Nick Corriveau-Lecavalier, Jeffrey L Gunter, Michael Kamykowski, Ellen Dicks, Hugo Botha, Walter K Kremers, Jonathan Graff-Radford, Daniela A Wiepert, Christopher G Schwarz, Essa Yacoub, David S Knopman, Bradley F Boeve, Kamil Ugurbil, Ronald C Petersen, Clifford R Jack, Melissa J Terpstra, David T Jones
From a complex systems perspective, clinical syndromes emerging from neurodegenerative diseases are thought to result from multiscale interactions between aggregates of misfolded proteins and the disequilibrium of large-scale networks coordinating functional operations underpinning cognitive phenomena. Across all syndromic presentations of Alzheimer's disease, age-related disruption of the default mode network is accelerated by amyloid deposition. Conversely, syndromic variability may reflect selective neurodegeneration of modular networks supporting specific cognitive abilities...
2023: Brain communications