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Ian Piper

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https://www.readbyqxmd.com/read/29492577/visualizing-cerebrovascular-autoregulation-insults-and-their-association-with-outcome-in-adult-and-paediatric-traumatic-brain-injury
#1
Marine Flechet, Geert Meyfroidt, Ian Piper, Giuseppe Citerio, Iain Chambers, Patricia A Jones, Tsz-Yan Milly Lo, Per Enblad, Pelle Nilsson, Bart Feyen, Philippe Jorens, Andrew Maas, Martin U Schuhmann, Rob Donald, Laura Moss, Greet Van den Berghe, Bart Depreitere, Fabian Güiza
OBJECTIVE:   The aim of this study is to assess visually the impact of duration and intensity of cerebrovascular autoregulation insults on 6-month neurological outcome in severe traumatic brain injury. MATERIAL AND METHODS:   Retrospective analysis of prospectively collected minute-by-minute intracranial pressure (ICP) and mean arterial blood pressure data of 259 adult and 99 paediatric traumatic brain injury (TBI) patients from multiple European centres. The relationship of the 6-month Glasgow Outcome Scale with cerebrovascular autoregulation insults (defined as the low-frequency autoregulation index above a certain threshold during a certain time) was visualized in a colour-coded plot...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29492562/investigation-of-the-relationship-between-the-burden-of-raised-icp-and-the-length-of-stay-in-a-neuro-intensive-care-unit
#2
Martin Shaw, Laura Moss, Chris Hawthorne, John Kinsella, Ian Piper
OBJECTIVES: Raised intracranial pressure (ICP) is well known to be indicative of a poor outcome in traumatic brain injury (TBI). This phenomenon was quantified using a pressure time index (PTI) model of raised ICP burden in a paediatric population. Using the PTI methodology, this pilot study is aimed at investigating the relationship between raised ICP and length of stay (LOS) in adults admitted to a neurological intensive care unit (neuro-ICU). MATERIALS AND METHODS: In 10 patients admitted to the neuro-ICU following TBI, ICP was measured and data from the first 24 h were analysed...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29492558/medical-waveform-format-encoding-rules-representation-of-neurointensive-care-waveform-data
#3
Ian Piper, Martin Shaw, Christopher Hawthorne, John Kinsella, Laura Moss
OBJECTIVE: Technology in neurointensive care units can collect and store vast amounts of complex patient data. The CHART-ADAPT project is aimed at developing technology that will allow for the collection, analysis and use of these big data at the patient's bedside in neurointensive care units. A requirement of this project is to automatically extract and transfer high-frequency waveform data (e.g. ICP) from monitoring equipment to high performance computing infrastructure for analysis...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29492539/transcranial-bioimpedance-measurement-as-a-non-invasive-estimate-of-intracranial-pressure
#4
Christopher Hawthorne, Martin Shaw, Ian Piper, Laura Moss, John Kinsella
OBJECTIVES: We have previously demonstrated a relationship between transcranial bioimpedance (TCB) measurements and intracranial pressure (ICP) in an animal model of raised ICP. The primary objective of this study was to explore the relationship between non-invasive bioelectrical impedance measurements of the brain and skull and ICP in traumatic brain injury (TBI) patients. MATERIALS AND METHODS: Included patients were adults admitted to the Neurological Intensive Care Unit with TBI and undergoing invasive ICP monitoring as part of their routine clinical care...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29492521/cerebral-perfusion-pressure-variability-between-patients-and-between-centres
#5
Bart Depreitere, Fabian Güiza, Ian Piper, Giuseppe Citerio, Iain Chambers, Patricia A Jones, Tsz-Yan M Lo, Per Enblad, Pelle Nilsson, Bart Feyen, Philippe Jorens, Andrew Maas, Martina U Schuhmann, Rob Donald, Laura Moss, Greet Van den Berghe, Geert Meyfroidt
INTRODUCTION:  The aim of this analysis was to investigate to what extent median cerebral perfusion pressure (CPP) differs between severe traumatic brain injury (TBI) patients and between centres, and whether the 2007 change in CPP threshold in the Brain Trauma Foundation guidelines is reflected in patient data collected at several centres over different time periods. METHODS:  Data were collected from the Brain-IT database, a multi-centre project between 2003 and 2005, and from a recent project in four centres between 2009 and 2013...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29184720/risk-factors-for-wound-complications-following-spine-surgery
#6
Keaton F Piper, Samuel B Tomlinson, Gabrielle Santangelo, Joseph Van Galen, Ian DeAndrea-Lazarus, James Towner, Kristopher T Kimmell, Howard Silberstein, George Edward Vates
Background: Wound complications, including surgical site infections (SSIs) and wound dehiscence, are among the most common complications following spine surgery often leading to readmission. The authors sought to identify preoperative characteristics predictive of wound complications after spine surgery. Methods: The American College of Surgeons National Surgical Quality Improvement Program database for years 2012-2014 was reviewed for patients undergoing spine surgery, defined by the Current Procedural Terminology codes...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29162528/risk-factors-associated-with-readmission-and-reoperation-in-patients-undergoing-spine-surgery
#7
Keaton Piper, Ian DeAndrea-Lazarus, Hanna Algattas, Kristopher T Kimmell, James Towner, Yan M Li, Kevin Walter, George E Vates
OBJECTIVE: Reoperation and readmission are often avoidable, costly, and difficult to predict. We sought to identify risk factors for readmission and reoperation after spine surgery and to use these factors to develop a scoring system predictive of readmission and reoperation. METHODS: The National Surgical Quality Improvement Project database for years 2012 to 2014 was reviewed for patients undergoing spinal surgery, and 68 perioperative characteristics were analyzed...
February 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29119473/preference-of-oral-tenofovir-disoproxil-fumarate-emtricitabine-versus-rectal-tenofovir-reduced-glycerin-1-gel-regimens-for-hiv-prevention-among-cisgender-men-and-transgender-women-who-engage-in-receptive-anal-intercourse-with-men
#8
Alex Carballo-Diéguez, Rebecca Giguere, Curtis Dolezal, Cheng-Shiun Leu, Iván C Balán, William Brown, Christine Rael, Barbra A Richardson, Jeanna M Piper, Linda-Gail Bekker, Suwat Chariyalertsak, Anupong Chitwarakorn, Pedro Gonzales, Timothy H Holtz, Albert Liu, Kenneth H Mayer, Carmen D Zorrilla, Javier R Lama, Ian McGowan, Ross D Cranston
Oral pre-exposure prophylaxis (PrEP) can prevent HIV transmission. Yet, some may prefer not to take systemic daily medication. MTN-017 was a 3-period, phase 2 safety and acceptability study of microbicide gel applied rectally either daily or before and after receptive anal intercourse (RAI), compared to daily oral tablet. At baseline, cisgender men and transgender women who reported RAI (N = 187) rated the daily oral regimen higher in overall liking, ease of use, and likelihood of future use than the gel regimens...
December 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29076032/brief-participant-centered-convergence-interviews-integrate-self-reports-product-returns-and-pharmacokinetic-results-to-improve-adherence-measurement-in-mtn-017
#9
Iván C Balán, Rebecca Giguere, William Brown, Alex Carballo-Diéguez, Stephanie Horn, Craig W Hendrix, Mark A Marzinke, Ratiya Pamela Kunjara Na Ayudhya, Karen Patterson, Jeanna M Piper, Ian McGowan, Javier R Lama, Ross D Cranston
MTN-017 compared the safety and acceptability of daily oral emtricitabine/tenofovir disoproxil fumarate, daily reduced-glycerin 1% tenofovir gel applied rectally, and the same gel applied before and after receptive anal intercourse. The Data Convergence Interview (DCI) and the Pharmacokinetic Data Convergence Interview (PK-DCI) were brief, collaborative interactions conducted with participants during adherence counseling sessions to improve accurate measurement of adherence to study product use. DCIs converged data from product return counts and participants' responses to daily text messages...
October 26, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28750059/high-levels-of-adherence-to-a-rectal-microbicide-gel-and-to-oral-pre-exposure-prophylaxis-prep-achieved-in-mtn-017-among-men-who-have-sex-with-men-msm-and-transgender-women
#10
RANDOMIZED CONTROLLED TRIAL
Alex Carballo-Diéguez, Ivan C Balán, William Brown, Rebecca Giguere, Curtis Dolezal, Cheng-Shiun Leu, Mark A Marzinke, Craig W Hendrix, Jeanna M Piper, Barbra A Richardson, Cynthia Grossman, Sherri Johnson, Kailazarid Gomez, Stephanie Horn, Ratiya Pamela Kunjara Na Ayudhya, Karen Patterson, Cindy Jacobson, Linda-Gail Bekker, Suwat Chariyalertsak, Anupong Chitwarakorn, Pedro Gonzales, Timothy H Holtz, Albert Liu, Kenneth H Mayer, Carmen Zorrilla, Javier Lama, Ian McGowan, Ross D Cranston
Trials to assess microbicide safety require strict adherence to prescribed regimens. If adherence is suboptimal, safety cannot be adequately assessed. MTN-017 was a phase 2, randomized sequence, open-label, expanded safety and acceptability crossover study comparing 1) daily oral emtricitabine/tenofovir disoproxil fumarate (FTC/TDF), 2) daily use of reduced-glycerin 1% tenofovir (RG-TFV) gel applied rectally, and 3) RG-TFV gel applied before and after receptive anal intercourse (RAI)-if participants had no RAI in a week, they were asked to use two doses of gel within 24 hours...
2017: PloS One
https://www.readbyqxmd.com/read/28385097/cerebral-perfusion-pressure-insults-and-associations-with-outcome-in-adult-traumatic-brain-injury
#11
Fabian Güiza, Geert Meyfroidt, Ian Piper, Giuseppe Citerio, Iain Chambers, Per Enblad, Pelle Nillson, Bart Feyen, Philippe Jorens, Andrew Maas, Martin U Schuhmann, Rob Donald, Laura Moss, Greet Van den Berghe, Bart Depreitere
The definition of cerebral perfusion pressure (CPP) secondary insults in severe traumatic brain injury remains unclear. The purpose of the present study is to visualize the association of intensity and duration of episodes below or above CPP thresholds and outcome. The analysis was based on prospectively collected minute-by-minute intracranial pressure (ICP) and blood pressure data and outcome from 259 adult patients. The relationship of episodes of CPP below or above a certain threshold for certain duration with the 6-month Glasgow Outcome Score was visualized separately for episodes of active or deficient autoregulation (AR)...
August 15, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28282371/increasing-efficiency-of-preclinical-research-by-group-sequential-designs
#12
Konrad Neumann, Ulrike Grittner, Sophie K Piper, Andre Rex, Oscar Florez-Vargas, George Karystianis, Alice Schneider, Ian Wellwood, Bob Siegerink, John P A Ioannidis, Jonathan Kimmelman, Ulrich Dirnagl
Despite the potential benefits of sequential designs, studies evaluating treatments or experimental manipulations in preclinical experimental biomedicine almost exclusively use classical block designs. Our aim with this article is to bring the existing methodology of group sequential designs to the attention of researchers in the preclinical field and to clearly illustrate its potential utility. Group sequential designs can offer higher efficiency than traditional methods and are increasingly used in clinical trials...
March 2017: PLoS Biology
https://www.readbyqxmd.com/read/28253393/comparison-of-pharmaceutical-psychological-and-exercise-treatments-for-cancer-related-fatigue-a-meta-analysis
#13
REVIEW
Karen M Mustian, Catherine M Alfano, Charles Heckler, Amber S Kleckner, Ian R Kleckner, Corinne R Leach, David Mohr, Oxana G Palesh, Luke J Peppone, Barbara F Piper, John Scarpato, Tenbroeck Smith, Lisa K Sprod, Suzanne M Miller
Importance: Cancer-related fatigue (CRF) remains one of the most prevalent and troublesome adverse events experienced by patients with cancer during and after therapy. Objective: To perform a meta-analysis to establish and compare the mean weighted effect sizes (WESs) of the 4 most commonly recommended treatments for CRF-exercise, psychological, combined exercise and psychological, and pharmaceutical-and to identify independent variables associated with treatment effectiveness...
July 1, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28245852/reverse-shoulder-arthroplasty-for-the-treatment-of-proximal-humeral-fractures-in-the-elderly-reshape-trial-study-protocol-for-a-multicentre-combined-randomised-controlled-and-observational-trial
#14
Geoffrey C S Smith, Ed Bateman, Ben Cass, Maurizio Damiani, Wade Harper, Hugh Jones, David Lieu, Jeff Petchell, Minas Petrelis, Kalman Piper, Doron Sher, Christopher J Smithers, John Trantalis, Sindy Vrancic, Ian A Harris
BACKGROUND: Proximal humeral fractures are common in older patients. The majority are minimally displaced and are associated with good outcomes after nonoperative treatment. Poorer outcomes are associated with displaced, multipart fractures. There is no clear benefit from surgical fracture fixation compared to nonoperative treatment. Replacement of the fractured humeral head with a hemiarthroplasty is another treatment option, but has not been shown to be clearly superior to nonoperative treatment or internal fixation...
February 28, 2017: Trials
https://www.readbyqxmd.com/read/27986684/mtn-017-a-rectal-phase-2-extended-safety-and-acceptability-study-of-tenofovir-reduced-glycerin-1-gel
#15
RANDOMIZED CONTROLLED TRIAL
Ross D Cranston, Javier R Lama, Barbra A Richardson, Alex Carballo-Diéguez, Ratiya Pamela Kunjara Na Ayudhya, Karen Liu, Karen B Patterson, Cheng-Shiun Leu, Beth Galaska, Cindy E Jacobson, Urvi M Parikh, Mark A Marzinke, Craig W Hendrix, Sherri Johnson, Jeanna M Piper, Cynthia Grossman, Ken S Ho, Jonathan Lucas, Jim Pickett, Linda-Gail Bekker, Suwat Chariyalertsak, Anupong Chitwarakorn, Pedro Gonzales, Timothy H Holtz, Albert Y Liu, Kenneth H Mayer, Carmen Zorrilla, Jill L Schwartz, James Rooney, Ian McGowan
Background: Human immunodeficiency virus (HIV) disproportionately affects men who have sex with men (MSM) and transgender women (TGW). Safe and acceptable topical HIV prevention methods that target the rectum are needed. Methods: MTN-017 was a phase 2, 3-period, randomized sequence, open-label, expanded safety and acceptability crossover study comparing rectally applied reduced-glycerin (RG) 1% tenofovir (TFV) and oral emtricitabine/TFV disoproxil fumarate (FTC/TDF)...
March 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27851213/1578-public-perception-of-the-use-of-critical-care-patient-data-beyond-treatment-a-pilot-study
#16
John Kinsella, Martin Shaw, Christopher Hawthorne, Ian Piper, Richard Elliott, Christine Lee, Laura Moss
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850399/761-improvements-to-the-optimal-cerebral-perfusion-pressure-calculation
#17
Christopher Hawthorne, Martin Shaw, Laura Moss, Ian Piper, Richard Elliott, Christine Lee, John Kinsella
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27632671/early-detection-of-increased-intracranial-pressure-episodes-in-traumatic-brain-injury-external-validation-in-an-adult-and-in-a-pediatric-cohort
#18
MULTICENTER STUDY
Fabian Güiza, Bart Depreitere, Ian Piper, Giuseppe Citerio, Philippe G Jorens, Andrew Maas, Martin U Schuhmann, Tsz-Yan Milly Lo, Rob Donald, Patricia Jones, Gottlieb Maier, Greet Van den Berghe, Geert Meyfroidt
OBJECTIVE: A model for early detection of episodes of increased intracranial pressure in traumatic brain injury patients has been previously developed and validated based on retrospective adult patient data from the multicenter Brain-IT database. The purpose of the present study is to validate this early detection model in different cohorts of recently treated adult and pediatric traumatic brain injury patients. DESIGN: Prognostic modeling. Noninterventional, observational, retrospective study...
March 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/27588916/risk-factors-associated-with-venous-thromboembolism-in-patients-undergoing-spine-surgery
#19
Keaton Piper, Hanna Algattas, Ian A DeAndrea-Lazarus, Kristopher T Kimmell, Yan Michael Li, Kevin A Walter, Howard J Silberstein, G Edward Vates
OBJECTIVE Patients undergoing spinal surgery are at risk for developing venous thromboembolism (VTE). The authors sought to identify risk factors for VTE in these patients. METHODS The American College of Surgeons National Surgical Quality Improvement Project database for the years 2006-2010 was reviewed for patients who had undergone spinal surgery according to their primary Current Procedural Terminology code(s). Clinical factors were analyzed to identify associations with VTE. RESULTS Patients who underwent spinal surgery (n = 22,434) were identified...
January 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27499914/nottingham-prognostic-index-plus-validation-of-a-clinical-decision-making-tool-in-breast-cancer-in-an-independent-series
#20
Andrew R Green, Daniele Soria, Jacqueline Stephen, Desmond G Powe, Christopher C Nolan, Ian Kunkler, Jeremy Thomas, Gillian R Kerr, Wilma Jack, David Cameron, Tammy Piper, Graham R Ball, Jonathan M Garibaldi, Emad A Rakha, John Ms Bartlett, Ian O Ellis
The Nottingham Prognostic Index Plus (NPI+) is a clinical decision making tool in breast cancer (BC) that aims to provide improved patient outcome stratification superior to the traditional NPI. This study aimed to validate the NPI+ in an independent series of BC. Eight hundred and eighty five primary early stage BC cases from Edinburgh were semi-quantitatively assessed for 10 biomarkers [Estrogen Receptor (ER), Progesterone Receptor (PgR), cytokeratin (CK) 5/6, CK7/8, epidermal growth factor receptor (EGFR), HER2, HER3, HER4, p53, and Mucin 1] using immunohistochemistry and classified into biological classes by fuzzy logic-derived algorithms previously developed in the Nottingham series...
January 2016: Journal of Pathology. Clinical Research
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