokers endorse the desire to quit, only a small percentage of quit attempts lead to full abstinence. Failure to achieve abstinence may arise from maladaptive reactivity in fronto-striatal regions that track positive and negative valence outcomes, thus biasing the choice to smoke in the presence of alternative, non-drug reinforcement. Alternatively, long-term nicotine abstinence may reveal neural substrates of adaptive valence outcome processing that promote and maintain smoking cessation...
December 11, 2017: Brain Research
https://www.readbyqxmd.com/read/29241901/comparison-of-timed-automata-with-discrete-event-simulation-for-modeling-of-biomarker-based-treatment-decisions-an-illustration-for-metastatic-castration-resistant-prostate-cancer
#15
Koen Degeling, Stefano Schivo, Niven Mehra, Hendrik Koffijberg, Rom Langerak, Johann S de Bono, Maarten J IJzerman
BACKGROUND: With the advent of personalized medicine, the field of health economic modeling is being challenged and the use of patient-level dynamic modeling techniques might be required. OBJECTIVES: To illustrate the usability of two such techniques, timed automata (TA) and discrete event simulation (DES), for modeling personalized treatment decisions. METHODS: An early health technology assessment on the use of circulating tumor cells, compared with prostate-specific antigen and bone scintigraphy, to inform treatment decisions in metastatic castration-resistant prostate cancer was performed...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29241900/a-latent-class-of-their-own-response-patterns-in-trading-off-quantity-and-quality-of-life-in-time-trade-off-exercises
#16
F E van Nooten, K Houghton, J van Exel, M van Agthoven, W B F Brouwer, D E Stull
BACKGROUND: Conflicting results regarding associations of time trade-off (TTO) valuations with respondent characteristics have been reported, mostly on the basis of regression analyses. Alternative approaches, such as the latent class analysis (LCA), may add to the further understanding of variations in TTO responses. OBJECTIVES: To identify whether subgroups of respondents can be identified on the basis of their responses to TTO exercises and to investigate which respondent characteristics are associated with membership of the identified subgroups...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29241890/value-of-information-analysis-of-multiparameter-tests-for-chemotherapy-in-early-breast-cancer-the-optima-prelim-trial
#17
Peter S Hall, Alison Smith, Claire Hulme, Armando Vargas-Palacios, Andreas Makris, Luke Hughes-Davies, Janet A Dunn, John M S Bartlett, David A Cameron, Andrea Marshall, Amy Campbell, Iain R Macpherson, Dan Rea, Adele Francis, Helena Earl, Adrienne Morgan, Robert C Stein, Christopher McCabe
BACKGROUND: Precision medicine is heralded as offering more effective treatments to smaller targeted patient populations. In breast cancer, adjuvant chemotherapy is standard for patients considered as high-risk after surgery. Molecular tests may identify patients who can safely avoid chemotherapy. OBJECTIVES: To use economic analysis before a large-scale clinical trial of molecular testing to confirm the value of the trial and help prioritize between candidate tests as randomized comparators...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29241674/ethnomedicinal-plant-diversity-in-thailand
#18
Methee Phumthum, Kamonnate Srithi, Angkhana Inta, Auemporn Junsongduang, Kornkanok Tangjitman, Wittaya Pongamornkul, Chusie Trisonthi, Henrik Balslev
ETHNOPHARMACOLOGICAL RELEVANCE: Plants have provided medicine to humans for thousands of years, and in most parts of the world people still use traditional plant-derived medicine. Knowledge related to traditional use provides an important alternative to unavailable or expensive western medicine in many rural communities. At the same time, ethnomedicinal discoveries are valuable for the development of modern medicine. Unfortunately, globalization and urbanization causes the disappearance of much traditional medicinal plant knowledge...
December 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29241598/organ-donation-after-controlled-cardiac-death-under-maastricht-category-iii-ethical-implications-and-end-of-life-care
#19
M Isabel González-Méndez, Luís López-Rodríguez
The decrease in potential donation after brain death has resulted in a need to evaluate alternative sources. Donation after cardiac death is a good option. The objectives of this article were to describe the Maastricht type iii controlled organ donation characteristics and to determine end-of-life care and the role of nurses in the donation process. In this type of donation, cardiocirculatory arrest is predictable after the limitation of life sustaining treatments. These are patients for whom there are no effective therapy options and, in the context of an organised and planned practice involving all the professionals involved in the care of the patient, the decision is made, in consultation with the family, to withdraw life support measures...
December 11, 2017: Enfermería Clínica
https://www.readbyqxmd.com/read/29241476/inahta-impact-story-legislative-and-accreditation-requirements-for-office-based-surgery-in-australia
#20
David Tivey, Ning Ma, Joanna Duncan, Yasoba Atukorale, Robyn Lambert, Guy Maddern
BACKGROUND: There is growing trend for some surgical procedures previously performed in hospitals to be done in alternative settings, including office-based facilities. There has been some safety concerns reported in the media, which document serious adverse events following procedures performed in an office-based setting. To understand the current regulatory oversight of surgery in this setting ASERNIP-S conducted a review of the legislative and accreditation process governing these facilities in Australia...
January 2017: International Journal of Technology Assessment in Health Care
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