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https://www.readbyqxmd.com/read/28205493/rethinking-the-cognitive-mechanisms-underlying-pantomime-of-tool-use-evidence-from-alzheimer-s-disease-and-semantic-dementia
#1
Mathieu Lesourd, Josselin Baumard, Christophe Jarry, Frédérique Etcharry-Bouyx, Serge Belliard, Olivier Moreaud, Bernard Croisile, Valérie Chauviré, Marine Granjon, Didier Le Gall, François Osiurak
OBJECTIVES: Pantomiming the use of familiar tools is a central test in the assessment of apraxia. However, surprisingly, the nature of the underlying cognitive mechanisms remains an unresolved issue. The aim of this study is to shed a new light on this issue by exploring the role of functional, mechanical, and manipulation knowledge in patients with Alzheimer's disease and semantic dementia and apraxia of tool use. METHODS: We performed multiple regression analyses with the global performance and the nature of errors (i...
February 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28100023/frontotemporal-lobar-degeneration-pathogenesis-pathology-and-pathways-to-phenotype
#2
REVIEW
David Ma Mann, Julie S Snowden
Frontotemporal Lobar Degeneration (FTLD) is a clinically, pathologically and genetically heterogeneous group of disorders that affect principally the frontal and temporal lobes of the brain. There are three major associated clinical syndromes, behavioural variant frontotemporal dementia (bvFTD), semantic dementia (SD) and progressive non-fluent aphasia (PNFA); three principal histologies, involving tau, TDP-43 and FUS proteins; and mutations in three major genes, MAPT, GRN and C9orf72, along with several other less common gene mutations...
January 18, 2017: Brain Pathology
https://www.readbyqxmd.com/read/28093855/typical-and-atypical-appearance-of-early-onset-alzheimer-s-disease-a-clinical-neuroimaging-and-neuropathological-study-symposium-fundamentals-learned-from-diversity-among-typical-and-atypical-appearances
#3
Shinobu Kawakatsu 川勝 忍, Ryota Kobayashi, Hiroshi Hayashi
The International Working Group (IWG) has classified Alzheimer's disease (AD) as two different types, the typical form and the atypical form, but clinicopathological studies of atypical AD are limited. Because atypical AD cases usually present with early-onset dementia, we investigated 12 patients with early-onset AD, including two patients with typical AD and 10 patients with atypical AD. Of these patients, six had the posterior variant, three had the frontal variant and one had the logopenic variant mixed with semantic dementia...
January 17, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28059782/differential-hemispheric-predilection-of%C3%A2-microstructural-white-matter-and%C3%A2-functional-connectivity-abnormalities-between-respectively-semantic-and%C3%A2-behavioral-variant-frontotemporal-dementia
#4
Rozanna Meijboom, Rebecca M E Steketee, Leontine S Ham, Aad van der Lugt, John C van Swieten, Marion Smits
Semantic dementia (SD) and behavioral variant frontotemporal dementia (bvFTD), subtypes of frontotemporal dementia, are characterized by distinct clinical symptoms and neuroimaging features, with predominant left temporal grey matter (GM) atrophy in SD and bilateral or right frontal GM atrophy in bvFTD. Such differential hemispheric predilection may also be reflected by other neuroimaging features, such as brain connectivity. This study investigated white matter (WM) microstructure and functional connectivity differences between SD and bvFTD, focusing on the hemispheric predilection of these differences...
December 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28019640/semantic-dementia-a-mini-review
#5
Blanka Klimova, Michal Novotny, Kamil Kuca
BACKGROUND: At present there are about 47.5 million people suffering from different types of dementia and by 2030 this number should reach 75.6 million. This obviously brings about serious social and economic burden for people suffering from any kind of dementia. OBJECTIVE: The purpose of this article is to explore only semantic dementia (SD) as one of the forms of frontotemporal dementia (FTD) and provide the latest information on its diagnosis and treatment which play a significant role in the maintenance of quality of life of both patients and their caregivers...
December 23, 2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28017247/clinical-characteristics-of-parkinsonism-in-frontotemporal-dementia-according-to-subtypes
#6
Hee Kyung Park, Kee Hyung Park, Bora Yoon, Jae-Hong Lee, Seong Hye Choi, Jee H Joung, Soo Jin Yoon, Byeong C Kim, Seung Hyun Kim, Eun-Joo Kim, Duk L Na, Kyung Won Park
BACKGROUND: We investigated the prevalence of parkinsonism in frontotemporal dementia (FTD) subtypes and the cognitive and behavioral differences between FTD with and without parkinsonism in a well-structured, prospective cohort. METHODS: One hundred and ninety-one FTD patients were enrolled and all patients underwent comprehensive neurological evaluations, neuropsychological tests, and the Unified Parkinson's Disease Rating Scale. RESULTS: The prevalence of parkinsonism was 38...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27981671/distinct-white-matter-injury-associated-with-medial-temporal-lobe-atrophy-in-alzheimer-s-versus-semantic-dementia
#7
Alexandre Bejanin, Béatrice Desgranges, Renaud La Joie, Brigitte Landeau, Audrey Perrotin, Florence Mézenge, Serge Belliard, Vincent de La Sayette, Francis Eustache, Gaël Chételat
This study aims at further understanding the distinct vulnerability of brain networks in Alzheimer's disease (AD) versus semantic dementia (SD) investigating the white matter injury associated with medial temporal lobe (MTL) atrophy in both conditions. Twenty-six AD patients, twenty-one SD patients, and thirty-nine controls underwent a high-resolution T1-MRI scan allowing to obtain maps of grey matter volume and white matter density. A statistical conjunction approach was used to identify MTL regions showing grey matter atrophy in both patient groups...
December 16, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27920731/do-you-read-how-i-read-systematic-individual-differences-in-semantic-reliance-amongst-normal-readers
#8
Anna M Woollams, Matthew A Lambon Ralph, Gaston Madrid, Karalyn E Patterson
The extent to which meaning is involved in reading aloud has proven an area of longstanding debate, and current computational models differ on this dimension. The connectionist triangle model proposes that normal individuals rely on semantic information for correct reading of words with atypical spelling-sound relationships, but to varying degrees. This proposed individual difference would account for the varying stage of decline at which patients with semantic dementia first show the reading impairment known as surface dyslexia...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27916672/famous-faces-and-voices-differential-profiles-in-early-right-and-left-semantic-dementia-and-in-alzheimer-s-disease
#9
Simona Luzzi, Sara Baldinelli, Valentina Ranaldi, Katia Fabi, Viviana Cafazzo, Fabio Fringuelli, Mauro Silvestrini, Leandro Provinciali, Carlo Reverberi, Guido Gainotti
BACKGROUND: Famous face and voice recognition is reported to be impaired both in semantic dementia (SD) and in Alzheimer's Disease (AD), although more severely in the former. In AD a coexistence of perceptual impairment in face and voice processing has also been reported and this could contribute to the altered performance in complex semantic tasks. On the other hand, in SD both face and voice recognition disorders could be related to the prevalence of atrophy in the right temporal lobe (RTL)...
January 8, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/27915998/an-update-on-semantic-dementia-genetics-imaging-and-pathology
#10
REVIEW
Ramon Landin-Romero, Rachel Tan, John R Hodges, Fiona Kumfor
Progressive and relatively circumscribed loss of semantic knowledge, referred to as semantic dementia (SD) which falls under the broader umbrella of frontotemporal dementia, was officially identified as a clinical syndrome less than 50 years ago. Here, we review recent neuroimaging, pathological, and genetic research in SD. From a neuroimaging perspective, SD is characterised by hallmark asymmetrical atrophy of the anterior temporal pole and anterior fusiform gyrus, which is usually left lateralised. Functional magnetic resonance imaging (fMRI) studies have revealed widespread changes in connectivity, implicating the anterior temporal regions in semantic deficits in SD...
December 5, 2016: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/27908787/fractionating-the-anterior-temporal-lobe-mvpa-reveals-differential-responses-to-input-and-conceptual-modality
#11
Charlotte Murphy, Shirley-Ann Rueschemeyer, David Watson, Theodoros Karapanagiotidis, Jonathan Smallwood, Elizabeth Jefferies
Words activate cortical regions in accordance with their modality of presentation (i.e., written vs. spoken), yet there is a long-standing debate about whether patterns of activity in any specific brain region capture modality-invariant conceptual information. Deficits in patients with semantic dementia highlight the anterior temporal lobe (ATL) as an amodal store of semantic knowledge but these studies do not permit precise localisation of this function. The current investigation used multiple imaging methods in healthy participants to examine functional dissociations within ATL...
February 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/27802229/diverging-progression-of-network-disruption-and-atrophy-in-alzheimer-s-disease-and-semantic-dementia
#12
Jennifer Andreotti, Thomas Dierks, Lars-Olof Wahlund, Matthias Grieder
The progression of cognitive deficits in Alzheimer's disease and semantic dementia is accompanied by grey matter atrophy and white matter deterioration. The impact of neuronal loss on the structural network connectivity in these dementia subtypes is, however, not well understood. In order to gain a more refined knowledge of the topological organization of white matter alterations in dementia, we used a network-based approach to analyze the brain's structural connectivity network. Diffusion-weighted and anatomical MRI images of groups with eighteen Alzheimer's disease and six semantic dementia patients, as well as twenty-one healthy controls were recorded to reconstruct individual connectivity networks...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27677318/successful-short-term-re-learning-and-generalisation-of-concepts-in-semantic-dementia
#13
Aida Suárez-González, Sharon A Savage, Diana Caine
Patients with semantic dementia (SD) can rapidly and successfully re-learn word labels during cognitive intervention. This new learning, however, usually remains rigid and context-dependent. Conceptual enrichment (COEN) training is a therapy approach aimed to produce more flexible and generalisable learning in SD. In this study we compare generalisation and maintenance of learning after COEN with performance achieved using a classical naming therapy (NT). The study recruited a 62-year-old woman with SD. An AB1ACAB2 experimental design was implemented, with naming performance assessed at baseline, post- intervention, 3 and 6 weeks after the end of each treatment phase...
September 28, 2016: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/27647568/somatic-symptom-disorder-in-semantic-dementia-the-role-of-alexisomia
#14
Joanna J Gan, Andrew Lin, Mersal S Samimi, Mario F Mendez
BACKGROUND: Semantic dementia (SD) is a neurodegenerative disorder characterized by loss of semantic knowledge. SD may be associated with somatic symptom disorder due to excessive preoccupation with unidentified somatic sensations. OBJECTIVE: To evaluate the frequency of somatic symptom disorder among patients with SD in comparison to comparably demented patients with Alzheimer׳s disease. METHODS: A retrospective cohort study was conducted using clinical data from a referral-based behavioral neurology program...
November 2016: Psychosomatics
https://www.readbyqxmd.com/read/27642207/what-matters-in-semantic-feature-processing-for-persons-with-stroke-aphasia-evidence-from-an-auditory-concept-feature-verification-task
#15
Sharon M Antonucci
BACKGROUND: The relationship between object concept domains (living vs. nonliving) and their underlying feature structures is a frequent area of investigation regarding semantic processing in healthy individuals and some individuals with neuropsychological impairment resulting from herpes simplex encephalitis, semantic dementia and Alzheimer's disease. However, this relationship has been less well-investigated in persons with stroke-aphasia (PWA), even though many treatments for anomia following stroke are predicated on the use of semantic feature cues...
2014: Aphasiology
https://www.readbyqxmd.com/read/27630558/anatomical-correlates-of-non-verbal-perception-in-dementia-patients
#16
Pin-Hsuan Lin, Hsiu-Hui Chen, Nai-Ching Chen, Wen-Neng Chang, Chi-Wei Huang, Ya-Ting Chang, Shih-Wei Hsu, Che-Wei Hsu, Chiung-Chih Chang
PURPOSE: Patients with dementia who have dissociations in verbal and non-verbal sound processing may offer insights into the anatomic basis for highly related auditory modes. METHODS: To determine the neuronal networks on non-verbal perception, 16 patients with Alzheimer's dementia (AD), 15 with behavior variant fronto-temporal dementia (bv-FTD), 14 with semantic dementia (SD) were evaluated and compared with 15 age-matched controls. Neuropsychological and auditory perceptive tasks were included to test the ability to compare pitch changes, scale-violated melody and for naming and associating with environmental sound...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27567843/atrophy-in-alzheimer-s-disease-and%C3%A2-semantic-dementia-an-ale-meta-analysis-of-voxel-based-morphometry-studies
#17
Marianne Chapleau, Joséphine Aldebert, Maxime Montembeault, Simona M Brambati
BACKGROUND/OBJECTIVES: Alzheimer's disease (AD) and semantic dementia (SD) have distinct episodic memory profiles despite the hippocampal atrophy that characterizes both diseases. The aim of this study was to delineate the pattern of gray matter (GM) atrophy associated with AD and SD as well as any differences in these patterns by pooling together the results of previous voxel-based morphometry (VBM) studies.Methods/Overview: We conducted a meta-analysis of VBM studies that investigated GM atrophy in AD patients versus controls (CTRLs) and in SD patients versus CTRLs using the activation likelihood estimation (ALE) approach...
October 4, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27489094/prosopagnosia-as-unusual-presentation-of-semantic-dementia-a-case-study
#18
Viviana Lo Buono, Francesco Corallo, Angela Marra, Rocco Salvatore Calabrò, Placido Bramanti, Silvia Marino
OBJECT: Semantic dementia is one of the main clinical variants of frontotemporal dementia and it is characterized by severe loss of conceptual knowledge with relative preservation of other cortical abilities. METHODS: We described a case of a patient affected by right temporal variant of frontotemporal lobar degeneration, characterized by prosopagnosia as an unusual disease onset. RESULTS: The neuropsychological evaluation showed a progressive deficit in face recognition and a slow decline in language in the absence of behavioral alterations...
August 4, 2016: Acta Clinica Belgica
https://www.readbyqxmd.com/read/27445249/case-studies-illustrating-focal-alzheimer-s-fluent-aphasia-late-onset-memory-loss-and-rapid-dementia
#19
REVIEW
Gamze Balci Camsari, Melissa E Murray, Neill R Graff-Radford
Many dementia subtypes have more shared signs and symptoms than defining ones. We review 8 cases with 4 overlapping syndromes and demonstrate how to distinguish the cases. These include focal cortical presentations of Alzheimer's disease (AD; posterior cortical atrophy and corticobasal syndrome [CBS]), fluent aphasia (semantic dementia and logopenic aphasia), late-onset slowly progressive dementia (hippocampal sclerosis and limbic predominant AD) and rapidly progressive dementia (Creutzfeldt-Jakob disease and limbic encephalitis)...
August 2016: Neurologic Clinics
https://www.readbyqxmd.com/read/27381147/integrated-pet-mri-imaging-of-semantic-dementia
#20
Amarnath Jena, Sangeeta Taneja, Aashish Gambhir, Pushpendra N Renjen
No abstract text is available yet for this article.
July 2016: Neurology India
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