Ivica Premuzic Mestrovic, Ivan Maria Smoday, Luka Kalogjera, Ivan Krezic, Helena Zizek, Hrvoje Vranes, Vlasta Vukovic, Katarina Oroz, Ivan Skorak, Ivan Brizic, Klaudija Hriberski, Luka Novosel, Ivana Kavelj, Ivan Barisic, Lidija Beketic Oreskovic, Slavica Zubcic, Sanja Strbe, Tomislav Mestrovic, Predrag Pavic, Mario Staresinic, Anita Skrtic, Alenka Boban Blagaic, Sven Seiwerth, Predrag Sikiric
We focused on the first demonstration that antiarrhythmics, particularly class II and class III antiarrhythmic and beta-blocker sotalol can induce severe occlusion/occlusion-like syndrome in rats. In this syndrome, as in similar syndromes with permanent occlusion of major vessels, peripheral and central, and other similar noxious procedures that severely disable endothelium function, the stable gastric pentadecapeptide BPC 157-collateral pathways activation, was a resolving therapy. After a high dose of sotalol (80 mg/kg intragastrically) in 180 min study, there were cause-consequence lesions in the brain (swelling, intracerebral hemorrhage), congestion in the heart, lung, liver, kidney, and gastrointestinal tract, severe bradycardia, and intracranial (superior sagittal sinus), portal and caval hypertension, and aortal hypotension, and widespread thrombosis, peripherally and centrally...
July 7, 2023: Pharmaceuticals