keyword
https://read.qxmd.com/read/38529099/clinical-presentation-and-6-month-outcomes-of-patients-with-peripartum-cardiomyopathy-in-indonesia
#1
JOURNAL ARTICLE
Hawani Sasmaya Prameswari, Triwedya Indra Dewi, Melawati Hasan, Erwan Martanto, Astri Astuti, Aninka Saboe, Charlotte Johanna Cool
BACKGROUND: Due to the rarity of peripartum cardiomyopathy (PPCM) globally, baseline characteristic data for PPCM patients are still scarce. Therefore, this study aims to determine the baseline characteristics and 6-month outcomes of PPCM patients in Indonesia. METHODS: From January 2014 to December 2021, all PPCM patients aged ≥18 years who were admitted to Dr. Hasan Sadikin General Hospital in Bandung, Indonesia, participated in this single-center, prospective cohort study...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38522619/trans-atlantic-differences-in-approach-to-sudden-death-prevention-in-hypertrophic-cardiomyopathy
#2
REVIEW
Max Liebregts
The American approach to predicting sudden cardiac death (SCD) in patients with hypertrophic cardiomyopathy (HCM) diverges from the European method in that it relies on major risk factors independently justifying the implantation of an (implantable cardioverter-defibrillator) ICD for primary prevention, whereas the European approach utilizes a mathematical equation to estimate a 5-year risk percentage. The aim of this review is to outline the differences between the American and European guidelines and to demonstrate how they have arisen...
March 22, 2024: Canadian Journal of Cardiology
https://read.qxmd.com/read/38516780/clinical-guideline-for-preimplantation-genetic-testing-in-inherited-cardiac-diseases
#3
JOURNAL ARTICLE
Job A J Verdonschot, Debby M E I Hellebrekers, Vanessa P M van Empel, Malou Heijligers, Sonja de Munnik, Edith Coonen, Jos C M F Dreesen, Arthur van den Wijngaard, Han G Brunner, Masoud Zamani Esteki, Stephane R B Heymans, Christine E M de Die-Smulders, Aimée D C Paulussen
BACKGROUND: Preimplantation genetic testing (PGT) is a reproductive technology that selects embryos without (familial) genetic variants. PGT has been applied in inherited cardiac disease and is included in the latest American Heart Association/American College of Cardiology guidelines. However, guidelines selecting eligible couples who will have the strongest risk reduction most from PGT are lacking. We developed an objective decision model to select eligibility for PGT and compared its results with those from a multidisciplinary team...
March 22, 2024: Circulation. Genomic and Precision Medicine
https://read.qxmd.com/read/38513737/clinical-characteristics-treatment-trajectories-and-outcome-of-patients-with-dilated-cardiomyopathy-in-a-national-heart-failure-registry
#4
JOURNAL ARTICLE
Samuela Carigi, Piero Gentile, Mauro Gori, Denitza Tinti, Luisa De Gennaro, Giuseppe Leonardi, Francesco Orso, Anna Rita Felici, Maria Rosaria Catalano, Marina Floresta, Vittoria Rizzello, Donata Lucci, Lucio Gonzini, Renata De Maria, Marco Marini
BACKGROUND: Available data on the clinical characteristics and prognosis of patients with heart failure (HF) due to dilated cardiomyopathy (DCM) derive mainly from tertiary care centres for cardiomyopathies or from drug trial sub-studies, which may entail a referral bias. METHODS: From 2008 to 2021, we enrolled in a nationwide HF Registry 1886 DCM patients and 3899 with ischemic heart disease (IHD). RESULTS: Patients with DCM were younger, more often female, had more commonly recent onset HF, left bundle branch block, and showed higher LV end-diastolic volume and lower LVEF than IHD...
March 19, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38510995/clinical-course-of-adults-with-co-occurring-hypertrophic-cardiomyopathy-and-hypertension-a-scoping-review
#5
REVIEW
Milla Arabadjian, Sophie Montgomery, Mitchell Pleasure, Barnaby Nicolas, Maxine Collins, Maria Reuter, Daniele Massera, Daichi Shimbo, Mark V Sherrid
INTRODUCTION: Hypertension affects approximately 50 % of patients with hypertrophic cardiomyopathy (HCM) but clinical course in adults with co-occurring HCM and hypertension is underexplored. Management may be challenging as routine anti-hypertensive medications may worsen obstructive HCM, the most common HCM phenotype. In this scoping review, we sought to synthesize the available literature related to clinical course and outcomes in adults with both conditions and to highlight knowledge gaps to inform future research directions...
March 2024: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38510948/a-randomized-controlled-trial-evaluating-a-theory-driven-complex-intervention-centered-on-task-sharing-and-mobile-health-to-improve-selfcare-and-outcomes-in-heart-failure-the-panacea-hf-rct-design-and-rationale
#6
JOURNAL ARTICLE
D Y Kamath, J Abdullakutty, B B Granger, S Kulkarni, K B Bhuvana, L J Salazar, S Shifra, J Idiculla, J Narendra, K Varghese, D Xavier
BACKGROUND: We developed a three-pronged complex intervention to improve selfcare and deliver whole person care for patients with heart failure, underpinned by the 'extant cycle' theory - a theory based on our formative work. METHODS: This is a 3 centre, 2-arm, 1:1, open, adaptive stratified, randomized controlled trial. We included patients aged ≥ 18 years with heart failure, taking any of the key guideline directed medical treatments, with a history of or currently on a high ceiling diuretic...
October 2023: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38510299/impact-of-the-esc-cardio-oncology-guidelines-biomarker-criteria-on-incidence%C3%A2-of-cancer-therapy-related-cardiac-dysfunction
#7
JOURNAL ARTICLE
Albulena Mecinaj, Geeta Gulati, Anne Hansen Ree, Berit Gravdehaug, Helge Røsjø, Kjetil Steine, Torbjørn Wisløff, Jürgen Geisler, Torbjørn Omland, Siri Lagethon Heck
BACKGROUND: The impact of recent consensus definitions of cancer therapy-related cardiac dysfunction (CTRCD) from the European Society of Cardiology cardio-oncology guidelines on the reported incidence of CTRCD has not yet been assessed. OBJECTIVES: The aim of this study was to assess the: 1) cumulative incidence; 2) point prevalence during and after adjuvant therapy; and 3) prognostic value of CTRCD as defined by different asymptomatic CTRCD guideline criteria...
February 2024: JACC CardioOncology
https://read.qxmd.com/read/38498097/effects-of-dapagliflozin-and-empagliflozin-on-6-min-walk-distance-in-heart-failure-with-preserved-and-reduced-ejection-fraction-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-involving-2624-patients
#8
REVIEW
Mohammad Tanashat, Almothana Manasrah, Mohamed Abouzid
BACKGROUND: Dapagliflozin and empagliflozin are antidiabetic medications. They are the first two sodium-glucose cotransporter-2 inhibitors (SGLT2i) to receive the US Food and Drug Administration approval to manage heart failure. Emerging new trials have examined changes in the 6-min walk distance as a clinically significant response to dapagliflozin and empagliflozin in patients with heart failure with reduced ejection fraction (HFpEF) and heart failure with preserved ejection fraction (HFrEF)...
March 18, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38497695/diagnosis-and-management-of-paroxysmal-supraventricular-tachycardia
#9
JOURNAL ARTICLE
Gary Peng, Paul C Zei
IMPORTANCE: Paroxysmal supraventricular tachycardia (PSVT), defined as tachyarrhythmias that originate from or conduct through the atria or atrioventricular node with abrupt onset, affects 168 to 332 per 100 000 individuals. Untreated PSVT is associated with adverse outcomes including high symptom burden and tachycardia-mediated cardiomyopathy. OBSERVATIONS: Approximately 50% of patients with PSVT are aged 45 to 64 years and 67.5% are female. Most common symptoms include palpitations (86%), chest discomfort (47%), and dyspnea (38%)...
February 20, 2024: JAMA
https://read.qxmd.com/read/38497201/development-and-validation-of-a-prognostic-score-integrating-remote-heart-failure-symptoms-and-clinical-variables-in-mortality-risk-prediction-after-myocardial-infarction-the-praguemi-score
#10
JOURNAL ARTICLE
Peter Wohlfahrt, Dominik Jenča, Vojtěch Melenovský, Josef Stehlik, Jolana Mrázková, Marek Šramko, Martin Kotrč, Michael Želízko, Věra Adámková, Jan Piťha, Josef Kautzner
AIMS: While heart failure (HF) symptoms are associated with adverse prognosis after myocardial infarction (MI), they are not routinely used for patients' stratification. The primary objective of this study was to develop and validate a score to predict mortality risk after MI, combining remotely recorded HF symptoms and clinical risk factors, and to compare it against the guideline-recommended GRACE score. METHODS: A cohort study design using prospectively collected data from consecutive patients hospitalized for MI at a large tertiary heart centre between June 2017 and September 2022 was used...
March 18, 2024: European Journal of Preventive Cardiology
https://read.qxmd.com/read/38491532/trastuzumab-in-patients-with-breast-cancer-and-pre-existing-left-ventricular-systolic-dysfunction
#11
JOURNAL ARTICLE
Azin Alizadehasl, Mina Mohseni, Kamran Roudini, Parisa Firoozbakhsh
BACKGROUND: Trastuzumab is one of the most effective treatments in HER-2 positive breast cancer patients. However, it is associated with development of cardiomyopathy/heart failure (HF) which is often a limiting side effect and associated with overall adverse outcomes. As a result, patients with pre-existing LV systolic dysfunction (LVSD) are often excluded from receiving anti-HER-2 therapy, which may lead to less effective cancer treatment and worse prognosis. OBJECTIVES: The current study aims to evaluate the safety of trastuzumab in patients with HER-2 positive breast cancer and pre-existing LVSD...
March 15, 2024: Cardio-Oncology
https://read.qxmd.com/read/38488292/sodium-glucose-cotransporter-2-inhibitors-for-transthyretin-amyloid-cardiomyopathy-analyses-of-short-term-efficacy-and-safety
#12
JOURNAL ARTICLE
Frederick M Lang, Sergio Teruya, Ariel Weinsaft, Margaret Cuomo, Alfonsina Mirabal Santos, Ani Nalbandian, Dimitrios Bampatsias, Mathew S Maurer
AIMS: Despite their potential, sodium-glucose cotransporter 2 inhibitors (SGLT2i) have not been well-studied in transthyretin amyloid cardiomyopathy (ATTR-CM) as randomized trials have excluded patients with this morbid disease. We performed a retrospective study assessing the short-term efficacy and safety of SGLT2i in ATTR-CM. METHODS AND RESULTS: We screened consecutive patients seen at a tertiary care centre and identified 87 ATTR-CM patients treated with SGLT2i and 95 untreated control patients...
March 15, 2024: European Journal of Heart Failure
https://read.qxmd.com/read/38485484/heart-failure-clinic-inclusion-and-exclusion-criteria-cross-sectional-study-of-clinic-s-and-referring-provider-s-perspectives
#13
JOURNAL ARTICLE
Taslima Mamataz, Sean A Virani, Michael McDonald, Heather Edgell, Sherry L Grace
OBJECTIVES: There are substantial variations in entry criteria for heart failure (HF) clinics, leading to variations in whom providers refer for these life-saving services. This study investigated actual versus ideal HF clinic inclusion or exclusion criteria and how that related to referring providers' perspectives of ideal criteria. DESIGN, SETTING AND PARTICIPANTS: Two cross-sectional surveys were administered via research electronic data capture to clinic providers and referrers (eg, cardiologists, family physicians and nurse practitioners) across Canada...
March 14, 2024: BMJ Open
https://read.qxmd.com/read/38467476/immediate-pharmacotherapy-intensification-after-cardiac-resynchronization-therapy-incidence-characteristics-and-impact
#14
JOURNAL ARTICLE
Kojiro Ogawa, Hiro Yamasaki, Kazutaka Aonuma, Masafumi Otani, Ai Hattori, Masako Baba, Kentaro Yoshida, Miyako Igarashi, Hidetaka Nishina, Kou Suzuki, Akihiko Nogami, Masaki Ieda
AIMS: Cardiac resynchronization therapy (CRT) is an established treatment for drug-refractory heart failure (HF) in patients with left bundle branch block (LBBB). Acute haemodynamic improvement after CRT implantation may enable the intensification of HF medication soon thereafter. Immediate pharmacotherapy intensification (IPI) after CRT implantation achieves a synergetic effect, possibly leading to a better prognosis. This study aimed to explore the incidence, characteristics, and impact of IPI on real-world outcomes among CRT recipients with a history of hospitalization for acute HF...
March 11, 2024: ESC Heart Failure
https://read.qxmd.com/read/38467416/longitudinal-adherence-to-surveillance-for-late-effects-of-cancer-treatment-a-population-based-study-of-adult-survivors-of-childhood-cancer
#15
JOURNAL ARTICLE
Jennifer Shuldiner, Rinku Sutradhar, Cindy Lau, Nida Shah, Emily Lam, Noah Ivers, Paul C Nathan
BACKGROUND: Adult survivors of childhood cancer are at elevated risk of morbidity and mortality compared to the general population, but their adherence to lifelong periodic surveillance is suboptimal. We aimed to examine adherence to surveillance guidelines for high-yield tests and identify risk factors for nonadherence in adult survivors of childhood cancer. METHODS: In this retrospective, population-based cohort study, we used health care administrative data from Ontario, Canada, to identify adult survivors of childhood cancer diagnosed between 1986 and 2014 who were at elevated risk of therapy-related colorectal cancer, breast cancer, or cardiomyopathy...
March 10, 2024: Canadian Medical Association Journal: CMAJ
https://read.qxmd.com/read/38457558/chronological-change-of-left-ventricular-global-longitudinal-strain-in-patients-with-maternally-inherited-diabetes-and-deafness-a-case-series
#16
JOURNAL ARTICLE
Jeong-Sook Seo
RATIONALE: Maternally inherited diabetes and deafness (MIDD) is a rare genetic disorder arising from mitochondrial DNA mutations, characterized by a combination of diabetes mellitus and sensorineural deafness. It is known that MIDD patients with cardiomyopathy have a poor prognosis, but there are no established guidelines for the diagnosis and follow-up of cardiomyopathy in MIDD patients. PATIENT CONCERNS: Patient 1 was a 48-year-old woman who visited the hospital with cardiomegaly and had been taking oral hypoglycemic agents for 8 years...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38434152/characterization-of-non-ischemic-dilated-cardiomyopathy-in-a-native-tanzanian-cohort-moyo-study
#17
JOURNAL ARTICLE
Lulu Said Fundikira, Pilly Chillo, Mohamed Z Alimohamed, Henry Mayala, Engerasiya Kifai, Geofrey M Aloyce, Appolinary Kamuhabwa, Gideon Kwesigabo, Linda W van Laake, Folkert W Asselbergs
BACKGROUND: Non-ischemic dilated cardiomyopathy (NIDCM) is a common cause of heart failure with progressive tendency. The disease occurs in one in every 2,500 individuals in the developed world, with high morbidity and mortality. However, detailed data on the role of NIDCM in heart failure in Tanzania is lacking. AIM: To characterize NIDCM in a Tanzanian cohort with respect to demographics, clinical profile, imaging findings and management. METHODS: Characterization of non-ischemic dilated cardioMyOpathY in a native Tanzanian cOhort (MOYO) is a prospective cohort study of NIDCM patients seen at the Jakaya Kikwete Cardiac Institute...
2024: Global Heart
https://read.qxmd.com/read/38432770/transcatheter-treatment-of-mitral-valve-regurgitation-in-the-setting-of-concomitant-coronary-or-multivalvular-heart-disease-a-focused-review
#18
REVIEW
Jay Ramsay, Yicheng Tang, Jin Kyung Kim, Antonio H Frangieh
Treatment for mixed valve disease has historically been limited, often surgery being the only option. With the recent advancement of transcatheter therapies, percutaneous approaches are quickly becoming viable therapeutic considerations in inoperable or high-risk patients, also offering the option for a staged or same-session treatment. Guidelines are primarily focused on single-valve disease. However, patients often present with multiple pathologies. This review summarizes the data and literature on transcatheter treatment of patients with mitral regurgitation who concomitantly have aortic stenosis or regurgitation, tricuspid regurgitation, or ischemic cardiomyopathy...
April 2024: Interventional Cardiology Clinics
https://read.qxmd.com/read/38432399/are-we-implanting-too-many-primary-prevention-implantable-cardioverter-defibrillators
#19
JOURNAL ARTICLE
Lebei Pi, Allan Skanes, Robert McKelvie
Canadian Cardiovascular Society/Canadian Heart Failure Society guidelines recommend optimizing patients with heart failure with reduced ejection fraction (HFrEF) on guideline directed medical therapy (GDMT) prior to implanting primary prevention implantable cardioverter defibrillators (ICDs). However, often GDMT is suboptimal at the time of ICD implantation, and is associated with reduced survival. Furthermore, with evidence for declining sudden cardiac death (SCD) rates in patients with cardiomyopathy, there is a need for better risk stratification to determine the indication for ICD...
March 1, 2024: Canadian Journal of Cardiology
https://read.qxmd.com/read/38429631/comparative-effectiveness-and-safety-of-doacs-vs-vkas-in-treatment-of-left-ventricular-thrombus-a-meta-analysis-update
#20
REVIEW
Tong Hu, Changli Chen, Kellina Maduray, Wenqiang Han, Tongshuai Chen, Jingquan Zhong
BACKGROUND AND OBJECTIVE: Left ventricular thrombus (LVT) formation in patients with acute myocardial infarction (AMI) or cardiomyopathies is not uncommon. The optimal oral anticoagulation therapy for resolving LVT has been under intense debate. Vitamin K antagonists (VKAs) remain the anticoagulant of choice for this condition, according to practice guidelines. Evidence supporting the use of direct oral anticoagulants (DOACs) in the management of LVT continues to grow. We performed a systematic review and meta-analysis to compare the efficacy and safety of DOACs versus VKAs...
March 1, 2024: Thrombosis Journal
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