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dog cholangiocarcinoma

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https://www.readbyqxmd.com/read/20579324/identification-of-hepatic-stem-progenitor-cells-in-canine-hepatocellular-and-cholangiocellular-carcinoma
#1
B Cogliati, T P A Aloia, R V Bosch, V A F Alves, F J Hernandez-Blazquez, M L Z Dagli
Hepatic progenitor cells (HPCs) are bipotential stem cells residing in human and animal livers that are able to differentiate towards the hepatocytic or cholangiocytic lineages. HPCs are present in both hepatocellular (HCC) and cholangiocellular carcinoma (CC) in humans; and a small percentage of HCC can originate from cancer stem cells. However, its distribution in canine liver tumour has not been studied. Herein, we searched for stem/progenitor cells in 13 HCC and 7 CC archived samples by immunohistochemical analysis...
June 2010: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/20503174/claudin-7-protein-differentiates-canine-cholangiocarcinoma-from-hepatocellular-carcinoma
#2
Cs Jakab, A Kiss, Zs Schaff, Z Szabó, M Rusvai, P Gálfi, A Szabára, A Sterczer, J Kulka
UNLABELLED: The aim of the present study was to characterise the expression pattern of claudin-7 tight junction protein in canine normal liver, hyperplastic and primary neoplastic lesions of the canine liver and whether this tight junction protein can help differentiate canine cholangiocarcinomas from canine hepatocellular carcinomas. METHODS AND RESULTS: Necropsy samples included 15 canine normal liver tissue samples, 10 hepatocellular nodular hyperplasias, 6 hepatocellular adenomas, 15 well-differentiated and 6 poorly differentiated hepatocellular carcinomas, 6 cholangiocellular hyperplasias, 10 cholangiocellular adenomas, 15 well-differentiated and 6 poorly differentiated cholangiocarcinomas, 6 normal extrahepatic bile ducts, 8 normal gall bladder tissue samples, and 5 cystic mucinous hyperplasias of the gall bladder...
July 2010: Histology and Histopathology
https://www.readbyqxmd.com/read/20166400/contrast-enhanced-ultrasonography-for-characterization-of-canine-focal-liver-lesions
#3
Kensuke Nakamura, Satoshi Takagi, Noboru Sasaki, Wickramasekara Rajapakshage Bandula Kumara, Masahiro Murakami, Hiroshi Ohta, Masahiro Yamasaki, Mitsuyoshi Takiguchi
In six normal beagles and 27 dogs with spontaneous focal or multifocal liver lesions, contrast-enhanced ultrasonography using Sonazoid was performed. Sonazoid is a newly developed second-generation contrast agent with the ability to be used for real-time contrast imaging along with parenchymal imaging. An appropriate protocol for the evaluation of all three phases (arterial, portal, and parenchymal) was established based on the results for normal beagles. By evaluation of the echogenicity of hepatic nodules during the arterial and parenchymal phases it was possible to differentiate malignant tumors from benign nodules with very high accuracy...
January 2010: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/16856607/-effects-of-different-liver-diseases-on-the-platelet-count-in-dogs
#4
St Neumann
Changes of the platelet count in liver diseases are described in humans. Thrombocytopenia was observed more frequently than thrombocytosis. There are only a few investigations on platelet counts in liver diseases in dogs. The goal of the present study was to investigate the influence of different liver diseases including degeneration, hepatitis and liver tumours, on the platelet count. Platelet counts of 52 dogs with different liver diseases were measured and compared with 52 healthy dogs. The results showed, that dogs with liver degeneration have thrombocytosis in 41% of the cases and a group of dogs with liver tumours (malignant histiocytosis, hepatoma, malignant lymphoma anaplastic sarcoma, cholangiocarcinoma, hepatocellular carcinoma) had thrombocytopenia in 50% of the cases...
June 2006: DTW. Deutsche Tierärztliche Wochenschrift
https://www.readbyqxmd.com/read/16153321/clonorchiasis-an-update
#5
REVIEW
H-J Rim
Clonorchis sinensis, the Chinese or oriental liver fluke, is an important human parasite and is widely distributed in southern Korea, China (including Taiwan), Japan, northern Vietnam and the far eastern part of Russia. Clonorchiasis occurs in all parts of the world where there are Asian immigrants from endemic areas. The human and animal reservoir hosts (dogs, pigs, cats and rats) acquire the infection from the ingestion of raw fish containing infectious metacercariae. The first intermediate snail hosts are mainly species of Parafossarulus and Bithynia...
September 2005: Journal of Helminthology
https://www.readbyqxmd.com/read/15276773/quantification-of-mdr-1-gene-expression-in-canine-tissues-by-real-time-reverse-transcription-quantitative-polymerase-chain-reaction
#6
K Culmsee, A D Gruber, G von Samson-Himmelstjerna, I Nolte
MDR-1 gene product mediated multidrug resistance is thought to play a major role in the outcome of chemotherapy in some canine tumors, especially malignant lymphoma. In the present study, MDR-1 RNA expression in normal lymph node and liver tissue as well as in tumor biopsies from 23 dogs with lymphomas and two dogs with liver tumors was measured by real-time RT-quantitative PCR. MDR-1 gene expression was detected in all samples analyzed. Comparably high MDR-1 RNA levels were measured in all normal liver tissues, one of the lymphomas and a cholangiocarcinoma...
December 2004: Research in Veterinary Science
https://www.readbyqxmd.com/read/14510332/immunocytological-confirmation-of-bone-marrow-metastases-in-a-dog-with-cholangiocarcinoma
#7
R Mischke, R Höinghaus, E Lütkefels, K Buhl, A Gerhardt, M Hewicker-Trautwein
The case history of a four-year-old, male Bernese mountain dog is presented. Carcinoma cells were detected in the liver by ultrasound-guided fine-needle aspiration. Bone marrow aspirated from the iliac crest and the left femur showed a distinct infiltration by carcinoma cells. Immunocytological examination of the liver and bone marrow metastases showed a negative staining result for large spectrum cytokeratin (CK) KL1, a strong positive result for CK7 and a focal weak positive result for CK20. The dog was euthanased due to the grave prognosis...
September 2003: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/12695556/detection-of-the-human-organic-anion-transporters-slc21a6-oatp2-and-slc21a8-oatp8-in-liver-and-hepatocellular-carcinoma
#8
Yunhai Cui, Jörg König, Anne T Nies, Marion Pfannschmidt, Michaela Hergt, Werner W Franke, Wibke Alt, Roland Moll, Dietrich Keppler
Transport proteins mediating the selective uptake of organic anions into human hepatocytes include the organic anion transporters SLC21A6 (also termed OATP2, OATP-C, or LST-1) and SLC21A8 (OATP8). Both transporters are localized to the basolateral membrane of human hepatocytes. Because of the importance of these transporters for hepatobiliary elimination, including the removal of bilirubin and its conjugates from the blood circulation, we have generated monoclonal antibodies for studies on the expression and localization of these transport proteins...
April 2003: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/11346190/combined-hepatocellular-and-cholangiocellular-carcinoma-in-a-dog
#9
A Shiga, K Shirota, M Enomoto
A transitional type of combined hepatocellular and cholangiocellular carcinoma developed in a 12-year-old male Yorkshire terrier dog. The tumor was histologically composed of both hepatocellular carcinoma and cholangiocellular carcinoma components, and both elements were closely intermingled. Intraluminal mucin accumulation in cytokeratin-positive tubular/glandular structures was observed within the cholangiocellular carcinoma components and this feature was useful histological marker for a differential diagnosis between combined hepatocellular and cholangiocellular carcinoma and a pseudoglandular type of hepatocellular carcinoma...
April 2001: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/10423688/serum-alpha-fetoprotein-values-in-dogs-with-various-hepatic-diseases
#10
T Yamada, M Fujita, S Kitao, Y Ashida, K Nishizono, R Tsuchiya, T Shida, K Kobayashi
Serum alpha-fetoprotein (AFP) values were measured in hepatic diseased dogs with or without tumor and non-hepatic tumor bearing dogs by a sandwich ELISA using anti-dog AFP antiserum. Serum AFP values were less than 70 ng/ml in clinically healthy dogs. The values in dogs with hepatocellular carcinoma were higher than 1,400 ng/ml in 7 of 9 dogs, wherever those in two dogs with cholangiocarcinoma were in the normal range. Serum AFP values in hepatic diseased dogs without tumor were also high, however, the values were below 500 ng/ml in 90% of the dogs...
June 1999: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/10332826/coordinate-expression-of-cytokeratins-7-and-20-in-feline-and-canine-carcinomas
#11
A Espinosa de los Monteros, A Fernández, M Y Millán, F Rodríguez, P Herráez, J Martín de las Mulas
Forty-seven feline and 60 canine epithelial tumors were studied to test the coordinate expression of cytokeratin 7 (CK 7) and cytokeratin 20 (CK 20) using commercially available monoclonal antibodies and an avidin-biotin immunoperoxidase staining technique. Previously, the distribution of both cytokeratins was examined in normal tissues from 4 cats and 4 dogs. The pattern of distribution of CK 7 in normal tissues was similar, with minor differences, to that described in humans, whereas the reactivity pattern of CK 20 in cats and dogs was wider than that in humans...
May 1999: Veterinary Pathology
https://www.readbyqxmd.com/read/8885180/immunohistochemical-detection-of-p-glycoprotein-in-formalin-fixed-and-paraffin-embedded-normal-and-neoplastic-canine-tissues
#12
P E Ginn
Expression of P-glycoprotein, a phylogenetically conserved integral plasma membrane protein, is implicated as one of the most important factors contributing to tumor cell multidrug resistance. Formalin-fixed, paraffin-embedded normal and neoplastic canine tissues were studied using an avidin-biotin complex technique employing three murine monoclonal antibodies (C494, C219, JSB-1) to different epitopes of the P-glycoprotein molecule. Evaluation of immunostaining of normal canine tissues revealed positive labeling detected by each antibody in the liver, proximal renal tubular epithelium, adrenal cortex, colonic epithelium, and capillary endothelial cells of the brain...
September 1996: Veterinary Pathology
https://www.readbyqxmd.com/read/8736384/hepatic-neoplasms-from-internally-deposited-144cecl3
#13
F F Hahn, B A Muggenburg, B B Boecker
Fifty-five dogs were exposed by inhalation to graded activity levels of 144CeCl3, a relatively soluble form of the beta-emitting radionuclide. A large portion of the 144Ce translocated from lung to liver and skeleton. Significant radiation doses were delivered to the respiratory tract, liver, and skeleton; however, the liver received the greatest cumulative absorbed dose. Liver tumors were the most frequently observed neoplasms in these exposed dogs and included 7 primary hepatic hemangiosarcomas, 1 cholangiocarcinoma, 1 hepatocellular carcinoma, 1 fibrosarcoma, 4 biliary cystadenomas, and 1 fibroma...
May 1996: Toxicologic Pathology
https://www.readbyqxmd.com/read/8525100/immunohistochemical-evaluation-of-canine-primary-liver-carcinomas-distribution-of-alpha-fetoprotein-carcinoembryonic-antigen-keratins-and-vimentin
#14
COMPARATIVE STUDY
J Martín de las Mulas, J C Gómez-Villamandos, J Pérez, E Mozos, M Estrado, A Méndez
The immunohistochemical expression of the oncofetal proteins alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA), and the intermediate filament proteins keratin and vimentin was analysed in 18 canine liver carcinomas. All the tumours other than hepatocellular carcinomas, with the exception of one poorly differentiated carcinoma, were AFP negative, and only cholangiocarcinomas and mixed (hepatocellular and cholangiocellular) carcinomas were CEA positive. All the histological types of tumours expressed high and low molecular weight keratins, and keratin and vimentin were both expressed in three tumours (one moderately differentiated hepatocellular carcinoma, one mixed carcinoma and one poorly differentiated carcinoma)...
September 1995: Research in Veterinary Science
https://www.readbyqxmd.com/read/7404966/canine-hepatic-neoplasms-a-clinicopathologic-study
#15
A K Patnaik, A I Hurvitz, P H Lieberman
One hundred ten primary hepatic neoplasms, excluding hematopoietic and vascular tumors, were diagnosed in 12,245 canine necropsies. Included were 55 hepatocellular carcinomas, 24 bile duct carcinomas, 2 combined hepatocellular and cholangiocarcinomas, 15 carcinoids and 14 sarcomas. A majority of the dogs with hepatocellular carcinoma (80%), bile duct carcinoma (65%) and sarcoma (61%) were 10 years old or older; 71% of the dogs with carcinoid were under 10 years old. Hepatocellular carcinoma and sarcoma occurred more often in males, bile duct carcinoma in females, and no sex predisposition was found in dogs with carcinoid...
September 1980: Veterinary Pathology
https://www.readbyqxmd.com/read/6841697/canine-biliary-carcinoma-epidemiological-comparisons-with-man
#16
COMPARATIVE STUDY
H M Hayes, M M Morin, D A Rubenstein
A retrospective study of abstracted data representing 1.1 million hospital examinations of dogs at veterinary university teaching facilities identified 77 with bile duct carcinoma. Using the hospital population, based on patient years at risk, as the expected frequency of particular zoographic characteristics, there was a suggestion of a familial (breed) predisposition in Labrador retrievers and limited evidence of a sex differential. Because mongrel dogs displayed about the same frequency of bile duct cancer as all breeds combined, other causal factors, besides genetics, are implied...
January 1983: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/6646663/a-survey-on-neoplasia-in-domestic-species-over-a-40-year-period-from-1935-to-1974-in-the-republic-of-south-africa-vi-tumours-occurring-in-dogs
#17
S S Bastianello
A survey was carried out on all canine neoplasms recorded in the registration files of the Section of Pathology of the Veterinary Research Institute at Onderstepoort over a 40-year period from 1935 to 1974. The neoplasms were divided and tabulated into 14 groups according to body systems or tissue types. A total of 3 388 neoplasms were recorded. The 5 most frequently affected body systems were the mesenchymal tissues (33,7%) the skin and adnexa (20,8%) the female genital tract (10,2%), the lymphohaemopoietic tissues (8,9%) and the male genital tract (5,8%)...
September 1983: Onderstepoort Journal of Veterinary Research
https://www.readbyqxmd.com/read/6266117/canine-bile-duct-carcinoma
#18
A K Patnaik, A I Hurvitz, P H Lieberman, G F Johnson
Twenty-four adenocarcinomas of the hepatobiliary system were found among 110 primary hepatic neoplasms: 22 of these were intrahepatic, one involved the extrahepatic bile duct and one the gall bladder. Histologically, 10 intrahepatic neoplasms were classified as cholangiocarcinoma, and 12 as bile duct cystadenocarcinoma. The former were characterized by tubular structures lined by anaplastic cuboidal or columnar cells with diffuse fibrous stroma, and the latter by multiple cystic structures with papillary and solid areas...
July 1981: Veterinary Pathology
https://www.readbyqxmd.com/read/6266116/canine-hepatocellular-carcinoma
#19
A K Patnaik, A I Hurvitz, P H Lieberman, G F Johnson
In a study of 110 primary hepatic neoplasms in dogs, 55 hepatocellular carcinomas and two combined hepatocellular and cholangiocarcinomas were diagnosed. These neoplasms were classified into the following 11 groups based on histo-architectural pattern: trabecular, peliod, cobblestone, peritheliomatous, anaplastic, pseudoglandular, pleomorphic, scirrhous, clear cell, solid, and combined hepatocellular and cholangiocarcinoma. The neoplastic hepatocytes varied from almost normal to highly anaplastic spindle cells...
July 1981: Veterinary Pathology
https://www.readbyqxmd.com/read/2544974/ulex-europaeus-agglutinin-1-lectin-histochemical-staining-of-dog-hepatocellular-and-bile-duct-carcinomas
#20
P J Brown, T J Stephenson
Ulex europaeus agglutinin 1 (UEA-1) lectin-binding is a feature of canine intrahepatic bile duct epithelial cells but not of canine hepatocytes. In tumours diagnosed histologically as cholangiocarcinomas or hepatocellular carcinomas, UEA-1 staining occurred in tumour cells regardless of histological appearance. The division of primary liver carcinomas into different presumed cell types of origin is not reflected by equivalent differentiation of the tumour cells and is not of diagnostic value.
May 1989: Research in Veterinary Science
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