keyword
https://read.qxmd.com/read/38521735/time-to-diagnosis-and-its-predictors-in-syndromes-associated-with-frontotemporal-lobar-degeneration
#1
JOURNAL ARTICLE
Ilenia Libri, Daniele Altomare, Valeria Bracca, Jasmine Rivolta, Valentina Cantoni, Irene Mattioli, Antonella Alberici, Barbara Borroni
OBJECTIVES: Frontotemporal Lobar Degeneration (FTLD) causes a heterogeneous group of neurodegenerative disorders with a wide range of clinical features. This might delay time to diagnosis. The aim of the present study is to establish time to diagnosis and its predictors in patients with FTLD-associated syndromes. DESIGN: Retrospective study. SETTING: Tertiary referral center. PARTICIPANTS: A total of 1029 patients with FTLD-associated syndromes (age: 68 [61-73] years, females: 46%) from 1999 to 2023 were included in the present study...
March 7, 2024: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/38514176/clinicoradiological-and-neuropathological-evaluation-of-primary-progressive-aphasia
#2
JOURNAL ARTICLE
Dror Shir, Nick Corriveau-Lecavalier, Camilo Bermudez Noguera, Leland Barnard, Nha Trang Thu Pham, Hugo Botha, Joseph R Duffy, Heather M Clark, Rene L Utianski, David S Knopman, Ronald C Petersen, Bradley F Boeve, Melissa E Murray, Aivi T Nguyen, R Ross Reichard, Dennis W Dickson, Gregory S Day, Walter K Kremers, Neill R Graff-Radford, David T Jones, Mary M Machulda, Julie A Fields, Jennifer L Whitwell, Keith A Josephs, Jonathan Graff-Radford
BACKGROUND: Primary progressive aphasia (PPA) defines a group of neurodegenerative disorders characterised by language decline. Three PPA variants correlate with distinct underlying pathologies: semantic variant PPA (svPPA) with transactive response DNA-binding protein of 43 kD (TDP-43) proteinopathy, agrammatic variant PPA (agPPA) with tau deposition and logopenic variant PPA (lvPPA) with Alzheimer's disease (AD). Our objectives were to differentiate PPA variants using clinical and neuroimaging features, assess progression and evaluate structural MRI and a novel 18-F fluorodeoxyglucose positron emission tomography (FDG-PET) image decomposition machine learning algorithm for neuropathology prediction...
March 21, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38512130/distinctive-whole-brain-cell-types-predict-tissue-damage-patterns-in-thirteen-neurodegenerative-conditions
#3
JOURNAL ARTICLE
Veronika Pak, Quadri Adewale, Danilo Bzdok, Mahsa Dadar, Yashar Zeighami, Yasser Iturria-Medina
For over a century, brain research narrative has mainly centered on neuron cells. Accordingly, most neurodegenerative studies focus on neuronal dysfunction and their selective vulnerability, while we lack comprehensive analyses of other major cell types' contribution. By unifying spatial gene expression, structural MRI, and cell deconvolution, here we describe how the human brain distribution of canonical cell types extensively predicts tissue damage in 13 neurodegenerative conditions, including early- and late-onset Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, amyotrophic lateral sclerosis, mutations in presenilin-1, and 3 clinical variants of frontotemporal lobar degeneration (behavioral variant, semantic and non-fluent primary progressive aphasia) along with associated three-repeat and four-repeat tauopathies and TDP43 proteinopathies types A and C...
March 21, 2024: ELife
https://read.qxmd.com/read/38498721/progress-in-primary-progressive-aphasia-a-review
#4
REVIEW
Andrew Kertesz, Elizabeth Finger, David G Munoz
We present a review of the definition, classification, and epidemiology of primary progressive aphasia (PPA); an update of the taxonomy of the clinical syndrome of PPA; and recent advances in the neuroanatomy, pathology, and genetics of PPA, as well as the search for biomarkers and treatment. PPA studies that have contributed to concepts of language organization and disease propagation in neurodegeneration are also reviewed. In addition, the issues of heterogeneity versus the relationships of the clinical phenotypes and their relationship to biological, pathological, and genetic advances are discussed, as is PPA's relationship to other conditions such as frontotemporal dementia, corticobasal degeneration, progressive supranuclear palsy, Pick disease, and amyotrophic lateral sclerosis...
March 1, 2024: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://read.qxmd.com/read/38494763/communicative-impairment-and-its-neural-correlates-in-alzheimer-s-disease-and-frontotemporal-dementia
#5
JOURNAL ARTICLE
Alexa Haeger, Janka Muising, Sandro Romanzetti, Bruno Fimm, Oliver Matz, Jörg B Schulz, Stefan Heim, Kathrin Reetz
OBJECTIVE: Communication skills can deteriorate in neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD); however, their clinical assessment and treatment in patient care can be challenging. In the present study, we aimed to quantify the distinctive communication resources and barriers reported by patients and their relatives in AD and FTD and associated these communicative characteristics with clinical parameters, such as the degree of cognitive impairment and atrophy in language-associated brain areas...
March 2024: Brain and Behavior
https://read.qxmd.com/read/38476397/editorial-rising-stars-in-neuropsychology-2021
#6
EDITORIAL
Micaela Mitolo, Daniela Smirni, Matteo De Marco, Nicola Canessa, Sara Palermo
No abstract text is available yet for this article.
2024: Frontiers in Psychology
https://read.qxmd.com/read/38448894/heterogeneity-and-overlap-in-the-continuum-of-linguistic-profile-of-logopenic-and-semantic-variants-of-primary-progressive-aphasia-a-profile-analysis-based-on-multidimensional-scaling-study
#7
JOURNAL ARTICLE
Gaia Chiara Santi, Francesca Conca, Valentina Esposito, Cristina Polito, Silvia Paola Caminiti, Cecilia Boccalini, Carmen Morinelli, Valentina Berti, Salvatore Mazzeo, Valentina Bessi, Alessandra Marcone, Sandro Iannaccone, Se-Kang Kim, Sandro Sorbi, Daniela Perani, Stefano F Cappa, Eleonora Catricalà
BACKGROUND: Primary progressive aphasia (PPA) diagnostic criteria underestimate the complex presentation of semantic (sv) and logopenic (lv) variants, in which symptoms partially overlap, and mixed clinical presentation (mixed-PPA) and heterogenous profile (lvPPA +) are frequent. Conceptualization of similarities and differences of these clinical conditions is still scarce. METHODS: Lexical, semantic, phonological, and working memory errors from nine language tasks of sixty-seven PPA were analyzed using Profile Analysis based on Multidimensional Scaling, which allowed us to create a distributed representation of patients' linguistic performance in a shared space...
March 7, 2024: Alzheimer's Research & Therapy
https://read.qxmd.com/read/38422549/love-anger-and-primary-progressive-aphasia-psychological-care-for-a-person-with-dementia
#8
JOURNAL ARTICLE
George Prigatano
No abstract text is available yet for this article.
February 29, 2024: Applied Neuropsychology. Adult
https://read.qxmd.com/read/38391708/high-frequency-language-therapy-with-semantic-feature-analysis-sfa-and-transcranial-direct-current-stimulation-tdcs-a-longitudinal-single-case-report-of-semantic-variant-of-primary-progressive-aphasia-svppa
#9
Katharina Strunk, Sabine Weiss, Horst M Müller
BACKGROUND: The goal of this study was to investigate whether the combination of semantic feature analysis (SFA) and transcranial direct current stimulation (tDCS) is effective in treating word retrieval in the semantic variant of primary progressive aphasia (svPPA) and how long the potential effects last. METHODS: A 56-year-old woman diagnosed with frontotemporal dementia (FTD) and svPPA participated in this longitudinal single-subject design. A total of four 2-week stimulation phases were conducted over a 14-month period, each of which was started depending on the participant's language performance...
January 27, 2024: Brain Sciences
https://read.qxmd.com/read/38389095/phenotypically-concordant-distribution-of-pick-bodies-in-aphasic-versus-behavioral-dementias
#10
JOURNAL ARTICLE
Allegra Kawles, Rachel Keszycki, Grace Minogue, Antonia Zouridakis, Ivan Ayala, Nathan Gill, Alyssa Macomber, Vivienne Lubbat, Christina Coventry, Emily Rogalski, Sandra Weintraub, Qinwen Mao, Margaret E Flanagan, Hui Zhang, Rudolph Castellani, Eileen H Bigio, M-Marsel Mesulam, Changiz Geula, Tamar Gefen
Pick's disease (PiD) is a subtype of the tauopathy form of frontotemporal lobar degeneration (FTLD-tau) characterized by intraneuronal 3R-tau inclusions. PiD can underly various dementia syndromes, including primary progressive aphasia (PPA), characterized by an isolated and progressive impairment of language and left-predominant atrophy, and behavioral variant frontotemporal dementia (bvFTD), characterized by progressive dysfunction in personality and bilateral frontotemporal atrophy. In this study, we investigated the neocortical and hippocampal distributions of Pick bodies in bvFTD and PPA to establish clinicopathologic concordance between PiD and the salience of the aphasic versus behavioral phenotype...
February 22, 2024: Acta Neuropathologica Communications
https://read.qxmd.com/read/38371357/-apoe-%C3%AE%C2%B54-allele-status-modulates-the-spatial-patterns-of-progressive-atrophy-in-the-temporal-lobes-after-mild-traumatic-brain-injury
#11
JOURNAL ARTICLE
Shuoqiu Gan, Yingxiang Sun, Kejia Liu, Xiaoyan Jia, Xuan Li, Ming Zhang, Lijun Bai
INTRODUCTION: We evaluated how the apolipoprotein E ( APOE ) ε4 allele modulated the spatial patterns of longitudinal atrophy in the Alzheimer's disease-vulnerable brain areas of patients with mild traumatic brain injury (mTBI) from the acute to chronic phase post injury. METHODS: Fifty-nine adult patients with acute mTBI and 48 healthy controls with APOE ε4 allele testing underwent T1-weighted magnetic resonance imaging and neuropsychological assessments with 6 to 12 months of follow-up...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/38363612/neuropsychiatric-symptoms-in-frontotemporal-dementia-more-than-just-noise
#12
JOURNAL ARTICLE
Daniele Altomare, Jasmine Rivolta, Ilenia Libri, Irene Mattioli, Valentina Cantoni, Alessandro Padovani, Barbara Borroni
BACKGROUND: Neuropsychiatric symptoms cause significant suffering and poor quality of life for patients and their caregivers. They are not considered specific to frontotemporal dementia (FTD); therefore, their clinical role and impact might be underestimated. OBJECTIVE: The aims of the present study are to: 1) describe the prevalence of neuropsychiatric symptoms in FTD starting from the prodromal stage, 2) define their association with disease severity, 3) identify symptoms which are unrelated to FTD-specific symptoms, and 4) assess their association with clinical features and outcomes...
February 13, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38359511/discriminating-nonfluent-agrammatic-and-logopenic-ppa-variants-with-automatically-extracted-morphosyntactic-measures-from-connected-speech
#13
JOURNAL ARTICLE
Sladjana Lukic, Zekai Fan, Adolfo M García, Ariane E Welch, Buddhika M Ratnasiri, Stephen M Wilson, Maya L Henry, Jet Vonk, Jessica Deleon, Bruce L Miller, Zachary Miller, Maria Luisa Mandelli, Maria Luisa Gorno-Tempini
Morphosyntactic assessments are important for characterizing individuals with nonfluent/agrammatic variant primary progressive aphasia (nfvPPA). Yet, standard tests are subject to examiner bias and often fail to differentiate between nfvPPA and logopenic variant PPA (lvPPA). Moreover, relevant neural signatures remain underexplored. Here, we leverage natural language processing tools to automatically capture morphosyntactic disturbances and their neuroanatomical correlates in 35 individuals with nfvPPA relative to 10 healthy controls (HC) and 26 individuals with lvPPA...
February 1, 2024: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://read.qxmd.com/read/38358112/comparing-high-definition-transcranial-direct-current-stimulation-to-left-temporoparietal-junction-and-left-inferior-frontal-gyrus-for-logopenic-primary-progressive-aphasia-a-single-case-study
#14
JOURNAL ARTICLE
Samuel J Crowley, Alexandru D Iordan, Kayla Rinna, Sami Barmada, Benjamin M Hampstead
Logopenic variant primary progressive aphasia (lvPPA) is characterized by word-finding deficits and phonologic errors in fluent speech. Transcranial direct current stimulation (tDCS) targeting either left temporoparietal junction (TPJ) or left inferior frontal gyrus (IFG) show evidence of improving language function in lvPPA. The present case study evaluated the effects of two separate rounds of high definition tDCS (HD-tDCS) (4 mA; 30 sessions) on language and functional neuroimaging in a 57-year-old woman with lvPPA...
February 15, 2024: Neuropsychological Rehabilitation
https://read.qxmd.com/read/38329409/-communication-is-difficult-speech-language-and-communication-needs-of-people-with-young-onset-or-rarer-forms-of-non-language-led-dementia
#15
JOURNAL ARTICLE
Anna Volkmer, Lisa Cross, Lily Highton, Connie Jackson, Chloe Smith, Emilie Brotherhood, Emma V Harding, Cath Mummery, Jonathan Rohrer, Rimona Weil, Keir Yong, Sebastian Crutch, Chris J D Hardy
BACKGROUND: People with behavioural variant frontotemporal dementia, Lewy body dementia, posterior cortical atrophy and young onset Alzheimer's disease may experience language and communication difficulties. However, the role of speech and language interventions for people with these non-language led dementias has received little attention. AIMS: This study aimed to explore the experiences and perspectives of people living with these conditions, and their families, regarding their language and communication difficulties and how speech and language therapy could address these needs...
February 8, 2024: International Journal of Language & Communication Disorders
https://read.qxmd.com/read/38327846/auditory-naming-is-impaired-in-posterior-cortical-atrophy-and-early-onset-alzheimer-s-disease
#16
JOURNAL ARTICLE
Deepti Putcha, Ana Eustace, Nicole Carvalho, Bonnie Wong, Megan Quimby, Bradford C Dickerson
INTRODUCTION: Visual naming ability reflects semantic memory retrieval and is a hallmark deficit of Alzheimer's disease (AD). Naming impairment is most prominently observed in the late-onset amnestic and logopenic variant Primary Progressive Aphasia (lvPPA) syndromes. However, little is known about how other patients across the atypical AD syndromic spectrum perform on tests of auditory naming, particularly those with primary visuospatial deficits (Posterior Cortical Atrophy; PCA) and early onset (EOAD) syndromes...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38324949/patterns-of-performance-on-the-animal-fluency-task-in-logopenic-variant-of-primary-progressive-aphasia-a-reflection-of-phonological-and-semantic-skills
#17
JOURNAL ARTICLE
Fatima Jebahi, Katlyn V Nickels, Aneta Kielar
PURPOSE: This study aimed to characterize the quantitative (total number of correct words generated) and qualitative (psycholinguistic properties of correct words generated) performance patterns on the animal fluency task in individuals with the logopenic variant of primary progressive aphasia and to investigate the influence of phonological and semantic abilities to these patterns. METHODS: Fifteen participants with lvPPA and twenty neurotypical adults completed the animal fluency task and an assessment battery to characterize their phonological and semantic abilities...
January 21, 2024: Journal of Communication Disorders
https://read.qxmd.com/read/38323346/are-pharmacotherapeutics-effective-for-treating-aphasia
#18
JOURNAL ARTICLE
Guadalupe Dávila, Marcelo L Berthier
INTRODUCTION: Aphasia is a communication disorder resulting from stroke and/or neurodegenerative conditions which involve the left cerebral hemisphere. It is a debilitating disorder affecting a person's ability to speak, understand, read, and write. Its impact on daily life necessitates therapeutic strategies to aid patients with aphasia. AREAS COVERED: In this special report, the authors speculate whether current pharmacotherapeutic strategies are effective in treating aphasia...
March 2024: Expert Review of Neurotherapeutics
https://read.qxmd.com/read/38319636/computer-based-naming-treatment-for-semantic-variant-primary-progressive-aphasia-with-history-of-traumatic-brain-injury-a-single-case-experimental-design
#19
JOURNAL ARTICLE
Gary Robinaugh, Maya L Henry, Robert Cavanaugh, Stephanie M Grasso
PURPOSE: The purpose of this study was to investigate the effectiveness of a self-administered naming treatment for one individual, B.N., presenting with semantic variant primary progressive aphasia (svPPA) and a history of traumatic brain injury (TBI). METHOD: Naming treatment included components of Lexical Retrieval Cascade Treatment and was self-administered using an adaptive spaced retrieval software, Anki. Using a multiple-baseline, single-case experimental design, naming accuracy probes were taken during pretreatment, treatment, posttreatment, and follow-up (through 12 months) for 60 trained words and 10 untrained words...
February 6, 2024: Journal of Speech, Language, and Hearing Research: JSLHR
https://read.qxmd.com/read/38305271/bridging-the-gap-between-scientific-research-of-rare-diseases-and-the-affected-patients-and-families
#20
JOURNAL ARTICLE
Olivia Lannom
In 2015, my father was diagnosed with primary progressive aphasia (PPA), a type of frontotemporal dementia that my family and I knew nothing about. Medical professionals told us that there was no research on the disease, and I believed this until very recently. I took a class in neurobiology, leading me to attempt to document this lack of research and create a call to action for the research and treatment of rare disorders. However, I was met with an overwhelming amount of information regarding PPA that I was not expecting to find...
February 2, 2024: Journal of Communication in Healthcare
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